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Notes from The Chairman Concerning ISCO Price Fluctuations

Posted: October 31, 2010 at 9:06 am


As a matter of policy, we at ISCO refrain from commenting on movements in the price of our stock. However, events yesterday were so unusual and have resulted in so many questions, that I think it is our duty to our shareholders to tell you what we know.

As best we can determine, Patrick Cox, who has been and continues to be a strong supporter of our company, was required yesterday by his publisher to cease coverage of our stock and issue a sell recommendation because he has an equity interest in a company with which we do business that could have been perceived as a conflict of interest. That has resulted in numerous negative comments on investor message boards that referred to the sell recommendation without giving the background or a full explanation. As a result, I felt it was important that we put the day's events into proper context. The following are what I believe to be the relevant excerpts from Patrick's article:

As you know, I've been a huge promoter of International Stem Cell Corp.'s (OTCBB: ISCO) parthenogenic stem cell technology. I've not only told you about the company, but I appeared on John Mauldin's podcast show with ISCO board chairman Ken Aldrich about six months ago. Aldrich and Mauldin subsequently became friends and found that their organizations were a perfect fit for marketing ISCO's cosmeceutical skin care product.

John Mauldin asked me to be a part of that organization. We looked hard at Agora Financial's policies as well as applicable SEC regulations and concluded that there would be no conflict of interest because the position gave me no direct interest in ISCO or its stock price....

My publisher, however, has grown increasingly uncomfortable with this arrangement. The reason is not that Agora Financial believes that there would be an actual conflict of interest. Rather, it is that it might be perceived as one by some, in particular SEC lawyers....

My publisher's trading policy's aim, however, is to keep me purely objective and disinterested. This policy is debatable, but I respect it. My only option, therefore, is to issue a sell order or face the wrath of a disappointed spouse.

You can probably guess what that means. I'm going to have to issue a sell order.

Patrick followed that with a supplement, in which he said, in part,

Just to re-iterate, now that I've seen the price action from this afternoon's sell alert, I'm not parting with the shares of International Stem Cell Corp. (OTCBB: ISCO) because I believe they are a bad investment (my feelings, as you probably know, are quite the opposite)...ISCO still has the transformational potential that I've told you about. The only real change is that I won't be able to update you from here on out -- due to an over abundance of caution from my publisher.

Obviously, we can't know for certain if these articles caused the price movement yesterday, but we believe they were a major factor. Moreover, the comments and the response of investors to them are beyond our control, but we do want to reassure all interested parties that there is no information of which we are aware to justify the price fluctuation that occurred yesterday.

I hope this will prove helpful.

Sincerely,

Ken Aldrich

Chairman

FORWARD-LOOKING STATEMENTS:

Statements pertaining to anticipated developments, the potential benefits of collaborations, affiliations, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products and the management of collaborations, regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update forward-looking statements.

International Stem Cell Corporation Announces Completion of Its First Manufacturing Run of Lifeline Skin Care’s Stem Cell-Based Skin Rejuvenation…

Posted: at 9:06 am


International Stem Cell Corporation Announces Completion of Its First Manufacturing Run of Lifeline Skin Care's Stem Cell-Based Skin Rejuvenation Products

International Stem Cell Corporation (OTCBB:ISCO), http://www.internationalstemcell.com, announced today that its wholly-owned subsidiary, Lifeline Skin Care, Inc., in partnership with an experienced OTC drug licensed manufacturer of cosmetic products, successfully manufactured its first scaled-up lots of stem cell-based skin creams, confirming that these unique products can be made in larger batch quantities and continue to meet Lifeline's high quality standards. This marks an important milestone in proving that two new technologies, the derivation of human parthenogenetic stem cells, and the packaging and delivery of critical anti-aging ingredients, including those derived from stem cells, can be scaled-up into a level of production suitable to meet commercial levels of demand.

Lifeline Skin Care's product development scientists have combined human parthenogenetic stem cell technology with the latest discoveries in skin rejuvenation to create its unique day and night skin care creams. ISCO's scientists were the first to intentionally create human parthenogenetic stem cells from unfertilized human eggs, thus avoiding the ethical concerns of harming a viable human embryo. ISCO's therapeutic research team discovered that such cells had qualities that made them suitable for skin care products, thus leading to the formation of ISCO's wholly-owned subsidiary, Lifeline Skin Care. Valuable assistance from ISCO's other wholly-owned subsidiary, Lifeline Cell Technology, allowed the rapid transition and scale-up of a research-based discovery into a quality-controlled commercial product. Lifeline Cell Technology is staffed with experts in the manufacture and quality control of cell based products.

According to Dr. Ruslan Semechkin, CEO of Lifeline Skin Care, "Although it will be necessary to continue to develop new technologies to further scale-up the production of our new skin care products, this first successful manufacturing run proves that the team of ISCO's therapeutic research scientists, in combination with Lifeline Skin Care's product development expertise and Lifeline Cell Technology's manufacturing and quality control expertise, has the ability to quickly develop and commercialize new products using stem cell technologies."

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB)

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO's core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). These proprietary cells avoid ethical issues associated with use or destruction of viable human embryos and, unlike most other major stem cell types, can be immune matched and be a source of therapeutic cells with minimal rejection after transplantation into hundreds of millions of individuals of differing racial groups. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary, Lifeline Cell Technology, and is developing a line of cosmeceutical products via its subsidiary, Lifeline Skin Care. ISCO is advancing novel human stem cell-based therapies where cells have been proven to be efficacious but traditional small molecule and protein therapeutics have not. More information is available on ISCO's website, http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated developments, the potential benefits of collaborations, affiliations, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products and the management of collaborations, regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update forward-looking statements.

Key Words: Stem cells, parthenogenesis, biotechnology, skin care

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
1-760-940-6383
kaldrich@intlstemcell.com
or
Lifeline Skin Care, Inc.
Ruslan Semechkin, Ph.D., President & CEO
Vice President, International Stem Cell Corporation
ras@intlstemcell.com

Tips on Arthritis and Obesity Prevention

Posted: October 25, 2010 at 1:13 am


A study showed that obesity can increase the risk of developing arthritis.

Obesity is a global problem and is thought to be second to smoking as one of the contributory cause of cancer. It is a medical condition associated with the excessive storage of body fat which can lead to serious health conditions and reduced life expectancy. A body mass index above 30 kilograms per square meter is considered obese. The list of common health conditions that are induced and intensified by obesity include some types of cancer, cardiovascular diseases and diabetes.

There are several factors that cause obesity. In a nutshell, the consumption of a greater number of calories than what the body burns results to the disproportionate storage of fat. An unhealthy diet and an inactive lifestyle are two of the primary causes of obesity and obviously, the best recommended cure is the modification of one’s diet and increased physical activity. Among the chronic conditions caused by obesity is arthritis.

The Morbidity and Mortality Weekly Report published on October 8 stated that arthritis limits the physical activity of over 21 million people. Obesity is now being linked to arthritis and the study showed that an excess in weight serves as a hindrance to having healthy joints basically because it affects joint movement. And according to the report, unless Americans learn to control their weight, the prevalence of arthritis will remain on the rise. Just like obesity, arthritis is a major public health problem that can be effectively prevented through weight management which includes increased physical activities, diet modification, and proper education.

The Link between Obesity and Arthritis

The National Health Interview Survey for the year 2007 to 2009 indicated that more than 22 percent of adults aged 18 and above are diagnosed with arthritis. This is an equivalent of almost 50 million people. More than 21 million people in this group had reported limited body movements and decreased physical activities. In the population suffering from obesity, on the other hand, more than 33 percent of women and over 25 percent of men have arthritis. This is more than twice of the arthritis prevalence in people with normal or below normal weight, with almost 14 percent in men and about 19 percent in women.

Though the prevalence of arthritis is commonly linked to a person’s age, issues such as lifestyle, physical activity, weight, and even educational attainment are also some of the factors that can increase the risk. The report also showed that the limitations in physical activities that cause arthritis are caused by the ageing population and rising rates of obesity.

The ageing population and increasing prevalence of obesity are expected to increase the rates of developing arthritis in the next 20 years according to the report. The expected number of adults with arthritis can go up as much as 67 million by 2010. The other findings of the study showed that more than 24 percent of women and 18 percent of men were surveyed with doctor-diagnosed arthritis. Almost 22 percent of the survey participants whose educational attainment was less than a high school diploma had arthritis, comparatively higher than the 20 percent of people who spent a few years in college. In addition to this, almost 24 percent of people with sedentary lifestyle have arthritis, a lot lesser than the 19 percent who engaged in increased physical activities.

The survey participants were asked if they were diagnosed with any form of arthritis, lupus, rheumatoid arthritis, gout or fibromyalgia by a medical expert. According to the report, arthritis results to an annual cost of $128 billion on a national scale and the condition is one of the common causes of disability. The risk of getting knee osteoarthritis is more than 60 percent in obese individuals. The report also suggested that even an 11-pound reduction in weight can reduce the risk of knee osteoarthritis by 50 percent and mortality rate also by half.

Tips to Prevent Obesity

Obesity and arthritis can come hand in hand. This suggests that one of the best ways to prevent the development of obesity is by properly managing weight. It’s like hitting two birds with one stone: you are avoiding obesity and at the same time reducing the risk of developing arthritis.

It needs to be understood that obesity is caused by the over-consumption of calories while getting less than recommended physical activities. The best approach is by being aware of your calorie intake while increasing physical activity at the same time in order to burn any stored fat. Identifying any early indications of obesity is also key to preventing the condition from becoming a serious problem.

Remember to:

  • Maintain an active lifestyle. Though going to the gym or jogging around the park may be more recommendable, having an active lifestyle can be achieved in the comforts of your own home like doing open backyard activities.
  • Monitor weight regularly. It’s difficult to always count the calories. Though you may always need to think about the food you eat, counting calories down to the last piece of candy may become too obsessive and stressful. The better way of doing it is by monitoring your weight on a regular basis. This will tell you if you have been eating well and if you are getting enough physical activities to burn the extra pounds.
  • Eat right. There’s no better way of managing your weight but by eating the right kind of foods. Fresh fruits, vegetables and foods rich in fiber, like whole grains, are best in flushing out saturated fats from the other foods you eat. Eating regularly and slowly will also help in the better digestion of food.

Tips to Prevent Arthritis

Food rich in bad cholesterol, saturated fats, sodium, and uric acid leads and worsens arthritis. The recommended diet to prevent and alleviate arthritic conditions consists of consuming healthy foods such as:

  • Parsley
  • Watercress
  • Celery
  • Carrots
  • wheat grass products
  • barley
  • pecans
  • avocados
  • soy products
  • whole grain products like oats, millet, barley, wheat
  • cold water fishes like sardines, salmon and herring.

Foods rich in antioxidants like omega-3 fatty acids, selenium, bioflavonoids, carotenes and vitamin C has also been found to reduce the inflammation of the joints caused by free radicals.

Meanwhile, foods containing high amounts of calcium inhibitors have been found to increase the risk of arthritis. So try to avoid the following:

  • red meat
  • chicken
  • eggs
  • dairy products
  • coffee
  • alcohol

Foods with high contents of oxalic acid like plums, cranberries, rhubarb, spinach and chard can also cause and worsen arthritis.


Sources

arthritis.webmd.com
healthtree.com
today.msnbc.msn.com

Discuss this post in Frank Mangano’s forum!

Longevity Meme Newsletter, October 25 2010

Posted: at 1:13 am


LONGEVITY MEME NEWSLETTER
October 25 2010

The Longevity Meme Newsletter is a weekly email containing news, opinions, and happenings for people interested in aging science and engineered longevity: making use of diet, lifestyle choices, technology, and proven medical advances to live healthy, longer lives. This newsletter is published under the Creative Commons Attribution 3.0 license. In short, this means that you are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to the Longevity Meme.

To subscribe or unsubscribe from the Longevity Meme Newsletter, please visit http://www.longevitymeme.org/newsletter/

______________________________

CONTENTS

- The Road to Commercial Tissue Engineering
- Considering Cryonics
- Discussion
- Latest Healthy Life Extension Headlines

THE ROAD TO COMMERCIAL TISSUE ENGINEERING

Accelerating progress is underway in cell science: the ability to control cell actions, manage their growth and self-organization into tissue, and transform one cell type into another. Commercial production of tissue, and then whole organs to order is not far away:

http://www.fightaging.org/archives/2010/10/stem-cells-at-our-beck-and-call.php

"Researchers are well underway in the quest to control human cells: transforming cells from one type into another, for example, with an eye to creating low cost methods of producing cells for transplant on demand. Today's stem cell therapies and technology demonstrations of controlled cellular differentiation are the foundations of tomorrow's regenerative medicine, organ regrowth, and repair of age-worn tissues."

http://www.fightaging.org/archives/2010/10/friday-science-tissue-engineering-nanotechnology-and-muscle-aging.php

"Your liver is failing critically. A transplant would save your life, but there's a long waiting list and the odds are stacked against you. So instead, doctors extract some of your bone marrow, liver and muscle cells, go back to their laboratory and return in a few weeks with ... a freshly grown liver! Does this sound like material from a Hollywood sci-fi movie? Well not anymore. Australian researchers in Melbourne are now hard at work growing spare parts, proving their stuff in animal - and even human trials!"

http://www.fightaging.org/archives/2010/10/hair-and-breasts-existing-markets-to-power-commercial-tissue-engineering.php

"A large existing market primed to accept a new medical technology is a powerful thing: it can help to drive commercial application of that new technology far more rapidly than would otherwise happen. I've noted in the past that the hair restoration industry is a good example of this process in action. It's a large enough industry to support its own research community, and the concept of applying tissue engineering to hair regrowth is not a great leap for a customer already thinking about hair loss.

"An article [on] the work of Cytori Therapeutics makes the case for the industry of breast reconstruction and augmentation to be in a similar position to help advance tissue engineering technologies. ... breast augmentation is just one development (so to speak) in the company's more ambitious plan: to introduce stem cell medicine to the mass market ... It makes sense to apply Cytori's technology to enhance breasts instead of, say, repair urinary sphincters as a strategic way to move the patented technology out of rats and into people as soon as possible. Hearts, kidneys, and even sphincters have to work in order for us to survive. But we can live just fine without breast tissue, and, outside of feeding offspring, breasts don't have to do much. The fact is, the scientific and regulatory hurdles to getting Cytori's cells into clinical use will be easier to clear for breasts than for other tissue: Breasts simply aren't as necessary as other organs, so the bar for proving to regulators that the technology works will be lower."

CONSIDERING CRYONICS

We live in a mad world, in which a billion people have died of old age and disease whilst dismissing the available chance of eluding that fate:

http://www.fightaging.org/archives/2010/10/considering-cryonics.php

"An ugly truth we have to face is that the technologies of rejuvenation, ways to repair the biochemical damage of aging in living bodies, will not arrive in time for everyone alive today. A billion, or two billion, or more people will die and decay to nothing simply because they were born too soon, or were on the cusp and didn't take good enough care of their health. For everyone who might paint a plausible picture of their lives on the wrong side of the line, cryonics is the best way forward - the only shot at a far longer and better life in a future age.

"As cryonics' determined subculture - clustered around a few companies such as Alcor - labors to make the theoretical into a reality, how close are we to actually making cryonics a real path to immortality? Well, in large measure, cryonics is real right here and now. Today, about a hundred people - including baseball legend Ted Williams who was frozen in 2003 - lie in liquid nitrogen baths awaiting resurrection and the cure for what ailed them. ... we're all left wondering why so few people step up to grasp this brass ring. Arranging your own cryopreservation requires time and effort - a lot of things can go wrong if you assume you don't need preparation and organization. But that isn't enough to explain why people don't go through with it.

"People's appetite for risk and change diminishes with age, it seems. The acceptance of personal oblivion seems to increase: it's the younger folk who are truly fiery on the topic of defeating death. One might argue on how much of that is physiological versus cultural - if you had the body and neurology of a 20 year old at 80, would you still have the same level of psychological inertia? It seems unlikely that we'll know the answer to that before there are 80 year olds with youthful physiques taking on the world."

DISCUSSION

The highlights and headlines from the past week follow below. If you have comments, please do send e-mail to newsletter@longevitymeme.org

Remember - if you like this newsletter, the chances are that your friends will find it useful too. Forward it on, or post a copy to your favorite online communities. Encourage the people you know to pitch in and make a difference to the future of health and longevity!

Reason
reason@longevitymeme.org

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LATEST HEALTHY LIFE EXTENSION HEADLINES

CORRELATIONS IN BIOCHEMISTRY AND WEALTH (October 22 2010)
http://www.longevitymeme.org/news/vnl.cfm?id=4955
We know that wealth correlates with greater life expectancy. Aging and late-life disease are the consequences of ongoing biological damage, and we might theorize that wealthier people on average have greater means and knowledge to reduce the rate at which that damage occurs - though I believe that knowledge and the will to use it are more important than means. No present day medical technology can do as much for a healthy person as exercise and calorie restriction, available to rich and poor alike. But all in all, we shouldn't be surprised to find statistically significant biological differences between the metabolisms of the wealthy and the poor, reflecting the differences in lifestyle and levels of biological damage: researchers "found evidence that biological ageing is slower among people with better socio-economic circumstances. ... It found that the wealthier people were, the higher their levels of DHEAS. The discovery raises the possibility that the hormone could be artificially produced and used to make people live longer. The scientists also found that those with higher levels of it tended to do greater amounts of exercise, lead a more active life with lots of pastimes, and have more friends and family. ... The research also found higher levels of a second hormone - growth factor I (IGF-I) - in those who are wealthier."

LINKING P53, P21, AND MTOR IN AGING AND REGENERATION (October 22 2010)
http://www.longevitymeme.org/news/vnl.cfm?id=4954
The p53 protein is a pivot point between aging and cancer: suppressing cancer at the cost of faster aging. p21 has a similar role, and is also a regulator of regeneration: p21-deficient mice are capable of regenerating injuries that normally don't heal in mammals. mTOR is a calorie restriction associated protein that when manipulated can extend life in mammals. These proteins influence many aspects of cell growth and other important metabolic processes, and are all tied together in the mechanisms of the cell: "The mechanism(s) by which p53 chooses between outcomes of senescence or quiescence has remained elusive. ... Recent studies [have] shown that [gene expression] of p21, a key p53 downstream target that is required for both senescence and quiescence, drives [cancer cells] into senescence ... Notably, rapamycin, a classical inhibitor of the mTOR pathway, can also suppress p21-mediated senescence suggesting the possibility that p53 might supress senescence by inhibiting mTOR signalling. Several key components of the mTOR pathway are, in fact, down-regulated by p53. ... Collectively, these analyses pinpoint p53-mediated inhibition of the mTOR pathway as a major effector in suppressing senescence, depending on whether p53 levels are above or below a critical threshold." This isn't all abstract low-level research: sophisticated manipulation of p53 can extend life in mice by 50%, and better understanding should mean better results.

BLOCKING RAGE AS AN ANTI-AGE STRATEGY (October 21 2010)
http://www.longevitymeme.org/news/vnl.cfm?id=4953
Advanced glycation endproducts (AGEs) build up with age and cause all sorts of issues. As this paper notes, some of these problematic effects stem from RAGE, the cellular receptor for AGEs - which you might think of as one key upon the control keyboard for a cell. If that key is being constantly hammered by too many AGEs in the system, then that is a problem. "The formation of advanced glycation endproducts (AGEs) occurs in diverse settings such as diabetes, aging, renal failure, inflammation and hypoxia. The chief cellular receptor for AGEs, RAGE, transduces the effects of AGEs via signal transduction ... Data suggest that RAGE perpetuates the inflammatory signals initiated by AGEs via multiple mechanisms. AGE-RAGE interaction stimulates generation of reactive oxygen species and inflammation-mechanisms which enhance AGE formation. ... Taken together, these considerations place RAGE in the center of biochemical and molecular stresses that characterize the complications of diabetes and chronic disease. Stopping RAGE-dependent signaling may hold the key to interrupting cycles of cellular perturbation and tissue damage in these disorders." I'm still in favor of breaking down AGEs as the primary strategy: interfering in RAGE doesn't stop the build up of AGEs that causes it to be a problem in the first place.

LARGE GENDER DIFFERENCES IN SPIDER LONGEVITY (October 21 2010)
http://www.longevitymeme.org/news/vnl.cfm?id=4952
Species with large differences in longevity between the genders - sometimes tenfold or more - might teach us something about the comparative importance of different mechanisms in aging. In bees, it appears to have much to do with resisting oxidative stress, and this looks to be the case for tarantulas as well: "Reactive oxygen species (ROS), i.e., the by-products of oxidative metabolism, have emerged as the main proximate cause of ageing. Because ROS are mainly produced by the mitochondria, their production is linked to metabolic rate, and this may explain the differences in longevity between large and small species. ... Mitochondrial superoxide production of hemolymph immune cells and antioxidant and oxidative damages plasma levels were measured in adult male and female [tarantulas] at different ages. We found that female spiders are producing less mitochondrial superoxide, are better protected against oxidative attack and are then suffering less oxidative damages than males at adulthood. ... once reaching sexual maturity, males have a life expectancy reduced to 1 to 2 years, while females can still live for 20 years, in spite of the fact that females continue to grow and moult. This study evidences an increased exposure of males to oxidative stress due to an increase in mitochondrial superoxide production and a decrease in hemolymph antioxidant defences. Such a phenomenon is likely to be part of the explanation for the sharp reduction of longevity accompanying male tarantula maturity."

SEX RATIOS AND MALE MORTALITY RATES (October 20 2010)
http://www.longevitymeme.org/news/vnl.cfm?id=4951
An interesting study: "In human populations, variation in mate availability has been linked to various biological and social outcomes, but the possible effect of mate availability on health or survival has not been studied. Unbalanced sex ratios are a concern in many parts of the world, and their implications for the health and survival of the constituent individuals warrant careful investigation. We indexed mate availability with contextual sex ratios and investigated the hypothesis that the sex ratio at sexual maturity might be associated with long-term survival for men. Using two unique data sets of 7,683,462 and 4,183 men who were followed for more than 50 years, we found that men who reached their sexual maturity in an environment with higher sex ratios (i.e., higher proportions of reproductively ready men) appeared to suffer higher long-term mortality risks than those in an environment with lower sex ratios. Mate availability at sexual maturity may be linked via several biological and social mechanisms to long-term survival in men."

ON OVERPOPULATION (October 20 2010)
http://www.longevitymeme.org/news/vnl.cfm?id=4950
A defining characteristic of Malthusianism is that no matter how often it is proved wrong, you'll still find many who people fervently believe it. Overpopulation is a baseless fear, caused by a fundamental misunderstanding of the way in which people respond to potential scarcity. New resources are developed and old ones made more efficient - demand spurs progress in free societies. From a recent Reason Magazine article: "According to research published by the Royal Society, it looks as though the world will be able to feed 9 billion people by 2050, perhaps even allowing some farmland to revert to nature. Water is a problem, but economic and technological solutions show promise in ameliorating it. But more importantly, [overpopulationists] get the causality backwards. Poverty is the cause and high fertility is the symptom. Poverty traps and failed states which result in high maternal death rates, starvation, pollution, and deforestation are not created by population, but by bad policies. Working to spread economic freedom and political liberty is a lot harder than self-righteously blaming poor people for breeding too much. But it's the only real option."

ON THE WORK OF LEGENDARY PHARMACEUTICALS (October 19 2010)
http://www.longevitymeme.org/news/vnl.cfm?id=4949
From Accelerating Future: "Yesterday I had the pleasure of meeting John Furber, an anti-aging scientist known as the founder of Legendary Pharmaceuticals. The company's homepage has an excellent introduction to the biology of aging and senescence, and a giant chart with over a hundred nodes and links describing the process of aging. (I got to see a large poster version, which really had an impressive visual effect.) Furber's analysis of the mechanisms of aging are interesting because it strongly parallels Aubrey de Grey's but with a slightly different emphasis and other things to say. Furber has an article out in the hot-off-the-press Springer compilation The Future of Aging 'Repairing Extracellular Aging and Glycation'." Furber is one of the few researchers presently interested in developing a way to break down glucosepane, the most common advanced glycation end-product that builds up with age in human tissue, damaging biochemistry and causing some fraction of the process of degenerative aging.

WIRED INTERVIEWS AUBREY DE GREY (October 19 2010)
http://www.longevitymeme.org/news/vnl.cfm?id=4948
An interview with the SENS Foundation founder: "I've always found that basic scientists who are interested in testing hypotheses think very differently from technologists who are interested in, you know, changing the world in some way. A large part of the difficulties I've had in getting my colleagues in gerontology to really understand what I'm saying is that they're all scientists and not really technologists. In this case what I'm saying is if we implement SENS properly, comprehensively, then it will actually postpone age-related ill health substantially. And we certainly don't have any data plus or minus on that because, of course, we haven't implemented it yet, right? ... 'theoreticians' or generalists are almost non-existent in biology. Unlike physics, where you've got whole departments of theoreticians trying to bring ideas together from disparate areas ... And to the extent it is known, it's given very little respect ... But the thing is, a small coterie of theoreticians in biology who do take care have a rather high hit rate. If you look at winners of the Nobel Prize in biology, you'll find a fair smattering of people who don't know how to work a pipette."

GOVERNMENT ENTITLEMENTS AND LONGEVITY RISK (October 18 2010)
http://www.longevitymeme.org/news/vnl.cfm?id=4947
Politicians in the developed nations long ago set themselves upon the course to financial disaster. Matters are accelerating now, but all along it has been about the growth of entitlements, and especially forced transfers to wealth from the (largely poor) young to the (largely wealthy) old. As longevity increases, the system becomes ever more bankrupt - and the sooner it breaks down the better. Nothing more is needed to fix these problems than for the hand of government to be removed. "First the good news: We're living longer, healthier lives than ever before. ... Now for the bad news: At this rate, we can't afford to live so long. And by 'we,' I don't just mean you, me and our often insufficient long-term-care insurance policies. I mean 'we the people.' I mean the bureaucratic 'we.' ... For the first time in human history, people aged 65 and over are about to outnumber children under 5. In many countries, older people entitled to government-funded pensions, health services and long-term care will soon outnumber the work force whose taxes help finance those benefits. ... How are the most developed countries handling preparations for the boom in the elderly population - and for the budget-busting expenditures that are sure to follow? For a majority, not very well."

MORE ON BRANCHED CHAIN AMINO ACIDS (October 18 2010)
http://www.longevitymeme.org/news/vnl.cfm?id=4946
A longer article on branched chain amino acids (BCAA) and mouse longevity from Singularity Hub: "First and foremost, the work is in mice. Yes, mice are one of the most common test animals for longevity, and yes, the same BCAA cocktail also worked with yeast cells (another common test organism), but none of that means that humans are guaranteed to benefit. Second, the mice used were all males, and as we've seen with previous work in longevity, some techniques simply do not translate from one sex to another. Third, only 30 mice were used in the BCAA test group (30 in the control as well). That's simply not a very big sample. ... Finally, we should point out that while the Italian experiment showed a 12% increase in median lifespan, the range of lifespans didn't improve nearly as much. Maximum longevity for the BCAA mice was 1043 days compared to 979 days in the control group - a more modest 6.5% increase. If we look at the top 10% of mice in each group, the BCAA mice only improved 4.5% (981 compared to 938). In other words, while the amino acid treatments helped the mice live longer as a group, they didn't produce any super old mice."

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If you have comments for us, please do send email to newsletter@longevitymeme.org.

Correlations in Biochemistry and Wealth

Posted: October 22, 2010 at 8:17 pm


We know that wealth correlates with greater life expectancy. Aging and late-life disease are the consequences of ongoing biological damage, and we might theorize that wealthier people on average have greater means and knowledge to reduce the rate at which that damage occurs - though I believe that knowledge and the will to use it are more important than means. No present day medical technology can do as much for a healthy person as exercise and calorie restriction, available to rich and poor alike. But all in all, we shouldn't be surprised to find statistically significant biological differences between the metabolisms of the wealthy and the poor, reflecting the differences in lifestyle and levels of biological damage: researchers "found evidence that biological ageing is slower among people with better socio-economic circumstances. ... It found that the wealthier people were, the higher their levels of DHEAS. The discovery raises the possibility that the hormone could be artificially produced and used to make people live longer. The scientists also found that those with higher levels of it tended to do greater amounts of exercise, lead a more active life with lots of pastimes, and have more friends and family. ... The research also found higher levels of a second hormone - growth factor I (IGF-I) - in those who are wealthier."

View the Article Under Discussion: http://www.telegraph.co.uk/health/healthnews/8077779/Hormone-research-suggests-rich-live-longer.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Linking p53, p21, and mTOR in Aging and Regeneration

Posted: at 8:16 pm


The p53 protein is a pivot point between aging and cancer: suppressing cancer at the cost of faster aging. p21 has a similar role, and is also a regulator of regeneration: p21-deficient mice are capable of regenerating injuries that normally don't heal in mammals. mTOR is a calorie restriction associated protein that when manipulated can extend life in mammals. These proteins influence many aspects of cell growth and other important metabolic processes, and are all tied together in the mechanisms of the cell: "The mechanism(s) by which p53 chooses between outcomes of senescence or quiescence has remained elusive. ... Recent studies [have] shown that [gene expression] of p21, a key p53 downstream target that is required for both senescence and quiescence, drives [cancer cells] into senescence ... Notably, rapamycin, a classical inhibitor of the mTOR pathway, can also suppress p21-mediated senescence suggesting the possibility that p53 might supress senescence by inhibiting mTOR signalling. Several key components of the mTOR pathway are, in fact, down-regulated by p53. ... Collectively, these analyses pinpoint p53-mediated inhibition of the mTOR pathway as a major effector in suppressing senescence, depending on whether p53 levels are above or below a critical threshold." This isn't all abstract low-level research: sophisticated manipulation of p53 can extend life in mice by 50%, and better understanding should mean better results.

View the Article Under Discussion: http://www.impactaging.com/papers/v2/n10/full/100212.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Blocking RAGE as an Anti-AGE Strategy

Posted: at 8:16 pm


Advanced glycation endproducts (AGEs) build up with age and cause all sorts of issues. As this paper notes, some of these problematic effects stem from RAGE, the cellular receptor for AGEs - which you might think of as one key upon the control keyboard for a cell. If that key is being constantly hammered by too many AGEs in the system, then that is a problem. "The formation of advanced glycation endproducts (AGEs) occurs in diverse settings such as diabetes, aging, renal failure, inflammation and hypoxia. The chief cellular receptor for AGEs, RAGE, transduces the effects of AGEs via signal transduction ... Data suggest that RAGE perpetuates the inflammatory signals initiated by AGEs via multiple mechanisms. AGE-RAGE interaction stimulates generation of reactive oxygen species and inflammation-mechanisms which enhance AGE formation. ... Taken together, these considerations place RAGE in the center of biochemical and molecular stresses that characterize the complications of diabetes and chronic disease. Stopping RAGE-dependent signaling may hold the key to interrupting cycles of cellular perturbation and tissue damage in these disorders." I'm still in favor of breaking down AGEs as the primary strategy: interfering in RAGE doesn't stop the build up of AGEs that causes it to be a problem in the first place.

View the Article Under Discussion: http://www.ncbi.nlm.nih.gov/pubmed/20957395

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Large Gender Differences in Spider Longevity

Posted: at 8:16 pm


Species with large differences in longevity between the genders - sometimes tenfold or more - might teach us something about the comparative importance of different mechanisms in aging. In bees, it appears to have much to do with resisting oxidative stress, and this looks to be the case for tarantulas as well: "Reactive oxygen species (ROS), i.e., the by-products of oxidative metabolism, have emerged as the main proximate cause of ageing. Because ROS are mainly produced by the mitochondria, their production is linked to metabolic rate, and this may explain the differences in longevity between large and small species. ... Mitochondrial superoxide production of hemolymph immune cells and antioxidant and oxidative damages plasma levels were measured in adult male and female [tarantulas] at different ages. We found that female spiders are producing less mitochondrial superoxide, are better protected against oxidative attack and are then suffering less oxidative damages than males at adulthood. ... once reaching sexual maturity, males have a life expectancy reduced to 1 to 2 years, while females can still live for 20 years, in spite of the fact that females continue to grow and moult. This study evidences an increased exposure of males to oxidative stress due to an increase in mitochondrial superoxide production and a decrease in hemolymph antioxidant defences. Such a phenomenon is likely to be part of the explanation for the sharp reduction of longevity accompanying male tarantula maturity."

View the Article Under Discussion: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013104

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Sex Ratios and Male Mortality Rates

Posted: October 20, 2010 at 6:16 pm


An interesting study: "In human populations, variation in mate availability has been linked to various biological and social outcomes, but the possible effect of mate availability on health or survival has not been studied. Unbalanced sex ratios are a concern in many parts of the world, and their implications for the health and survival of the constituent individuals warrant careful investigation. We indexed mate availability with contextual sex ratios and investigated the hypothesis that the sex ratio at sexual maturity might be associated with long-term survival for men. Using two unique data sets of 7,683,462 and 4,183 men who were followed for more than 50 years, we found that men who reached their sexual maturity in an environment with higher sex ratios (i.e., higher proportions of reproductively ready men) appeared to suffer higher long-term mortality risks than those in an environment with lower sex ratios. Mate availability at sexual maturity may be linked via several biological and social mechanisms to long-term survival in men."

View the Article Under Discussion: http://www.ncbi.nlm.nih.gov/pubmed/20879678

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

On Overpopulation

Posted: at 6:16 pm


A defining characteristic of Malthusianism is that no matter how often it is proved wrong, you'll still find many who people fervently believe it. Overpopulation is a baseless fear, caused by a fundamental misunderstanding of the way in which people respond to potential scarcity. New resources are developed and old ones made more efficient - demand spurs progress in free societies. From a recent Reason Magazine article: "According to research published by the Royal Society, it looks as though the world will be able to feed 9 billion people by 2050, perhaps even allowing some farmland to revert to nature. Water is a problem, but economic and technological solutions show promise in ameliorating it. But more importantly, [overpopulationists] get the causality backwards. Poverty is the cause and high fertility is the symptom. Poverty traps and failed states which result in high maternal death rates, starvation, pollution, and deforestation are not created by population, but by bad policies. Working to spread economic freedom and political liberty is a lot harder than self-righteously blaming poor people for breeding too much. But it's the only real option."

View the Article Under Discussion: http://reason.com/archives/2010/10/19/the-eternal-return-of-overpopu

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

On the Work of Legendary Pharmaceuticals

Posted: at 6:15 pm


From Accelerating Future: "Yesterday I had the pleasure of meeting John Furber, an anti-aging scientist known as the founder of Legendary Pharmaceuticals. The company's homepage has an excellent introduction to the biology of aging and senescence, and a giant chart with over a hundred nodes and links describing the process of aging. (I got to see a large poster version, which really had an impressive visual effect.) Furber's analysis of the mechanisms of aging are interesting because it strongly parallels Aubrey de Grey's but with a slightly different emphasis and other things to say. Furber has an article out in the hot-off-the-press Springer compilation The Future of Aging 'Repairing Extracellular Aging and Glycation'." Furber is one of the few researchers presently interested in developing a way to break down glucosepane, the most common advanced glycation end-product that builds up with age in human tissue, damaging biochemistry and causing some fraction of the process of degenerative aging.

View the Article Under Discussion: http://www.acceleratingfuture.com/michael/blog/2010/10/john-d-furbers-comprehensive-aging-graph/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Wired Interviews Aubrey de Grey

Posted: at 6:15 pm


An interview with the SENS Foundation founder: "I've always found that basic scientists who are interested in testing hypotheses think very differently from technologists who are interested in, you know, changing the world in some way. A large part of the difficulties I've had in getting my colleagues in gerontology to really understand what I'm saying is that they're all scientists and not really technologists. In this case what I'm saying is if we implement SENS properly, comprehensively, then it will actually postpone age-related ill health substantially. And we certainly don't have any data plus or minus on that because, of course, we haven't implemented it yet, right? ... 'theoreticians' or generalists are almost non-existent in biology. Unlike physics, where you've got whole departments of theoreticians trying to bring ideas together from disparate areas ... And to the extent it is known, it's given very little respect ... But the thing is, a small coterie of theoreticians in biology who do take care have a rather high hit rate. If you look at winners of the Nobel Prize in biology, you'll find a fair smattering of people who don't know how to work a pipette."

View the Article Under Discussion: http://www.wired.com/wiredscience/2010/10/aubrey-de-grey/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Government Entitlements and Longevity Risk

Posted: at 6:15 pm


Politicians in the developed nations long ago set themselves upon the course to financial disaster. Matters are accelerating now, but all along it has been about the growth of entitlements, and especially forced transfers to wealth from the (largely poor) young to the (largely wealthy) old. As longevity increases, the system becomes ever more bankrupt - and the sooner it breaks down the better. Nothing more is needed to fix these problems than for the hand of government to be removed. "First the good news: We're living longer, healthier lives than ever before. ... Now for the bad news: At this rate, we can't afford to live so long. And by 'we,' I don't just mean you, me and our often insufficient long-term-care insurance policies. I mean 'we the people.' I mean the bureaucratic 'we.' ... For the first time in human history, people aged 65 and over are about to outnumber children under 5. In many countries, older people entitled to government-funded pensions, health services and long-term care will soon outnumber the work force whose taxes help finance those benefits. ... How are the most developed countries handling preparations for the boom in the elderly population - and for the budget-busting expenditures that are sure to follow? For a majority, not very well."

View the Article Under Discussion: http://www.nytimes.com/2010/10/17/business/17stream.html

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

More on Branched Chain Amino Acids

Posted: at 6:15 pm


A longer article on branched chain amino acids (BCAA) and mouse longevity from Singularity Hub: "First and foremost, the work is in mice. Yes, mice are one of the most common test animals for longevity, and yes, the same BCAA cocktail also worked with yeast cells (another common test organism), but none of that means that humans are guaranteed to benefit. Second, the mice used were all males, and as we've seen with previous work in longevity, some techniques simply do not translate from one sex to another. Third, only 30 mice were used in the BCAA test group (30 in the control as well). That's simply not a very big sample. ... Finally, we should point out that while the Italian experiment showed a 12% increase in median lifespan, the range of lifespans didn't improve nearly as much. Maximum longevity for the BCAA mice was 1043 days compared to 979 days in the control group - a more modest 6.5% increase. If we look at the top 10% of mice in each group, the BCAA mice only improved 4.5% (981 compared to 938). In other words, while the amino acid treatments helped the mice live longer as a group, they didn't produce any super old mice."

View the Article Under Discussion: http://singularityhub.com/2010/10/15/amino-acids-extend-mice-life-by-12-humans-might-easily-benefit-from-same/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Calorie Restriction and Fat Tissue Proteomics

Posted: at 6:14 pm


From Spectroscopy Now: "Eat less and you could live longer. That's the view held by an increasing number of people around the world, with the Calorie Restriction Society one of the main standard bearers. ... Following this diet brings about a reduction in the white adipose tissue mass and this has been proposed as a principal factor in longevity. Aging itself tends to have the opposite effect, increasing adipose tissue stores and insulin resistance and this is where clarification is needed. What are the effects of CR and how do they relate to those of aging? ... [researchers] studied the protein profiles of white adipose tissue of rats. One set was maintained on a 40% CR diet from age 12-24 months, with a second age-matched set fed ad libitum (AD). Proteins were extracted from the white adipose tissue ... a total of 133 proteins were found to be differentially expressed between the CR and AD animals. Many of the CR-induced changes were unaffected by age, implying that CR does not simply arrest or reverse age-associated changes. The influences of the two processes appear to operate under different mechanisms. ... [some] protein expression changes induced by CR gave improved protection against oxidative stress by halting the age-associated reduction in the levels of several antioxidant enzymes and decreasing the levels of stress-induced proteins. ... Both CR and aging also changed the expression of proteins involved in the cytoskeleton, iron storage and energy metabolism ... In the long term, the results could also lead to the identification of novel biomarkers of aging and possible targets for mimetics of CR that could provide the same outcome, an extended lifespan, without having to follow a rigorous and controlled diet."

View the Article Under Discussion: http://www.spectroscopynow.com/coi/cda/detail.cda?id=24357&type=Feature&chId=10&page=1

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

On Chaperone Mediated Autophagy

Posted: at 6:14 pm


Maria Konovalenko looks at the work of researcher Ana Cuervo: "the current challenges in the field of aging are two-fold: To continue and complete the molecular dissection of the factors that contribute to aging and to promote the translation of these novel findings into interventions to improve the health-span of the aging human population. ... Dr. Cuervo identified certain defects that lead to decreased activity of chaperone-mediated autophagy (CMA) with age and how to correct and improve cellular function. Dr. Cuervo theorized that the decrease of autophagy could be a determining factor in why some older organisms are unable to fight off cell abnormalities. Her research looked at the breakdown of the various autophagic pathways as the body ages and if restoring these pathways would jumpstart normal cellular activity. ... CMA is involved in at least 30% of the body's cell degradation processes and upon studying this pathway, Cuervo determined that the LAMP-2A protein acts as a vital receptor in the pathway. In recent experiments, livers in genetically modified mice 22 to 26 months old (the equivalent of octogenarians in human years), that were injected with the LAMP-2A protein, cleaned blood as efficiently as those in animals a quarter their age! By contrast, the livers of normal mice in a control group began to fail."

View the Article Under Discussion: http://mariakonovalenko.wordpress.com/2010/10/15/expert-on-cellular-and-organ-aging-%E2%80%9Cthe-bodys-ability-to-dispose-of-cell-debris-could-extend-life-%E2%80%9D/

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Metallothionein and the Biology of Aging

Posted: at 6:14 pm


Researchers continue to catalog the parts of our cellular machinery that are affected by longevity-enhancing changes in metabolism, such as the practice of calorie restriction: "Metallothionein (MT) is a low molecular weight protein with anti-apoptotic properties that has been demonstrated to scavenge free radicals in vitro. MT has not been extensively investigated within the context of aging biology. The purpose of this review, therefore, is to discuss findings on MT that are relevant to basic aging mechanisms and to draw attention to the possible role of MT in pro-longevity interventions. MT is one of just a handful of proteins that, when overexpressed, has been demonstrated to increase mouse lifespan. MT also protects against development of obesity in mice provided a high fat diet as well as diet-induced oxidative stress damage. Abundance of MT is responsive to caloric restriction (CR) and inhibition of the insulin/insulin-like signaling (IIS) pathway, and elevated MT gene expression has been observed in tissues from fasted and CR-fed mice, long-lived dwarf mice, worms maintained under CR conditions, and long-lived daf-2 mutant worms. The dysregulation of MT in these systems is likely to have tissue-specific effects on aging outcomes. Further investigation will therefore be needed to understand how MT contributes to the response of invertebrates and mice to CR and the endocrine mutations studied by aging researchers."

View the Article Under Discussion: http://www.ncbi.nlm.nih.gov/pubmed/20933613

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Adaptive Senectitude

Posted: at 6:13 pm


This is a novel formulation of aging, though I don't think it has any great impact on the justification for repair strategies such as SENS: "In the past, it has been assumed that all the biological and medical changes that occur in old age are deleterious. It has therefore been concluded that treatment and prevention of such changes in old age should increase healthspan and delay death. However, accruing epidemiological and clinical trial evidence in older humans suggests that this is not the case. Some studies have shown that antioxidants and hormone supplements increase mortality, whereas high blood pressure, obesity, and metabolic syndrome are often associated with improved outcomes in very elderly people. Perhaps, some of these supposedly detrimental changes accompanying old age are in fact evolutionary adaptations to prolong life after reproduction in humans. Indeed, a form of reverse antagonistic pleiotropy or adaptive senectitude might be occurring. Some common biological and medical changes in old age might actually enhance longevity and represent novel targets for improving health in older people."

View the Article Under Discussion: http://www.ncbi.nlm.nih.gov/pubmed/20937675

Read More Longevity Meme Commentary: http://www.longevitymeme.org/news/

Experimental Treatment Could Fight Muscular Dystrophy

Posted: October 18, 2010 at 8:33 am


(HealthDay News) -- Injecting a therapeutic molecule into muscle appears to jump-start the production of a crucial protein that's missing in patients with Duchenne muscular dystrophy, British researchers report.

The treatment so far is only applicable to about 13 percent of people with the debilitating and ultimately fatal disease, but scientists are hopeful that similar molecules might expand the treatment to a wider range of patients.

Duchenne muscular dystrophy affects about one in 3,500 males, and involves a progressive wasting of muscle due to a genetic inability to produce the protein dystrophin, a key component of muscle structure. No treatments are available for the illness, and most of those affected die by age 30.

Recently, molecules called antisense oligonucleotides have shown some promise. These molecules work by "skipping over" portions of the defective gene that would otherwise block dystrophin production. Read more...

Heart health

International Stem Cell Corporation Announces Launch Plans for New Skin Care Products

Posted: October 15, 2010 at 12:11 pm


International Stem Cell Corporation (OTCBB:ISCO), http://www.internationalstemcell.com, and a new firm to be formed by John Mauldin announced today the formation of a new joint marketing venture to launch a line of skin care products developed by ISCO's wholly owned subsidiary, Lifeline Skin Care, Inc. ('LSC'). Mauldin, a significant marketing talent, is president of Millennium Wave Investments and author of an economic letter that goes to over 1.5 million readers.

Lifeline Skin Care's products have been in active development for well over a year and involve a unique high-technology, patent pending formulation for skin rejuvenation crèmes, developed using ISCO's proprietary 'parthenogenetic' stem cells that do not require the use of fertilized embryos. The product was discovered during ISCO's therapeutic stem cell research that revealed the stem cell's potential applications in skin cell rejuvenation. Part of the discovery included developing a way to surround the proteins from the stem cells with a nanovesicle allowing for extended shelf life and enhanced delivery of the product to the skin. Independent third party testing indicates that the crèmes (one for day and one for nighttime application) have significant positive effects on the look and feel of the skin.

'This represents an amazing leap forward in the combination of a variety of cutting edge technologies to yield products that have the potential to find significant consumer acceptance. The anti-aging market is extremely large, and Lifeline Skin Care is offering something completely new and different. We are excited about the prospects,' said Kenneth Aldrich, Chairman of ISCO.

Because the LSC products involve a unique extract from living parthenogenetic stem cells, rather than 'off the shelf' ingredients used by most skin care products, it takes additional time to manufacture the products. Building inventory in advance of demand is critical to avoid disappointing customers.

ISCO and LSC believe the collaboration with Mauldin will provide a much broader potential customer base and a much lower market cost per customer than the alternative marketing programs previously considered. As a result, LSC has revised its previously announced marketing launch plans to be certain that it will have adequate product on hand to meet initial demand.

The initial product offering will be to ISCO's own database of investors and followers, originally set to launch October and now scheduled for November to coordinate with Mauldin's timetable. That will be followed with an offering to Mauldin's extensive subscription base and to a select market of other potential purchasers.

Only after these initial offerings have been completed, involving a total of over 1.5 million potential customers, will more broad scale product offerings be made. 'This will enable us to measure probable future demand, assure our loyal investors and Mauldin's subscribers and affiliates that they will be able to purchase all the products they require while allowing LSC to build an inventory of the unique stem cell extract that is at the heart of this new product,' said Dr. Ruslan Semechkin, CEO of Lifeline Skin Care.

'We are extraordinarily excited to be able to offer LSC's products to our loyal client base in a way that assures they will be able to obtain the product they want, plus monthly refills as required, in spite of the fact that LSC's products are unique and require time and care by many people to bring to market,' said John Mauldin, founder and Chairman of Millennium. 'This is a truly revolutionary approach to skin care. Early test results are very promising and I am excited to be associated with a company of the scientific reputation of International Stem Cell Corporation and their world-renowned staff.'

ABOUT INTERNATIONAL STEM CELL CORPORATION (ISCO.OB)

International Stem Cell Corporation is a California-based biotechnology company focused on therapeutic and research products. ISCO's core technology, parthenogenesis, results in creation of pluripotent human stem cells from unfertilized oocytes (eggs). These proprietary cells avoid ethical issues associated with use or destruction of viable human embryos and, unlike most other major stem cell types, can be immune matched and be a source of therapeutic cells with minimal rejection after transplantation into hundreds of millions of individuals of differing racial groups. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary, Lifeline Cell Technology, and is developing a line of cosmeceutical products via its subsidiary, Lifeline Skin Care. ISCO is advancing novel human stem cell-based therapies where cells have been proven to be efficacious but traditional small molecule and protein therapeutics have not. More information is available on ISCO's website, http://www.internationalstemcell.com.

To subscribe to receive ongoing corporate communications please click on the following link: http://www.b2i.us/irpass.asp?BzID=1468&to=ea&s=0.

FORWARD-LOOKING STATEMENTS

Statements pertaining to anticipated developments and therapeutic applications, the potential benefits of collaborations, affiliations, and other opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as "will," "believes," "plans," "anticipates," "expects," "estimates,") should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products and the management of collaborations, regulatory approvals, need and ability to obtain future capital, application of capital resources among competing uses, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update forward-looking statements.

Key Words: Stem cells, parthenogenesis, biotechnology, skin care

International Stem Cell Corporation
Kenneth C. Aldrich, Chairman
1-760-940-6383
kaldrich@intlstemcell.com
or
Lifeine Skin Care, Inc.
Ruslan Semechkin, Ph.D., President & CEO
Vice President, ISCO
ras@intlstemcell.com

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