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Our Biology Already Accomplishes Rejuvenation

Posted: September 25, 2011 at 4:03 pm

No-one should be surprised by the plausibility of rejuvenation biotechnology, as old people create young children, and only a tiny hint of the damage that makes people old seeps through that process. So we know that there exist ways for cells and larger structures to extremely effectively manage their level of damage - and some of the explorers in stem cell science have already recreated these processes outside their normal context. Here is a further exploration of what happens when old animals create young animals: "Although the body is constantly replacing cells and cell constituents, damage and imperfections accumulate over time. Cleanup efforts are saved for when it really matters. ... I have a daughter. She is made of my cells yet has much less cellular damage than my cells. Why didn't she inherit my cells including the damaged proteins? That's the process I'm interested in. ... A few days after conception, the cells in the embryo all look the same - they are unspecified stem cells that can develop into any bodily cell type. As the process of cell specification (differentiation) begins, they go from being able to keep dividing infinitely to being able to do so only a limited number of times. This is when they start cleansing themselves. ... Quite unexpectedly we found that the level of protein damage was relatively high in the embryo's unspecified cells, but then it decreased dramatically. A few days after the onset of cell differentiation, the protein damage level had gone down by 80-90 percent. We think this is a result of the damaged material being broken down. ... In the past, researchers have believed that the body keeps cells involved in reproduction isolated and protected from damage. Now it has been shown that these types of cells go through a rejuvenation process that rids them of the inherited damage." Can this process be isolated and applied safely to ordinary cells elsewhere in the body? Time will tell, but it's a worthy goal to aim for given its demonstrated effectiveness.

Link: http://www.physorg.com/news/2011-09-body.html


The Potential to Grow Immune Cells to Order

Posted: at 4:03 pm

One possible form of future immune therapy involves growing vast numbers of tailored immune cells, far more than would ever naturally be present in the body, and then infusing them to sweep away the target problem - cancer being an early target for this sort of approach. Here is some groundwork for these future therapies: "Adult stem cells from mice converted to antigen-specific T cells - the immune cells that fight cancer tumor cells - show promise in cancer immunotherapy and may lead to a simpler, more efficient way to use the body's immune system to fight cancer ... Tumors grow because patients lack the kind of antigen-specific T cells needed to kill the cancer. An approach called adoptive T cell immunotherapy generates the T cells outside the body, which are then used inside the body to target cancer cells. ... It is complex and expensive to expand T cell lines in the lab, so researchers have been searching for ways to simplify the process. [They] found a way to use induced pluripotent stem (iPS) cells, which are adult cells that are genetically changed to be stem cells. ... Any cell can become a stem cell. It's a very good approach to generating the antigen-specific T cells and creates an unlimited source of cells for adoptive immunotherapy. ... By inserting DNA, researchers change the mouse iPS cells into immune cells and inject them into mice with tumors. After 50 days, 100 percent of the mice in the study were still alive, compared to 55 percent of control mice, which received tumor-reactive immune cells isolated from donors."

Link: http://www.sciencedaily.com/releases/2011/09/110920111812.htm


Sirtuins are Increasingly Looking Like a Dead End

Posted: at 4:02 pm

Sirtuins are most likely a dead end, or more charitably a stepping stone for researchers seeking after the mechanisms that link natural variations in metabolism to natural variations in life span, especially those induced by the practice of calorie restriction. It was one of the earliest identified pieces of the puzzle, but possibly not a useful piece in the final analysis. This has become increasingly likely as an outcome over the years as meaningful results failed to emerge from drug development based on the manipulation of sirtuins. But this happens all the time: it's larger than usual news in the scientific community only, I think, because very large sums of money have moved into this line of research over the past years, and it's one of the earliest threads that might have led to drugs that modestly slowed aging.

Though I should note, as usual, that it is a massive strategic error for the research community to focus on undertaking expensive research programs that can - at best reasonable expectation - only produce a very modest slowing of aging after the usual couple of decades of work from early results to broadly available clinical application. That strategic error is, unfortunately, well entrenched and well underway. The real and important battle of the next decade is to convince the research community, on the merits of the proposal, to ditch work on metabolic manipulation in favor of SENS-like biological repair approaches that offer the possibility of actual, working, meaningful rejuvenation of the old at the end of an expensive, large-scale twenty year research program.

But back to sirtuins, which are today's news. Here are a couple of items for you from around the web:

Longevity Gene Debate Opens Trans-Atlantic Rift

the idea that sirtuins promote longevity appeals to scientists because of experiments that were started in yeast and repeated in two other standard laboratory organisms, the roundworm and the fruit fly. It is these foundation experiments that have now come under attack by David Gems and Linda Partridge, researchers on aging at University College London. In an article published Wednesday in the journal Nature, they and colleagues have re-examined experiments in which roundworms and flies, genetically manipulated to produce more sirtuin than normal, were reported to live longer. Both experiments were flawed, they say, because the worms and flies used as a control were not genetically identical to the test organisms. The London researchers report that they have repeated the experiments with proper controls and found that extra sirtuin does not, after all, make the worms or flies live longer.

Is The 'Longevity' Gene Sirtuin One Big Research Error?

And in the last decade, sirtuin has probably been one of the industry's biggest bets, ever since high levels of this protein were linked to longer, healthier lives in a variety of animals and it was suggested that they could be behind the increased longevity seen with calorie restriction (drastic restriction of calories, without malnutrition is known to increase longevity and retard age-related diseases). So how did we get here, 10 years on, concluding that it is all a mistake?

So it all goes. The bottom line for us is, however, that even if sirtuins were the key to replicating calorie restriction, they wouldn't be the basis of the future medicines of rejuvenation. Rejuvenation biotechnology can only be based on means of repairing the damage of aging, not changing metabolism a little to gently slow down aging. Other than the SENS Foundation, I don't see any research-focused organization seriously pushing this viewpoint at the present time. That's a big problem: it means that most of the money going into aging and longevity science will have little to no effect on the future of your life span: it will be going towards a continuation of the present trend that adds a small fraction of a year to the life expectancy of adults with each passing year. The newborns get a bigger fraction of a year for their measure of life expectancy at birth, but none of us reading this now are lucky enough to be that fresh to the picture. Bigger gains than this modest trend, a trend that will see us dead with only a couple of additional years to show for it if it continues as-is, will require a radical shift in the research community's strategic vision, and a focus on repair-based biotechnologies. Not surtuins, in other words, and nothing that looks much like sirtuin research either.


On Supercentenarians

Posted: at 4:02 pm

A general interest article on supercentenarians from the Sacramento Bee: "Avice Nelson Clarke paused in her recollections of her long-ago childhood in England to make a remarkable understatement. 'I've seen lots of life already,' she said. At 111, with memories spanning the horse-and-buggy age, the Space Age and the digital age, she is on the outside edge of the nation's trend toward increasing longevity. The oldest old - supercentenarians, as aging experts refer to them - remain rare: Clarke is one of four Sacramento-region residents who reported their ages as 110 or older in the 2010 U.S. census. ... The census recorded a total of 46 Californians in the supercentenarian category. Another 27 people in the Sacramento region reported their ages as 105 to 109, census figures show. While the number of centenarians has boomed in recent decades 96,000 across the country in 2010, according to the Social Security Administration, up from 37,000 only 20 years ago the nation's population of people 110 and older has remained fairly stable. ... The world's verified oldest person ever, Jeanne Calment, died in France in 1997, age 122 years and 164 days. ... Despite the world's aging population, no one's come close to that since then. That speaks to the limits of the human life span. ... Through blood tests and gene sequencing of the oldest old, scientists want to discover the secret of their extraordinary longevity ... How have they managed to live so long? We think their longevity is inherited. They have virtually nothing else in common. Some are smokers, and some never smoked. Some are drinkers, and some never drank. They don't have the same diets. But they have long-lived parents and siblings. It must be in the DNA. ... The key age is the early 80s for men and 90 for women. If you can get to that age without dementia or major heart disease or stroke, it's the idea of getting over the hump into healthy aging. ... Even so, 40 percent of the oldest old [survive] illnesses that prove fatal to others. ... Maybe they have some kind of functional reserve. The people who live the longest seem better able to deal with illness. They have a propensity to remain independent much longer than the rest of us."

Link: http://www.sacbee.com/2011/09/20/3923381/supercentenarians-the-oldest-old.html


Restoring the Regenerative Power of Old Stem Cells

Posted: at 4:02 pm

A possible road to rejuvenating some portions of the declining mechanisms of tissue regeneration in the old: "The regenerative power of tissues and organs declines as we age. The modern day stem cell hypothesis of aging suggests that living organisms are as old as are its tissue specific or adult stem cells. Therefore, an understanding of the molecules and processes that enable human adult stem cells to initiate self-renewal and to divide, proliferate and then differentiate in order to rejuvenate damaged tissue might be the key to regenerative medicine and an eventual cure for many age-related diseases. ... We demonstrated that we were able to reverse the process of aging for human adult stem cells by intervening with the activity of non-protein coding RNAs originated from genomic regions once dismissed as non-functional 'genomic junk' ... adult stem cells undergo age-related damage. And when this happens, the body can't replace damaged tissue as well as it once could, leading to a host of diseases and conditions. ... The team began by hypothesizing that DNA damage in the genome of adult stem cells would look very different from age-related damage occurring in regular body cells. ... They compared freshly isolated human adult stem cells from young individuals, which can self-renew, to cells from the same individuals that were subjected to prolonged passaging in culture. This accelerated model of adult stem cell aging exhausts the regenerative capacity of the adult stem cells. Researchers looked at the changes in genomic sites that accumulate DNA damage in both groups. ... We found the majority of DNA damage and associated chromatin changes that occurred with adult stem cell aging were due to parts of the genome known as retrotransposons ... By suppressing the accumulation of toxic transcripts from retrotransposons, we were able to reverse the process of human adult stem cell aging in culture." The next step would be to look at this process in old animals, and see what happens when it is reversed.

Link: http://www.sciencedaily.com/releases/2011/09/110920163215.htm


Interviews With Sonia Arrison

Posted: at 4:02 pm

I'd mentioned the book "100 Plus" a couple of weeks ago, authored by Sonia Arrison:

To my eyes, the book is essentially a fast overview of the last ten years of science, debate, important subjects, and noteworthy people in the aging research and longevity advocacy communities. ... 100 Plus is, I think, a good book to give to the average fellow in the street who would be flattened and slain by the attempt to read Aubrey de Grey and Michael Rae's Ending Aging. That book is where the meat is - but 100 Plus is a Cliff's Notes for the current state and direction of longevity science and the advocacy community supporting it. That is a useful thing: a person reading 100 Plus will wind up in roughly the same place as a casual reader of the high points of Fight Aging!

I notice that Arrison is doing the book promotion rounds with vigor. The resulting materials include a number of audio and video interviews, such as these from Changesurfer Radio:

100 Plus: The Coming Age of Longevity pt1

100 Plus: The Coming Age of Longevity pt2

Dr. J. chats with Sonia Arrison, a futurist and policy analyst who has studied the impact of new technologies for the Pacific Research Institute (PRI). They discuss her new book 100+: How the Coming Age of Longevity Will Change Everything, from Careers and Relationships to Family and Faith.

There is also official video of her presentation at the recent SENS5 conference, which you will find is posted to the conference YouTube channel, with thanks to the SENS Foundation volunteers for the time they take to make that happen:


Healthy Living Can Cut Chances of Developing Diabetes

Posted: at 4:02 pm

(HealthDay News) -- Living a healthy lifestyle can cut your risk of diabetes by as much as 80 percent, researchers from the U.S. National Institutes of Health report.

It has been clear that diet, exercise, smoking and drinking have an impact on whether one is likely to develop type 2 diabetes, but how each individual factor affects the risk had been unclear.

"The lifestyle factors we looked at were physical activity, healthy diet, body weight, alcohol consumption and smoking," said lead researcher Jarad Reis, a researcher from the U.S. Division of Cardiovascular Sciences at the National Heart, Lung, and Blood Institute.

"For each one of those, there was a significant reduction in risk for developing diabetes," he said. "Having a normal weight by itself reduced the risk of developing diabetes by 60 to 70 percent."

For example, eating a healthy diet reduced the risk by about 15 percent, while not smoking lowered the risk by about 20 percent, he said.

The more healthy lifestyle factors one has, the lower the risk for developing diabetes, Reis noted. Overall, risk reduction can reach 80 percent, he said. Read more...

Immunice for Immune Support


Cell Therapy & Regenerative Medicine Domains Available

Posted: at 4:02 pm


Please pardon the crass commercial nature of this post.  I try to keep self-promotion to a minimum here but I'm looking to unload a number of domains I have the related to cell therapy and regenerative medicine and thought this might be the easiest way to get the word out.  Let me know if you are interested in any of the following: 


Funky ones: 

I have others - some of which are variations of ones listed above (such as with "the" in front) and would be available - some of which I'm still wanting to hold.

 * ~$1,500 
** ~$5,000 
*** ~$10,000
**** ~$20,000

http://www.celltherapyblog.com hosted by http://www.celltherapygroup.com


Lifeline Skin Care Video: Care For Your Skin with Lifeline Skin Care

Posted: at 4:02 pm

Stem Cell Skin Care
Born Different.

Lifeline Skin Care® (Lifeline) is a wholly owned subsidiary of International Stem Cell Corporation (OTCBB:ISCO), a publicly traded biotechnology company which has developed a powerful and ethical new stem cell technology called “parthenogenesis”.  ISCO created Lifeline Skin Care® to further develop its discoveries that extracts from human parthenogenetic stem cells had beneficial effects on human skin cells.
International Stem Cell is focused on advancing its human parthenogenetic stem cell technology towards finding treatments for blinding diseases of the eye, liver disease, diseases of the nervous system and diabetes.
Our goal at Lifeline Skin Care® is to help individuals improve the look and feel of their skin by combining the latest discoveries in the fields of stem cell biology, nanotechnology and skin cream formulation technology to create the highest quality, scientifically tested and most effective skin care products.


Tom Campbell at Emory University April 2011

Posted: at 1:16 pm

The world's foremost experts in their field gathered at The Global Health and Humanitarian Summit over the weekend of April 1-3 held at Emory University, Atlanta, GA. Holism: Physics to Holistic/Alternative Medicine was host Eva Herr's theme for this segment of the conference

Go here to read the rest:
Tom Campbell at Emory University April 2011

tig welder / plasma cutter multi process longevity LC-518d welding machine

Posted: at 1:15 pm

plasma / welder review of a longevity multi process tig stick and plasma cutter. longevity-inc.com part 1 This is just the unboxing and basic overview of the machine

Read the original here:
tig welder / plasma cutter multi process longevity LC-518d welding machine

100 Life Saving Health Food Tips

Posted: at 5:33 am

http://www.healthfitnesssite.com 100 Life Saving Health Food Tips-

The rest is here:
100 Life Saving Health Food Tips

Chris Kehler Holistic/alternative medicine ( part 2 )

Posted: at 5:33 am

Thoughts and insights of health problems

See the original post here:
Chris Kehler Holistic/alternative medicine ( part 2 )

Fitness – Hard Body Workout

Posted: September 23, 2011 at 10:10 pm

To ask Zuzana a question about fitness, diet or exercise visit her blog: http://www.BodyRock.Tv

Visit link:
Fitness - Hard Body Workout


Posted: at 10:10 pm


Read more from the original source:

Perfect Skin Foods (Diet

Posted: September 21, 2011 at 8:18 pm

Instead of washing your money down the drain, try shifting your focus to the fridge.

Follow this link:
Perfect Skin Foods (Diet

SENS5 – 100 Plus: How the Coming Age of Longevity Will Change Everything – Part 1

Posted: at 8:18 pm

The Fifth SENS conference - Sonia Arrison Authors: S. Arrison Pacific Research Institute Humanity is on the cusp of an exciting longevity revolution. The first person to live to 150 years has probably already been born

Excerpt from:
SENS5 - 100 Plus: How the Coming Age of Longevity Will Change Everything - Part 1

Dr. Norm Shealy on Energy Medicine

Posted: September 19, 2011 at 7:50 pm

C. NORMAN SHEALY, MD, PhD, is a neurosurgeon, psychologist, and founding president of the American Holistic Medical Association (AHMA). For over three decades, he has been at the forefront of alternative medicine and alternative health care.

See the rest here:
Dr. Norm Shealy on Energy Medicine

Changing of the Guard at the SENS Foundation

Posted: September 18, 2011 at 4:00 pm

Time flies - it really doesn't seem like it's been two and a half years since the SENS Foundation was launched to steer the SENS research program independently of the Methuselah Foundation umbrella. Come to think of it, it really doesn't seem like eight years since the Methuselah Foundation was just a tiny thing, a couple of advocates and the first few $5,000 checks in the bank. If you look back in the Fight Aging! archives, some of the first blog posts relate to the early days of the Methuselah Foundation.

People come and go across any organization's life span - and here is news of the departure of one of the SENS Foundation co-founders for a new venture:

On 19 September, 2011, Sarah Marr will be stepping down as our Executive Vice President at SENS Foundation. She has been a committed co-founder, and she will of course continue to be a trusted advisor and closely involved with the organization. But we couldn't have her term of full-time service with us pass without noting the significant contribution she has made to the professionalism of the organization and to the quality of our overall message. She helped make us, in a very real way.

From Sarah Marr's blog:

I think it's important to understand that the Foundation is a lifetime commitment for me. I'm a co-founder, after all, and I can't imagine a world in which I'm not extolling the virtues of the organization, its mission, and the wider concept of rejuvenation biotechnology; whatever else I'm doing, or whatever environment surrounds me.

Why am I stepping down? Because I have a personal project which I wish to pursue. And given the criticality of rejuvation biotechnology, you should get a feeling for just how important I consider this next project, but also how hard it has been to reach this decision. Why can I step down now? Because the team which we've built at the Foundation over the past two-and-a-half years is so very, very talented and capable.

Non profits set up for the long term must be able to thrive independently of the turnover of their staff and leaders - to have a continuation of capabilities and culture that are too robust to much miss the loss of any one individual's time and skills. Indeed, this is one of the implicit goals for the early stages of any venture, and a very good way of measuring success in advance of more obvious results in research, fundraising, licensing, and so forth.


Hormesis, Cell Death, and Aging

Posted: at 4:00 pm

A short open access paper: "Hormesis (a neologism coined from the ancient Greek term hormáein, which literally means 'to set in motion, impel, urge on') describes a favorable biological response to harmless doses of toxins and other stressors. Hormesis-stimulating compounds initiate an adaptive stress response that renders cells/organisms resistant against high (and normally harmful) doses of the same agent. On the theoretical level, hormesis may constitute (one of) the mechanisms that allows stressed cells to avoid senescence and death, and hence might have some impact on the (patho)physiology of aging. Thus, measures that reportedly prolong the healthy lifespan of multiple species, such as caloric restriction and the administration of resveratrol, may do so by inducing a hormetic response ... [Hormesis] is best represented by ischemic preconditioning, the situation in which short ischemic episodes protect the brain and the heart against prolonged shortage of oxygen and nutrients. Many molecules that cause cell death also elicit autophagy, a cytoprotective mechanism relying on the digestion of potentially harmful intracellular structures, notably mitochondria. When high doses of these agents are employed, cells undergo mitochondrial outer membrane permeabilization and die. In contrast, low doses of such cytotoxic agents can activate hormesis in several paradigms, and this may explain the lifespan-prolonging potential of autophagy inducers including resveratrol and caloric restriction."

Link: http://impactaging.com/papers/v3/n9/full/100380.html


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