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SENS5 Video: Talking About AGEs and Aging

Posted: April 1, 2012 at 3:49 pm

Advanced glycation end-products (AGEs) such as glucosepane are what you might think of as a sort of biological rust. They build up as an undesirable side-product of the chemistry of life and damage important molecular machinery in and around cells by sticking to molecules or sticking molecules together, making it impossible for them to do their jobs. The increase in AGE levels in the body with advancing age isn't a matter of straight accumulation over time - it's more dynamic than that, and the level of AGEs in the diet may play some role - but eventually it becomes enough to cause serious harm. Aging is little more than damage, and AGEs are one form of that damage.

The SENS Foundation is currently sponsoring research into therapies to break down glucosepane, what is probably the most important AGE in humans. I see that the UK-based research group has a few web pages devoted to their work, on one of which is offered some explanation as to why the drug industry isn't all that much help when it comes to building ways to tackle AGEs:

There are two difficulties with creating AGE-breaker drugs. Firstly, AGEs are chemical targets, not genes or proteins. Almost all of pharmaceutical research over the last 40 years has been orientated to finding drugs that interact with proteins, and with the genes that make those proteins. So we cannot call on the trillions of dollars of research and technology development that have created the modern drug industry to help us (very much - we can use some of it). Secondly, AGEs are pretty stable and tough. That is inevitable - they are in essence the physiological equivalent of the black stuff on the bottom of your baking tin - what is left after years of use and the dishwasher. (In the case of humans, 'the dishwasher' is an array of mechanisms that take care of nearly all the waste products of metabolism.) We know how to break them quite easily, but only using a process that would also dissolve every protein in your body. The trick is finding a way to cleave them and leave all the rest of you intact.

Here is a recently posted video from last year's SENS5 conference in which one of the research groups focused on AGEs discusses their work:

Advanced glycation end-products are a class of natural products that form non-enzymatically on exposed protein residues in the human body. AGEs accumulate as a result of normal metabolism and aging, and significant elevations in these molecules have also been observed in the plasma of patients with chronic diseases, such as diabetes, cancer, arthritis, cardiovascular disease, and others. Our laboratory is taking an orthodox approach to studying these materials; we have initiated a synthetic program to prepare AGE- adducts on large scale and in chemically homogenous form. This talk will describe ongoing efforts along these lines, with a particular focus on exploring a class of arginine-derived AGEs. Chemical and biological insight arising from these studies will also be discussed. It is our hope that this small molecule-based strategy will serve to shed new light on the role of AGEs in both healthy and disease physiology.


Investigating Intestinal Bacteria and Aging in Nematodes

Posted: at 3:49 pm

There's a range of research to indicate that gut bacteria are important in the relationship between metabolism and aging, though the situation in higher animals is probably far more complex than in nematode worms: "A powerful approach to understanding complex processes such as aging is to use model organisms amenable to genetic manipulation, and to seek relevant phenotypes to measure. Caenorhabditis elegans is particularly suited to studies of aging, since numerous single-gene mutations have been identified that affect its lifespan; it possesses an innate immune system employing evolutionarily conserved signaling pathways affecting longevity. As worms age, bacteria accumulate in the intestinal tract. However, quantitative relationships between worm genotype, lifespan, and intestinal lumen bacterial load have not been examined. We hypothesized that gut immunity is less efficient in older animals, leading to enhanced bacterial accumulation, reducing longevity. To address this question, we evaluated the ability of worms to control bacterial accumulation as a functional marker of intestinal immunity. ... We show that as adult worms age, several C. elegans genotypes show diminished capacity to control intestinal bacterial accumulation. We provide evidence that intestinal bacterial load, regulated by gut immunity, is an important causative factor of lifespan determination; the effects are specified by bacterial strain, worm genotype, and biologic age, all acting in concert. ... In total, these studies focus attention on the worm intestine as a locus that influences longevity in the presence of an accumulating bacterial population. Further studies defining the interplay between bacterial species and host immunity in C. elegans may provide insights into the general mechanisms of aging and age-related diseases."

Link: http://www.ncbi.nlm.nih.gov/pubmed/22452899


More Visceral Fat Means More Inflammation

Posted: at 3:49 pm

Yet another study showing a correlation between chronic inflammation and abdominal fat: "Obesity-related increases in multiple inflammatory markers may contribute to the persistent subclinical inflammation common with advancing age. ... We used factor analysis to identify inflammatory factor(s) and examine their associations with adiposity in older adults at risk for disability. ... [Inflammatory markers] were measured in 179 participants from the Lifestyle Interventions and Independence for Elders Pilot (Mean ± SD age 77 ± 4 years, 76% white, 70% women). Body mass index, waist circumference, and total fat mass were assessed by anthropometry and dual-energy x-ray absorptiometry. ... Greater total and abdominal adiposity are associated with higher levels of an inflammatory factor related to CRP, IL-1ra, and IL-6 in older adults, which may provide a clinically useful measure of inflammation in this population. ... [The associations were determined] after adjusting for age, gender, race/ethnicity, site, smoking, anti-inflammatory medications, comorbidity index, health-related quality of life, and physical function. These associations remained significant after further adjustment for grip strength, but only waist circumference remained associated with inflammation after adjusting for total lean mass." Waist circumference is a better correlation with the amount of visceral fat packed around the organs in comparison to body mass index.

Link: http://www.ncbi.nlm.nih.gov/pubmed/22451470


Greeting Your Personal Future with Indifference

Posted: at 3:49 pm

Someone who didn't take note of the eagerness with which people throw money at the shams, fakes, and security blankets of the "anti-aging" marketplace might be forced to conclude that the world's inhabitants are on balance indifferent as to whether they live long or die young, whether they suffer for decades or live healthily some years down the line. There are many common sense health practices that people can undertake to maximize their remaining life expectancy and reduce the risk of age-related disease - and that's even before we start in on supporting research and development of rejuvenation biotechnology - but the majority don't do anywhere near as much as they might, and in consequence they come to suffer for it.

Are we a species whose dominant trait is actually nihilism? One wonders at times.

But the personal future of aging isn't the only thing that most people, judging by their actions, are indifferent to. We might also consider the preventable nature of well known conditions like cancer, to pick one example. Most people know that they should be exercising, they should not let themselves get fat, and they also know how to halve the risk of suffering cancer - but do they adopt the necessary changes in lifestyle? Largely no:

More than half of all cancer is preventable, and society has the knowledge to act on this information today ... What we know [is] that lifestyle choices people make and that society can influence in a number of ways - from tobacco use to diet and exercise - play a significant role in causing cancer. Specifically, the researchers cite data demonstrating that smoking alone is responsible for a third of all cancer cases in the United States. Excess body weight and obesity account for another 20 percent.

This all might be viewed as another facet of the difficulty faced by groups trying to do something about aging and age-related disease - which is to say trying to help people avoid a future that many to most seem to be largely indifferent to, judging by their actions. If a person doesn't care enough about their future trajectory to take basic, simple care of their health today, why would they care enough to donate money to medical research and development? Fortunately, it isn't necessary to persuade everyone - even a few tens of millions of casual supporters, a tiny fraction of the population of the world, could between them generate enough resources to carry the SENS research program to completion, for example. Cancer research is itself an example of what it looks like some decades after that initial group of casual supporter is amassed - once the ball starts rolling and achieves a critical mass, the research programs become accepted as a part of what is.

But we are still left wonder on the rationality of humans, and the degree to which the average person is prepared to let their future self suffer.


Excess Body Fat Damages the Mind

Posted: at 3:49 pm

There is plenty of evidence to show that being overweight for any great length of time in life causes harm, either fairly directly by boosting levels of chronic inflammation, or because that fat tissue is associated with a lack of exercise and consequent development of vascular dementia, or for a range of other possible reasons. Here is another study on this topic: "High midlife body mass index (BMI) has been linked to a greater risk of dementia in late life, but few have studied the effect of BMI across midlife on cognitive abilities and cognitive change in a dementia-free sample. ... We investigated the association between BMI, measured twice across midlife (mean age 40 and 61 years, respectively), and cognitive change in four domains across two decades in the Swedish Adoption/Twin Study of Aging. ... Latent growth curve models fitted to data from 657 non-demented participants showed that persons who were overweight/obese in early midlife had significantly lower cognitive performance across domains in late life and significantly steeper decline in perceptual speed, adjusting for cardio-metabolic factors. Both underweight and overweight/obesity in late midlife were associated with lower cognitive abilities in late life. However, the association between underweight and low cognitive abilities did not remain significant when weight decline between early and late midlife was controlled for. ... There is a negative effect on cognitive abilities later in life related to being overweight/obese across midlife. Moreover, weight decline across midlife rather than low weight in late midlife per se was associated with low cognitive abilities." The weight decline association shows up in a range of studies on weight and health; one common conclusion is that it reflects the impact that more serious medical conditions - related to weight or otherwise - can have on people.

Link: http://www.ncbi.nlm.nih.gov/pubmed/22450854


Analyzing the Metabolisms of Long-Lived Mice

Posted: at 3:48 pm

Advances in biotechnology are greatly reducing the cost of performing broad analyses of metabolism - and so researchers are gathering ever more data on the various breeds of long-lived mice that have been created in recent years: "Significant advances in understanding aging have been achieved through studying model organisms with extended healthy lifespans. Employing (1)H NMR spectroscopy, we characterized the plasma metabolic phenotype (metabotype) of three long-lived murine models: 30% dietary restricted (DR), insulin receptor substrate 1 null (Irs1(-/-)), and Ames dwarf (Prop1(df/df)). A panel of metabolic differences were generated for each model relative to their controls, and subsequently, the three long-lived models were compared to one another. Concentrations of mobile very low density lipoproteins, trimethylamine, and choline were significantly decreased in the plasma of all three models. Metabolites including glucose, choline, glycerophosphocholine, and various lipids were significantly reduced, while acetoacetate, d-3-hydroxybutyrate and trimethylamine-N-oxide levels were increased in DR compared to ad libitum fed controls. Plasma lipids and glycerophosphocholine were also decreased in Irs1(-/-) mice compared to controls, as were methionine and citrate. In contrast, high density lipoproteins and glycerophosphocholine were increased in Ames dwarf mice, as were methionine and citrate. Pairwise comparisons indicated that differences existed between the metabotypes of the different long-lived mice models. Irs1(-/-) mice, for example, had elevated glucose, acetate, acetone, and creatine but lower methionine relative to DR mice and Ames dwarfs. Our study identified several potential candidate biomarkers directionally altered across all three models that may be predictive of longevity but also identified differences in the metabolic signatures. This comparative approach suggests that the metabolic networks underlying lifespan extension may not be exactly the same for each model of longevity and is consistent with multifactorial control of the aging process."

Link: http://www.ncbi.nlm.nih.gov/pubmed/22225495


The Automation of Tissue Engineering is Underway

Posted: at 3:48 pm

Not all tissue structures need to be tailored to the patient - indeed, most of the present tissue engineering industry is in fact directly serving the research and development community rather than clinics. Engineered tissue is used for a broad range of testing, for example, and many life science research programs can progress more effectively with access to tissue structures rather than cells in a petri dish. As costs fall, that becomes an ever more practical alternative, meaning that research becomes more efficient and faster. Behind these falling costs lies a world of automation and infrastructure, leading towards assembly lines that produce pieces of living tissue for use in research and medical development:

Artificial skin for use in transplants or to verify the safety of the active ingredients of drugs, cosmetics and chemicals is a rare commodity. It is currently produced manually on a laboratory scale, and cultivation takes six weeks. The production volume is therefore limited to 2,000 pieces of skin per month, each one only a square centimetre in size. At a lab in Germany's Fraunhofer Institute, automation technology supplier Festo has helped to marry process automation with skin cultivation. The company's automation specialists recently helped the lab change its systems to achieve faster skin cell production


The new BioPoLiS organic production laboratory at the Fraunhofer IPA is home to what it says is the only facility in the world for the fully automatic in vitro production of up to 5,000 human skin models a month. The plant reflects the importance of bio-production, a combination of biology and automation technology. ... A particularly noteworthy feature is the continuous process chain. A single production line is used to handle cell extraction, cell proliferation, the cultivation of a three-dimensional tissue structure and cryonic preservation of skin models. Each process step is conducted without interrupting any of the others.


The scientists involved in the project are not content merely to produce skin. They say they plan to develop the technology further in the next two years to the point where other types of tissue, such as cartilage, can also be produced automatically.

Tissue is machinery, and we humans have accumulated a great deal of experience in how to build large amounts of homogeneous, quality-controlled machinery in a short period of time. So there is every reason to think that mass production of tissue structures for research and regenerative medicine will result in industrial processes that have much in common with the automated assembly lines that produce appliances or cars. As demand increases, and especially if therapies that use standardized tissues rather than patient-specific tissues become widespread, then we will see a much more of this sort of thing. An industry of large, specialized tissue factories is not an unrealistic expectation for the 2020s, though I would imagine that such a factory will look a lot more like a hospital, clinic, or microchip fabrication plant on the inside than the name might suggest.


Obesity Surgery Complications on the Decline

Posted: at 3:48 pm

(HealthDay News) -- Obesity surgery-related complications in the United States declined 21 percent between 2001 and 2006, and payments to hospitals for obesity surgery decreased by as much as 13 percent, partly because there were fewer patient readmissions due to complications, a new study reports.

The findings from a study by the U.S. Agency for Healthcare Research and Quality are based on an analysis of more than 9,500 patients under age 65 who had obesity surgery, also known as bariatric surgery, at 652 hospitals between 2001 and 2002 and between 2005 and 2006.

The researchers found that the complication rate among obesity surgery patients dropped from 24 percent to about 15 percent. Contributing to that decrease were declines in post-surgical infection rates (58 percent lower), abdominal hernias, staple leakage, respiratory failure and pneumonia (29 percent to 50 percent lower).

There was little change in rates of other complications such as ulcers, dumping (involuntary vomiting or defecation), hemorrhage, wound re-opening, deep-vein thrombosis and pulmonary embolism, heart attack and stroke, the researchers noted. Read more...

AyurGold for Healthy Blood


Oracle acquire cloud based clinical operations and analytics vendor ClearTrial

Posted: at 3:48 pm

Via Scoop.itinPharmatics

On March 29, 2012, Oracle announced that it has agreed to acquire ClearTrial, a leading provider of cloud-based Clinical Trial Operations and analytics products that make the planning, sourcing, and tracking of clinical projects and financial performance…

Via http://www.oracle.com


Trounson on Cancellation of Vatican Appearance: ‘I Am Disappointed’

Posted: at 3:48 pm

The California stem cell agency has issued a statement from its president, Alan Trounson, concerning the cancellation of a Vatican stem cell conference at which Trounson was scheduled to speak.

According to the Catholic News Agency, the meeting was terminated because of the scheduled appearances of researchers such as Trounson, who support hESC research. The Catholic church opposes such research.

The news agency last week quoted one Vatican insider as saying the conference had generated a scandal within the higher echelons of the church. However, the Vatican later claimed it was cancelling the meeting because of "organizational, logistical and economic factors."

Trounson's statement said,

"I am disappointed that the decision was made to cancel the conference because it offered the opportunity for a constructive dialogue on all types of stem cell research.

"Open dialogue can enhance the field as a whole and accelerate our efforts to provide new therapies for patients in need."


Stem Cell Agency Budget Up for Review on Monday: 7 Percent Increase Proposed

Posted: at 3:48 pm

The proposed $17.8 million operational budget for the California stem cell agency will receive more public scrutiny at a meeting next week in San Francisco, with additional public participation sites ranging from Boston to La Jolla.

The spending plan for 2012-13 is 7.2 percent higher than the estimated expenditures for the current year. By law, CIRM's budget is not subject to cuts by the legislature or the governor, who are trying to find solutions to the state's ongoing financial crisis.

Next week's hearing will be the last before approval of the budget in late May by the directors of the $3 billion research program. No significant changes are expected from the document to be presented on Monday.

Public sites where the public can participate in the CIRM directors' Finance Subcommittee meeting include South San Francisco, Stanford, Berkeley and Boston. You can find more information about the specific locations on the meeting agenda, but if you are interested in attending you need even more details from CIRM prior to the actual meeting. Email a request to info@cirm.ca.gov.


Ghana to scale up interventions to improve nutrition

Posted: at 12:08 am

Health News of Friday, 30 March 2012

Source: GNA

Ms Wilhelmina Okwabi, Deputy Director, Nutrition Department of Ghana Health Service, on Friday noted that Ghana has not done well in terms of scaling up interventions to improve upon the nutritional status of the citizenry.

She however admitted that, there have been pockets of success in various areas of interventions.

Ms Okwabi said, there are evidence of the increasing rate of malnutrition and obesity particularly among children as well as other nutritional related illnesses such as diabetes among the younger population.

Ms Okwabi, who was addressing a West African Health Organisation (WAHO) Peer Reviewing Meeting in Accra on Strengthening National Nutrition in West Africa, called for stakeholder support and political commitment towards the implementation of nutritional policies and programmes, to reduce malnutrition rates among the populace.

She said, challenges such as effective implementation and sustained impact backed by political commitment and fair share of the national budget remained elusive.

Ms Okwabi noted that, although nutrition was a critical item in the development status of a country, it had remained trapped in a low priority cycle in most sub Saharan African countries including Ghana.

She emphasised that, malnutritions complex determinants and its low visibility, as well as lack of political commitment and weak institutional and operational capacities at all levels of government were some of the biggest constraints.

Ms Okwabi explained that, the South-South Peer Review initiative which was sponsored by the World Bank and led by the WAHO of ECOWAS is aimed at enhancing policies and programmes through South-South exchange and learning.

The rest is here:
Ghana to scale up interventions to improve nutrition

Instructor adds Polynesian flavor to fitness

Posted: at 12:07 am

By CLOE CABRERA | The Tampa Tribune Published: March 31, 2012 Updated: March 31, 2012 - 12:00 AM

When new students walk into Molly Tanuvasa's Hot Hula fitness class, the first question they usually ask is, "Where are the hula hoops?"

Uh no hoops here. No gear or even shoes, for that matter. Bare feet are preferred. All you really need is a sarong and a smile.

Hot Hula is a fitness routine that combines Pacific Island dance movements with Polynesian drumbeats and hip-hop and reggae rhythms. Tanuvasa, who teaches the class in Tampa and Brandon, is originally from Hawaii.

"In Hawaii, we love curves," says Tanuvasa, who began hula dancing when she was 16. "When I saw how effortless my hips moved, it made me feel so beautiful. It was very hard at first, but I got through it. And I was hooked."

The one-hour routine targets your core and works your body from the naval down abs, quads, glutes, obliques and also engages your shoulders and arms, and improves your balance, says Hot Hula creator Anna-Rita Sloss, who is based in Orange County, Calif.

And since you're constantly moving, you can expect lots of cardio benefits as well.

"This is such a wonderful way to keep fit," Sloss says. "The movements are varied and low impact, so anyone can do it. You tailor it to your fitness level."

"Hula in Hawaiian is dance; putting all the Polynesian cultures together makes it sexy and hot," she says. "Of course, it helps you get your sexy back, and your sensuality."

But after the workout, she admits, "We look a hot mess."

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Instructor adds Polynesian flavor to fitness

AdCare Health Systems Closes $4.1 Million Public Offering of Common Stock

Posted: at 12:07 am

SPRINGFIELD, OH--(Marketwire -03/30/12)- AdCare Health Systems, Inc. (AMEX: ADK - News) announced today that it completed its previously announced firm commitment underwritten offering of 1,100,000 shares of AdCare's common stock at a price per share to the public of $3.75, for an aggregate offering amount of approximately $4.1 million. The net proceeds from the offering, after underwriting discounts and commissions and other offering expenses, are approximately $3.7 million. AdCare intends to use the net proceeds from the offering for working capital and other general corporate purposes.

Noble Financial Capital Markets acted as sole underwriter for the offering.

All conditions to the closing of the offering were satisfied.

The shares of common stock described above were offered pursuant to AdCare's existing effective shelf registration statement that was previously filed with the Securities and Exchange Commission and declared effective on June 27, 2011. A final prospectus supplement relating to the offering was filed with the Securities and Exchange Commission on March 27, 2012. Copies of the final prospectus supplement and the accompanying prospectus may be obtained from Noble Financial Capital Markets, 951 Yamato Road, Suite 210, Boca Raton, Florida 33431, telephone (561) 994-1191.

This press release does not constitute an offer to sell or the solicitation of an offer to buy shares of common stock, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction.

About AdCare Health SystemsAdCare Health Systems, Inc. (AMEX: ADK - News) is a recognized innovator in senior living and health care facility management. AdCare develops, owns and manages long-term care facilities and retirement communities, and since the company's inception in 1988, its mission has been to provide the highest quality of healthcare services to the elderly, including a broad range of skilled nursing and sub-acute care services. For more information about AdCare, visit http://www.adcarehealth.com.

Important Cautions Regarding Forward-Looking StatementsStatements contained in this press release that are not historical facts may be forward-looking statements within the meaning of federal law. Such statements can be identified by the use of forward-looking terminology, such as "believes," "expects," "plans," "intends," "anticipates" and variations of such words or similar expressions, but their absence does not mean that the statement is not forward-looking. Such forward-looking statements reflect management's beliefs and assumptions and are based upon information currently available to management and involve known and unknown risks, results, performance or achievements of AdCare, which may differ materially from those expressed or implied in such statements. Such factors are identified in the public filings made by AdCare with the Securities and Exchange Commission and include, among others, AdCare's ability to secure lines of credit and/or an acquisition credit facility, find suitable acquisition properties at favorable terms, changes in the health care industry because of political and economic influences, changes in regulations governing the health care industry, changes in reimbursement levels including those under the Medicare and Medicaid programs and changes in the competitive marketplace. There is no assurance that such factors or other factors will not affect the accuracy of such forward-looking statements. Except where required by law, AdCare undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this press release.

References to the consolidated company and its assets and activities, as well as the use of terms such as "we," "us," "our," and similar verbiage, is not meant to imply that AdCare Health Systems, Inc. has direct operating assets, employees or revenue or that any of the facilities, the home health business or other related businesses are operated by the same entity.

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AdCare Health Systems Closes $4.1 Million Public Offering of Common Stock

Health Benefits of Chocolate Growing

Posted: at 12:07 am

Latest Nutrition, Food & Recipes News

Moderate Amounts May Help Heart Health and More, Researchers Find

By Kathleen Doheny WebMD Health News

Reviewed by Brunilda Nazario, MD

March 29, 2012 (San Diego) -- Chocolate is increasingly shedding its reputation as a sweet treat only. More research is uncovering health benefits when the dark stuff is eaten in moderation.

At the annual meeting of the American Chemical Society here, a three-hour symposium was devoted to cocoa science and technology. Cocoa researchers from around the world gathered to share their latest findings, passing chocolate bars around the audience as they talked science.

Here is an update on questions chocolate lovers may have.

While some heart benefits of chocolate are solid, others are still under debate, says Eric Ding, PhD, instructor of medicine and nutritional epidemiologist at Harvard Medical School. At the symposium, he discussed his review of 24 published studies on chocolate.

The studies included more than 1,100 people. Researchers looked at how their chocolate-eating habits affected their heart disease risk factors such as high blood pressure.

"The blood pressure-lowering effect is well known," he says. His team found that, on average, systolic blood pressure declined slightly, less than two points on average, in chocolate eaters. Systolic blood pressure is the top number of a blood pressure measurement, and in people older than 50, this can be a stronger risk factor for heart disease than the lower, or diastolic, measurement.

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Health Benefits of Chocolate Growing

The Kind of Stress That Doesn't Kill You, but Makes You Stronger

Posted: at 12:07 am

Digging into an eight-decade landmark study on longevity, the author finds that stress brought on by hard work can keep you happy and healthy.


More than a half century after Dr. Terman collected his data on work and occupational success, we looked into the long-term consequences on health and longevity. Would Paul's easygoing, free-flowing approach to his career as a bookstore manager be a benefit or a curse? Would John's dedication to physics lead to a stressful but long life like that of fellow physicist Norris Bradbury, or was Bradbury's very long life an anomaly -- an exception to the rule?

We gathered together our research assistants, filling our computer programs with a whole host of relevant information, including the personality indexes we had constructed and validated earlier. We recorded how much alcohol they drank, the participants' reports of their ambition, and even their parents' reports. Most importantly, we used the death certificates to see how long they lived.

The results were very clear: Those with the most career success were the least likely to die young. In fact, on average the most successful men lived five years longer than the least successful.

Especially convincing about this finding is that the men who were independently rated by Dr. Terman as most successful more than a half century ago were the ones least likely to die at any given age in the decades that followed. Some studies in this field of research might be inadvertently biased by the classifications or judgments used by the epidemiologists, but in this case, we did not have to do any job classifications or make any judgments -- we simply relied on those careful categorizations Terman and his associates had made decades ago.


Conscientiousness, as we have established, is a strong predictor of longevity, and it turns out that the professionally successful Terman subjects were indeed more conscientious than their peers. But conscientiousness didn't explain everything: those with a successful career lived much longer even after taking their conscientiousness into account.

Unsurprisingly, ambition predicted career success. More to the point, ambition, coupled with perseverance, impulse control, and high motivation, was not only good for achievement but was part of the package of a resilient work life. It is not a coincidence that Edward Dmytryk was a prominent director and lived a long life or that Norris Bradbury headed a powerful agency and lived a long life. Symphony conductors, company presidents, and bosses of all sorts tend to live longer than their subordinates.

Complementing our own analyses, the sociologist Glen Elder and his colleagues looked at career changes between 1940 and 1960 and found evidence that the Terman participants who moved among various jobs without a clear progression were less likely to live long lives than those with steadily increasing responsibilities in their field. Usually this increasing responsibility brings more challenges and a heavier workload, but paradoxically this is helpful to long-term health.

The Kind of Stress That Doesn't Kill You, but Makes You Stronger

New Product Reviews at AntiAgingCreams.co on Anti Wrinkle Creams to Help Ease the Confusion

Posted: at 12:07 am

Newark, NJ (PRWEB) March 31, 2012

Choosing the best among the many anti aging creams available in the market today can be a confusing test to users whose only aim is to fight unwanted premature signs of aging. AntiAgingCreams.co has added wrinkle cream reviews on its site to help in this area.

Rejuvenating the skin with skin care products like wrinkle creams have probably been the best solution for those who seek to feel better by looking their best. They save many users from going to expensive dermatologists and undergo treatments and procedures that can be painful not only physically but on the pocket, too.

However, because the market is flooded with so many products, customers are often confused and misled into buying products that they dont really need. To ease the confusion and help customers make the right choice, antiagingcreams.co added anti aging reviews on their site.

Anti aging creams are so common place they can be found in almost in every drug store, department store and online dealers. But what really is an anti-aging cream that works? It has to be more than a moisturizing cream; one that can erase many years off of your face, right? Honest reviews of products and their active ingredients can greatly facilitate the process. Reviews that highlight product users testimonials that describe the effects on the skin and fine facial lines that normally come with aging.

This is probably the most ideal way for consumers to be guided in choosing the best anti wrinkle cream that can really work for them. To buy the best wrinkle cream means one that is suited to a particular skin type and a review on Dermology anti aging cream or on Revitol anti aging cream for instance can help establish this.

Skin care especially those related to fighting off premature aging should probably not be dependent on whats advised by relatives or friends. Ideally, when choosing a product to use, it has to be supported by research and reliability facts stated in product reviews. With the new anti aging reviews added on AntiAgingCreams.co, customers may be guided to making the right choice, bid confusion farewell and say hello to the skin they have been aiming for.

Originally posted here:
New Product Reviews at AntiAgingCreams.co on Anti Wrinkle Creams to Help Ease the Confusion

Harnessing the youth gene to fight skin aging

Posted: at 12:07 am

Paulina Porizkova is the face of Avon Cosmetics latest breakthrough anti-aging miracle, Anew Genics.

Paulina who? To a generation more familiar with the likes of Gisele, Kate and Heidi, the name might not ring the loudest of bells. Ask any true-blue beauty and fashion hound, however, and she (or hegays will kill for their mastery of supermodel lore) will tell you that some two decades ago, even before Linda, Naomi, Elle and Christy became global first-name icons who hogged the same headlines as Hollywood stars, the Czech-born Porizkova was the fashion worlds model du jour, her Alpine cheekbones adorning every magazine cover from Vogue to Sports Illustrated and her $6-million dollar modeling contract with Este Lauder then the highest ever paid to a mannequin.

Porizkova is now 46, ancient by modelling standards, but in Avons recently rolled out Anew Genics ad campaign, she looks as stunning as ever. The beauty brand is not caught up in some trendy retro mode in hiring Porizkova for its latest product. Here, the medium is unmistakably the message, for the seemingly ageless Porizkova is hawking what Avon says is a skincare breakthrough serum that helps you look up to 10 years younger.

One look at its spectacular-looking poster girl, just four years shy of 50, and the product makes it point.

Pioneer status

The Anew Genics line, beginning with the Treatment Concentrate that is now available in the Philippines exclusively through Avon representatives (at P1,799), is the latest iteration of the beauty companys flagship anti-aging brand, Anew, which celebrates its 20th anniversary this year. Launched in 1992, the brand has become a worldwide $1-billion bestseller, with some 11,000 units of Anew reportedly sold every hour.

Avon claims pioneer status in the skincare industry as the first to mass-market alpha hydroxy acidnow a standard part of many anti-aging productsas the main ingredient of its Anew line. The brand has regularly introduced variants through the yearsamong them Anew Clinical, Anew Rejuvenate, Anew Reversalist, Anew Ultimate, Anew Platinum and Anew Solar Advanceto incorporate the latest skincare innovations its scientists and researchers have come up with.

Anew Genics, says Dr. Xiaochun Luo, chief scientific officer and group vice president for Avons global research and development, is another groundbreaking product that women will definitely be excited to try. Our international team of researchers and product developers invested 10 years in developing this product to make younger and reenergized skin accessible to women.


Look up to 10 years younger! is Anew Genics come-onmade possible, says Xiaochun, by a patented YouthGen technology thats supposed to stimulate the activity of a youth gene in the body, which in turn leads to younger-looking skin.

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Harnessing the youth gene to fight skin aging

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