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Study: Being Cold May Promote Longevity

Posted: February 19, 2013 at 7:41 pm


Alternatively, wasabi

Reuters

Roundworms, also known as nematodes, live longer in colder temperatures. According to new research from the University of Michigan, this is because cold air acts as a trigger for a gene receptor -- TRPA-1 -- that, once triggered, sets off a chain of reactions that culminates in the activation of a gene known to be tied to longevity.

The findings contradict the previous understanding that cold temperatures promote longer lifespan because they put the organisms' bodies in a sort of frozen hibernation. The researchers showed that this theory can't fully account for the phenomenon; what's more, mutant nematodes that lacked the TRPA-1 channel, when chilled, actually had shorter lifespans than them TRPA1-positive worms.

So what does this mean for us?

Well, despite the basically zero things we humans have in common with roundworms, we house a human version of TRPA1 (distinguished by its lack of a hyphen).

The old theory for why roundworms live longer in the cold wouldn't have applied to us at all -- the worms are cold-blooded, meaning that their bodies take on the temperature of the environment, allowing for that hibernation-like state. Warm-blooded mammals such as ourselves do our best to remain at a constant temperature, so that particular strategy wouldn't work too well.

But if it's true that activating TRPA1 would set off the same process contributing to longevity in the roundworms, a case could be made for standing out in the cold. The active ingredient in wasabi and mustard oil acts as a trigger for human TRPA1 as well. So as an alternative, in the expert advice of lead author Shawn Xu, "Maybe we should be going to sushi restaurants more often."

File this one under the mostly hypothetical, for now. But we do know that mice (mammals) can live up to 20 percent longer when their core temperature is lowered by just .9 degrees Fahrenheit. And calorie restriction -- theorized to extend life -- also functions to reduce core body temperature. It's all, at the very least, intriguing. And, if you're not into the calorie restriction idea, potentially delicious: wasabi goes best with omega-3-rich seafood.

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Study: Being Cold May Promote Longevity

Longevity Global Inc Now Offers a Range of Plasma Cutting Machines and Others

Posted: at 7:41 pm


The US based company welding machine seller, Longevity Global Inc, has a limited but successful series of plasma cutting machines. These come in 1 phase plasma cutters and 2 phase plasma cutters to meet specific requirements.

Hayward, CA (PRWEB) February 18, 2013

Nevertheless, the companys 1 phase plasma cutter comes with force cut series, which has ForceCut 40D (40 A, 5000 watts), ForceCut 50D (50 A, 5000 watts), ForceCut 40i(40 A, 6500 watts), ForceCut 50i(50 A, 6500 watts) ForceCut 60i(60 A, 7000 watts) and ForceCut 80i(80 A, 9000 watts), etc. amongst others.

Various welding equipment and devices like plasma cutting machines and plasma cutting equipment including of its specially crafted plasma cutters and plasma cutter consumable kits are now available online at http://www.longevity-inc.com. Buyers can select the item and pay online to buy these.

Plasma Cutter Consumable Kits by the company include tips, electrodes, shield cups and gas diffusers, etc. amongst others. Nonetheless, the consumable kits are tailored perfectly to insure users get maximizes use.

According to a company source, The consumables are available at various amperes 40 amp, 50 amp, 60 amp, 70 amp, 80 amp and 100 amp, all at discounted prices that are available during the festive Christmas season.

Best part associated with Longevity Global Inc is that it has a wide distribution network in UK, Mexico, Brazil, Canada, Australia and several other countries. Moreover, it has carved a niche with its exceptional and effective services.

Longevity believes in building an immense ethical and professional relationship with its customers and for that it always tries to bring innovative and highly useful welding equipment.

About the company:

Longevity Global Inc has been providing quality products and exceptional service for over five years. At Longevity, customers get prime quality welding machines and welding equipment. It ensures quality with the help of inspections during production. Each product is tested before it is sold to customers so that it is in compliance with the quality standards set by the company.

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Longevity Global Inc Now Offers a Range of Plasma Cutting Machines and Others

How to find good nutrition advice

Posted: February 18, 2013 at 9:47 am


Anyone can claim to be a nutritionist, which is why finding a good one can be a challenge. Licensure and credentials are an important place to start, but they dont necessarily ensure quality, some experts say.

Nutrition is a controversial and changing area. Keeping up to date requires a lot of work, said Dr. Stephen Devries, executive director of the nonprofit Gaples Institute for Integrative Cardiology in Deerfield, Ill.

The best professionals, he said, have undergone a rigorous formal training program and continuously update their nutrition knowledge.

Red flags that your nutrition professional may be unqualified include over-the-top promises such as a guarantee of permanent or quick weight loss or the idea that diet can cure cancer. Also be wary of practitioners who sell products and who have a one-size-fits-all philosophy. If they cant support their claims with scientific research instead of anecdotes, consider one who can.

Marion Nestle, who has spent her career telling people how to eat, is not a registered dietitian but holds a New York State license as a nutritionist/dietitian. She has a masters in public health nutrition and a doctorate in molecular biology.

Nestle suggests approaching anyones advice, including her own, with skepticism. She likes nutritionists with critical thinking skills, those who understand how and why people eat the way they do, focus on food rather than nutrients, and are able to read current research as well as interpret and apply it in context.

I know people trained in dietetics who can do that, said Nestle, a professor in the department of nutrition, food studies and public health at New York University. But I know even more nutritionists who are not dietitians who also do that. Would licensing straighten all this out? Only if it sets academic standards that all nutritionists must meet.

TYPES OF NUTRITIONISTS

Consumers should know theres a big difference between the training of a certified nutrition specialist and a certified nutrition consultant. Heres a look at the meaning behind the credentials.

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How to find good nutrition advice

gym mate fitness center – Video

Posted: at 9:46 am



gym mate fitness center

By: Ariel Serdena

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gym mate fitness center - Video

TITLE Boxing Club Belton Harlem Shake | Fitness Clubs | Workout Exercises – Video

Posted: at 9:46 am



TITLE Boxing Club Belton Harlem Shake | Fitness Clubs | Workout Exercises
TITLE Boxing Club Belton not only knows how to HIT IT HARD, but SHAKE it too! We #39;re changing lives ONE HOUR at a time and even though we HIT IT HARD, we know how to have some fun too! http://www.titleboxingclub.com/belton-mo twitter.com http://www.facebook.com

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TITLE Boxing Club Belton Harlem Shake | Fitness Clubs | Workout Exercises - Video

Fitness center intends to boost city’s public health

Posted: at 9:46 am


The new Robert Wood Johnson University Hospital Fitness & Wellness Center is offering residents in New Brunswick half-price membership in an effort to improve urban public health.

The new center attracted more than 100 people Friday for its official ribbon-cutting ceremony and held its grand opening celebration and health fair all weekend.

The celebration featured autographs from the New York Giants, magic shows, free health screenings for blood pressure, body fat and cholesterol, community health information desks and snacks provided by the Fresh Grocer.

Mayor James Cahill said the centers most important mission is to improve the quality of New Brunswick residents life and health.

I think were well on our way to that mission, he said. Notwithstanding its complexity, were very pleased with what we accomplished with it so far and what it looks to do going forward in the future.

The 60,000 square-foot center includes a room for free weight and aerobic machines, three swimming pools, three studios for a variety of fitness classes, including Zumba, pilates and kickboxing, locker rooms and on-site childcare, said Christopher J. Paladino, president of the New Brunswick Development Corporation.

He said the center, which has been open for two months and offers half-price membership to New Brunswick residents, is a great asset to the community.

Its an opportunity to bring state-of-the-art fitness and wellness to our urban community, and weve really been without a state-of-the-art facility since our YMCAs, and YWCAs closed 20 years ago, Paladino said.

Paladino said the Universitys students that live in on-campus housing or rent properties in the New Brunswick area could also enjoy half-price membership.

Bruce Traub, chief financial officer of the new fitness center, said the center took eight years to complete.

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Fitness center intends to boost city’s public health

Aussies wait on Warner fitness

Posted: at 9:46 am


Australia are waiting on the fitness of opening batsman David Warner, whose thumb injury has not recovered as quickly as anticipated ahead of the first Test against India in Chennai on Friday.

Warner picked up the injury while training in the nets, struck on the hand by Mitchell Johnson. If he does not recover in time, it means Ed Cowan is likely to open with Shane Watson, who would otherwise bat lower down, despite preferring the top role.

Meanwhile, skipper Michael Clarke has made a good recovery after his hamstring niggle and is set to play. He didn't feature in the warm-up against India A though, while Watson made 84 in the drawn match.

Chief selector John Inverarity said on ABC Radio: "David's thumb has improved in the last couple of days, he wasn't fit enough to play in this game, he had some throw-downs yesterday with a cricket ball, and we're hoping his fitness improves a great deal in the next couple of days so he comes into contention.

"We won't make a decision on that until a few days out from the Test.

"There is some concern with David because he hasn't been able to practice, but Michael had an hour's batting in the nets yesterday and he played beautifully, so I'd say there are very few concerns around Michael because of his experience and the fact he was able to practice."

Looking towards the bowling side of things, Inverarity hinted that while the Chennai deck would be suited to a spinner or two, they would likely still go with a seam attack, adding a spinner and an all-rounder.

He added: "The wicket for the Test match is already prepared. We could've played on it today, we could have played on it yesterday or the day before.

"There is not one blade of grass, so you'd suggest it is a wicket for spinners. But with our Australian team I think the strength lies more with the pace bowlers than with the spinners.

"We've got the option of playing two pace bowlers and two spinners, but it'd more likely that we'd go in with three pace bowlers and one spinner, plus some spin support. I don't think it's clouded. We know what we're going to do.

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Aussies wait on Warner fitness

Fort Collins Club Fitness Center to Host 20th Annual Chili Cook-Off

Posted: at 9:46 am


FORT COLLINS, CO--(Marketwire - Feb 18, 2013) - Fort Collins Club, a full-service health and fitness center in Fort Collins, Colorado, announces their 20th Annual Chili Cook-Off competition which will take place at the club on Friday, February 22nd. The Annual Chili Cook-Off competition will feature some of the best chili in northern Colorado, as well as prizes for the winners.

"Every year our Chili Cook-Off is a smashing success," said Todd Heenan, General Manager. "This year definitely won't be any different. We expect to have between 15 and 25 different entries competing for the top prize."

This year marks the 20th anniversary of the first Fort Collins Club Chili Cook-Off, and it is expected to be bigger and better than ever before. The best chili recipes in Colorado will square off to see who will take home the prize. Multiple prizes will be presented for various categories, including: Best Green Chili, Best Red Chili, Best Exotic Chili, and Best Overall Chili.

Do you make a mean chili? If you are interested in entering the competition, there is still time to register at the health club. You can sign up at the Fort Collins Club front desk until 5 PM on competition day, February 22nd. Judging will begin at 5:30 PM and attendees can sample, eat and enjoy all of the delicious chili's starting at 6 PM. Fort Collins Club has a number of member chili experts who will be doing the tasting and judging of all the different chili recipes to decide the winners.

"We always look forward to the Chili Cook-Off," said Heenan "It never fails to be a lot of fun for everyone involved. Who doesn't love delicious chili and prizes?"

Fort Collins Club is a premier health club and fitness center located in Fort Collins, Colorado. They offer state-of-the-art fitness facilities, including multiple pools and weight rooms, a spin room (cycling machines), cardio deck, basketball courts, group fitness rooms, a climbing wall and a club room. Many different types of fitness classes are also available, including yoga and Pilates.

Fort Collins Club also features an impressive range of health and wellness services, including the Salon Giorgio, a full-service spa with tanning and massage facilities. Members can workout in the fitness center and then head to the Salon to relax and be pampered for a full health club experience.

Membership at Fort Collins Club is available at very reasonable monthly rates, and without any of the hassle of long-term contracts. If you are interested in learning more, stop by and take a tour at 1307 East Prospect Road (on Prospect Road, just east of Lemay Avenue). You can also call 970-224-2582 for more information on the Chili Cook-Off, or with any other questions. Fort Collins Club is available on the web at http://www.fortcollinsclub.net.

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Fort Collins Club Fitness Center to Host 20th Annual Chili Cook-Off

mafm pakal veed health class – Video

Posted: at 9:46 am



mafm pakal veed health class

By: Kunhahammed k.v.

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mafm pakal veed health class - Video

Rema health talk – Video

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Rema health talk
Long to http://www.oobaweightwatchers.com

By: Rema King

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Rema health talk - Video

Thunder and Lightning – UK Bedford (Do not watch if you have health problems) – Video

Posted: at 9:46 am



Thunder and Lightning - UK Bedford (Do not watch if you have health problems)
My various videos of thunder and lightning caught on camera over the years, the loudest and nearest strikes caught just above our houses. A few of them unexpected and lucky to even record them as no one else would have. They are not tropical, they are not in America, we don #39;t usually get big storms or spectacular lightning affects here where we are so it is a rarity. Some shake the windows. Put volume on half way to get the real sound affect, if you want that is. (Do not watch if you have a heart condition, feel weesey, faint or Epilepsy of any kind).

By: studentdebts

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Thunder and Lightning - UK Bedford (Do not watch if you have health problems) - Video

Link: Dirty diapers, childhood health

Posted: at 9:46 am


Babies who are breast-fed have a different set of bacteria in their digestive tracts than formula-fed infants, researchers say.

STORY HIGHLIGHTS

(TIME.com) -- Cesarean sections and breast feeding can have lifelong effects on a baby's health, and researchers may have uncovered why.

It's all about the bugs. Or, to be more precise, the bacteria that live in the gut to help digest food and, it turns out, perform a host of other important functions.

In a study published in the Canadian Medical Association Journal, researchers led by Anita Kozyrskyj found that babies born by C-section harbored a different set of microbes in their digestive tracts than those born vaginally, and that infants who were breast-fed had a different recipe of bacteria in their guts than those who were given formula.

"Our goal is to show that some decision about elective C-sections may cause changes that parents can't see but nevertheless affect development," says Kozyrskyj.

TIME.com: Gut bugs: They are what you eat

The findings add to the growing number of studies that expose more of the hidden universe of these microbes and the role they may play in the risk of conditions ranging from asthma to autism, obesity and cancer. The researchers studied 24 babies and compared the bacteria found in stool samples collected when the infants were 3 months old.

Previous studies have linked cesarean delivery to a higher risk of asthma, diabetes and obesity, but the reason wasn't clear. Now, Kozyrskyj and her colleagues, led by Meghan Azad, suggest that at least part of that heightened risk may be due to the microbes colonizing the babies' guts.

TIME.com: The good bugs: How the germs in your body keep you healthy

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Link: Dirty diapers, childhood health

Coaled hard facts: Health alliance takes on miners

Posted: at 9:46 am


Feb. 18, 2013, 10 p.m.

THE heavy hitters of Australias health and climate sector have called for urgent action on the health risks associated with coal mining and coal seam gas extraction.

A new collaborative network of health organisations has met in Canberra and endorsed a plan to raise awareness about the adverse health effects of Australias current minerals and energy policy, which has allowed for the rapid expansion of mining, coal seam gas operations and exploration projects across the nation, including the Gunnedah basin and Pilliga region.

The Health and Energy Roundtable was hosted by five national health organisations: the Public Health Association of Australia, Climate and Health Alliance, National Rural Health Alliance, Climate Change Health Research Network and the Australian Healthcare and Hospitals Association.

It involved energy experts, community activists and health professionals, including doctors, physicians, nurses, physiotherapists and GPs, from dozens of organisations around the country.

These included Cancer Council Australia, Heart Foundation, Australian Research Alliance for Children and Youth, National Toxics Network, Australian Physiotherapy Association and NSW Nurses and Midwives Association.

The risks to human health from energy and resources policy are not being well accounted for in current policy decisions, a joint statement from the meeting said.

Significant policy reform is needed to ensure health and wellbeing is not compromised by policy decisions in other sectors.

Recognising the importance of the social and environmental determinants of health is an important part of that.

Climate and Health Alliance convenor Fiona Armstrong said the overriding concern was that climate change was being driven by energy choices and minerals policies that favoured fossil fuels over renewable energy resources.

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Coaled hard facts: Health alliance takes on miners

Analysis says health care providers could recoups cost of caring for uninsured

Posted: at 9:46 am


Health care providers in Harris County could recoup most, if not all, of the uncompensated care costs incurred by the uninsured and paid by local taxpayers and charitable organizations if the state Legislature expands Medicaid under the federal Affordable Care Act, according to an analysis released by Methodist Healthcare Ministries of South Texas and the nonprofit Texas Impact.

Hospital districts, county health care services, jails and charities in Harris County spent $920 million providing services to the uninsured for which they were not reimbursed, according to 2011 figures. If the Texas Legislature approves Medicaid expansion, at least $645 million and as much as $1.4 billion in federal funding would reach Harris County in 2016 to provide services for many of the currently uninsured, depending on how state leaders would structure the expanded coverage, according to estimates.

Using data from hospitals, the census and current legislative proposals, the report also estimated increases to local tax revenue from expanding services to an additional one million adults, which in Harris County could be as high as $411.5 million over four years starting in 2014.

Costs analyzed

The report was compiled to highlight the burden uninsured Texans place on local health care systems and how an expansion of Medicaid would not only give many uninsured access to basic care, but free up local tax and charity dollars to further improve care or to fund other local priorities like schools and roads, said Bee Moorhead, executive director of the interfaith advocacy organization Texas Impact.

"Now we have a chance to use the federal income tax money that Texas is paying to help alleviate some of those costs," Moorhead said.

Elena Marks, a health policy expert at Rice University's Baker Institute for Public Policy, said federally funded Medicaid expansion is too good to pass up, citing a 2012 study by The Perryman Group titled, "Only One Rational Choice."

Rather than looking at the flow of federal, state and local tax dollars in health care, that study looked at the overall economic impact of reducing uncompensated care, enhanced productivity from healthier Texans and other multiplier effects. It concluded that every dollar spent by the state on Medicaid would return $1.29 in revenue over the first 10 years of the expansion.

Marks warns, however, that expanding Medicaid would not be enough, hoping that local funds freed by federal and state dollars could go toward improving care.

She points to a federal grant program operated through Regional Healthcare Partnerships that funds innovative improvements to providing primary care, serving at-risk populations and targeting particular diseases.

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Analysis says health care providers could recoups cost of caring for uninsured

Louisiana Behavioral Health Partnership Nears End of First Year

Posted: at 9:46 am


BATON ROUGE, La.--(BUSINESS WIRE)--

Nearly one year ago, Louisiana began a new approach to behavioral health care with the Louisiana Behavioral Health Partnership a broad collaboration that has expanded access to services and enhanced quality of care for people with behavioral health needs.

Magellan Behavioral Health in Louisiana, a wholly-owned subsidiary of Magellan Health Services Inc. (MGLN), which is managing the Partnership, is holding a series of nine public forums throughout the state in February and March to provide a report to the community on the Partnerships first year and continue the dialogue on transforming behavioral health care as Year 2 begins. All forums will be held from 5-7 p.m.

Since March 2012, our work with the Department of Health and Hospitals and hundreds of stakeholders across the state has accelerated the transformation of the behavioral health system in Louisiana. Working together, we have supported nearly 100,000 individuals and families on their journey toward recovery and securing a healthier future, and our work is just beginning, Craig Coenson, M.D., CEO of Magellan in Louisiana, said. We are eager to share our first year results, which show a clear trend away from institutionalization to more effective home and community-based care. And we look forward to hearing from the community about how to continue to improve behavioral health care in our state through roundtable discussions and question and answer sessions.

LSU Shreveport University Center Ballroom

McNeese Student Union La Jeunesse Room

Best Western Conference Center Plantation Room

One University Place

375 Beauregard Drive

2720 North MacArthur Drive

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Louisiana Behavioral Health Partnership Nears End of First Year

Priority Health Recognizes Chief Medical Officer Dr. Jim Byrne and His Legacy of Work as He Announces His Retirement

Posted: at 9:46 am


GRAND RAPIDS, Mich.--(BUSINESS WIRE)--

Priority Health announced today that Jim Byrne, M.D., will retire from his position as chief medical officer after 20 years with the award-winning health plan, effective July 1, 2013.

Dr. Byrnes tenure as a valuable medical leader and advisor for Priority Health has helped build the foundation for a truly integrated health system, said Michael P. Freed, president and CEO for Priority Health. He has modeled an excellent example, using his passions for primary care, evidence-based medicine and chronic disease management for not only Priority Health, but for the medical community as a whole. His legacy will be long-lasting, and the entire Priority Health family wishes him nothing but the very best.

Since joining Priority Health in 1993, Dr. Byrne has been at the forefront of supporting primary care and improving the quality of care for patients. One of his key initiatives Priority Healths Partners in Performance (PIP) program led Priority Health to create programs and services that far exceed the industry. As a result, patients in Michigan are more likely to get breast and colon cancer screenings and help managing their chronic diseases than anywhere else in the nation. Since the program launched in 1996, Priority Health has paid $170 million in support of primary care above standard payment.

Dr. Byrne helped strengthen the health plans national reputation. In 2007, the Michigan Association of Health Plans (MAHP) presented him with the Ellis J. Bonner Award in recognition of his leadership and contributions to the managed care industry. Also under his leadership, Priority Health earned an Excellent accreditation by the National Committee for Quality Assurance (NCQA) in 2012, the highest level a health plan can earn, for its Commercial HMO/POS, Medicaid, Medicare PPO and Medicare HMO/POS plans.

Dr. Byrnes influence is felt nationally through his leadership of the primary care transformation initiative for the Alliance of Community Health Plans. Working with a group of the nations best community-based health plans, Jim shaped new standards for primary care and relentlessly pressed to keep the patient at the center of care delivery. Multiple organizations across the country have adopted the approach to managing back pain that was developed by Jim and his team and pioneered by Priority Health, said Patricia Smith, president and CEO of the Alliance of Community Health Plans, based in Washington, D.C.

The White House Health Policy Committee, the Centers for Medicare and Medicaid Services, and the Alliance of Community Health Plans frequently request Dr. Byrne to speak as a national expert in patient-centered care and evidence-based medicine. Prior to joining Priority Health, he practiced family medicine at Lakewood Family Medicine in Holland, Mich., which he helped found in 1977.

Dr. Byrne will continue to work with the executive team and physician leadership at Priority Health until his successor is chosen.

About Priority Health

Priority Health is an award-winning, Michigan-based health plan nationally recognized for creating innovative solutions that impact health care costs while maximizing customer experience. It offers a broad portfolio of products for employer groups and individuals, including Medicare and Medicaid beneficiaries. As a nonprofit company, Priority Health serves more than 600,000 people and continues to be rated among the best health plans in the nation by the National Committee for Quality Assurance.

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Priority Health Recognizes Chief Medical Officer Dr. Jim Byrne and His Legacy of Work as He Announces His Retirement

Jump For Joy Foundation and Longevity Rehab 1000 at TAO Nightclub – Video

Posted: at 9:45 am



Jump For Joy Foundation and Longevity Rehab 1000 at TAO Nightclub
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Sox reliever Thornton seeks longevity

Posted: at 9:45 am


GLENDALE, Ariz. Matt Thornton addressed the issue of junk food with bullpen coach Bobby Thigpen at SoxFest, and the White Sox left-hander sent another message to his fellow relievers this week when he reported to spring training at least 20 pounds lighter than last season.

In addition to helping his longevity, Thornton, 36, hopes to set an example for younger relievers whose habits might not be so healthy.

"It's on each person. You're a major league player, you're a grown man and make good money, whether it's league minimum or under contract. It's a lifestyle and habit you have to pick up to take care of yourself."

Left-hander Hector Santiago admitted he likes Gummy Bears candy, but he since has elected to change his eating habits at the ballpark once he saw a much slimmer Thornton at SoxFest and spoke to him about his altered diet. Santiago and Nate Jones plan to visit a doctor to have their blood tested to see what foods affect their diet more than others.

"I've never been a big fan of the candy bag in the bullpen," said Thornton, who was listed at 6-foot-6 and 240 pounds last season and prefers an occasional bag of sunflower seeds. "Bobby sounds like he's the same way. He doesn't want us eating Butterfingers before you get in the game.

"You have to take care of yourself out there. Some guys have their own sugar rush. I don't understand it, but everyone is their own person."

Bulky Beckham: Second baseman Gordon Beckham added muscle to his upper body, even after hitting a career-high 16 home runs last season.

Beckham wasn't concerned that the added weight would cut down his flexibility.

"I feel capable of driving some balls to the point where I can check that off the list," Beckham said. "I didn't want it to be a situation where I'd want to ask myself, 'If I would have gotten stronger, I would have done this.' "

Danks passes test: John Danks said his left shoulder felt fine one day after throwing his first bullpen session at Camelback Ranch following surgery in August.

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Sox reliever Thornton seeks longevity

Stay cool and live longer? Genetic program promotes longevity in cold environments

Posted: at 9:45 am


Feb. 14, 2013 Scientists have known for nearly a century that cold-blooded animals, such as worms, flies and fish all live longer in cold environments, but have not known exactly why.

Researchers at the University of Michigan Life Sciences Institute have identified a genetic program that promotes longevity of roundworms in cold environments -- and this genetic program also exists in warm-blooded animals, including humans.

"This raises the intriguing possibility that exposure to cold air -- or pharmacological stimulation of the cold-sensitive genetic program -- may promote longevity in mammals," said Shawn Xu, LSI faculty member and the Bernard W. Agranoff Collegiate Professor in the Life Sciences at the U-M Medical School.

The research was published online Feb. 14 in the journal Cell.

Scientists had long assumed that animals live longer in cold environments because of a passive thermodynamic process, reasoning that low temperatures reduce the rate of chemical reactions and thereby slow the rate of aging.

"But now, at least in roundworms, the extended lifespan observed at low temperature cannot be simply explained by a reduced rate of chemical reactions," Xu said. "It's, in fact, an active process that is regulated by genes."

Xu found that cold air activates a receptor known as the TRPA1 channel, found in nerve and fat cells in nematodes, and TRPA1 then passes calcium into cells. The resulting chain of signaling ultimately reaches DAF-16/FOXO, a gene associated with longevity. Mutant worms that lacked TRPA1 had shorter life spans at lower temperatures.

Because the mechanisms identified by Xu and his collaborators also exist in a range of other organisms, including humans, the research suggests that a similar effect might be possible.

The study also links calcium signaling to longevity for the first time and makes a novel connection between fat tissue and temperature response.

Researchers have known that lowering the core body temperature of warm-blooded animals, such as mice, by 0.9 degrees Fahrenheit can extend lifespan by 20 percent, but it hasn't been practical for humans to attempt to lower the core body temperature, Xu said.

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Stay cool and live longer? Genetic program promotes longevity in cold environments

Anti Aging Medicine Cleveland OH – Video

Posted: at 9:45 am



Anti Aging Medicine Cleveland OH
Independencewellness.com Call (216) 485-3204 for Dr. Juguilon at Innovative Health Wellness Center, a Wellness Center in Cleveland OH. Get a Free anti aging medicine Consultation Today!

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