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Thomas Tries IFORCE Nutrition Red Velvet Protean – Video

Posted: March 31, 2013 at 7:48 am

Thomas Tries IFORCE Nutrition Red Velvet Protean
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Thomas Tries IFORCE Nutrition Red Velvet Protean - Video

Tribute to National Nutrition Month

Posted: at 7:48 am

The American Academy of Nutrition and Dietetics designated March as National Nutrition Month. The 2013 theme, Eat Right, Your Way, Every Day, reminds us that we all are to daily focus on fueling our bodies with healthy nutritious food daily, regardless of culture and social influences.

For a practical example, the holidays of Easter and Passover are upon us. Both celebrations are traditional and have their staple food items we are all enjoy eating with family and friends. However, for some, coming around the meal table produces an anxiety to eating, especially in front of others. One reason may be because of the fear of eating too much of such a tasty meal. Another reason is the fear that one serving of this particular food item will cause them to cheat and destroy on their diet.

The solution to this dilemma rises from the scientific realization that there is no such thing as a bad food. The clue is simply the fact that the person has the authority to choose how much of a food item he would eat at a meal. Obviously if a person chooses to eat caramel cake, for example, he should need to make sure that he is reaching all of the other food groups that day and not over eating the cake to the demise of other food with higher nutritional value. He should eat the caramel in the proper portion. These food items would be found in the grains, vegetables, fruit, dairy, and meat groups.

In the same merit, there is also no such thing as a good food or a good food group as many in the media are proclaiming. Eating one eats all of his nutrients from a particular food group, for example the fruit group, he will actually become malnourished. If someone says, Coconuts are the best food on the planet to eat, for example, one would still need to focus on eating all of the other food groups and eat the coconut in moderate portion (1/2 cup). The same goes for food labeled as fat-free, sugar-free, dairy-free, taste-free ? This does not give us the green light to eat that food all day long worry-free. This too my friend is not healthy eating.

TIPS to Eat Right, Your Way, Every Day:

1) Remember there is no such thing as a good food or bad food Just eat your food in moderation. Visit http://www.eatright.org for ideas.

2) Decide if the food you are eating is being eaten because of the situation or because of an emotion

3) Remember you have choice! When you make your food choice, choose to eat it in the proper portion based on the nutrition information on the nutrition facts label or using tools like myfitnesspal.com.

4) Aim to eat food from the grains, dairy, fruit, vegetables, and meat/meatsubstitutes food groups every day.

So, whether your grandmother makes your favorite potato latkes or your favorite hometown sweet potato salad, choose to eat the food in the proper portion (about 15 grams of carbohydrate or a half-cup scoop) without guilt and anxiety that you will gain 5 pounds from one meal.

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Tribute to National Nutrition Month

Harlem Shake – Celebrity Fitness Bangsar – Video

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Harlem Shake - Celebrity Fitness Bangsar

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Harlem Shake - Celebrity Fitness Bangsar - Video

Fitness Class – Zumba Sunday

Posted: at 7:47 am


Events, Outdoors | Recreation, Sports

Zumba Latin Dance-Fitness fuses hypnotic Latin rhythms and easy to follow moves to create a dynamic fitness program that will blow you away. Zumba fanatics achieve long term health benefits while experiencing an absolute blast in one exhilarating hour of caloric-burning, body-energizing, awe-inspiring movements meant to engage and captivate for life! Marlene's routines feature interval training sessions where fast and slow rhythms, plus resistance training are combined to tone and sculpt your body while burning fat. She focuses strongly on increasing your strength and flexibility in the core. Add some Latin flavor and international zest into the mix and you've got Zumba! ?Ditch the Workout - Join the PARTY? Zumba Latin Dance-Fitness fuses hypnotic Latin rhythms and easy to follow moves to create a dynamic fitness program that will blow you away. Zumba fanatics achieve long term health benefits while experiencing an absolute blast in one exhilarating hour of caloric-burning, body-energizing, awe-inspiring movements meant to engage and captivate for life! Marlene's routines feature interval training sessions where fast and slow rhythms, plus resistance training are combined to tone and sculpt your body while burning fat. She focuses strongly on increasing your strength and flexibility in the core. Add some Latin flavor and international zest into the mix and you've got Zumba! ?Ditch the Workout - Join the PARTY?

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Fitness Class - Zumba Sunday

Fairfax Fitness ‘Best of the Best’ Awarded to Fitness Together Tysons for Excellence by Follow Media Consulting, Inc.

Posted: at 7:47 am

Fitness Together Tysons was awarded the "Best of the Best" designation for excellence in Fairfax Fitness by Follow Media Consulting, Inc.

Washington, DC (PRWEB) March 30, 2013

People sometimes wonder why killing themselves in the weight room, buying the latest greatest diet book, or waking up early to get a morning run in may help them feel like they're getting in better shape - but still falls short? Thats because people need the right strength, cardio and nutrition approaches all working together. Fitness Together's proprietary systems work in harmony, utilizing the most current science for a complete fitness solution.

All Fitness Together trainers hold degrees and additional certifications and fitness training. They also undergo a rigorous in-house training program where they become experts at helping people succeed. At different times a good trainer should function as a colleague, coach, or teacher.

Fitness Together also offers 3 unique fitness programs in their gym:

To know more about their health and fitness program, visit their website at http://www.fttysons.com or call them at 703-289-9909.

About Follow Media Consulting, Inc.

Named one of the best SEO companies by Jonas Marketing, Follow Media Consulting, Inc. is a rapidly growing worldwide firm of SEO, Social Media, and Mobile Marketing Professionals. Follow Media Consulting, Inc. headquarters is located in Richmond, VA. However, our professional team is networked across the world, with regional offices across the United States, in the United Kingdom, Canada, Australia, France, South Africa, the Philippines, and India.

Tom Marshall Follow Media Consulting, Inc. 800-909-7648 Email Information

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Fairfax Fitness 'Best of the Best' Awarded to Fitness Together Tysons for Excellence by Follow Media Consulting, Inc.

Fitness Marketing Expert Reveals at Fitness Business Summit ’13 that Today’s Economy is Just Right for New Fitness …

Posted: at 7:47 am

The economy has been hard on many new businesses, but fitness marketing expert Bedros Keuilian explains during FBS 2013 that its a great time to start a fitness boot camp.

Chino Hills, CA (PRWEB) March 27, 2013

Starting a fitness boot camp was hard and scary then and it can be hard and scary now, says Keuilian. But this is a great time to do it, because the boot camp model is actually much more economical to start and run than a traditional personal training business.

Keuilian explains during FBS 2013, fitness boot camps utilize time much more efficiently than one-on-one training. A fitness boot camp class generally has ten or twenty people in it, so owners can earn much more money per hour than with one-on-one personal training.

Keuilian says that fitness boot camps are also one of the hottest trends in fitness today, which makes them an easy sell.

Clients like the boot camp model because they can get an awesome workout in a very short time and they can usually get classes at times that other fitness facilities dont offer. That makes it really appealing to people today, because everyone is so incredibly overscheduled.

Keuilian explains that the trendiness of boot camps makes marketing them a great deal easier, as well.

On my website, I teach a lot of personal trainer marketing techniques and with a fitness boot camp there are so many ways to present your business, build your credibility and build trust through some really inexpensive and effective marketing methods, he says. People just starting out dont usually have huge marketing budgets, so having free or really cheap marketing programs to use is a really important thing.

The website offers a great deal of marketing help through blog posts, free videos and even free sales and marketing materials that fitness boot camp owners can use to help build their client bases.

There really has never been a better time to start a boot camp, Keuilian goes on. Personal trainers need a business model thats easy to sell and economical to run, and clients need a program that offers plenty of value for their money and workouts that get great results without a huge time investment. Its really a win-win for both personal trainers and their clients, especially in todays economy. Its not too often that a tough economy makes it easier to start a business and build it into something successful and profitable in a very short time.

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Fitness Marketing Expert Reveals at Fitness Business Summit '13 that Today's Economy is Just Right for New Fitness ...

Chunk Fitness Releases Micronutrient Nutritional Section

Posted: at 7:47 am

CHICAGO, March 30, 2013 (GLOBE NEWSWIRE) -- via PRWEB - Micronutrients are vital to a healthy life and Chunk Fitness has gone out and compiled every aspect an individual would need to know about any vitamin or mineral. With data on food sources, daily requirements (males, females, various age ranges), over-consumption consequences, and more, Chunk Fitness provides one of the most complete and informative resources for micronutrients on the Internet.

By scouring scientific studies, researching government recommendations, and compiling this data together in a cohesive fashion, Chunk Fitness has achieved something that has not been seen before. CEO and owner Michael Lepore says, "The amount of time it took to sift through the inaccuracies out there was immense but in the end it was worth it. We have a great resource for people and this section will be the go-to resource regarding micronutrients for years to come."

The effects of too much or too little of a particular micronutrient can throw one's entire body off. If you think you may be experiencing something like this, visit the micronutrient section of Chunk Fitness, you will not regret it.

About the Company: Chunk Fitness was founded in 2010 on the principle that information about exercise and fitness should be available for everyone, not just one select group of people. This information is presented in a clear and non-partisan fashion. Chunk Fitness is a direct result of personal confusion and dissatisfaction with what was currently available on the Internet in regards to exercise and its related fields of nutrition. For more information, visit http://www.chunkfitness.com.

This article was originally distributed on PRWeb. For the original version including any supplementary images or video, visit http://www.prweb.com/releases/2013/3/prweb10577781.htm

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Chunk Fitness Releases Micronutrient Nutritional Section

Health care divides hopefuls

Posted: at 7:47 am

BOSTON Three years after it split Massachusetts voters in the 2010 special U.S. Senate election, the debate over President Barack Obamas health care law has lost little of its political punch.

Of the five candidates vying to fill the seat left vacant by John Kerrys resignation, just one has offered a full-throated defense of the law. Democratic U.S. Rep. Edward Markey has described his vote for the Affordable Care Act as the proudest vote of my career.

Markeys primary opponent, fellow Democratic U.S. Rep. Stephen Lynch, voted against the bill and continues to point to what he says are serious flaws. But Lynch has stopped short of calling for its repeal.

The three Republicans in the race former U.S. Attorney Michael Sullivan, Norfolk state Rep. Daniel Winslow and Cohasset businessman Gabriel Gomez are all strong critics of the law.

Sullivan and Gomez say they support repealing the law; Winslow says hed push to give states a chance to opt out of it.

The jousting is more vigorous on the Democratic side.

Lynch has described the 2010 law as a giveaway to the insurance industry. He said the decision to abandon a proposed public option that would have created government insurance plans that could have competed with private plans ended up benefiting insurance companies even as the law requires tens of millions of Americans to obtain health insurance.

What the insurance companies wanted, they wanted 31 million new customers. We gave them everything they wanted, Lynch said in a recent debate. It was like a hostage situation where we not only paid the ransom, but we let the insurance companies keep the hostages.

Lynch also said the law includes so many new taxes that employers are running away from their health care obligations.

Markey said that when Lynch had a chance to cast a vote for the broadest expansion of health care in generations a decades-long Democratic quest he sided with Republicans.

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Health care divides hopefuls

Health reform’s changes stir worries as they take shape in Md.

Posted: at 7:47 am

State lawmakers put finishing touches last week on plans to apply federal health care reforms in Maryland come Jan. 1. But who becomes newly insured and at what cost still worries stakeholders as the state speeds toward becoming one of the first to adopt a revamped system.

Under legislation passed by the House of Delegates and Senate, more low-income Marylanders would qualify for government-funded health care through Medicaid, and an existing tax on health insurers would sustain a new insurance marketplace once federal support wanes.

State health and insurance officials face a long to-do list during the next nine months as they implement reforms needed before the Affordable Care Act takes effect. They will decide what health plans will be offered in the state, and at what prices; recruit uninsured residents for new coverage; and launch a complex computer system to parse who is eligible for new government assistance.

Given all the work yet to be done, there are still questions about how health care and insurance will look to consumers and how much it will cost. How many people take advantage of the new coverage and how healthy they are will help determine whether patients' bills will continue, slow or reverse their rise.

And a dramatic proposed change in the way state hospitals can charge for services could add to the upheaval. On Tuesday, state hospital regulators submitted an application to change the state's Medicare waiver, which allows them to set hospital rates. In other states, hospitals are reimbursed based on rates negotiated with insurers or dictated by Medicare. The proposal would create incentives for Maryland hospitals to reduce the cost of care, ending compensation based on inpatient admissions and thus removing an incentive to fill more hospital beds.

State leaders who embraced adoption of the Obama administration's 2010 reform law acknowledge the uncertainty. But Gov. Martin O'Malley's top health care deputy said the administration crafted the complex new system over three years hand-in-hand with key players in the state's health care industry.

"I think it's natural that when you have the type of reform we have seen in the Affordable Care Act, and whether it's in health care or any other policy area, there's always going to be some trepidation. It's pretty much around the uncertainty or the unknown of what's to come," Lt. Gov. Anthony G. Brown said. "I believe in Maryland, given the nature of our process, we have done a good deal to tamp down the anxiety."

That process began when O'Malley's issued an executive order the day President Barack Obama signed the health act into law, launching a program to oversee health reform changes in the state. Since then, the O'Malley administration and state lawmakers have passed laws including one in April 2012 creating the Maryland Health Benefit Exchange.

Now the state aims to open the exchange Oct. 1, so those in search of affordable insurance can enroll in plans by the start of 2014. To meet that timeline, "every day counts," said Rebecca Pearce, the exchange's executive director.

Insurers must submit proposed plans and rates Monday to the Maryland Insurance Administration, giving an idea of what choices the exchange might offer consumers. The state's regulatory review of those plans is expected to take months; state insurance officials have broad authority to ask for changes before approving plans for sale.

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Health reform's changes stir worries as they take shape in Md.

Travel with Val: Okinawan elders share their secrets for healthy longevity

Posted: at 7:46 am

Residents of Japan's Okinawa Islands are famously known for their longevity, and the locals give a few tips on the right foods to eat. YNN's Valarie D'Elia filed the following report.

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OKINAWA ISLANDS -- Japans Okinawan island group has a global reputation for longevity, with a healthy number of elderly becoming centenarians.

Rice farmer Hitoshi Nane, 78, can expect many more good years because his parents both lived to be 99. But Nane isn't counting on genes alone, so he doesn't stuff himself.

"People don't eat until they are full, but 80 percent full," Nane said through an interpreter.

He also enjoys a stiff drink of awamori, the rice-based local alcoholic beverage.

Nane lives on Iriomote, the largest island in Okinawa's Yaeyama Islands, where in the village, a group of octogenarians gather regularly for a game of "gate ball."

With the help of an interpreter, they share their tips for a long life.

"Smiling, talking to people, it's very good for health," said one elder.

"Take a nap. Also, I live by myself, so it's not stressful," said another.

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Travel with Val: Okinawan elders share their secrets for healthy longevity

Longevity Global Inc. Now Offers the Most Prolific Welders and Welding Equipment

Posted: at 7:46 am

Longevity Global Inc. stores all top quality welding equipment and welders for cutting and welding. These can also be used for a wide variety of welding tasks with ease and with fine precision.

Hayward, ca (PRWEB) March 30, 2013

One spokesperson at Longevity Global Inc. stated, Through innovation, experience, and engineering, we provide customers with affordable and reliable welding machines in all ranges of production from the garage users, to pipe welders, and ship builders. We are one of the biggest sellers of the equipment we offer, and we import and sell more units than any other company in America.

Welders and welding machines that Longevity Global Inc. brings into the market always outperform the leading brands in terms of quality, pricing and customer services. It believes there is always an area of improvement to excel and outperform the competitors and hence, constantly improves welding equipment in terms of technology, customer services or anything else.

It offers an unmatched five year parts and labor warranty on welders. Longevity also has a hassle-free warranty system in place i.e. if customers face any sort of issue regarding the bought welding equipment; they can get the same replaced. Notwithstanding, the organization offers a full line of welding equipment for both Do-It-Yourself (DIY) and professional welding purposes.

About the Company

Since they started in 2001 Longevity Global Inc. is recognized worldwide for providing reliable wielding, cutting, and power generating equipment. Most of their equipment comes with an unmatched warranty of 5-Years on both parts and labor. They provide customer with affordable and reliable welding machines in all ranges of production from the garage users, to pipe welders, and ship builders. It has wide network of global distributors to bring better welding equipment and devices.

For further information on their offerings visit http://www.longevity-inc.com

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Longevity Global Inc.

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Longevity Global Inc. Now Offers the Most Prolific Welders and Welding Equipment

A Late Tissue Engineering Year in Review for 2012

Posted: at 3:04 am

Some publicity materials are presently doing the (late) rounds for a January review of progress in tissue engineering over the course of 2012. The review paper is open access, so I'm assuming that this is the standard process of picking a paper at some point after it is published and allowing open access for a while to draw some attention to the journal in question. Still, it's an interesting read, providing a perspective from inside the field on what is actually important enough to mention.

The merging of tissue engineering and regenerative medicine (TERM) forms an enormously broad, energetic, and important field of medical research. Not a week goes by without something new and vital happening in a regenerative medicine laboratory somewhere in the world, and vast sums of money flow into advancing the state of the art. Arbitrary tissues and organ structures grown from a patient's own cells are not so far ahead in the future now, and neither are ways to coerce the body to rebuild itself from the inside out. There is a certainly a sense of excitement among those involved.

Tissue Engineering and Regenerative Medicine: Recent Innovations and the Transition to Translation

The first challenge in conducting this review was the sheer number of recent publications in the TERM field. [The] number of TERM articles continues to rise with nearly 4000 original articles published in 2010, compared to a mere 360 a decade earlier. This can be partially attributed to the increasing use of the same common terminology, particularly for the more recent "regenerative medicine." Still, there is no doubt that our field is expanding and capturing a larger portion of the work done across the biomedical sciences.

Many seemingly discordant lines of research have now become intertwined in TERM and constitute the fabric of our field, with these concepts arising from the blurring of boundaries between traditional disciplines. While this point is sometimes easy to forget, much of what we now consider commonplace in TERM was only a short time ago separated by barriers of dogma and discipline. As these lines continue to blur, and multi-disciplinary research becomes more the rule than the exception, our field is experiencing tremendous growth.

The pace of growth is now so fast that it impossible for most of us to keep up with the field as a whole, or even a small subset of it. For example, a TERM search specific to "cartilage" returns more than 450 articles published in 2011 alone, meaning that one would need to read more than one article per day just to stay abreast of this small portion of the TERM terrain.

We found considerable innovation in a number of traditional TERM fields, but also new ideas that are beginning to take hold in emerging focal areas. For instance, in the realm of tissue replacement, we are now seeing not just scaffolds of ever-increasing complexity derived from standard engineering methods, but also complex scaffolds predicated on natural designs (and native tissues themselves, once decellularized). In the broader field of regenerative medicine, we are seeing developmental biology begin to address not just the formation of tissues, but the specific role that endogenous stem cells play in both generative and regenerative processes. Integrating these basic science findings with novel materials that specifically recruit endogenous populations may provide a next wave in smart biomaterials for tissue repair. Likewise, new cell sources, most prominently iPSCs, have come to the fore, making autologous cell-based therapies for any tissue a real possibility.

Finally, our objective screen showed that ours is truly a translational field, and that TERM advances are being reduced to clinical practice at an ever-increasing rate. [Both] the quantitative nature of these outcome measures and levels of evidence in support of these applications are advancing as well. Together, these advances are now beginning to change the lives of small subsets of the population, and in the future, these novel approaches will be able to address a host of diseases and instances of tissue degeneration that were heretofore untreatable.


Metformin May Act to Reduce Chronic Inflammation

Posted: at 3:04 am

Metformin, used as a treatment for diabetes, is a weak candidate for a calorie restriction mimetic drug, one that causes some of the same metabolic changes (and thus hopefully health and longevity benefits) as calorie restriction. The evidence for health and longevity benefits actually resulting from this usage is mixed and debatable, however; certainly nowhere near as clear as for, say, rapamycin. Here researchers propose that metfomin's method of action stems in part from suppressing chronic inflammation, which is known to contribute to the progression of age-related frailty and disease:

[Researchers] found that the antidiabetic drug metformin reduces the production of inflammatory cytokines that normally activate the immune system, but if overproduced can lead to pathological inflammation, a condition that both damages tissues in aging and favors tumor growth. Cells normally secrete these inflammatory cytokines when they need to mount an immune response to infection, but chronic production of these same cytokines can also cause cells to age. Such chronic inflammation can be induced, for example by smoking, and old cells are particular proficient at making and releasing cytokines.

"We were surprised by our finding that metformin could prevent the production of inflammatory cytokines by old cells. The genes that code for cytokines are normal, but a protein that normally triggers their activation called NF-kB can't reach them in the cell nucleus in metformin treated cells. We also found that metformin does not exert its effects through a pathway commonly thought to mediate its antidiabetic effects. We have suspected that metformin acts in different ways on different pathways to cause effects on aging and cancer. Our studies now point to one mechanism."

Link: http://www.sciencedaily.com/releases/2013/03/130327093604.htm


More on CD47 as a Potentially Broad Cancer Therapy Target

Posted: at 3:04 am

All commonalities in cancer are interesting, as part of the high cost of dealing with cancer is based on the many, many different varieties and the great variability of its biochemistry even between individual tumors. Anything that is common between many types of cancer and between tumors offers a possibility of a lower-cost and broader therapy. The cell surface marker CD47 has shown up of late as a possible commonality, and work continues to see whether a therapy can be built on this:

A decade ago, [researchers] discovered that leukemia cells produce higher levels of a protein called CD47 than do healthy cells. CD47 [is] also displayed on healthy blood cells; it's a marker that blocks the immune system from destroying them as they circulate. Cancers take advantage of this flag to trick the immune system into ignoring them. In the past few years, [researchers] showed that blocking CD47 with an antibody cured some cases of lymphomas and leukemias in mice by stimulating the immune system to recognize the cancer cells as invaders. Now, [researchers] have shown that the CD47-blocking antibody may have a far wider impact than just blood cancers.

"What we've shown is that CD47 isn't just important on leukemias and lymphomas. It's on every single human primary tumor that we tested." Moreover, [the scientists] found that cancer cells always had higher levels of CD47 than did healthy cells. How much CD47 a tumor made could predict the survival odds of a patient. To determine whether blocking CD47 was beneficial, the scientists exposed tumor cells to macrophages, a type of immune cell, and anti-CD47 molecules in petri dishes. Without the drug, the macrophages ignored the cancerous cells. But when the CD47 was [blocked], the macrophages engulfed and destroyed cancer cells from all tumor types.

Next, the team transplanted human tumors into the feet of mice, where tumors can be easily monitored. When they treated the rodents with anti-CD47, the tumors shrank and did not spread to the rest of the body. In mice given human bladder cancer tumors, for example, 10 of 10 untreated mice had cancer that spread to their lymph nodes. Only one of 10 mice treated with anti-CD47 had a lymph node with signs of cancer. Moreover, the implanted tumor often got smaller after treatment - colon cancers transplanted into the mice shrank to less than one-third of their original size, on average.

Link: http://news.sciencemag.org/sciencenow/2012/03/one-drug-to-shrink-all-tumors.html


Why Prioritize SENS Research for Human Longevity?

Posted: at 3:04 am

Why do I vocally support rejuvenation research based on the Strategies for Engineered Negligible Senescence (SENS) over other forms of longevity science? Why do I hold the view that SENS and SENS-like research should be prioritized and massively funded? The short answer to this question is that SENS-derived medical biotechnology has a much greater expected utility - it will most likely produce far better outcomes, and at a lower cost - than other presently ongoing lines of research into creating greater human longevity.

What is SENS?

But firstly, what is SENS? It is more an umbrella collection of categories than a specific program, though it is the case that narrowly focused SENS research initiatives run under the auspices of the SENS Research Foundation. On the science side of the house, SENS is a synthesis of existing knowledge from the broad mainstream position regarding aging and the diseases of aging: that aging is caused by a stochastic accumulation of damage at the level of cells and protein machinery in and around these cells. SENS is a proposal, based on recent decades of research, as to which of the identified forms of damage and change in old tissues are fundamental - i.e. which are direct byproducts of metabolic operation rather than cascading effects of other fundamental damage. On the development side of the house, SENS pulls together work from many subfields of medical research to show that there are clear and well-defined ways to produce therapies that can repair, reverse, or make irrelevant these fundamental forms of biological damage associated with aging.

(You can read about the various forms of low-level damage that cause aging at the SENS Research Foundation website and elsewhere. This list includes: mitochondrial DNA mutations; buildup of resilient waste products inside and around cells; growing numbers of senescent and other malfunctioning cells; loss of stem cells; and a few others).

Present arguments within the mainstream of aging research are largely over the relative importance of damage type A versus damage type B, and how exactly the extremely complex interaction of damage with metabolism progresses - but not what that damage actually is. A large fraction of modern funding for aging research goes towards building a greater understanding this progression; certainly more than goes towards actually doing anything about it. Here is the thing, however: while understanding the dynamics of damage in aging is very much a work in progress, the damage itself is well known. The research community can accurately enumerate the differences between old tissue and young tissue, or an old cell and a young cell - and it has been a good number of years since anything new was added to that list.

If you can repair the cellular damage that causes aging, it doesn't matter how it happens or how it affects the organism when it's there. This is the important realization for SENS - that much of the ongoing work of the aging research community is largely irrelevant if the goal is to get to human rejuvenation as rapidly as possible. Enough is already known of the likely causes of aging to have a reasonable expectation of being able to produce laboratory demonstrations of rejuvenation in animal models within a decade or two, given large-scale funding.

Comparing Expected Values

Expected value drives human endeavor. What path ahead do we expect to produce the greatest gain? In longevity science the investment is concretely measured in money and time, and we might think of the expected value in terms of years of healthy life added by the resulting therapies. The cost of these therapies really isn't much of a factor - all major medical procedures and other therapies tend to converge to similar costs over time, based on their category: consider a surgery versus an infusion versus a course of pills, for example, where it's fairly obvious that the pricing derives from how much skilled labor is involved and how much care the patient requires as a direct result of the process.

On the input side, there are estimates for the cost in time and money to implement SENS therapies for laboratory mice. For the sake of keeping things simple, I'll note that these oscillate around the figures of a billion dollars and ten years for the crash program of fully-funded research. A billion dollars is about the yearly budget of the NIA these days, give or take, which might be a third of all research funding directed towards aging - by some estimates, anyway, though this is a very hard figure to verify in any way. It's by no means certain the that the general one third/two thirds split between government and private research funding extends to aging research.

On the output side, early SENS implementations would be expected to take an old mouse and double its remaining life expectancy - e.g. produce actual rejuvenation, actual repair and reversal of the low-level damage that causes aging, with repeated applications at intervals producing diminishing but still measurable further gains. This is the thing about a rejuvenation therapy that works; you can keep on applying it to sweep up newly accruing damage.

So what other longevity science do we have to compare against? The only large running programs are those that have grown out of the search for calorie restriction mimetic drugs. So there is the past decade or so of research into surtuins, and there is growing interest in mTOR and rapamycin analogs that looks to be more of the same, but slightly better (though that is a low bar to clear).

In the case of sirtuins, money has certainly flowed. Sirtris itself sold for ~$700 million, and it's probably not unreasonable to suggest that a billion dollars has gone into broader sirtuin-related research and development over the past decade. What does the research community have to show for that? Basically nothing other than an increased understanding of some aspects of metabolism relating to calorie restriction and other adaptations that alter life span in response to environmental circumstances. Certainly no mice living longer in widely replicated studies as is the case for mTOR and rapamycin - the sirtuin results and underlying science are still much debated, much in dispute.

The historical ratio of dollars to results for any sort of way to manipulate our metabolism to slow aging is exceedingly poor. The thing is, this ratio shouldn't be expected to get all that much better. Even if marvelously successful, the best possible realistic end result of a drug that slows aging based on what is known today - say something that extracts the best side of mTOR manipulation with none of the side-effects of rapamycin - is a very modest gain in human longevity. It can't greatly repair or reverse existing damage, it can't much help those who are already old become less damaged, it will likely not even be as effective as actual, old-fashioned calorie restriction. The current consensus is that calorie restriction itself is not going to add more than a few years to a human life - though it certainly has impressive health benefits.

(A sidebar: we can hope that one thing that ultimately emerges from all this research is an explanation as to how humans can enjoy such large health benefits from calorie restriction, commensurate with those seen in animals such as mice, without also gaining longer lives to match. But if just eating fewer calories while obtaining good nutrition could make humans reliably live 40% longer, I think that would have been noted at some point in the last few thousand years, or at least certainly in the last few hundred).

From this perspective, traditional drug research turned into longevity science looks like a long, slow slog to nowhere. It keeps people working, but to what end? Not producing significant results in extending human longevity, that's for sure.


The cost of demonstrating that SENS is the right path or the wrong path - i.e. that aging is simply an accumulation of damage, and the many disparate research results making up the SENS vision are largely correct about which forms of change in aged tissue are the fundamental forms of damage that cause aging - is tiny compared to the cost of trying to safely eke out modest reductions in the pace of aging by manipulating metabolism via sirtuins or mTOR.

The end result of implementing SENS is true rejuvenation if aging is caused by damage: actual repair, actual reversal of aging. The end result of spending the same money and time on trying to manipulate metabolism to slow aging can already be observed in sirtuin research, and can reasonably be expected to be much the same the next time around the block with mTOR - it produces new knowledge and little else of concrete use, and even when it does eventually produce a drug candidate, it will likely be the case that you could do better yourself by simply practicing calorie restriction.

The expectation value of SENS is much greater than that of trying to slow aging via the traditional drug discovery and development industry. Ergo the research and development community should be implementing SENS. It conforms to the consensus position on what causes aging, it costs far less than all other proposed interventions into the aging process, and the potential payoff is much greater.


On Nanoscale-Featured Scaffolds in Regenerative Medicine

Posted: at 3:04 am

An interesting piece on the use of scaffold materials to guide regrowth in regenerative medicine:

A research group [is] weaving nanoscale nerve-guide scaffolds from a mixture of natural chitosan and an industrial polyester polymer, using a process called electrospinning. The raw materials are dissolved in solvents and placed into a syringe, the needle of which is attached to a high-voltage supply. Charged liquid is then expelled from the needle towards an earthed collector plate. Like a spark between a cloud and a lightning conductor, the liquid stretches out to the collector, and the molecules within it form into a solid but incredibly thin thread.

The resulting minuscule fibres accrete into a dense mesh whose texture is similar to that of the body's own connective tissue. In laboratory tests, prototype nerve guides built from this nanomaterial sustained the growth of new neural cells, produced no immune reactions and were much stronger and more flexible than commercial collagen tubes. By adjusting the electrospinning process, the orientation of the nanofibres can be controlled to build scaffolds suitable for cultivating cells that need precise alignment, such as elongated muscle fibres and heart tissue.

Link: http://www.economist.com/news/technology-quarterly/21573056-biomedical-technology-tiny-forms-scaffolding-combining-biological-and-synthetic


More about Funding for Personalized Medicine Research

Posted: at 3:03 am

A post entitled Funding for Personalized Medicine Research, dated January 31, 2012, provided information about the participation of the Cancer Stem Cell Consortium (CSCC) in the Large-Scale Applied Research Project Competition of Genome Canada, in collaboration with the first phase of the Personalized Medicine Signature Initiative of the Canadian Institutes of Health Research (CIHR).

On March 26, 2013, it was announced that 17 projects will be supported. A list of these project is available (PDF). One of the 17 projects is entitled "Innovative chemogenomic tools to improve outcome in acute myeloid leukemia". The Project leader is Guy Sauvageau of the Institute for Research in Immunology and Cancer (IRIC) at the Université de Montréal. The Project co-leader is Josée Hébert of the Centre de Recherche Hôpital Maisonneuve-Rosemont, Montréal. One of the aims of this project is to develop new models for tracking cancer stem cells that are left behind after a patient is treated.


Bodybuilding Macros – Tracking Foods With No Nutrition Facts – Video

Posted: March 30, 2013 at 1:44 am

Bodybuilding Macros - Tracking Foods With No Nutrition Facts
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ETX nutrition carnival today–Education, fresh fruit, and more!

Posted: at 1:44 am

Released by: NET HEALTH

Tyler (TX) National Nutrition Month is a nutrition education and information campaign created annually in March by the American Dietetic Association. The campaign focuses attention on the importance of making informed food choices and developing sound eating and physical activity habits. This year the Northeast Texas Public Health District (NET Health) will focus on healthier food choices you can make to incorporate into your daily lifestyle.

National Nutrition Month also promotes the American Dietetic Association and its members to the public and the media as the most valuable and credible source of timely, scientifically based food and nutrition information. The theme for March 2013 is "Eat Right, Your Way, and Every Day."

"Making a positive change in your eating habits can impact your entire family. Poor nutrition and sedentary lifestyles are the most important factors in contributing to the rise of obesity in the adults and children of East Texas", says George Roberts, CEO of NET Health.

The food and physical activity choices made everyday affect your health and how you feel today and in the future. Eating a nutritious diet and engaging in regular physical activity may reduce chronic diseases, such as heart disease, type 2 diabetes and certain cancers. Furthermore, poor diet and physical inactivity are the most important factors contributing to the rise in obesity in this country.

George T. Roberts, Jr. Chief Executive Officer

You can participate in the Nutrition Carnival Friday at the NET Health WIC Clinic, 815 N Broadway, Tyler, from 9:30 a.m. until noon.

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ETX nutrition carnival today--Education, fresh fruit, and more!

Murray, Ferrer, Berdych On Importance Of Fitness – Video

Posted: at 1:44 am

Murray, Ferrer, Berdych On Importance Of Fitness

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Murray, Ferrer, Berdych On Importance Of Fitness - Video

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