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Alzheimer’s disease – five simple ways YOU can reduce dementia risk with DIET – Express.co.uk

Posted: April 29, 2017 at 5:49 pm


Alzheimers disease is the most common form of dementia, affecting an estimated 500,000 people in the UK - but not all dementia is Alzheimers disease.

Other types of dementia include vascular dementia and mixed dementia.

There are approximately 850,000 people with dementia in the UK; and whilst weve always known that food can affect how our bodies look, we are now learning more about how foods can affect our brain function.

Researchers revealed this week that running, walking, yoga and tai chi have all been shown to significantly boost brain power in the over 50s, adding that any exercise which leaves people breathless helps with the benefits evident irrespective of the current state of someones brain health.

But what what brain boosting foods should people be eating?

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Your brain function does change as you get old

Dr Marilyn Glenville, nutritionist and author of the brand new Natural Solutions for Dementia and Alzheimers has listed the top five foods to eat to reduce the risk of developing the disease.

She said: Your brain function does change as you get older.

Age tends to affect your ability to store and retrieve information and you may find that words and putting faces to names sometimes eludes you.

As I am a nutritionist the aspect of self-care in preventing Alzheimers and dementia I am most interested in is, of course, diet and I believe that what you eat can have a huge impact on the health of your brain.

The nutritionist has listed five types of food to eat and why they are beneficial.

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10 things to eat to live past 100

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1. Eat unrefined carbohydrates

We used to think that the only purpose of insulin was to regulate blood sugar, but we now know that it also regulates our neurotransmitters the brain chemicals, such as acetylcholine, that are important for learning and memory.

A diet that included unrefined carbohydrates rather than refined ones, is the best way to prevent or reverse the insulin resistance that has been linked to Alzheimers.

If you switch from quick-burn white food to slow burn whole foods, you create a speedy, gradual rise in your blood sugar.

The body hardly has to respond at all having to release only a small amount of insulin to deal with it. 2. Eat protein with every meal

You can improve the low GI-effect of unrefined carbohydrates even further if you try to include protein in every meal and most snacks.

The body takes longer to process proteins than other foods, so adding protein effectively slows down the absorption of nutrients in your food, including the carbohydrate.

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3. Eat less sugar

It is really important to cut down on added sugar as much as you possibly can. Sugar is one of the most refined carbohydrates available and a real enemy for anyone trying to avoid dementia and Alzheimers.

4. Eat little and often

It is obvious that what you eat can have a huge impact on your blood sugar levels, but also important is the timing of when you eat.

To keep blood sugar levels stable you need to create a slow, low rise in blood sugar after a meal, so your pancreas does not have to produce large amounts of insulin to deal with a quick sugar rush.

And you need to try and maintain a steady level until you eat the next meal or snack.

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5. Eat more healthy fats

Forget switching to a tasteless low-fat diet and boost your intake of the sort of healthy fats you find in oily fish, such as salmon, nuts and seeds.

These good fats are called essential fatty acids because they are essential to your health.

They include polyunsaturated fats, omega 6 fats and omega 3 fats, the most important of which for brain health are the omega 3s.

Natural Solutions for Dementia and Alzheimers is available from all good stockists, paperback RRP 12.77.

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Alzheimer's disease - five simple ways YOU can reduce dementia risk with DIET - Express.co.uk

Davina McCall’s on her fear of developing Alzheimer’s disease – Metro

Posted: at 5:49 pm


Davina McCalls opened up about her fear of Alzheimers (Picture: FilmMagic)

Davina McCall has revealed a deep fear of suffering from Alzheimers after her dadand grandmother were diagnosed.

The TV presenter revealed she is so afraid shell develop the disease too, she twice made heartbreaking calls to her doctor convinced she had already noticed symptoms.

Speaking to Good Housekeeping magazine, she said: I have called my doctor twice in floods of tears saying Ive definitely got it.

She told me If you had Alzheimers you wouldnt be calling me about it.

Im only forgetful because my inbox is full and I have cognitive overload. I dont drink, dont smoke and Im in good health. If I get ill, I get ill its a lottery.

Alzheimers disease, which is the most common form of dementia, is very personal toDavina as her dad and grandmother both suffer from it.

The mum-of-three gushed about how brave her dad is and how encouraged she was by his extraordinary positive attitude, even though hes been having problems with his short-term memory.

She explained: In certain aspects he is getting worse. His short-term memory is a struggle.

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But he is living a great life. When you see the way he is dealing with it, you realise you cant mope around.

My granny is very confused but shes happy. They are both pretty inspirational.

The former Big Brother host also recentlyadmittedthat managed to beat herheroin addiction in her 20s whenher last remaining friend gave her an ultimatum.

MORE: Davina McCall reveals friend gave her the wake up call that made her quit heroin

MORE: Davina McCall gets X-rated and fakes an orgasm on The Nightly Show

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Davina McCall's on her fear of developing Alzheimer's disease - Metro

Quinn on Nutrition: Domino effect – Circleville Herald

Posted: at 5:49 pm


They call it the domino effect when one event sets off a chain of similar incidents. I prefer when life dominoes in a positive direction, such as when lunch with an old friend leads to an unexpected meeting with another old friend and another all in the same day.

When stressful events domino, however, they seem to throw my food choices out of whack. One recent example: Right after I checked in for a flight out of my small hometown airport where travelers are welcomed with beverages, cookies and familiar smiles (really) I was informed our plane would be delayed about a half hour.

No worries. I settled down with a nice cup of tea and was confident I would make my Denver connection in plenty of time.

Another announcement came soon after. Our flight was now delayed about 2 hours.

Thats just an estimate, I was assured by an airline employee. You should still make your next flight.

I made another cup of tea. Time ticked by.

Two hours later, I clearly had missed my connection. And I suddenly had this urge to eat a cookie make that 3 cookies.

When we finally landed in Denver, I was informed I had missed all other flights to my destination that day. I was given a hotel voucher and was told if all went according to plan (hahahaha) I would arrive at my destination in time to rush to my scheduled event.

Realizing I had only eaten three cookies in the past 8 hours, I resisted the urge to walk to the nearest restaurant and order a bottle of wine and the biggest juiciest bacon cheeseburger on the menu.

Why is that? Why do we when life throws curves that domino suddenly want to slam down the nearest source of sugar and fat?

Its physiological, says brain and hormone experts. Animal and human studies have discovered that hormones released during times of physical or emotional stress can make us want to eat more (or less) depending on the severity of what we experience. Chronic stress when negative life events continue to domino can trigger a desire for, you guessed it, foods high in fat and sugar.

Its almost as if our brain tells our body, You need to fortify yourself to get through this difficult event. Here, have a cookie.

There is hope, however. Here are some ideas:

Be kind to yourself. Believe it or not, life rarely goes as planned. And we usually survive these crises and momentary lapses in judgement.

Plan ahead. I was extremely thankful I had placed an apple and bag of nuts in my carry-on bag that prevented me from seeking out M&Ms in my distress. And knowing that I desperately needed sleep instead of heartburn, I ordered a meal that brought me real nutritional comfort grilled fish with vegetables, a large glass of lemon water and a small glass of wine.

The goods news: I made it to my destination on time, with just a few nutritional bruises. Thats the chain of events I appreciate.

2017 The Monterey County Herald

Distributed by Tribune Content Agency, LLC.

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Quinn on Nutrition: Domino effect - Circleville Herald

Nutrition: How to identify chronic dehydration when the weather heats up – LA Daily News

Posted: at 5:49 pm


Summer may be a few months away, but warmer weather has already arrived.

Drinking adequate fluids is an essential part of staying cool and chronic dehydration can cause a wide range of unpleasant symptoms and health problems.

With temperatures soaring and plenty of outdoor activities filling up your calendar, its time to rethink your hydration plan.

You may already be aware that close to 60 percent of the human body is water. Most of this fluid is inside our cells, but a significant amount makes up our blood and circulatory system.

Correct balance of fluids and electrolytes is a basic requirement for proper bodily functioning. When fluid volume goes down there can be various unintentional consequences.

Here are some symptoms of chronic dehydration:

Fatigue and tiredness are common signs of dehydration that can kick in before you even start to feel thirsty. When the body lacks fluid, blood volume decreases, which results in reduced oxygenation of the muscles.

This can cause a feeling of sluggishness and weakness. Have a bottle of water easily accessible throughout the day to remind yourself to drink regularly and keep up with your fluid needs.

Along with inadequate dietary fiber intake and a lack of movement, dehydration is a common cause of constipation.

If the body is not well-hydrated, additional fluids from foods will be absorbed by the large intestine during the digestive process. This leads to difficulty having regular bowl movements. Be sure to reach for foods with a high water content such as fruits and vegetables to help ensure sufficient fluid intake.

It is not unusual to confuse thirst with hunger and reach for a bite to eat when, in fact, drinking more fluids can quench your thirst and satiate your appetite.

Studies have shown that drinking water right before a meal can curb the amount of food consumed at that meal. Keep in mind that water is a vital part of the continuous chemical reactions that take place in the body, also known as metabolism.

Although drinking in excess wont speed up an individuals metabolism, dehydration can certainly slow it down, leading to decreased energy production in the body.

Headaches, including migraines, are a common symptom of mild to moderate dehydration. When you feel a headache developing, consider if it may be due to dehydration.

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Rehydrating will likely help, but it may take from 30 minutes to a few hours to resolve the headache.

The amount of fluid you need each day depends on different factors like your size, activity level and even the climate. On average, most adults require about two liters of fluids per day. Water is the best drink to stay hydrated, but other beverages like milk, 100 percent fruit juice, sports drinks, coconut water, and tea are also hydrating.

Keep in mind that combining physical activity, sun exposure and high temperatures will significantly increase your fluid needs and the inability to stay hydrated and cool down in these conditions can lead to dangerous overheating, known as heatstroke. A proactive approach is key to staying hydrated this time of year and curbing the symptoms of dehydration.

LeeAnn Weintraub, a registered dietitian, provides nutrition counseling and consulting to individuals, families and businesses. She can be reached at RD@halfacup.com.

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Nutrition: How to identify chronic dehydration when the weather heats up - LA Daily News

USDA Set to Relax School Lunch Nutrition Rules – Education Week (subscription) (blog)

Posted: at 5:49 pm



Education Week (subscription) (blog)
USDA Set to Relax School Lunch Nutrition Rules
Education Week (subscription) (blog)
An announcement from the agency didn't provide specifics, but it's likely the rule will touch on concerns long voiced by congressional Republicans and school nutrition groups, who say that current regulations are overly restrictive and costly to implement.
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USDA Set to Relax School Lunch Nutrition Rules - Education Week (subscription) (blog)

Give like MADD in May at CENTER Mind/Body Fitness – Herald Review

Posted: at 5:48 pm


CENTER Mind/Body Fitness will be celebrating Mothers Day this year by organizing a month-long fundraiser for Mothers Against Drunk Driving, commonly known as MADD.

Founded more than three decades ago by a mother who lost her daughter to a drunk driver, MADD, according to their website, is the nations largest nonprofit aiming to protect families from drunk driving, drugged driving as well as underage drinking.

According to CENTER owner Christina Andersen, many of CENTERs clients are women and mothers. But more importantly, all of them have a passion for making a positive impact on the lives of others.

For this reason, CENTER Fitness hopes to tap into their health-minded community, while also remaining true to their mission to improve lives, by organizing a month-long fundraiser for MADD. This year is the first of what CENTER staff hope will become an annual event.

"This fundraiser is a win-win-win, said Andersen. CENTER gets to see new faces, students get to give back and improve their mental and physical health while doing it, and MADD gets the fruits of our labor to put to use preventing drunk driving and the fatalities associated with it.

CENTER, which specializes in Pilates and yoga, also offers various other forms of fitness, including RIDE classes, kettlebell boxing, TRX and more. For staff, it just made sense to create a take on an already existing MADD Fundraiser, known as Walk Like MADD, and instead call theirs Ride Like MADD.

For Andersen, the decision to host a month-long fundraiser was based on a number of factors, the two most prevalent being the CENTER-hosted Sukha Into Spring 5K which took place on April 15, as well as the upcoming MS Walk, taking place on May 7.

CENTER aims to raise $1,000 during their first annual Ride Like MADD Fundraiser.

Its lofty, for sure, said Andersen. But goals are good and our students continue to amaze me with their enthusiasm and generosity.

Throughout the month of May, CENTER will donate $10 for every 1,000 watts accumulated during all their ride classes. (According to Andersen, the average rider, depending on size and conditioning, can produce anywhere from 60 watts to 230 watts during an hour-long RIDE class.)

People love a challenge, said Andersen. "They get so much more out of their workout when they are doing it for something, or someone, else. Maya Angelou had it right: Giving liberates the soul.

CENTER will also donate 20 percent of all new Trial Month Memberships and 20 percent of all registrations for their Sip n Spin: Biker Barre with Mocktails event taking place on May 19 at 5 p.m. The latter will be an hour-long event co-taught by Andersen and Rhonda Peters, co-owners of Bala Day and Med Spa.

Biker Barre will allow participants to experience 30 minutes of RIDE, followed by 30 minutes of Barre. At the end, mocktails will be provided.

You definitely do not need to be a member, or even have been to CENTER before to partake in this fundraiser, said Andersen. In fact, this is the perfect excuse to come and check out who we are and what we do."

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Give like MADD in May at CENTER Mind/Body Fitness - Herald Review

Fitness Buff Turned Trash At The Beach Into Full-Fledged Gym – Huffington Post

Posted: at 5:48 pm


Most people go to the beach to kick back. Not Alcindo Soares.

Soares always dreamed of becoming a professional athlete, Great Big Story reported in its profile of the exercise buff. But when he couldnt afford to join a gym in Cape Verde, an island country off the coast of West Africa, he decided to build his own.

Soares, who works in construction, collects the detritus he finds on the shores of Santa Maria beach and fashions it into workout equipment. The outdoor facility is replete with many of the trappings youd find at a standard fitness club, including weights, pull-up bars and a bench for dips. But theres no membership fee here.

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Theres a dual purpose behind Soares mission. Hes is cleaning up his beach at a time when environmentalists are particularly concerned about the amount of pollution in our oceans. There are more than 150 million tons of plastic in marine waters today. At this rate, there will be more plastics than fish (by weight) in the oceans by 2050.

Soares is also providing a free community center to an area thats been ravaged by poverty. In Cape Verde, 21 percent of the population lives below the international poverty line, meaning they subsist on less than $1.25 a day.

For as long as I live, Ill continue to use it, Soares told Great Big Story of his gym. Train, then go swim in the ocean, and the day is complete.

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Fitness Buff Turned Trash At The Beach Into Full-Fledged Gym - Huffington Post

Fitness guru has 10 tips for people unhappy with their weight. Why? She’s been there – San Angelo Standard Times

Posted: at 5:48 pm


Robert Rodriguez, The Fresno Bee (TNS) 5:54 a.m. CT April 29, 2017

Dina Juve, owner of Fitness Social, is photographed Monday, April 3, 2017 in Fresno, Calif.(Photo: ERIC PAUL ZAMORA, TNS)

FRESNO, Calif. Dina Juve, a rising star in Fresnos health and fitness community, didnt always have a sculpted body, a taste for healthy foods or a positive attitude.

At one time, she was known as the fast food queen, weighed 202 pounds, and was an 18-year-old single mom. She suffered from juvenile arthritis and autoimmune disease. She was in physical pain most of the time, depressed and had little energy to keep up with a toddler.

I sat on the couch on day, looked at him and just started crying, says Juve. I didnt want him to see me like this, I wanted him to be healthy and happy.

It was a low point for Juve, but also the beginning of what would become her new life. She gave up sugary soda and eating fast food. She focused on healthier, minimally processed food. After a while, she also began to exercise. She stayed out of the health clubs in favor of her VCR at home and exercise tapes of Buns of Steel and Tae Bo.

I was too embarrassed to go to a gym; I did not want people to see me trying, she says. What if I failed?

Except Juve didnt fail. She got stronger, she got healthier and she became a new person. She immersed herself in the study of nutrition and exercise, earning certifications in kettle bells and TRX a band resistance program. Shes a battling ropes coach, Barre instructor and a weight-loss specialist, counseling clients on how to live and maintain a healthier lifestyle. She dropped 90 pounds and her weight these days ranges between 110-114.

Fresno's newest health and fitness guru, Dina Juve, 44, right, leads a class on how to create a healthy hamburger with Chef Hillori Hansen on Thursday, April 20, 2017, at Whole Foods, in Fresno, Calif. Along with owning a fitness studio, Juve is also a popular guest speaker, motivator and healthy food advocate.(Photo: Silvia Flores, TNS)

Along with her business partner, Melissa Oberti, she also founded FitnessSocial, a northeast Fresno fitness studio with a growing following.

Juve, who admits to living comfortably outside of the spotlight, was thrust into the public eye by friends and clients. With their encouragement she rose to national prominence after being selected one of five women vying for Womens Health 2015 Next Fitness Star. She appeared in the July/August issue of Womens Health magazine. Although she didnt win, she appeared on the Today show twice and made many valuable connections.

Today, the 43-year-old wife and mother of four is in demand as a public speaker, cooking instructor, and weight-loss expert. She has a spot on the Patio Cafes menu under the label Dinas Picks where she and restaurant owner Robyn Richardson have come up with menu items that are under 550 calories. And this year Juve will be speaking at Central California Womens Conference on Sept. 19. Her topic is Real Fast Food.

Friends say they arent surprised that Juve has become a health and fitness guru.

People talk about finding their passion or their calling and for Dina it is fitness and nutrition, says K.C. Cornwell. I really think that Dina was put on the planet to make people feel better about themselves.

Fresno's newest health and fitness guru, Dina Juve, creates healthier version of food favorites such as hamburgers made of ground beef, turkey or chicken topped with healthy greens during a class on how to create a healthy hamburger on Thursday, April 20, 2017, at Whole Foods, in Fresno, Calif. Along with owning a fitness studio, Juve is also a popular guest speaker, motivator and healthy food advocate.(Photo: Silvia Flores, TNS)

Hillori Hansen, culinary director for Whole Foods Market Fresno, has tapped Juve to lead several cooking classes. Recently, Juve and Hansen taught a class on how to make a healthier hamburger using five ingredients or fewer.

One of things that people love about Dina is that she is real, she has gone through struggles in her life and has overcome them, Hansen says. I can see her taking her message to a national stage.

That may be happening as Juve explores writing a book and more speaking engagements.

This is a whole new life for me, Juve says. But it is one that allows me to share my story and help others become healthier and happier.

To help you get started on living a healthy life, Juve has come up with 10 tips to follow:

Dina Juve, owner of Fitness Social, is photographed Monday, April 3, 2017 in Fresno, Calif.(Photo: ERIC PAUL ZAMORA, TNS)

1. Before embarking on a change in your diet, ask yourself why you are doing it. If you can dig deeper than just vanity, you are more likely to be successful. If you dont know why you are doing it, chances are you wont continue to truly live a healthy lifestyle. If you are doing it to feel better, have more energy, for health reasons, to be around for your children and grandchildren, etc., then you stand a better chance of success.

2. Drink water. Every system in your body depends on water. My recommendation to my clients is to drink 16 ounces of water before each meal and snack to keep it simple. On average, try drinking 48 to 96 ounces of water per day. I find that when my clients have water before eating they tend to eat less.

3. Stick to whole, real food. Avoid foods that are heavily processed or contain large amounts of artificial sweeteners, dyes or chemicals. Try to eat foods with ingredients you can pronounce. Think fresh fruits, vegetables, complex carbohydrates, and animal- and plant-based proteins.

4. Add healthy fats from fish, avocado, olives, nuts and tropical oils. Nuts have a lot of health benefits and help you lose fat by improving metabolism, balancing hormones and eliminating constant cravings by keeping you feeling full longer. Healthy fat calories do add up quickly, so be mindful of portion sizes if you are trying to lose weight.

5. If you crave something, eat it guilt free just dont overdo it. Eat the serving size, enjoy it, savor it and be done with it. If your indulgence doesnt satisfy you, ask yourself why. Are there other things going on in your life that need to be addressed?

Fresno's newest health and fitness guru, Dina Juve, 44, right, leads a class on how to create a healthy hamburger with Chef Hillori Hansen on Thursday, April 20, 2017, at Whole Foods, in Fresno, Calif. Along with owning a fitness studio, Juve is also a popular guest speaker, motivator and healthy food advocate.(Photo: Silvia Flores, TNS)

6. Avoid categorizing foods with words like good or bad. Negative words make you feel bad about yourself and thats not helpful. Aim to eat foods that give you energy and not make you sluggish.

7. Mindful eating. Eat when you are hungry and do not eat when you are not. We have gotten into a routine of eating on a schedule, even when we are not actually hungry, or we skip meals. Try listening to your body. When you pay attention to your body, you will find yourself fueling your body and using that fuel before you eat again.

8. Slow down when you eat. Try to take 20-30 minutes to eat a meal. Put your silverware down between bites. Try to chew your food fully. You will most likely find yourself eating less. Try to not eat when you are stressed, anxious, angry or rushed because this can be the cause of overeating.

9. Aim to eat the rainbow by adding more fruits and vegetables. The more colorful your plate looks the more appetizing it will appear to your eyes. It will also most likely ensure that you will receive the vitamins and minerals your body needs.

10. Yes, you can still eat out and have the body you desire. You just have to balance it like a checking account. If you overeat the debt will show up on your body. If you do not go out to eat, stay at home and do not enjoy life, thats not creating a long-term healthy enjoyable lifestyle you can maintain. We call that a diet and diets dont last long term. A healthy eating lifestyle has variety and it includes occasional indulgences. You know you have the plan that works best for you when you feel, move and look your very best. It really is not as hard as it seems.

A Honey Almond Strawberry Shortcake with Vanilla Bean Whipping Cream made by Fresno's newest health and fitness guru, Dina Juve, and Chef Hillori Hansen, on Thursday, April 20, 2017, at Whole Foods, in Fresno, Calif.(Photo: Silvia Flores, TNS)

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Fitness guru has 10 tips for people unhappy with their weight. Why? She's been there - San Angelo Standard Times

GOP health plan for pre-existing conditions spawns worries – PBS NewsHour

Posted: at 5:48 pm


The latest version of House Republicans American Health Care Act would allow states to opt out of the requirement for standard premiums, under certain circumstances. Photo by Getty Images

WASHINGTON From cancer to addiction, doctors and patient groups are warning that the latest Republican health care bill would gut hard-won protections for people with pre-existing medical conditions. Some GOP moderates who may seal the legislations fate are echoing those concerns.

In a strongly worded statement this week, the American Medical Association said the Republican protections may be illusory. The American Cancer Society Cancer Action Network said the plan could take the nation back to a patchwork system that pushes costs on people with life-threatening conditions.

Such stark messages may be connecting with lawmakers anxious about making the right decision on issues that touch every family. Rep. Patrick Meehan, R-Pa., said the rewritten bill doesnt change the fundamental concerns I had at the outset making sure people with serious medical conditions could get affordable and adequate coverage. Count him among the GOP moderates who remain opposed.

The latest version of House Republicans American Health Care Act would allow states to opt out of the requirement for standard premiums, under certain circumstances.

And veteran Rep. Fred Upton, R-Mich., said Friday hes not comfortable with the bill and would like to see it changed. A former chairman of the Energy and Commerce Committee, Upton said he was concerned people with pre-existing medical problems could face unaffordable premiums.

The Affordable Care Act passed under President Barack Obama requires insurers to take all applicants, regardless of medical history. Patients with health problems pay the same standard premiums as healthy ones.

The latest version of House Republicans American Health Care Act would allow states to opt out of the requirement for standard premiums, under certain circumstances.

214160214166214166Why the U.S. pays more for health careWhy are American health care costs by far the highest in the world? Journalist and former practicing physician Elisabeth Rosenthal chronicles how we got here in her new book, "An American Sickness." Economics correspondent Paul Solman talks with Rosenthal about the forces driving high prices and what could be done to bring costs down.2017-04-27 06:00 pmdisabled3000369204gXBPKE28UF0

If a state maintains safeguards such as a high-risk pool, it can allow insurers to use health status as a factor in setting premiums for people who have had a break in coverage and are trying to get a new individual policy. Critics of the Republican approach say there is no requirement that a state must provide an affordable coverage option for those consumers.

Proponents say people in poor health would still be protected as long as they maintain coverage. And the higher premiums would revert back to standard rates after 12 months, assuming the customer could afford to keep paying.

All they are doing is moving the venue where people are going to be discriminated against, said AMA President Andrew Gurman. It would simply give them an escape clause for 50 states. The nations largest doctors group supported passage of the Obama-era law, and is now pressing for a bipartisan approach to fix problems with the program.

Gurman used the hypothetical example of a low-income worker with a new cancer diagnosis.

This is not the kind of thing you can put off for a while, he said. Theyre going to need urgent surgery, radiation. They are not going to be able to work. If they lose coverage for more than 60 days, how are they going to afford huge insurance premiums? That scenario is all too common, unfortunately.

Along with the AMA and other groups, the advocacy arm of the American Cancer Society is raising concerns about another GOP provision that would let states to get waivers from essential health benefits. Thats the requirement in the Obama-era law that insurers must cover 10 broad categories of services, from hospitalization to preventive care, from lab tests to mental health and substance abuse treatment.

READ NEXT: Column: 6 questions to ask at every doctors appointment

Part of the risk is that the ACAs financial protections, including no annual or lifetime dollar limits on coverage, are tied to medical care under the essential benefits.

Without these protections in place, we are returning to the Wild West again, said Kirsten Sloan, vice president for policy at the Cancer Action Network.

Nonetheless House Speaker Paul Ryan, R-Wis., said recently he thought people with pre-existing medical conditions would be better off under the GOP plan because theyd have more options. Thats the whole goal, he said, to make it easier for people.

But Republican health economist Gail Wilensky said shes greatly concerned about the latest shift on pre-existing conditions.

It definitely gives the state the option, in a waiver process, of greatly diminishing if not gutting the pre-existing conditions protections, she said. High-risk pools can serve effectively as a backstop, she added, but House Republicans have not provided enough money for them.

I think this is flawed, Wilensky said. The moderates in the House are pushing back, and I cant imagine it getting out of the Senate.

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GOP health plan for pre-existing conditions spawns worries - PBS NewsHour

A new idea for filling hard-to-fill health-care jobs: Ex-offenders – Washington Post

Posted: at 5:48 pm


By Sophie Quinton By Sophie Quinton April 29 at 7:00 AM

BALTIMORE Collie Thomas sat in the courtyard outside Johns Hopkins Hospital and marveled at her luck. She works as an orderly in one of the most prestigious hospitals in the country. She was promoted about a year ago. She just moved into a snug new rowhouse.

I stayed 10 years in prison, and I worked hard in prison for like a dollar, dollar fifty for so little, said Thomas, 51, her bedazzled pink smartphone glinting in the April sunshine. So when you get these kinds of jobs here, you work your best.

With unemployment falling and workers hard to find, a growing number of health-care employers are following Johns Hopkinss lead and giving people with criminal records a second chance hiring them mainly into entry-level jobs in food service, janitorial services and housekeeping. Studies show that employees with records stay in their jobs longer and are no more likely to commit workplace crimes than hires without them.

This year, Illinois began allowing people with some forcible felony convictions to petition for professional licenses in health care. In 2015, Pennsylvanias Supreme Court struck down a decades-old law that had prohibited people with certain offenses including theft and murder from working in long-term-care facilities, home care agencies and adult day centers.

But health care isnt quite like any other business. Hospitals, nursing homes and doctors offices care for people in the most vulnerable moments of their lives. Citing public-safety concerns, some states have gone in the opposite direction, passing laws to keep people with criminal records out of clinical jobs.

For instance, a bill in Colorado would require doctors, nurses, dentists and other health-care professionals to submit a fingerprint-based background check before they can be licensed, and it would permit licensing boards to disqualify applicants who have been convicted of unlawful sexual behavior or diversion of controlled substances. A 2016 Indiana law expanded background checks for people who work at home health agencies. Existing state law already bars home health agencies from hiring people who have been convicted of certain crimes, such as theft and rape.

But about 1 in 4 Americans has a criminal record. As the health-care sector continues to add jobs, state lawmakers and employers will have to decide whether ex-offenders will be allowed to fill them.

Beyond Ban the box

Johns Hopkinss willingness to hire ex-offenders dates to the late 1990s. At that time, the economy was booming and the hospital was desperate for workers, said Michele Sedney, senior director for central recruitment services at the health system.

Thats also around the time that we started doing background checks and we started to find, Gee, theres lots of people that have backgrounds. And if were going to exclude all of them, then how are we ever going to staff the hospital? she said.

Today the Johns Hopkins health system doesnt run a background check until after a conditional offer of employment is made. If theres a problem, a former Baltimore police officer who works in the human resources department will review the applicants record. HR will consider mitigating factors, such as how long ago the offense took place.

Sedney says that in the four years shes been in her role at the health system, there has been no theft, drug diversion or other criminal incident involving an employee with a criminal record. In a five-year study of almost 500 ex-offender employees, Hopkins found that ex-offenders were more likely to stay in their jobs for more than three years than non-offenders.

Other research supports the idea that people with criminal records are reliable workers. A Northwestern University study of tens of thousands of hires into low-skill white-collar jobs found that hires with records stayed in their jobs longer and were no more likely to get fired than hires without records.

This evidence taken together suggests that employees with a criminal background are, in fact, a better pool for employers, the study said.

The federal government put pressure on all employers to consider applicants with a criminal record in 2012, when the Equal Employment Opportunity Commission warned that employers that exclude applicants because of their records may violate anti-discrimination laws. Some states and cities, including Baltimore, ban employers from asking about arrest and conviction records until late in the hiring process.

Thats not to say that hiring an ex-offender doesnt pose risks. Employers are wary of opening themselves up to negligent-hiring lawsuits. And the public blowback when someone with a criminal record commits a crime can be huge. Colorados background-check law was proposed after the Denver Post exposed the large number of nurses with criminal records working in the state.

But now that workers are once again hard to find, more health-care systems are becoming open to hiring people with arrest and conviction records. Johns Hopkins has hired people with records for hard-to-fill positions such as a night-shift job cleaning floors in the emergency department.

A second chance

Thomas, the Johns Hopkins employee, is warm and chatty and dresses up her beige uniform with purple lipstick and glittery gold nail polish. She has worked in the health-care industry most of her life, as a nurses aide and housekeeper. In her current role, she makes sure patients rooms are stocked with the right supplies and helps out with other nonclinical tasks, such as moving patients and delivering medical records.

She doesnt seem like someone who has been to prison least of all for murder.

Heres what happened, as Thomas tells it. In the early 2000s, during a fight at home with her on-again, off-again boyfriend, she grabbed a knife and waved it at him. She wanted to scare him into leaving her alone. Instead, he rushed at her. By the time the scuffle was over, a table was broken and her boyfriend had a stab wound in his chest.

I never thought the man was going to die, Thomas said. But later, in the hospital, he did. Her knife had punctured his lung. When she found out, she was at the police station explaining what had happened. She didnt think to call a lawyer.

After her sentencing, Thomas requested to be sent to a prison that specialized in inmates with mental illness, because she knew she needed therapy. My life was just shattered, she recalled. She had struggled with drug use. One of her sons had been killed less than two years earlier. In prison, shed be locked away from her 12-year-old daughter and college-age son.

When Thomas was released a few years ago, her daughter advised her to join a reentry program shed seen on Facebook, Turnaround Tuesday.

Employers often feel more comfortable hiring felons who have been vetted by a community organization or workforce intermediary, a role that Turnaround Tuesday plays in Baltimore.

Turnaround Tuesday is a nonprofit initiative that operates out of two church basements on opposite sides of the city. (Both groups meet on Tuesdays.) Its open to anyone who is struggling to find work, but about two-thirds of participants have a criminal history, says Melvin Wilson, one of the program directors.

Turnaround Tuesday has a reputation for getting people jobs, thanks to its strong relationship with Baltimore employers. Participants learn to manage conflict, set boundaries, advocate for themselves and others, and tell their story in a way that emphasizes personal growth. They can keep showing up to the meetings for as long as they want.

In the end, Thomas said, her incarceration made me a much better person. In prison, she gained new job skills and worked through the trauma of her past. At Turnaround Tuesday, she learned how to conduct herself professionally. She still goes to the meetings when she can.

Thomas is grateful for her job and plans to work hard to keep it. The truth about ex-cons, she said, leaning forward conspiratorially, is that employers can get more work out of them. Thats why you should always give them a chance, she said.

Stateline

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A new idea for filling hard-to-fill health-care jobs: Ex-offenders - Washington Post

Anti-abortion leader to be named to top health position, White House says – CBS News

Posted: at 5:48 pm


In this July 1, 2010, file photo, Dr. Charmaine Yoest testifies on Capitol Hill in Washington.

Pablo Martinez Monsivais / AP

NEW YORK -- The White House says President Donald Trump is appointing the former president of a leading anti-abortion organization to a senior position at the Department of Health and Human Services.

Charmaine Yoest, who actively supported Trump in his campaign, will serve as assistant secretary of public affairs at HHS. From 2008 until February 2016, she was president of Americans United for Life, which campaigned at the federal and state level for tough restrictions on abortion.

Among the many state bills backed by the group under Yoest's leadership were measures that would ban most abortions after 20 weeks of pregnancy, require women seeking abortions to undergo a sonogram and impose tough regulations on abortion clinics that could lead to their closure.

The appointment was assailed by abortion-rights groups.

"Charmaine Yoest has spent her whole professional life opposing access to birth control and a woman's right to a safe, legal abortion," said Dawn Laguens, executive vice president of Planned Parenthood. "While President Trump claims to empower women, he is appointing government officials who believe just the opposite."

Anti-abortion leader Marjorie Dannenfelser, president of the Susan B. Anthony List, praised Yoest as "one of the pro-life movement's most articulate and powerful communicators."

Dannenfelser also noted that Yoest - in a sign of the ideological shift taking place in Washington - will be replacing Kevin Griffis, who joined Planned Parenthood earlier this month as vice president of communications.

Many anti-abortion leaders, including Yoest, were initially cautious about Trump's bid for the presidency, but became staunch supporters after he pledged to support several of their key goals. These included a federal 20-week abortion ban, a halt to federal funding for Planned Parenthood, and appointment of Supreme Court justices who would be open to overturning Roe v. Wade, the 1973 decision that established a constitutional right to abortion.

Yoest began her career serving under Ronald Reagan in the Office of Presidential Personnel and was an adviser to former Arkansas Gov. Mike Huckabee's 2008 presidential campaign. Most recently she has served as a senior fellow at American Values, a conservative group in Washington.

2017 The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed.

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Anti-abortion leader to be named to top health position, White House says - CBS News

Revised GOP health care bill aims to win over conservative House members – The Daily Citizen

Posted: at 5:48 pm


WASHINGTON Like she has done every week for the last three months, Kathy Adin, a 70-year-old retired school librarian, went to Congressman John Fasos upstate New York district office Friday to urge him not to repeal the Affordable Care Act.

Adin said shes concerned the Republican health care bill under consideration by House Republicans will mean a friend who had breast cancer, and others with pre-existing conditions, wont be able to pay the higher price for their health care insurance.

House Speaker Paul Ryan and House leaders have revised their original, failed legislation to repeal and replace the Affordable Care Act, also known as Obamacare, and are now bent on winning over conservative Republican support for the new measure.

Adin, along with 10 others from New York who accompanied her to Fasos office, filled out comment cards urging the congressman to vote no.

The House may again try to vote on health care as early as next week, about a month after opposition from moderates and conservatives forced Ryan to cancel a vote on the measure at the last minute.

While public attention focused last time on conservatives who didnt think the bill went far enough to repeal Obamacare, lawmakers like Faso from moderate districts around the country are on the hot seat this time around.

Still, even a few conservatives say they wont support the new version. Rep. Tom Massie, R-Ky., said in a statement he will continue to oppose the bill because it does not fulfill my campaign promise to fully repeal Obamacare.

Many moderates say they oppose the revised bill. Or, like Faso, are on the fence, leaving Republicans still without enough votes to win approval by the House. Democrats are again expected to oppose the GOP bill en masse.

The American Medical Association, which says it has been left out of the GOP discussions, plans to run online ads urging lawmakers to vote against the measure.

Other groups are organizing thousands of phone calls and rallies like one Friday in Jeffersonville, Ind., near the offices of another undecided Republican, Rep. Trey Hollingsworth.

To win over conservatives, House leaders added new provisions to the bill that would give states the option to allow insurers to charge people with pre-existing medical conditions higher rates. It would also give states the option to do away with a requirement that all plans cover a minimum set of benefits, including mental health and maternity care.

As it did before, the House proposal also removes the mandate that every American have health insurance or pay a penalty.

It would leave in place subsidies to help lower- and middle-income individuals buy insurance, but would increase help for younger people and lower it for older people to encourage healthier individuals to get coverage.

The expanded Medicaid insurance program for lower-income recipients who had too much income to qualify for traditional Medicaid would no longer accept additional individuals.

Republican supporters argue the latest proposal will allow states to lower health care insurance premiums because covering individuals with pre-existing conditions means other people had to pick up the cost through higher premiums. They contend letting insurers offer plans with fewer benefits would allow people to buy cheaper insurance if they dont want to be covered for services like maternity care.

But the changes put moderates in a bind. The guarantee to cover those with pre-existing conditions and coverage for mental health and maternity care are among the more popular aspects of the Affordable Care Act.

At a press conference Thursday, House Democratic Leader Nancy Pelosi of California said a national poll found only 17 percent support for the original GOP health care bill. She said Republicans who support the revised version will have doo-doo on their shoe, a tattoo on their forehead.

The changes also heightened opposition from groups like the AARP, which had also opposed the earlier version, saying fewer people would be able to get coverage. The groups said the changes made the bill worse, not better.

Confronted by about 70 people at a town hall meeting in Johnstown, N.Y., on Monday, Rep. Elise Stefanik, who represents the area around Plattsburgh, said shed push to protect coverage for people with medical conditions and maternity health.

She faces having to go before her constituents again at a town hall meeting in Plattsburgh, potentially a few days after a health care vote.

In an email Friday, spokesman Tom Flanigan said Stefanik will push for coverage for people with pre-existing conditions as negotiations continue. He wouldnt say whether she would support the bill as currently written.

Moderate Republicans are in a tough spot no matter how Republican leaders try to dress up the bill, said Claire McAndrew, director of campaign strategy for FamiliesUSA, which has been pushing hard against the bill. Im not sure they can dress it up to convince people its not going to be harmful.

Kery Murakami is the CNHI Washington reporter.

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Revised GOP health care bill aims to win over conservative House members - The Daily Citizen

Functional Medicine, Naturopathy, Peak 2017 U.S. Health Trends … – Digital Journal

Posted: at 5:47 pm


USA Alternative treatments have caught mainstream medias attention not only owing to their increased patient following, but also to the many testimonials provided by those who have found relief after years of battling with western medicine red tape - feeling as if though they are passed from one specialist to another, without ever receiving a whole-system evaluation.

It is through the principles of functional medicine that patients report finding renewed hope at the end of a long string of disappointments, as well as the peace both physical, and mental that has long eluded them. Combining the best of integrative and holistic medicine, functional medicine has been deemed the future of western medicine, as it stands for a groundbreaking, all-encompassing approach towards treating patients with regards to their overall wellbeing, rather than focusing on a particular issue that might be traditionally correlated with a single symptom-system-drug treatment trifecta.

Doctor Kate Kasss media representative spoke of the practices that fall under the functional medicine umbrella, saying As functional medicine principles dictate a holistic approach to solving any health issue that might arise, virtually any bodily disturbance can be addressed through its practices. Since ones body depends on its many systems working in tandem, functional medicine comes in to fill in the gap left by western medicine which is missing out on the correlation between symptoms, and often the reluctance to look into the underlying causes behind them, as they are often more complex than what they appear on the surface.

Wellness, reproductive health, and anti-aging concerns are among the top reasons that people turn to functional medicine to find relief from. Most patients report that, in addition to being pleased with the outcome of their custom treatment regimens, what surprised them the most and boosted their positive attitude towards getting better was the incredible care they received by their dedicated, thoughtful doctors. It is the one-on-one, case-by-case approach that essentially sets functional medicine miles apart from western medicine, and the main contributing factor that will render it the most dominant approach in the medical field in the near future.

For more information about this industry, you can visit Doctor Kate Kass at drkatekass.com, who is an expert in the field.

Media Contact Company Name: National Press Distributors Contact Person: Mary Smith Email: info@nationalpressdistributors.com Phone: (206) 800-7756 Address:500 Mercer Street City: Seattle State: WA 98109 Country: United States Website: http://drkatekass.com/

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Cheese Compound Curtails Cancer – Anti Aging News

Posted: at 5:47 pm


Posted on April 25, 2017, 6 a.m. in Cancer Functional Foods Longevity

Spermidine, found in foods such as cheese, mushrooms, and whole grains, is shown to prevent liver cancer and boost longevity.

A new study indicates that spermidine may minimize the risk of liver cancer and simultaneously boost lifespan. The beauty of this finding is that most people will enjoy consuming the foods that provide such benefits: aged cheese, mushrooms, whole grains, soy, corn, legumes and other foods with plenty of spermidine.

Researchers fed mice an oral supplement of spermidine. The results were quite intriguing. These mice were less inclined to incur liver fibrosis. They were also less inclined to develop hepatocellular carcinoma, the most prevalent form of liver cancer. The Texas A&M research team also found that the consumption of spermidine boosts the lifespan of mice by 25 percent. The study's findings were recently published in Cancer Research, a popular medical journal.

About the Study

The study was spearheaded by Leyuan Liu, Ph.D. She works at Texas A&M's Institute of Biosciences & Technology. Liu and her research team keyed in on spermidine, a polyamine compound with a minimum of two amino groups. It is named as such as it was separated from sperm. Spermidine is commonly found in an array of food products like those listed above.

Previous studies indicated dietary spermidine might produce health benefits. As an example, a previous study linked oral supplementation of spermidine to improved longevity and heart health in mice. A recent study tied the compound to decreased blood pressure.

Liu's research team was more concerned with whether spermidine has anti-cancer properties. The researchers provided an oral spermidine supplement to mice that had a predisposition to the development of liver fibrosis or hepatocellular carcinoma, meaning an accumulation of scar tissue in the liver that has the potential to cause liver cancer. Study Results

The spermidine supplement reduced the odds of the development of liver fibrosis or hepatocellular carcinoma in mice. Furthermore, the mice given the supplement lived longer than the mice that were not provided with it. In fact, the increase in lifespan was about 25 percent which equates to a human being living to 100 instead of 81 years-old. However, it is important to note that this boost in lifespan was only observed in mice with lifelong spermidine supplementation. Mice that were provided the supplement at a later point in life enjoyed a longer life but the extension topped out at about 10 percent.

Previous Research of Note

Liu's research team also conducted previous research that determined the lack of autophagy played a role in the development of cancer. Autophagy is the process through which cells consume their debris. The researchers determined the benefits of spermidine were reduced when the protein known as MAP1S was absent. This protein is a common trigger of autophagy. As a result, Liu's research crew believes the cancer-fighting properties of the compound are determined by the enhancement of autophagy related to MAP1S. A Look to the Future

Additional studies must be conducted to determine if spermidine supplementation is safe for human use. It is anticipated that this supplementation will provide meaningful health benefits. Spermidine might one day be added to bottled sodas or alcohol to balance out the beverages' negative ingredients and simultaneously enhance the liver, prolong lifespan and combat hepatocellular carcinoma.

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Cheese Compound Curtails Cancer - Anti Aging News

2 new drugs being studied could help Alzheimer’s patients … – 13newsnow.com

Posted: at 2:47 am


Here in St. Louis, there's new hope: Two new drugs, under study, by a university.

Christina Coleman, KSDK 8:40 AM. EDT April 26, 2017

(Photo: BILL GREENBLATT, Custom)

ST. LOUIS - Alzheimer's is a disease that robs patients of their memories, personality and independence. Now, there's a groundbreaking international study taking place in St. Louis that might prevent it.

Its called the Dominantly Inherited Alzheimer's Network trial by Washington University. Participants have a rare gene that can lead to what doctors call Early Onset Familial Alzheimer's disease, which means people can develop it younger than 65.

Early onset familial Alzheimer disease is hereditary and marked by Alzheimer symptoms that appear at an unusually early age. The study tests the idea of how to prevent the disease from starting in the first place.

Carrie Richardson Whitfield, 35, lost her father and three uncles to Early Onset Alzheimers, the oldest living to just 45. The mother of three carries the gene for the disease of which her 36-year-old brother is already showing signs.

The study has more than 260 participants from various countries including Spain, France, Australia and the United Kingdom. Participants from Germany will be joining the study too.

Whitfield said she hasnt showed any symptoms so far. Brian Whitney showed 5On Your Side a family photo from 1959. He has fourteen relatives in the picture. Eleven of them died from the disease.

Whitney has the gene that leads to Early Onset Alzheimers Disease. His father does too. However, they are not showing any symptoms. Whitney said he wants to take part in the study to help find a cure, so that his daughter can avoid the hereditary disease. Whitney said he also wants to bring awareness to Early Onset Alzheimers Disease.

Its not an old persons disease," he said. "In our family, our average age of onset is 50. I know families who are dealing with people who lost parents at the age of 35 or 36 to Early Onset Alzheimers, with symptoms shown as early as 31 or 30.

Dr. Randall Batemann of Washington Universitys School of Medicine is the lead investigator of the DIAN-TU study. He said they might know by 2019 if the first two drugs being tested in the study could help fight the disease.

Batemann said the families that have the genetic mutations are incredibly rare and exist in different pockets throughout the world. Most of these families have never met another family who has the same kind of disease and many of these families thought they were the only people in the world to have the disease.

Bateman said the study is giving the family hope. If you would like to see if you qualify for the study, click here.

Alzheimers is the sixth leading cause of death in this country, and is the only disease among the 10 deadliest that cannot be prevented, slowed or cured.

2017 KSDK-TV

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A promising new treatment for Alzheimer's

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2 new drugs being studied could help Alzheimer's patients ... - 13newsnow.com

Alzheimer’s clinical research lacks leadership – Baltimore Sun

Posted: at 2:47 am


Can a childhood cancer doctor like me have insights about that other end of medicine older adults with dementia? A baby acutely ill with leukemia seems like the polar opposite of a woman with Alzheimer's disease (AD), with her slow, insidious deterioration. Yet each can be progressive and fatal. I've cared for both, in different ways.

As a husband and caregiver, confronting my wife's Alzheimer's disease, I am appalled by the lack of effective therapy for her. As a clinical investigator, I'm appalled by what I see as a lack of direction in clinical dementia research, a lack of structure and a lack of ambitious leadership.

"Every Minute Counts," the PBS TV documentary that aired recently, showed the heart-rending personal devastation of Alzheimer's disease and dementia, and the enormous cost of care for those affected. It ended with a plea for more funding and research. But after decades of research and billions already spent, why aren't we further?

Alzheimer's is now the sixth leading cause of death in the U.S.; it was only 13th two decades ago. Many AD experts acknowledge the lack of progress. Last year, two researchers even wrote that seeking an AD cure is a notion "many believe unrealistic," and that advocating for curative therapy "verges on the promotion of false hope."

Since my wife was diagnosed, just one new drug really a combination of two older drugs has been approved for Alzheimer's. As a cancer doctor, I've watched more than 70 cancer treatments get approved during those same five years.

Even the Alzheimer's Association plainly states "there is no cure for Alzheimer's." Not so plainly stated is that we don't know what causes it, how it happens or how to prevent it.

Of course, we don't really know what causes childhood leukemia either, how it happens or how to prevent it, even with our current sophisticated molecular descriptions and theories. But the survival rate for the most common childhood leukemia has gone from less than 10 percent in the 1960s to over 90 percent now, with incremental progress every five years. Most kids are cured with combination chemotherapy that was developed decades ago, before molecular testing.

Most AD funding goes for molecular or non-therapeutic research, at the expense of clinical work. Sickle cell anemia was called the first "molecular disease" over 60 years ago; we still don't have a cure, even though just this year we might have a gene therapy for it. In AD, the molecular genetics seems more complicated. AD patients have waited years for any therapy, much less one from "precision medicine." Is this the right strategy?

It's not all bad news. Last year, three commercial drug trials announced results, and they showed glimmers of hope. Two were reported as failures by the media, but company press releases (TauRx, Lilly) reported modest positive effects. The third drug, from Biogen, seemed better at slowing the decline in some patients, but it evidently did not stop the disease.

AIDS therapy, like cancer, is an area of medicine that seemed hopeless at first. The leadership of Dr. William Paul, an "AIDS Czar," is credited with accelerating clinical progress in that condition. Still incurable, nevertheless AIDS patients' lives are now extended from months to years.

Nothing has really changed for Alzheimer's patients over the past five years. Brilliant scientists are working, but in the usual atmosphere of creative academic chaos. There are a few AD clinical trial groups, much like cancer trials groups, but the comparison of their activity is stark. In the state of Washington, where I live, there are over 600 cancer studies recruiting patients; in AD there are about a dozen such studies.

Much foundational AD work still needs to be done at the bedside, in overall strategy, trial coordination, informed consents, vigorous subject recruitment and consensus development, so appointing an accountable, identifiable, directive clinical research leader seems like an important way to accelerate progress.

Dr. Ron Louie is a clinical professor of pediatrics at the University of Washington, Seattle; his email is ronlouie@u.washington.edu.

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Alzheimer's clinical research lacks leadership - Baltimore Sun

Neurotrope Bioscience to Release Results From Phase 2 Clinical Trial in Moderate to Severe Alzheimer’s Disease on … – Yahoo Finance

Posted: at 2:47 am


NEW YORK, April 28, 2017 /PRNewswire/ --Neurotrope, Inc. (NTRP), a clinical-stage biopharmaceutical company developing novel therapies for neurodegenerative diseases, including Alzheimer's disease, will issue a press release announcing results of top-line data from its 148 patient, Phase 2 clinical trial in moderate to severe Alzheimer's Disease, on Monday May 1, 2017, at 6:30 am, Eastern Time. A conference call will follow at 8:30 am Eastern Time on that date.

The dial-in information to access the live call is listed below:

Participant Toll Free Dial-In Number:(877) 245-7303 Participant International Dial-In Number: (478) 219-0731 Conference ID:16070779

The dial-in information to access the call replay, available for 30 days after the live call, is listed below:

Replay Toll Free Dial-In Number:(800) 585-8367 Replay International Dial-In Number: (404) 537-3406 Conference ID:16070779

Callers should dial in approximately 10 minutes before the live call begins.

About Neurotrope

Neurotrope is at the forefront of developing a novel therapy to treat and potentially reverse moderate to severe Alzheimer's dementia and other neurodegenerative diseases. The Company's world-class science is a paradigm shifting approach that treats some of the underlying causes of Alzheimer's disease.

The scientific basis of our treatment is activation of Protein Kinase C isozymes and by Bryostatin-1, a natural product, which in mouse Alzheimer's disease models was demonstrated to result in repair of damaged synapses as well as synaptogenesis, the induction of new neuronal networks, reduction of toxic beta-amyloid generation, prevention of neuronal death, and enhancement of memory and learning, thus having the potential to improve cognition and behavior in Alzheimer's dementia.

Neurotrope has conducted a Phase 2 trial of Bryostatin-1 in the treatment of moderate to severe Alzheimer's dementia, as well as preclinical studies of Bryostatin-1 as a treatment for Fragile X Syndrome, Niemann-Pick Type C disease and Rett Syndrome, three rare genetic diseases for which only symptomatic treatments are currently available. The FDA has granted Orphan Drug Designation to Neurotrope for Bryostatin-1 as a treatment for Fragile X Syndrome. Bryostatin-1 has undergone testing in over 1,500 people establishing a large safety database.

Forward-Looking Statements

Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements. These forward-looking statements include statements regarding the Phase 2 study and further studies, and continued development of use of Bryostatin-1 for Alzheimer's dementia and other cognitive diseases. Such forward-looking statements are subject to risks and uncertainties and other influences, many of which the Company has no control over. There can be no assurance that the clinical program for Bryostatin-1 will be successful in demonstrating safety and/or efficacy, that we will not encounter problems or delays in clinical development, or that Bryostatin-1 will ever receive regulatory approval or be successfully commercialized. Actual results and the timing of certain events and circumstances may differ materially from those described by the forward-looking statements as a result of these risks and uncertainties. Additional factors that may influence or cause actual results to differ materially from expected or desired results may include, without limitation, the Company's inability to obtain adequate financing, the significant length of time associated with drug development and related insufficient cash flows and resulting illiquidity, the Company's patent portfolio, the Company's inability to expand the Company's business, significant government regulation of pharmaceuticals and the healthcare industry, lack of product diversification, availability of the Company's raw materials, existing or increased competition, stock volatility and illiquidity, and the Company's failure to implement the Company's business plans or strategies. These and other factors are identified and described in more detail in the Company's filings with the SEC, including the Company's Annual Report on Form 10-K for the year ended December 31, 2016. The Company does not undertake to update these forward-looking statements.

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Neurotrope Bioscience to Release Results From Phase 2 Clinical Trial in Moderate to Severe Alzheimer's Disease on ... - Yahoo Finance

Acadia Pharmaceuticals May Just Be the Best Long-Term Play on … – Motley Fool

Posted: at 2:47 am


Investor confidence in a potential acquisition of Acadia Pharmaceuticals (NASDAQ:ACAD) seems to have waned, and the stock's price has suffered as a result. However, with share prices at their current depressed level, Acadia could be a bargain should its key drug Nuplazid succeed in Alzheimer's disease psychosis.

For pharmaceutical companies, a treatment for Alzheimer's disease (AD) has remained the holy grail. This devastating disease impacts millions of people, and potential treatments have garnered significant attention from patients and investors alike.

Famous "breakthrough" therapies such as Pfizer/Johnson & Johnson's bapineuzumab and, most recently,Eli Lilly's solanezumab have all failed to demonstrate disease-slowing effects in late-stage clinical trials. In fact, over the last decade, it has been estimated that around 99% of potential Alzheimer's treatments have failed.

The issue with each of these products is that they all realy on the "amyloid hypothesis" of understanding Alzheimer's disease. The underlying cause of AD is still unknown, but scientists have a theory based on the observation that a protein called "amyloid-beta" tends to build up in large quantities in the brains of patients with AD. These proteins then group together to form a plaque, which blocks cell-to-cell communication. The amyloid hypothesis (which is as yet unproven) says that the underlying cause of AD is this buildup of amyloid-beta plaque.

Image source: Getty Images.

Assuming the amyloid hypothesis has merit, the next logical step would be to destroy the plaque buildups in patients' brains. And that's exactly what the aforementioned bapineuzumab and solanezumab set out to do. Both drugs were highly effective in clearing amyloid plaques from the brain. However, in long-term, phase 3 studies, neither drug showed an ability to halt or slow the progression of the underlying disease.

Following the failures of bapineuzumab and solanezumab, the industry has now turned its watchful gaze to Biogen's aducanumab, which is currently in phase 3 trials. Although this drug did show potential efficacy in phase 2 studies, this product still fundamentally adheres to the amyloid hypothesis of Alzheimer's. Although the entire Alzheimer's disease community would love to see aducanumab succeed, the odds are long.

Could a different approach hold the solution?

Acadia's main product, Nuplazid, takes a different approach to the treatment of Alzheimer's. Rather than attempting to halt or slow the progression of the underlying disease, Nuplazid is being studied in Alzheimer's disease psychosis (ADP), a psychiatric condition associated with the progression of Alzheimer's disease.

Nuplazid is currently approved as atreatment for Parkinson's disease psychosis (PDP). According to company estimates, Parkinson's disease affects an estimated 1 million Americans, and around 40% of this population is affected by PDP. Since Nuplazid is currently priced at $24,000 for an annual treatment, the U.S. market alone is, in theory, worth $9.6 billion. As Nuplazid is both the first and only drug approved for this indication, Acadia shares could have more room to run based on continual growth in PDP alone.

The Alzheimer's disease psychosis market has even more potential:Alzheimer's disease affects an estimated 5.4 million people in the United States alone. The company estimates that between 25% to 50% of patients diagnosed with Alzheimer's will eventually develop ADP. Should Nuplazid succeed in phase 3 studies for ADP, assuming annual pricing remains similar to PDP, Acadia would be targeting a total addressable market of between $32 billion and $65 billion.

In December of last year, Acadia released positive top-line data for Nuplazid in a phase 2 study in ADP. In this 181-patient study, Nuplazid met its primary endpoint of demonstrating significant improvement over placebo at week 6 of the study. The company has indicated that it intends to begin phase 3 trials in the second half of 2017.

Aside from Alzheimer's disease psychosis, Acadia is also in the process of advancing Nuplazid in mid-stage trials as atreatment for Alzheimer's disease agitation as well as adjunctive therapy for both schizophrenia and major depressive disorder. As all three of these are large indications with patient populations numbering in the millions, a hit in any one of these indications could be huge for Acadia.

While Nuplazid has multiple large shots-on-goal, this stock is definitely not for the faint-of-heart. As I have pointed out before, while Nuplazid did succeed in its phase 2 study as treatment for ADP, this study was not without its controversies. Namely, while the results were significant, they were barely so, with Nuplazid beating placebo at a p-value of .0451 (for reference, the cutoff for p-values is .05, and the closer to "0" the better).

In addition, while Acadia ended 2016 with $163 million in cash and cash equivalents, commercializing a drug is expensive. The company may need to undergo future equity raises -- thus diluting existing shareholders.

Finally, it must be said that even for PDP, the results are still too early to discern trends. First launched commercially in May of 2016, Nuplazid has only been on the market for 11 months now. However, with so many shots-on-goal and the potential to tackle one of the largest indications out there, I would say Acadia is well worth the risk. After a significant pullback in April, I'd say now is a good time for risk-tolerant investors to consider buying shares of Acadia.

David Liang has no position in any stocks mentioned. The Motley Fool owns shares of and recommends Biogen and Johnson & Johnson. The Motley Fool has a disclosure policy.

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Acadia Pharmaceuticals May Just Be the Best Long-Term Play on ... - Motley Fool

Nutrition label readers favor food quality over quantity – Feedstuffs

Posted: at 2:46 am


People who closely eyeball nutrition labels tend to eat differently from less-discerning diners in one key regard, according to research from a University of Illinois expert in food and nutrition policy and consumer food preferences and behaviors.

Although users and non-users of nutrition labels eat roughly the same amount of food, the two groups diverge when it comes to the quality of the food they eat, a new paper co-written by Brenna Ellison, Illinois professor of agriculture and consumer economics, noted.

Research has often concluded that people who use nutrition labels eat better, but we dont necessarily talk about what 'better' means, Ellison said. Is it eating less food, or is it eating better food? This study looks at peoples plates and considers both what they selected to eat and what they actually ate in an effort to determine which difference (volume or quality) is occurring.

To examine the relationship between label use and food selection, servings and consumption, Ellison and co-author Mary Christoph of the University of Minnesota combined survey and photographic data ofcollege students' lunch plates at two different university dining halls. Food selection, servings and consumption were assessed using digital photography -- a method with strong reliability for validating portion sizes compared with weighing food and visual estimation.

In terms of measuring and evaluating the plates, we had students who built their own plates because it was a self-serve dining environment, Ellison said. Diners were only eligible if they were just sitting down to eat. It couldnt be someone who was halfway through their meal, which would misrepresent what they were eating and skew the results.

Based on the meals assessed, the quantity of foods served and consumed were roughly similar between the two groups. There were, however, distinct differences in the types of foods plated and consumed within the federal government's MyPlate food categories between those who tended to read nutrition labels and those who didnt, the researchers found.

The results indicate that a greater proportion of nutrition label users select more fruits, vegetables and beans and fewer potatoes and refined grains compared with non-label users. Additionally, fewer label users selected fried foods and foods with added sugars, Ellison said.

We find that its more about the types of food rather than the quantity of the food, Ellison said. The amount of food between label users and non-label users was roughly the same amount. Its the differences in quality that are more prevalent than the sheer amount of food selected.

Using digital photography also provided a more objective assessment of food selection, servings and consumption compared with self-reporting, because you dont have to rely on students remembering how much of each food they ate, Ellison said.

Thats one big advantage to this study," she added. "Another one is that diners did not interact with our data collectors until after their plate was built. So, our data collection methods shouldnt have affected what they chose. For example, people werent picking more salad because they knew there was going to be a picture taken of their plate.

Participants were further surveyed on socio-demographic and behavioral variables -- such as gender, body mass index, exercise frequency and nutrition education -- to better assess the possible link between label use and food selection, servings and consumption, according to the paper.

Doctors and dietitians often recommend that people examine nutrition labels to improve food choices, but choice does not always translate to consumption. Furthermore, evidence on the effectiveness of labels is mixed, and few studies can identify how labels actually influence behavior, Ellison said.

Previous research has focused on portion control for weight loss or weight management -- generally eating less -- but more recent research indicates this may not be the most effective message. By eating less, consumers may feel deprived or even hangry, which can make it difficult to sustain long-term dietary behaviors, she said. Newer research indicates that eating less of certain types of foods, rather than all foods, may matter more.

Although the results show label users and non-users eat differently, the implications of the research suggest that there may be a need for greater consumption of fruit, vegetables, beans, whole grains and low-fat dairy among both groups.

In addition to posting labels, Ellison said dining facilities may want to increase offerings of nutrient-dense foods (whole grains and vegetables, for example) or consider product reformulations that creatively incorporate these foods to encourage healthy eating behaviors.

Ellison noted, however, that the studys findings should still be interpreted cautiously, because the conclusions are based on only one meal.

The paper will appear in the Journal of the Academy of Nutrition and Dietetics.

Link:
Nutrition label readers favor food quality over quantity - Feedstuffs

Food Zoo removes nutrition labels because students take time to read them – Montana Kaimin

Posted: at 2:46 am


University of Montana Dining has removed printed nutritional labels from items in the Food Zoo because students reading the labels take longer in line, according to Campbell Howard, director of UM Dining. This leaves students with reduced access to nutritional information.

Howard said in an email that nutritional labels were removed because students caused delays in the serving line while they evaluated the posted nutrition information.

Howard also said that some items that UM Dining considers nutritionally sound are passed up by students because they contain ingredients or nutrients that have a negative connotation, like chicken strips.

UM Dining strives to promote a diet of variety and moderation, Howard said.

Howard said nutritional information provided on UM Dinings website is more accurate than the printed tags. It was difficult to reprint tags when food formulas were changed, he said.

Nutritional information for every menu item we serve is available online, Howard said.

The Montana Kaimin could not find nutritional information for many items served in the Food Zoo, including hot dogs, salad dressings, fruit, yogurt, tater tots, french fries, onion rings, bagel and toast spreads, lunch meat, sandwich rolls, egg salad, bacon, salad toppings, cottage cheese, yogurt, hard boiled eggs, sliced cheese, sandwich toppings and desserts.

Online information about selected foods includes ingredients, preferences, major allergens, portion size, calories, fat, carbohydrates and protein.

UM dining recognizes the top eight major food allergens, including wheat, egg, fish, milk, soy, tree, shell fish, peanuts and gluten. Menu items are also labeled for dietary preferences including vegan, vegetarian, gluten, gluten friendly, halal and haram.

Our custom, web-based nutrition labeling system provides you with detailed information on all menu items, the Campus Dining Guide says. UM Dining accommodates all medical dietary restrictions.

Students concerned with food choices offered at UM can consult with a registered dietician on campus by calling (406) 243-6325.

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Food Zoo removes nutrition labels because students take time to read them - Montana Kaimin

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