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How The Longevity Project Is Reimagining Our Longer Lives – Forbes

Posted: January 31, 2020 at 6:52 am


By Holly Lawrence, Next Avenue Contributor

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As life expectancies are growing and the 100-year-life is becoming more common, how can Americans, the U.S. government and employers best prepare for the challenges and opportunities of longevity? Meet the Longevity Project, the new initiative designed to come up with some answers.

The Longevity Project, developed in collaboration with the Stanford Center on Longevity (its lead content creator), is generating research and engaging in public conversation on the many impacts of longer lives. It just released a poll of 2,200 adults, conducted by Morning Consult, to see what Americans think needs to change to support increasing longevity.

Longevity is, in many ways, one of the greatest achievements of the last century and a half lifespan has almost doubled in that time in the U.S., says Ken Stern, chair of the Longevity Project and the former CEO of National Public Radio. But in many ways, we still organize our institutions as if this great advance in longevity had never occurred.

Based on the Longevity Projects poll, the public agrees, especially regarding both the nations retirement financing system and Americas employers. A full 54% of respondents supported personal retirement savings plans offered by the government. And 76% called age diversity an important consideration for employers, but only 12% of employed respondents said their employers are actively recruiting older workers.

The poll also found that 53% of respondents view longer life as a net positive for the U.S. economy.

When announcing the Longevity Project, Stanford Center on Longevity founder Laura Carstensen (a Next Avenue 2015 Influencer in Aging), said: "With Americans living longer and healthier, we have a unique opportunity to reimagine healthy, successful century long lives, but we can't achieve what we can't imagine, and we are pleased to help launch this initiative to foster public understanding and engagement on longevity."

The Longevity Project, Stern said, flows from my conversations with Stanford Center on Longevity about a shared interest in engaging the public businesses, government, media and others on these important topics.

The Longevity Projects coalition also includes the Urban Institute think tank, the National Academy of Medicine, and companies such as Principal Financial Group, Wells Fargo and Instructure. The initiative dovetails with Stanford Center on Longevitys five-year project, New Map of Life, which is a rethink of how we organize civil society in light of greater longevity, said Stern.

The Longevity Projects websiteserves as the hub for the public to stay informed and become engaged in the initiative. Americans will weigh in through a series of Longevity Project polls and social media.

Stern said two findingsjumped out at him from the recent Longevity Project poll.

The first was how much Americans value older workers. Stern noted that age diversity in the workplace outpolled race, gender and LGBTQ as an important consideration for employers.Yet only 13% of employed respondents said their companies are implementing multi-generational work groups; just 17% said theyre providing physical accommodations for older workers and a mere 24% said the employers provided training to stay current on new technologies.

The public seems to understand the importance of older workers to the economy, but companies are trailing, said Stern.

The second poll finding that intrigued Stern: how millennials and Gen Z view family support.

Generation Z is skeptical about the adequacy of Social Security and corporate pension plans to financing their longer life. Rather, among Generation Z adults, one in five are counting on financial support from family if, or when, they decide to retire,ahead of other options like pension plans from an employer, traditional or Roth IRAs and annuities, said Stern.

But, he added, young Americans polled also talked about their own shared responsibility for family members. Younger cohorts are nearly twice as likely [as older ones] to believe that at sixty-five they will be raising a family or helping their children raise their families, Stern said.

In the next series of Longevity Project polls, he noted, Were going to look more deeply at financing longer life, lifelong learning and the future of work. I think the topic of financing longer life is particularly important. We are in a time of transition on how we fund retirement in this country and people feel very uncertain about this transition.

Two Longevity Project conferences at Stanford in June may offer revealing and insightful ideas about the implications of longevity.

One conference will be The Century Summit, on June 24, bringing together business, media, policy and research leaders. The other will be The Longevity Next Conference, on June 25, convening young leaders to discuss the implications of the longer life for their generations.

Im particularly excited about Longevity Next, which is the first conference to look at the topic of longevity specifically for younger generations, said Stern. How will millennials and Generation Z engage with a longer life? How will they finance a longer life? How do you work over a sixty-year career? What are issues surrounding inequality and longevity? And how do we think about the intersection of sustainability and longevity?

This fall, the Longevity Project will launch a podcast called Life At.

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How The Longevity Project Is Reimagining Our Longer Lives - Forbes

Longevity expert says these are the foods you must eat to add years to your life – Ladders

Posted: at 6:52 am


We all need more vegetables in our life, but including them in our core three meals is easier said than done. As it turns out plant-based diets actually work the best when an individual drafts their own guidelines around unique health needs and objectives.

A plan that encourages plant-based meals while allowing room for animal products on occasion is alternatively known as the Flexitarian diet.

Helping Ladders navigate the specifics of an optimal Flexitarian diet is the expertise ofSergeyYoung, founder of the Longevity Vision Fund.

For years Young has dedicated his assets, network connections and global research community toward developing affordable and scientifically proven wellness habits. His self-professed mission is to fund the next phase in the longevity revolution.

In Youngs estimation, the first step begins with debunking the falsehoods keeping too many people from breaking away from their toxic dietary habits.

Young explains to Ladders, You dont need to stick to a vegan or vegetarian diet to reap the health benefits. Focusing on getting the majority of your calories from plant foods without excluding animal products completely will have a positive impact on your health. Some nutrients like EPA and DHA are best obtained from fish, seafood, and eggs.

According to the latest U.S. News & World Report Best Diet Rankings, the regimen Young intimates above is one of the healthiest and easiest to follow of all the many plans currently circulating the diet sphere.

Lowering your intake of processed meats will dramatically improve cognition, reduce your risk for developingType 2 diabetesandheart disease, help regulate weight gain and boost longevity as a consequence of the previously mentioned attributes.

More than the rich sources of energy and protein provided by lean meats like chicken and omega-3 rich sources like fish, allowing room in any regimen for foods you enjoy makes any plan that much more sustainable over time.

With a Flexitarian diet youre getting the macro-nutrients you need from organic sources most of the time but when you want to have maybe a piece of grass-fed steak or even just a piece of steak at a restaurant, or you want to have eggs, you can. It allows room for these other kinds of food without being so hardcore, dietitian Keri Glassman recently told Ladders.

One of the critiques lobed at plant-based diets the most often claims that it isnt plausible to get the majority of the daily calories needed from plants. While its true that even the most balanced plant-based regimens are not as calorically dense as other plans, this isnt necessarily a bad thing.

Young continues, Habits common among areas where people live the longest include a reduced calorie intake and fasting and a25-year study in monkeysfound that eating 30% fewer calories than normal led to a significantly longer life and less age-related diseases. Even if your calorie requirements are higher, youre still able to get enough from other calorie-dense foods like sweet potatoes, nuts, and oils.

Of course, calorie intake is much more about where youre getting your calories than it is about how many calories youre consuming day to day. Protein is the nutrient most often lamented by those skeptical of taking on a plant based diet.

Although not as packed with amino acids, proteins obtained from plants actually contain more nutrients and fiber than protein derived from animal sources.

Tofu (contains about 10 g of protein per cup), lentils (cooked contains 8.84 g of protein per cup) and chickpeas(7.25 g per cup) all on their own sufficiently fuel vegan bodybuildersa group with a protein demand significantly higher than yours and mine.

Make no mistake, its not enough to limit meat intake and increase plant consumption in order to boost longevity. the source matters a great deal. Variety is key to any diet plan.

Local, farm-grown and organic produce nurtured without the use of pesticides, manmade fertilizers or genetic modifications is more nutritious than non-organic commercial foods, Young informed Ladders. Superfoods like maca, spirulina, goji berry, etc. might be marketed as nutritional powerhouses but food variety is even more important than its nutritional density. Its important to make sure you eat a full rainbow of fruits and vegetables for a balanced and varied diet.

Longevity is bolstered by a panoply of physiological factors: optimal brain health, metabolicregulation, weight management, cellular vascular health, cardiovascularhealth, and emotional stability. Every one of these requires balance, especially when it comes to our diet.

Although there arent many studies that have been done on this topic,there appears to be a link showingthat plant-based diets can influence brain function positivity through altered microbial status and systematic metabolic alterations. However, despite the positive effect of plant-based diets on brain health, there is a risk of these diets creating a deficiency in the essential brain nutrient cholinewhich is why some proportion of eggs and other animal-based products must still be kept in your diet, said Young.

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Longevity expert says these are the foods you must eat to add years to your life - Ladders

ProblemWe’re Really Bad at Guessing When We’ll Die – The 401(k) Specialist

Posted: at 6:52 am


As any life insurance salesman can attest, death is rarely (never) a pleasant subject, but a new survey from the Society of Actuaries reveals just how bad we are at predicting our own demiseweird, but true.

Attempting to determine the age at which it will happen certainly makes sense, given high-profile concerns over longevity, a supposed retirement crisis, as well as paltry savings and assets that many of us will easily outlive.

The SOA reported that half of consumers misestimate their life expectancy by five or more years, with 23 percent overestimating and 28 percent underestimating.

This can have major implications on retirement preparedness, with those who underestimate their life expectancy facing a greater risk of outliving their financial assets and experiencing financial stress in retirement, while those who overestimate may not prepare properly for the care of financial dependents in the future, according to the research.

The survey found:

The most important finding of this study is that 51% of the U.S. population misestimated their life expectancy by at least five yearseither too high or too low, the SOA noted.

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ProblemWe're Really Bad at Guessing When We'll Die - The 401(k) Specialist

Improve Longevity By Immediately Avoiding These Four Habits – International Business Times

Posted: at 6:52 am


KEY POINTS

Dying at an early age was once the subject of superstitious beliefs. Breakthroughs in scientific studies, however, as well as observational data, have all dispelled the myths.

The truth, as established by these studies, is even more empowering. It revealed that lifestyle practices could determine hugely the length of your lifespan.

For instance, particular habits have been proven to be clearly unhealthy. This means that avoiding them can help improve longevity.

Smoking

Smoking was once a common norm in society. Depressing statistics, however, show that this habit poses one of the most hazardous risks to longevity. habits to avoid to increase longevity Photo: geralt - Pixabay

Large-Scale research revealed that smokers might decrease their lifespan by up to ten years. They are three times more likely to die prematurely compared to people who never held a cigarette in all their lives.

Another study reported that those who got rid of the habit by age 35 might improve longevity by up to 8.5 years. This means it is never too late to stop smoking.

Binge Drinking

Consuming too much alcohol has been linked to pancreatic, liver, and heart diseases, as well as an increased risk of premature death.Moderate consumption of alcohol, however, has been linked to a lower risk of developing several diseases and a 17% to 18% decrease in the risk of early death.

One particularly beneficial alcoholic beverage is wine. It has received much favor because of its rich polyphenol antioxidant content.29-year research showed that those who opted to drink wine are 34% less likely to prematurely die compared to those who prefer spirits or beer. The NHS said the recommended amount of wine to drink should not exceed 14 units per week.

Stress and Anxiety

High levels of stress and anxiety have been shown to shorten lifespan.One study showed that women who suffer from anxiety or stress are two times more likely to die early from stroke, lung cancer, or heart disease. The risk of early death is also three times higher for stressed or anxious men compared to their relaxed counterparts.

The findings of the study also proved that pessimistic persons are at a 42% higher risk of premature death compared to optimistic people.Having a positive outlook and laughing always have also been found to minimize stress and can prolong your life.

Binge Eating

The relationship between calorie intake and lifespan has also been drawing the interest of researchers.Studies made on populations that have been known to enjoy longer lifespans showed that lower calorie intake could extend lifespan and minimize the likelihood of developing some ailments.Calorie restriction has also been showed to greatly help in reducing excess belly fat and total body weight, both of which are linked to shorter lifespans.

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Improve Longevity By Immediately Avoiding These Four Habits - International Business Times

Life Expectancy in US Increases for First Time in 4 Years – HealthDay

Posted: at 6:52 am


THURSDAY, Jan. 30, 2020 (HealthDay News) -- After four years of declines, life expectancy in the United States increased in 2018, health officials reported Thursday.

The jump in longevity comes as deaths from opioid overdoses dropped for the first time in 28 years, as did deaths from six of the 10 leading causes.

The new data could be a glimmer of good news for Americans' health, with recent declines in average lifespans initially casting doubt on progress made over the past decades.

"The three-year trend in life expectancy for the total population either decreasing or remaining steady has stopped, with the increase in life expectancy in 2018," said lead researcher Kenneth Kochanek, from the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

"The decrease in mortality from unintentional injuries in 2018 is a reverse from the 2014-to-2017 trend," he added.

"From 2014 to 2017, the increase in deaths from unintentional injuries contributed the most to the decrease in life expectancy, with decreases in cancer mortality offsetting this change in life expectancy," Kochanek said.

Between 2010 and 2014, life expectancy increased from 78.7 years to 78.9 years, then fell between 2014 and 2017 from 78.9 years to 78.6 years.

But in 2018, it went back to 78.7 years, which is still below the peak of 78.9 years in 2014, Kochanek said.

The 10 leading causes of death in the United States are heart disease, stroke, chronic respiratory disease, Alzheimer's disease, diabetes, flu, kidney disease, suicide, cancer and accidents.

Between 2017 and 2018, decreases in deaths from cancer and unintentional injuries contributed the most to the increase in life expectancy, with increases in mortality from influenza and pneumonia offsetting the change in life expectancy, Kochanek added.

According to Dr. Howard Koh, a professor at Harvard T.H. Chan School of Public Health in Boston, "After years of plateauing and declining U.S. life expectancy, this one-year uptick is certainly welcome news."

But more detailed evaluation over time is needed to judge whether declining trends are truly being reversed, he said.

Another expert agreed that the increase in life expectancy was welcome news, but must be taken with a grain of salt.

"It's good news U.S. life expectancy increased for one year, interrupting its fall over the past three years, but the overall picture remains bleak," said Dr. Steven Woolf, director emeritus and senior advisor at the Center on Society and Health at Virginia Commonwealth University School of Medicine, in Richmond.

For many years, life expectancy in other wealthy nations has been higher than in the United States, and their life expectancy rates have been climbing, Woolf said.

The increase in life expectancy between 2017 and 2018 is statistically significant, but time will tell whether it holds, he added. A similar increase occurred between 2013 and 2014 before falling the following year.

Other findings in the report include:

Koh pointed out that, "while the overall decline in drug overdose deaths is notable and must continue, rising mortality from synthetic opioids -- as well as from cocaine and methamphetamine -- represent the next disturbing wave of the nation's ongoing substance use challenge."

Woolf added that it's good news that the rate of fatal drug overdoses has decreased.

"But this, too, should be put in perspective," he said. "It's still higher than it was in 2016 and alarmingly higher than it's been in the past two decades."

The report was published Jan. 30 in the CDC's NCHS Data Brief.

More information

For more on life expectancy, head to the CDC's National Center for Health Statistics.

SOURCES: Kenneth Kochanek, National Center for Health Statistics (NCHS), U.S. Centers for Disease Control and Prevention; Howard Koh, M.D., MPH, professor, Harvard T.H. Chan School of Public Health, Harvard Kennedy School, Boston; Steven Woolf, M.D., M.P.H., director emeritus and senior advisor, Center on Society and Health, Virginia Commonwealth University School of Medicine, Richmond; Jan. 30, 2020, NCHS Data Brief

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Life Expectancy in US Increases for First Time in 4 Years - HealthDay

Is This Year Jaguars LT Tony Bosellis Best Chance Yet to Make the Hall of Fame? – Sports Illustrated

Posted: at 6:52 am


The Pro Football Hall of Fame has eluded Jacksonville Jaguars legend Tony Boselli ever since the first year he was eligible. And in the last three years, Boselli has had his induction into the hall teased as a finalist, but the gold jacket has remained unattainable.

Will 2020 be any different? Boselli, the entire Jaguars organization, and their legion of fans certainly hope so. And there just might be reason enough to believe that it could be.

This year's class will be named during NFL Honors, which will air Saturday at 8 p.m. Earlier in the day, cases for Boselli and the other finalists will be made to the 48-member Pro Football Hall of Fame Selection Committee, which will eventually pick five finalists from the Modern-Era group.

Unlike in past years, Boselli isn't facing a stacked room of fellow finalistsperhaps the primary reason it almost feels as if the Jaguars' first-ever draft pick has more momentum this year than in past seasons.

In 2017, Boselli's first year of eligibility, he had to try to crack into a top-five which included first-ballot Hall of Fame players in defensive end Jason Taylor and running back LaDainian Tomlinson. He also had to compete with a two-time MVP and Super Bowl-winning quarterback in Kurt Warner, making his chances small. Finally, the dagger was when running back Terrell Davis was inducted.

But today, Davis' induction could serve as a reason to finally elect Boselli to Canton. The knock against Boselli has never been about his play, but for his lack of longevity. He played only seven seasons (1995-2001) and 91 regular-season games due to shoulder injuries. Davis, who got his gold jacket and bust in 2017? He played only seven seasons and 78 regular-season games. This is not a point to compare their accomplishments or arguments for the hall, but instead to point out voters have recently inducted players with the same longevity issues as Boselli.

In 2018, Boselli had virtually no shot to begin with due to the sheer strength of the class. Linebackers Ray Lewis and Brian Urlacher and wide receiver Randy Moss were all first-ballot inductees, while safety Brian Dawkins and wide receiver Terrell Owens made it a packed group.

Entering 2019, the hope was Boselli would finally stand a chance due to two potentially open slots in the class. Cornerback Champ Bailey, tight end Tony Gonzalez, and safety Ed Reed were all obvious first-ballot inductees, but who would join them was the question.

But in perhaps the most deflating decision in the previous three years that Boselli was a finalist saw another offensive lineman earn the honor instead in center Kevin Mawae. Cornerback Ty Law took the final spot, and Boselli was once again shut out.

The trend in the Hall of Fame classes Boselli has been blocked from in the same fashion he shut down opposing defensive ends is that first-ballot inductees have filled each class, making it tougher for a player with Boselli's resume to make it in.

But in 2020, there are not nearly as many sure things as there was in 2017, 2018, or 2019. Safety Troy Polamalu and wide receiver Reggie Wayne are each in the first year of eligibility, and Polamalu at this point looks to be the closest one to being a lock for election into the hall.

There are other offensive linemen Boselli will have to compete for a spot in this year's class, each deserving of their own spots in Canton. Guards Steve Hutchinson and Alan Faneca, like Boselli, have been kept out of the Hall of Fame for multiple yearsHutchinson is in his third as a finalist while Faneca is in his fifth.

Luckily for Boselli, he played a more premium position than Hutchinson and Faneca. Boselli was a cornerstone left tackle. There are currently 19 guards in Canton, compared to nearly 30 tackles. This could give Boselli an edge he hadn't found in prior years.

Nobody knows for sure how this year's class will play out. With so much uncertainty, as well as so many deserving players, it is near impossible to attempt to predict who will make it into Canton. But on the surface, it appears as if Boselli's fourth attempt has a better shot than any of his previous three.

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Is This Year Jaguars LT Tony Bosellis Best Chance Yet to Make the Hall of Fame? - Sports Illustrated

NASA’s Voyager 2 probe suffers glitch at the edge of the solar system – CNET

Posted: at 6:52 am


When it comes to longevity, NASA's Voyager 1 and Voyager 2 spacecraft are champions. They both launched in 1977 are still going today. This is an NASA artist's rendition of Voyager.

Humanity's most distant messengers in the universe are NASA's Voyager 1 and Voyager 2 spacecraft, both of which are now exploring interstellar space. Voyager 2 experienced a technical hiccup over the weekend and NASA is working is get the spacecraft back on track.

"Here's the skinny: My twin went to do a roll to calibrate the onboard magnetometer, overdrew power and tripped software designed to automatically protect the spacecraft," the NASA Voyager account tweeted on Tuesday. The probe appeared to turn off its science instruments to compensate for the overdraw.

"Voyager 2's power state is good and instruments are back on. Resuming science soon," NASA tweeted.

It's a challenge to diagnose and fix problems on the twin probes due to their sheer distance from Earth. Voyager 2 is located about 11.5 billion miles (18.5 billion kilometers) away.

"Communications traveling at the speed of light take about 17 hours to reach the spacecraft, and it takes another 17 hours for a response from the spacecraft to return to Earth," NASA said in a statement on Tuesday.

Voyager 2 launched in 1977. It has shown remarkable resilience despite the great distance it has covered. The spacecraft's power availability shrinks a little every year, but it is still gathering datato help scientists learn about what's happening at the edge of our solar system.

So far, it looks like Voyager 2's safety systems worked as designed and that it should be able to continue its epic journey into the cosmos.

Now playing: Watch this: Meet the Mars 2020 rover launching this year

4:47

Originally published 9:55 a.m. PT

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NASA's Voyager 2 probe suffers glitch at the edge of the solar system - CNET

Named seven products to ensure longevity – The Times Hub

Posted: at 6:52 am


Experts have called 7 foods that ensure longevity and preserve health to old age. Foremost among them was the hazelnut.

Nuts contain large amounts of unsaturated fats, which are quickly absorbed, but remain in the body in the form of deposits. They support the functioning of the brain and all cells, slowing down their aging. Hazelnuts are also an alternative source of unsaturated fats and protein for vegetarians.

On the second place among the products longevity is salmon. This fish contributes to the stable operation of the heart. Also the list includes leafy vegetables, including watercress, arugula, chard, broccoli and others. They are all rich in folic acid, which speeds up the metabolism and rejuvenates the body.

Dairy products can help protect bones from destruction over the years. Experts also recommend to use tomatoes that are rich in antioxidants. Groats quinoa has beneficial properties for the heart and circulatory system. It is recommended to include in the diet of dark chocolate, stabilizing the cholesterol level in the blood. It is important that the product have less sugar.

Natasha Kumar is a general assignment reporter at the Times Hub. She has covered sports, entertainment and many other beats in her journalism career, and has lived in Manhattan for more than 8 years. She studies in University of Calcutta. Natasha has appeared periodically on national television shows and has been published in (among others) Hindustan Times, Times of India

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Named seven products to ensure longevity - The Times Hub

Pacific Life Re and Lloyds agree 10bn longevity swap – Verdict

Posted: at 6:52 am


Pacific Life Re has assumed 10bn ($13bn) of longevity risk from pension schemes of Lloyds Banking Group.

The transaction, arranged with Lloyds Banking Group Pensions Trustees, is said to be the reinsurers second-largest UK longevity swap.

The 16bn deal between BT Pension Scheme and PICA, executed in 2014, is the first largest deal in this regard.

The latest deal offers coverage to Lloyds Bank Pension Scheme No 1, Lloyds Bank Pension Scheme No 2, and HBOS Final Salary Pension Scheme members.

The arrangement involved Scottish Widows served as the insurer.

The plan is aimed at protecting the pension schemes against the financial risk of an unexpected life expectancy increase and boosting their security.

Pacific Life Re head of longevity Andy McAleese said: Pacific Life Re has been a long-term supporter of longevity risk transfer, having completed the first UK pension scheme longevity swap in 2009.

There have been record volumes of pension risk transfer in 2019 and we are continuing to see very strong demand carrying over into 2020.

This milestone arrangement demonstrates that longevity swaps continue to be an important risk transfer tool for pension schemes.

Lloyds was advised by Willis Towers Watson on the transaction.

Willis Towers Watson head of transactions Ian Aley said: This material transaction is further evidence of pensions schemes appetite to manage longevity risk.

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Pacific Life Re and Lloyds agree 10bn longevity swap - Verdict

Resveratrol Found To Be One Of The Most Unique Antioxidants – Newswire

Posted: at 6:51 am


Purest Vantage Resveratrol formula is highly potent, and this is why it continues to gain an increasing interest and trust among many consumers.

(Newswire.net -- January 31, 2020) Orlando, FL -- There are many types of antioxidants that can be found in plant sources. However, it is resveratrol that appears to be gaining an increasing interest among many researchers and clinicians.

Resveratrol is found to be one of the most unique antioxidants. Today, there are many people who do not have adequate levels of antioxidants in their bodies. Most of these people suffer from certain symptoms and diseases.

Antioxidants have long been found to be highly therapeutic. It is believed to be useful in fighting free radical damage, which is essential for human health and longevity.

According to some experts, resveratrol has the potential to cross the blood-brain barrier. This helps offer protection to the brain as well as the nervous system.

Some studies even reveled that resveratrol could protect cells from free radical damage as well as inhibit the spread of cancer. This is especially true to individuals who suffer from prostate cancer. This antioxidant could also reduce blood pressure levels and keep the heart healthy.

Some researchers even suggest that resveratrol has the ability to enhance the elasticity of the blood vessels. Further, this powerful antioxidant could also help normalize anti-inflammatory response and aid in the prevention of Alzheimers disease.

Resveratrol has been found to be highly effective in warding off a variety of diseases linked with aging. It is even called the fountain of youth due to its high potential in increasing lifespan.

In animal studies, it was found that this powerful healing antioxidant aided in the improved running performance of mice. It also successfully increased the lifespan of human cells. Further, this therapeutic agent could also offer the same health benefits as exercise.

Individuals who want to utilize the therapeutic effects of resveratrol may take into account consuming more grapes and other plant sources such as peanuts and dark chocolate. There are also formulas available like Purest Vantage Resveratrol supplement.

It would be quite easy to obtain the healing effects of resveratrol through supplementation. Supplements are handy and are easy to swallow. What makes them even more beneficial is that they normally contain abundant levels of resveratrols therapeutic goodness.

Purest Vantage Resveratrol formula is highly potent, and this is why it continues to gain an increasing interest and trust among many consumers. What makes it even more beneficial is that it also contains other therapeutic ingredients, and is free from GMOs, binders, and fillers.

It is a proudly U.S.-made formula that is manufactured without the involvement of dangerous processes. It even comes with a complete customer satisfaction guarantee offer (http://www.amazon.com/Resveratrol-Supplement-Trans-Resveratrol-Additional-Polyphenol/dp/B01N3LZY3O).

Purest Vantage is passionate and dedicated to developing high-quality products that assist people in maintaining optimal health, enabling them to enjoy all the benefits a healthy lifestyle offers.

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Resveratrol Found To Be One Of The Most Unique Antioxidants - Newswire

Kensh Healthcare publicly launches its ‘antithesis of Goop’ – Yahoo Tech

Posted: at 6:49 am


Last year, when co-founders Danny Steiner and Krista Berlincourt debuted Kensh Health, their directory and information service for holistic medicine, Berlincourt called it "the antithesis of Goop."

While Gwyneth Paltrow's lifestyle brand startup serves up a heady mix of unverified pseudo-scientific claims alongside longstanding holistic practices, Steiner and Berlincourt focused on the verified and verifiable claims coming out of the medical community.

Kensh, the antithesis of Goop, launches a research-based guide to natural medicine

The two founders and their Los Angeles-based team amassed a group of healthcare providers hailing from Stanford University, Harvard University, Columbia University and others -- all with a concentration on accreditation.

Now the service is publicly available and serving up the latest information on holistic medicine -- powered by a partnership with the academic publisher Wiley -- and a verified list of local practitioners for consumers seeking treatments.

"We have six points of verification," says Steiner. "We look at accreditation, experience, peer reviews, customer reviews, we speak to the providers themselves to make sure were on the same page of what were trying to provide and for premier providers we do a background check."

That vetting has gone a long way toward providing what the company's founders say are tens of thousands of beta users with a search and discovery tool for information on holistic health and wellness and direct access to holistic health practitioners.

While "wellness" is a nebulous term often representing therapies with questionable clinical value, it's a huge business in the U.S. and around the world. Some estimates from industry organizations like the Global Wellness Institute put the dollar value of the industry at roughly $4.2 trillion, encompassing everything from medical tourism to personalized and complementary medicine.

The complementary medicine component alone is a $360 billion market opportunity, according to the GWI, and it's there that Berlincourt and Steiner are focusing their attention.

Kensh Health co-founders Danny Steiner and Krista Berlincourt

"We wanted to create something that acted at the right point of intervention," says Berlincourt, a former public relations professional who launched the business after turning to holistic medicine to treat her chronic adrenal failure. "So we curated a provider network and made [complementary medicine] easy to understand through research."

The company encourages providers on its platform to offer their services on a sliding scale to improve accessibility and ensure that "this isn't only for the wealthy elite," says Berlincourt.

While the service is currently free, both Berlincourt and Steiner say there are obvious paths to making money that the company will explore after it builds out a solid base of users. Various potential revenue streams involve selling treatment or instructional packages or charging for listings on the site.

Kensh's thesis on a broader market embracing the principles of holistic medicine seems to be supported by recent moves from the nation's largest public healthcare providers. For the first time, Medicare and Medicaid are now officially covering acupuncture as a verified treatment option for certain conditions, the Center for Medicare and Medicaid Services announced last week.

There's also a broader recognition of the role that lifestyle and general health and fitness play in most illnesses, says Berlincourt.

"Eighty-seven percent of deaths are related to lifestyle-related disease according to the CDC," she says. "And 75% of what were spending on healthcare is on the conditions associated with these chronic diseases. We don't treat the root cause and people don't know that there are other options."

Now, with the public launch and financial support for investors like CrossCut Ventures, Female Founders Fund and Evolve Ventures, the company is hoping to create the "Good Housekeeping seal of approval" for wellness providers, according to Berlincourt.

"Conventional medicine wants to play with holistic medicine, but there's a lack of connection. Our goal is to provide that connection."

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Kensh Healthcare publicly launches its 'antithesis of Goop' - Yahoo Tech

New Round Rock library series aims to keep people Well! Well! Well! – The Glen Rose Reporter

Posted: at 6:49 am


The Round Rock Public Library, in partnership with St. Davids Healthcare, is hosting a new series in February to raise health care literacy within the community.

The Well! Well! Well! series beginning Feb. 12 features five presentations by medical and holistic professionals from the Round Rock area, including hospital CEOs, chiropractors and a neurosurgeon. Each demonstration will focus on a different health topic and general ways to combat medical issues.

Combating misinformation is one part of this program, said Geeta Halley, the librarys assistant director. Its our mission as librarians to advocate for literacy on all fronts by providing quality information to the public.

The series begins with cardiologist Dr. Craig Siegels Heart-to-Heart Talk on heart health and EKG screening for young adults. His seminar will focus on trends in medicine and preventive measures for young athletes to avoid heart problems.

Dr. Siegel is very serious and passionate about this talk, Halley said. His seminar will be very concise.

Well! Well! Well! continues on Feb. 19 with From the Top: St. Davids CEOs Explain the Ins and Outs of Hospital Care. Jeremy Barclay, CEO of St. Davids Round Rock Medical Center, and Hugh Brown, CEO of St. Davids Georgetown Hospital, will provide insider information on how to become an experienced health care consumer.

This is our way to partner with our local health care team to provide the Round Rock community with information while introducing them to health care professionals in the area, adult services librarian Julie Chapa said.

The series five seminars offer both scientific and holistic approaches to common ailments and preventive care, a feature Chapa said makes the program all the better for the community.

This series meets our goal of serving the community by teaching where to receive important health information, she said. By teaching a wide variety of approaches, the event offers a little something for everyone.

Chiropractor Dr. Nilou Zahid will host the first holistic presentation, How to Defy Aging Naturally & Holistically, on Feb. 26. Zahid will demonstrate do-it-yourself acupressure techniques as she shares insight into how Chinese energy points, posture and hydration can play a role in premature aging.

Dr. Violet Song, director of DOAM Program and Department of Herbal Studies and clinic supervisor of AOMA Graduate School of Integrative Medicine, will offer herbal treatments to health issues during her seminar, Herbal Medicine - Mother Natures Gifts, on March 4. The presentation will teach attendees how to take herbal supplements in order to avoid side effects and maximize benefits. Song will have herb and root samples on site for curious guests.

We put education first, but for this series, I dont want to forget about fun, Halley said.

The last presentation, Surgical Spotlight, features insight from surgeons Dr. Chance Conner and Dr. Carl Lauryssen on the latest research on heart and brain health. Both panelists will provide information to the community on a spectrum of conditions, particularly those that are focused on the spine, chest and brain. The panel will be moderated by Jeremy Barclay, CEO of St. Davids Round Rock Hospital.

All five presentations are from 6:30-8 p.m. each Wednesday from Feb. 12 to March 11 in Meeting Room A at the Round Rock Public Library. For more information, visit roundrocktexas.gov/organizer/well-well-well.

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New Round Rock library series aims to keep people Well! Well! Well! - The Glen Rose Reporter

India’s Government Recommends Homeopathy For Coronavirus Prevention. What’s The Harm? – ScienceAlert

Posted: at 6:49 am


As the coronavirus continues to spread, health authorities and scientists around the world are offering people the same advice: wash your hands, cover up your coughs, try not to touch your face.

Except, that is, in India. Along with the usual hygienic niceties, a government authority this week told the public exactly what to do while we wait for a vaccine: on an empty stomach, take one dose of the homeopathic solution, Arsenicum album30, each day for three days.

Then,in a month, if the outbreak still poses a threat, rinse and repeat.

Far from being a "prophylactic medicine", as the ministry suggests, this miracle concoction is, in reality, a super-diluted form of arsenic trioxide. Not only is the compoundknown to be fatalif improperly used, but there's also no evidence to suggest it works on the coronavirus, or any other condition for that matter.

If it weren't for the Dalai Lama recently telling his followers to chant a mantra as protection, India's purported tips to fend off the coronavirus might be the least effective advice offered yet.

Now, the two will have to battle for that top spot, and India's ministry of AYUSH (Ayurveda, Yoga & Naturopathy, Unani, Siddha, Sowa Rigpa and Homoeopathy) has even more nonsensical suggestions to offer in the fight.

Among them are a whole array of herbal potions and mixes, a drop of sesame oil in each nostril upon waking, and a "light and soft" diet.

The announcement was laughed at by many online, but in India, Ayurveda and other traditional medicines, like Unani, are seen as a legitimate andburgeoning industry.

The Prime Minister himself has said he wants tomake them "a way of life" - he's the one who set up the ministry of AYUSH in the first place - and as holistic medicine becomes ever more profitable, the government has started promoting traditional remedies more and more.

Ayurveda is said to deal with the "physical, mental, and spiritual world of mankind", and while it translates to the "science of life", actual evidence for its benefits are lacking.

Most of the practices involved in Ayurveda centre around herbal remedies, yoga, and massage - nothing particularly dangerous - but the fact that it's widely endorsed by a powerful government and its health institutions is noteworthy.

'Traditional' medicines like this are seeing a revival in recent decades in some parts of the world, in part as a way to create a sense of shared nationality, some suggest. While their historical authenticity as medical remedies is questionable, governments nonetheless sometimes encourage them, ostensibly as a way to unite cultural groups.

Right now, there's not a whole lot we know about the coronavirus or how to treat it. Patients with mild symptoms are told to rest and stay hydrated, and most of the deaths have been among elderly folk, or those with vulnerable immune systems.

Given the contagious nature of the coronavirus, a vaccine is clearly the best route for prevention, and work on this has alreadybegun at multiple organisations.

But while the rest of the world prepares for the outbreak with evidence-based measures, India is taking a different route.

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India's Government Recommends Homeopathy For Coronavirus Prevention. What's The Harm? - ScienceAlert

The Benefits of an Address to Call Home for LVHN Street Medicine Patients – LVHN News

Posted: at 6:49 am


Through the combined efforts of Lehigh Valley Health Networks (LVHN) Street Medicine program, LVHNs Courier Services and the United States Postal Service, Street Medicine patients now can receive mail at a specially created address at LVHN.

Mail can now be separated and couriered to the Street Medicine office and distributed by the administrative coordinator at designated clinics. Patients requiring the mail service sign a contract and agree to follow the designated protocol.

Without a home or family support, LVHN Street Medicine patients without a street address cannot receive most government benefits that will help them out of their current situation, says Nani Cuadrado, program director for LVHN Street Medicine. A street address is needed to obtain Medicaid/Medicare, identification, food stamps, social security and veteran benefits, government-issued phones, and to obtain employment. Providing a mailing address to our patients is a win-win opportunity. Our patients get more holistic care, addressing not only their health care needs, but their social barriers as well.

Cuadrado says the LVHN network benefits because patients who were previously uninsured (due to lack of an address) are now insured and the hospital, in turn, receives reimbursements.

Before Street Medicines intervention, 24 percent of the programs patients had Medicaid. By 2017, almost 85 percent of LVHNs patients were enrolled in Medicaid. Those who werent staying in a shelter or had no friends or family support (to use their street address), utilized one of three places in the Lehigh Valley for a street address to receive their benefitsSt. Pauls Church at 8th and Walnut streets in Allentown; the Lehigh County Conference of Churches at 10th and Linden streets; or New Bethany Ministries on 4th St. in Bethlehem. With the sale of St. Pauls Church in June 2018 and the inability to utilize its street address, Medicaid coverage has decreased from 85 percent to 64 percent for LVHN Street Medicine patients.

US Postal Service policy requires that mail addressed to patients at institutions is delivered to the institutional authorities who, in turn, deliver the mail to the addressee under the institution's rules and regulations. Since LVHN Street Medicine, LVHN Courier Services, and the U.S. Postal Service have partnered and instituted this mail service for their patients, we have seen tremendous benefits for ourpatients. Some are receiving food stamps (and had been struggling with food insecurities), some are able toopen a bank account (with identification), some are able to connect with family/friends with a government-issued phone, and some have even transitioned from homeless to being housed with social security income or disability benefits, Cuadrado says. I am so proud that LVHN is helping patients address many of their barriers. A persons overall health is so much more than health care, its about looking at the person as a whole and doing the best we can to assist with other conditions that are affecting their well-being. Something as simple as a mailing address is certainly a great start.

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The Benefits of an Address to Call Home for LVHN Street Medicine Patients - LVHN News

Olean Woman Attends ‘Health Justice 2020: Visions of Equity’ at SUNY Upstate Medical University – TAPinto.net

Posted: at 6:49 am


SYRACUSE, NY Taylor North of Olean was one of 25Canisius College pre-medical and pre-health undergraduate students who attended Health Justice Conference 2020: Visions of Equity on Jan. 20. Hosted by SUNY Upstate Medical University in Syracuse, New York, the conference highlighted structural inequalities in health care and provided insights into the underlying causes and potential remedies.

Breakout sessions at this year's conference included Sickle Cell Disease and Its Inequalities;Gun Violence as a Public Health Issue; Health Justice for the Indigenous;Living Undocumented, and Infant Mortality in America.

As part of the event, Undergraduate Health Justice Scholars Awards were presented to students who have demonstrated a commitment to the health professions and racial equity in medicine. The conference takes place each year on Dr. Martin Luther King Jr. Day, the federal holiday that celebrates the life and legacy of the American civil rights leader.

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Canisius College notes that guided by Jesuit values, the college's undergraduate pre-medical and pre-health offerings emphasize a holistic perspective on health issues, including the social, cultural and economic determinants of health.

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Olean Woman Attends 'Health Justice 2020: Visions of Equity' at SUNY Upstate Medical University - TAPinto.net

American Meditation Institute to Host the Nation’s Only Physician CME Conference on the Training of Yoga Science and Meditation as Holistic Mind/Body…

Posted: at 6:49 am


Offering attendees the opportunity to rediscover their love of medicine and life, The American Meditation Institute (AMI) will present its 12th annual "Heart and Science of Yoga Mind/Body Medicine CME conference" for physicians and other health care professionals. This 32 credit CME curriculum, which includes 36 proven tools to reduce and prevent burnout, will be held October 20-24, 2020 at the Wyndhurst Manor & Club at the Miraval Berkshires resort in Lenox, Massachusetts.

AVERILL PARK, N.Y., Jan. 28, 2020 /PRNewswire-PRWeb/ --Offering attendees the opportunity to rediscover their love of medicine and life, The American Meditation Institute (AMI) will present its 12th annual Heart and Science of Yoga Mind/Body Medicine CME conference for physicians and other health care professionals. This 32 credit CME curriculum, which includes 36 proven tools to reduce and prevent burnout, will be held October 20-24, 2020 at the Wyndhurst Manor & Club at the Miraval Berkshires resort in Lenox, Massachusetts.

Now in its 12th year, The Heart and Science of Yoga is a leading-edge conference that helps physicians bring back the joy in medicine, achieve personal and professional balance and fulfillment, and provide more compassionate and insightful care to patients. Topics this year will include an encyclopedic overview and instruction on AMI Meditation, diaphragmatic breathing, mantra science, yoga psychology, resiliency, mind function optimization, Epigenetics, food as medicine, Ayurveda, easy-gentle yoga, lymph system detoxification and an in-depth survey of the chakra system as a diagnostic tool.

Through provocative and engaging presentations, informative panel discussions, ongoing Q&A and practicums, this year's 12th annual Heart and Science of Yoga conference will offer an exciting format featuring an accomplished faculty. The conference will share innovative and proven techniques, strategies and tools that will inspire physicians to reimagine their own 21st century medical practices, and support medical colleagues in combatting burnout and promoting wellness.

This year's conference presenters will include Leonard Perlmutter, AMI founder, meditational therapist, philosopher and award-winning author; Michael Greger MD, founding member and Fellow of the American College of Lifestyle Medicine and internationally recognized speaker and best-selling author; Sat Bir Singh Khalsa PhD, Director of Research for the Kundalini Research Institute, and Assistant Professor of Medicine at Harvard Medical School; Anthony Santilli MD, board-certified in Pulmonary and Critical Care Medicine; Jesse Ritvo MD, Assistant Medical Director, Inpatient Psychiatry, University of Vermont Health Center; Renee Rodriguez-Goodemote MD, Medical Director of the Saratoga Hospital Community Health Center; Joshua Zamer MD, Medical Director for Addiction Medicine at Saratoga Hospital Community Health Center and Chairman of the Department of Family Practice; Anita Burock-Stotts MD, board certified in Internal Medicine; Janine Pardo MD, board-certified Internist emphasizing Preventive Care, and founder of the Weston Internal Medicine and Wellness Center in Weston, MA; Gustavo Grodnitzky PhD, Chair of the AMI Psychological Education Committee; Kristin Kaelber, MD, board-certified in Internal Medicine and Pediatrics in Cleveland, Ohio; Jenness Cortez Perlmutter, faculty member of The American Meditation Institute, and Lee Albert, NMT, acclaimed neuromuscular therapist and gentle yoga instructor.

Noted physicians Dean Ornish MD, Bernie Siegel MD, Larry Dossey MD and Mehmet Oz MD, have endorsed Leonard Perlmutter's "Heart and Science of Yoga" treatise, which serves as the core curriculum for this year's CME conference.

Linkedin https://www.linkedin.com/in/leonard-perlmutter-ram-lev/30-

About the American Meditation Institute The American Meditation Institute is a 501(c)3 non-profit educational organization devoted to the teaching and practice of Yoga Science, meditation and its allied disciplines as mind/body medicine. In its holistic approach to wellness, AMI combines the healing arts of the East with the practicality of modern Western science. The American Meditation Institute offers a wide variety of Yoga Science classes, conferences and retreats. AMI also publishes Transformation, a quarterly journal of meditation as holistic mind/body medicine. Call 518.674.8714 for a mail or email subscription.

Media Contact: Robert Washington 60 Garner Road Averill Park, NY 12018 Tel: 518-674-8714 Fax: 518-674-8714

SOURCE American Meditation Institute

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American Meditation Institute to Host the Nation's Only Physician CME Conference on the Training of Yoga Science and Meditation as Holistic Mind/Body...

Foundation donates $18M to expand psychosocial care for cancer patients – Daily Bruin

Posted: at 6:49 am


A foundation has gifted $18 million to UCLA Health to expand an integrative patient-care program, according to a university press release Thursday.

The Simms/Mann Family Foundations donation will expand the Simms/Mann-UCLA Center for Integrative Oncology which focuses on psychosocial care intended for cancer patients and their families in California. This holistic approach includes psychiatric care, along with educational programs about nutrition and meditation.

The foundations donation is led by Victoria Mann Simms and Ronald Simms, who have previously donated to programs that work to advance integrative medicine and provide care to cancer patients. Their donation will provide funding for the center.

The endowment will also improve a training program offered by the center that trains providers in integrative care.

Since the centers founding, it has cared for over 50,000 patients, held more than 310 lectures and provided training for over 100 fellows for oncology-based psychosocial care around the country.

The Simms/Mann Foundation has now donated over $33 million to UCLA. The donors are also founding board members of the Geffen Playhouse and are credited with supporting other UCLA programs, such as the Jules Stein Eye Institute.

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Foundation donates $18M to expand psychosocial care for cancer patients - Daily Bruin

Marketing, not medicine: Gwyneth Paltrows The Goop Lab whitewashes traditional health therapies for profit – The Conversation AU

Posted: at 6:49 am


In Gwyneth Paltrows new Netflix series, The Goop Lab, Paltrow explores a variety of wellness management approaches, from energy healing to psychedelic psychotherapy.

Goop has long been criticised for making unsubstantiated health claims and advancing pseudoscience, but the brand is incredibly popular. It was valued at over US$250 million (A$370 million) in 2019.

The alternative health industry is worth A$4.1 billion in Australia alone and projected to grow.

A key driver of the industry is increased health consciousness. With easier access to information, better health literacy, and open minds, consumers are increasingly seeking alternatives to managing their well-being.

Goop has capitalised on the rise in popularity of alternative health therapies treatments not commonly practised under mainstream Western medicine.

Health systems in countries such as Australia are based on Western medicine, eschewing traditional and indigenous practices. These Western systems operate on measurable and objective indicators of health and well-being, ignoring the fact subjective assessments such as job satisfaction and life contentment are just as important in evaluating quality of life.

This gap between objective measures and subjective assessments creates a gap in the marketplace brands can capitalise on not always for the benefit of the consumer.

The Goop Lab fails to engage with the cultural heritage of traditional health and well-being practices in any meaningful way, missing an important opportunity to forward the holistic health cause.

Read more: Gwyneth Paltrow's new Goop Lab is an infomercial for her pseudoscience business

The uncritical manner in which these therapies are presented, failure to attribute their traditional origins, absence of fact-checking, and lack of balanced representation of the arguments for and against these therapies only serve to set back the wellness cause.

Many of the historical and cultural origins of the therapies in The Goop Lab are not investigated, effectively whitewashing them.

The first episode, The Healing Trip, explores psychedelic psychotherapy, suggesting this is a new and novel approach to managing mental health.

In reality, psychedelics have been used in non-Western cultures for thousands of years, only recently enjoying a re-emergence in the Western world.

In the second episode, Cold Comfort, the Wim Hof Method (breathing techniques and cold therapy) is also marketed as a novel therapy.

The meditation component of Hofs method ignores its Hindu origins, documented in the Vedas from around 1500 BCE. The breathing component closely resembles pryma, a yogic breathing practice. The Hof dance looks a lot like tai chi, an ancient Chinese movement practice.

Whitewashing these alternative therapies represents a form of colonisation and commodification of non-Western practices that have existed for centuries.

The experts showcased are usually white and from Western cultures, rather than people of the cultures and ethnicities practising these therapies as part of their centuries-old traditions.

Rather than accessing these therapies from authentic, original sources, often the consumers only option is to turn to Western purveyors. Like Paltrow, these purveyors are business people capitalising on consumers desire and pursuit of wellness.

Paltrow describes Goop as a resource to help people optimise the self. But many of these therapies are economically inaccessible.

In The Health-Span Plan, Paltrow undergoes the five-day Fast Mimicking Diet by ProLon a diet designed to reap the health benefits of fasting while extremely restricting calories. The food for the treatment period costs US$249 (A$368) (but shipping is free!). The average Australian household spends just over A$250 on groceries weekly.

Paltrow also undergoes a vampire facial, where platelet-rich plasma extracted from your own blood is applied to your skin. This facial is available at one Sydney skin clinic for between A$550 and A$1,499.

These therapies commodify wellness and health as a luxury product, implying only the wealthy deserve to live well, and longer.

This sits in stark odds with the goals of the World Health Organisation, which views health as a fundamental human right without distinction of race, religion, political belief, economic, or social condition.

Companies like Goop have a responsibility to explain the science and the origins of the methods they explore.

Given their profit-driven motive, many absolve themselves of this responsibility with an easy disclaimer their content is intended to entertain and inform not provide medical advice. This pushes the burden of critically researching these therapies onto the consumer.

Governments should seek to fund public health systems, such as Medicare, to integrate traditional health practices from other cultures through consultation and working in collaboration with those cultures.

Read more: Traditional medicines must be integrated into health care for culturally diverse groups

Perhaps this will give everyone access to a wellness system to help us live well, longer. This way, citizens are less likely to be driven towards opportunists such as Goop seeking to capitalise on our fundamental human right to live well.

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Marketing, not medicine: Gwyneth Paltrows The Goop Lab whitewashes traditional health therapies for profit - The Conversation AU

Realizing The Full Potential Of Precision Medicine In Oncology – Contract Pharma

Posted: at 6:49 am


Precision medicine promises a new paradigm in oncology where every patient receives truly personalized treatment. This approach to disease diagnosis, treatment and prevention utilizes a holistic view of the patientfrom their genes and their environment to their lifestyleto make more accurate decisions.

Growing at a rate of 10.7 percent, the precision medicine market is expected to exceed $96 billion by 2024.1 Bioinformatics represent a significant share of the market, as bioinformatics tools enable the data mining necessary for rapid identification of new drug targets and repurposing of existing treatments for new indications.1 (Reuters) The oncology segment of the precision market is expected to experience an 11.1 percent compounded annual growth rate (CAGR) leading up to 2024 due to the success of recent targeted therapies and subsequent high demand.

Still, precision medicine is in its infancy, and making personalized treatment a reality for all patients requires a transformation in how novel therapies are developed and delivered. New regulatory, technical, clinical and economic frameworks are needed to ensure that the right patients are able to access the right therapy at the right time. In this article, we review the current state of precision medicine in oncology and explore some of the challenges that must be addressed for precision medicine to reach its full potential.

Great strides toward precision medicine are being made in the area of cancer immunotherapy, which is designed to boost a patients own immunity to combat tumor cells. The introduction of immune checkpoint inhibitors (PD-1/PD-L1 and CTLA-4 inhibitors) revolutionized treatment for certain hematologic malignancies and solid tumors. To date, immune checkpoint inhibitors have been approved by the U.S. Food and Drug Administration (FDA) for more than 15 cancer indications, but their widespread use has been hampered by unpredictable response rates and immune-related adverse events.

The approvals of the first chimeric antigen receptor (CAR)-T cell (CAR-T) therapies in 2017 were the next leap forward in precision medicine. These immunotherapies demonstrated that it was possible to take out a patients own T-cells, genetically modify them, and then put them back in to target cancer cells. With complete remission rates as high as 83 percent within three months of treatment, CAR-T therapies represent a seismic shift in our approach to cancer, bringing the elusive possibility of a cure one step closer. However, longer-term follow-up has shown that these remissions may not be durable2 and prevention of relapse must still be studied.

Ultimately, the goal of cancer immunotherapy is to stimulate the suppressed immune system of a patient with cancer so that it can launch a sustained attack against tumor cells.3 This is complicated, as the interactions between tumors and immune systemsometimes called the Cancer-Immunity Cycle (see Figure 1 in the slider above)4are complex and dynamic. The Cancer-Immunity Cycle manages the delicate balance between the immune systems ability to recognize non-self and the development of autoimmunity.

In some cases, the immune system may fail to recognize tumor cells as non-self and may develop a tolerance to them. Moreover, tumors have an armamentarium of methods for evading the immune system. Given this elaborate interplay between cancer and immunity, there is a wide range of potential cancer immunotherapy approaches:

The immune response to cancer involves a series of carefully regulated events that are optimally addressed as a group, rather than individually.4 The complexity of the immune response to cancer provides a strong rationale for combination therapies, for instance:

Increasingly, the development and deployment of immunotherapy relies on harnessing genomic data to identify the patients most likely to respond to immunotherapy and to customize immunotherapy for a given patient.6 Thus, molecular profiling technologies, such as next-generation sequencing, have become integral to drug development and patient selection. At the same time, researchers are focusing on identifying molecular alterations in tumors that may be linked to response.7 The molecular fingerprints of a tumor can be quite complex and heterogeneous, not only across tumors, but also within a single patient. Consequently, molecular tumor characterization requires both multidimensional data from laboratory and imaging tests and advanced software and computational methods for analyzing these data.8 This emergence of computational precision oncology is associated with both opportunities and challenges, from validation and translation to regulatory oversight and reimbursement.

The regulatory landscape is evolving to keep pace with technological advances in cell engineering and gene editing. Since 2013, the FDA has published four guidance documents on cellular and gene therapy products, as well as two guidance documents providing recommendations on regenerative medicine advanced therapies (RMATs). Specifically, their Expedited Programs for Regenerative Medicine Therapies for Serious Conditions, published in November 2017, provides guidance on the expedited development and review of regenerative medicine therapies for serious or life-threatening diseases and conditions. This document also provides information on the use of the accelerated approval pathway for therapies that have been granted the RMAT designation.9

In the EU, the European Medicines Agency (EMA) published a draft revision of its Guideline on quality, non-clinical and clinical aspects of medicinal products containing genetically modified cells in July 2018.10 This draft revision includes current thinking on the requirements for nonclinical and clinical studies, as well as specific sections on the scientific principles and clinical aspects of CAR-T products.

Precision medicines such as CAR-T therapies require manufacturers to transform a complex, individualized treatment into a commercial product. In conventional manufacturing, the entire manufacturing process occurs within the confines of the manufacturing facility. With cell therapies, however, the process begins with the collection of cells from the patient and ends with administration of the final product (see Figure 2 in the slider above). In between, the cells are handed off multiple times for the process of genetic modification, creating a complex supply chain that blends manufacturing and administration.11

Moreover, in contrast to traditional manufacturing where the starting materials are standardized or well-defined, the starting materials for cell therapies are derived from patients and, thus, highly variable.

As evidenced by the manufacturing challenges that plagued the launch of Kymriah (tisagenlecleucel), even pharmaceutical giants have struggled with meeting label specifications for commercial use.13 To help address its manufacturing hurdles, Novartis acquired CellforCure, a contract development manufacturing organization, and plans to transform by focusing on data and digital technologies.14,15 What this means for sponsors is that robust, scalable manufacturing must be incorporated into clinical developing planning at its earliest stages.

The high price tags associated with CAR-T therapies illustrate how expensive targeted therapies are in comparison to their traditional counterparts.16 Existing health insurance models have not been structured to reimburse for costly treatments that offer the potential for long-term benefit or even cure. The pricing model for CAR-T therapies may be especially challenging for private insurance companies, which have higher turnover and shorter coverage windows than national health insurance programs. For sponsors of precision medicine therapies, one way to address the challenge of reimbursement is to create innovative, value- or outcomes-based pricing models, rather than focusing on sales volume. The success of these new pricing models will rely on patient selection. To demonstrate value and optimizing outcomes, sponsors will need to develop profiles of patients who are most likely to respond and provide tools for identifying these patients.8

Of note, on August 7, 2019, the Centers for Medicare & Medicaid Services (CMS) finalized the decision to cover FDA-approved CAR-T therapies when provided in healthcare facilities enrolled in the FDA risk evaluation and mitigation strategies (REMS) for FDA-approved indications. Medicare will also cover FDA-approved CAR-T treatments for off-label uses that are recommended by CMS-approved compendia.17

Beyond the pharmaceutical companies that are working to develop personalized treatments, the precision medicine ecosystem has a number of other key stakeholdersregulators, payers, diagnostic companies, healthcare technology companies, healthcare providers and, of course, patients. Pharmaceutical companies need to engage with each of these stakeholders by providing education or developing partnerships that help demonstrate the need for high-quality data collection, the value of precision medicine, and the process for identifying the right patients.

Sponsors may also benefit from engaging with patient advocacy groups as these groups play a critical role in connecting patients and caregivers with scientific and healthcare experts to learn about how new immunotherapy breakthroughs are changing the standard of care.

Empowered patients pushing for the latest innovations are propelling precision medicine forward, but we still have a way to go before the full potential of precision medicine is realized. In its maturity, precision medicine will not only enable the personalization of treatments for individual patients, but also inform public health at a population level as insights from the genetic and molecular data collected are used to advance our understanding of disease. Robust data collection and analysis, along with standardization, are required for building this foundation of precision medicine, and multi-stakeholder buy-in is necessary for addressing issues around data integration and privacy.

While significant challenges remain, the opportunity to transform patient outcomes and population health with precision medicine is tantalizing. Increasingly, we are seeing advanced technologiessuch as artificial intelligence and machine learningbeing incorporated into the drug discovery and development process. This underscores the critical need for a multidisciplinary approach to precision medicine, from discovery at the bench all the way through to delivery at the bedside, to help ensure that more patients can access the right therapy at the right time, and the right price.

References

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Realizing The Full Potential Of Precision Medicine In Oncology - Contract Pharma

Ross University School of Veterinary Medicine joins the World Association for Disaster and Emergency Medicine – Business Wire

Posted: at 6:49 am


BASSETERRE, St. Kitts--(BUSINESS WIRE)--The number of natural disasters worldwide has more than quadrupled in the last 50 years1. In 2018 alone, there were 315 natural disasters, resulting in nearly 12,000 deaths and $131.7 billion in global economic losses2.

In recognition of the need for improved resilience in the face of disasters and the important contributions of the veterinary field, Ross University School of Veterinary Medicine (RUSVM) has established a Disaster Research Working Group (DRWG). With expertise in disaster management and disaster related public health & epidemiology, livestock health and safety, small animal medicine and sheltering, infectious disease and veterinary education, the group will elevate the understanding, knowledge and capacity to prepare for and respond to disasters, both regionally and globally.

It is critical that veterinarians have a seat at the table in preparing for and responding to natural disasters, said Sean Callanan, Ph.D., MVB, MRCVS, CertVR, DipECVP, FRCPath, dean of RUSVM. Disasters involve people, animals and the environment we share, and Ross University School of Veterinary Medicines Disaster Research Working Group will improve the resiliency of these groups through a holistic One Health approach.

As part of this mission, RUSVM has been accepted as an affiliated organization to the World Association for Disaster and Emergency Medicine (WADEM), becoming the first veterinary school to do so. WADEM is a multidisciplinary professional association whose mission is to improve global prehospital and emergency medicine, public health and disaster health care and preparedness. As an affiliate organization, RUSVM joins its sister institution, American University of the Caribbean School of Medicine (AUC) in bringing a multidisciplinary approach to this critical field.

WADEM supports organizations worldwide that promote academic research and the preparedness capabilities of local and regional disaster response, said Gregory Ciottone, M.D., FACEP, FFSEM, president of WADEM. In that capacity, WADEM supports Ross University School of Veterinary Medicines Disaster Research Working Group and its important work promoting disaster resiliency in St. Kitts and the Caribbean.

The DRWG will focus on the following areas:

RUSVMs research will take a cross-disciplinary approach, collaborating with other healthcare institutions within the institutions parent company, Adtalem Global Education. The DRWG will join AUCs Caribbean Center for Disaster Medicine while using a One Health focus to contribute on a global scale to the safety and security of people, animals and the environment. To learn more about the DRWG, click here.

About Ross University School of Veterinary Medicine

Ross University School of Veterinary Medicine (RUSVM) is an institution of Adtalem Global Education (NYSE: ATGE). Founded in 1982, RUSVM is committed to preparing students to become members and leaders of the worldwide public and professional healthcare team and to advance human, animal and ecosystem health (One Health Initiative) through research and knowledge exchange. RUSVM has focused research programs with an emphasis on emerging infectious and zoonotic diseases, conservation medicine and ecosystem health. RUSVM offers postgraduate Masters, Ph.D. and Doctor of Veterinary Medicine (DVM) programs accredited by the St. Christopher & Nevis Accreditation Board. Ross University School of Veterinary Medicine confers a Doctor of Veterinary Medicine (DVM) degree, which is accredited by the American Veterinary Medical Association Council on Education (AVMA COE), 1931 N. Meacham Road, Suite 100, Schaumburg, IL 60173, Tel: 800.248.2862. For more information please visit https://www.avma.org/ProfessionalDevelopment/Education/Accreditation/Colleges/Pages/default.aspx. Ross Veterinary Clinic is accredited by the American Animal Hospital Association. The RUSVM Counseling Center is accredited by the International Association of Counseling Services, Inc. For more information about RUSVM, visit http://veterinary.rossu.edu/ and follow RUSVM on Twitter (@RossVetSchool), Instagram (@rossvetschool) and Facebook (@RossVetSchool).

About Adtalem Global Education

The purpose of Adtalem Global Education is to empower students to achieve their goals, find success, and make inspiring contributions to our global community. Adtalem Global Education Inc. (NYSE: ATGE; member S&P MidCap 400 Index) is a leading global education provider and the parent organization of Adtalem Educacional do Brasil (IBMEC, Damsio and Wyden institutions), American University of the Caribbean School of Medicine, Association of Certified Anti-Money Laundering Specialists, Becker Professional Education, Chamberlain University, EduPristine, Ross University School of Medicine and Ross University School of Veterinary Medicine. For more information, please visit adtalem.com and follow us on Twitter (@adtalemglobal) and LinkedIn.

1Emergency Events Database (EM-DAT) (2019) Disaster Trends. Available at https://www.emdat.be/emdat_db/.2Centre for Research on the Epidemiology of Disasters (CRED) (2019) Natural disasters 2018. Available at https://www.cred.be/natural-disasters-2018

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Ross University School of Veterinary Medicine joins the World Association for Disaster and Emergency Medicine - Business Wire

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