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Oyster Point Pharma to Participate in the LifeSci Partners Genetic Medicines Summit

Posted: June 22, 2021 at 1:49 am


PRINCETON, N.J., June 21, 2021 (GLOBE NEWSWIRE) -- Oyster Point Pharma, Inc. (Nasdaq: OYST), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of first-in-class therapies to treat ophthalmic diseases, today announced that the Company will participate virtually in the LifeSci Partners Genetic Medicines Summit on Tuesday, June 22, 2021, at 2:00 p.m. ET.

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Oyster Point Pharma to Participate in the LifeSci Partners Genetic Medicines Summit

NextCure and Collaborators Publish Preclinical Data on Novel Immunomedicine NC410

Posted: at 1:49 am


BELTSVILLE, Md., June 21, 2021 (GLOBE NEWSWIRE) -- NextCure, Inc. (Nasdaq: NXTC), a clinical-stage biopharmaceutical company discovering and developing novel, first-in-class immunomedicines to treat cancer and other immune-related diseases, today announced the publication of preclinical data in the online journal eLife establishing NC410 as a novel immunomedicine targeting immune-excluded regions of collagen-rich tumors and enabling normalization of the tumor immune microenvironment. NC410, currently being evaluated in a Phase 1/2 clinical trial in patients with advanced or metastatic solid tumors, is a first-in-class immunomedicine designed to block immune suppression mediated by LAIR-1, an immunomodulatory receptor expressed on T cells and myeloid cells, including dendritic cells.

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NextCure and Collaborators Publish Preclinical Data on Novel Immunomedicine NC410

Cassava Sciences Selects Clinical Research Organization for Phase 3 Clinical Program in Alzheimer’s Disease

Posted: at 1:49 am


Selection of Premier Research as CRO Marks Significant Milestone Toward Initiation of Phase 3 Program of Simufilam in Alzheimer’s Disease Selection of Premier Research as CRO Marks Significant Milestone Toward Initiation of Phase 3 Program of Simufilam in Alzheimer’s Disease

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Cassava Sciences Selects Clinical Research Organization for Phase 3 Clinical Program in Alzheimer’s Disease

Eve & Co Announces the Launch of a New Product The Optimist CBD Bath Bomb

Posted: at 1:49 am


STRATHROY, Ontario, June 21, 2021 (GLOBE NEWSWIRE) -- Eve & Co Incorporated (“Eve & Co”, “we”, “us” or the “Company”) (TSX-V: EVE; OTCQX: EEVVF) is pleased to announce that its wholly-owned subsidiary, Natural MedCo Ltd. (“NMC”) successfully shipped its first order of new cannabis-infused bath bombs “The Optimist CBD Bath Bomb” to retailers in Newfoundland and Labrador and Saskatchewan.

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Eve & Co Announces the Launch of a New Product The Optimist CBD Bath Bomb

eureKARE Establishes Scientific Advisory Board of World Leading Experts from Microbiome and Synthetic Biology Research

Posted: at 1:49 am


eureKARE Establishes Scientific Advisory Board of World Leading Experts from Microbiome and Synthetic Biology Research

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eureKARE Establishes Scientific Advisory Board of World Leading Experts from Microbiome and Synthetic Biology Research

Sanofi and Translate Bio Initiate Phase 1 Clinical Trial of mRNA Influenza Vaccine

Posted: at 1:49 am


-- Trial will evaluate potential of next generation of influenza vaccines with combined mRNA technology and flu vaccine development expertise ---- Positive preclinical safety and immunogenicity data for mRNA influenza vaccine candidates support initiation of Phase 1 clinical trial --

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Sanofi and Translate Bio Initiate Phase 1 Clinical Trial of mRNA Influenza Vaccine

Secret to longevity: Common personality traits of people who live to be 100 years old – Times Now

Posted: at 1:49 am


Geriatrics is about care and medical attention to the needs of the old  |  Photo Credit: iStock Images

Normally, most researches that centre around longevity or healthy, long life, probe what foods the people who live long eat or what sets of genes they have inherited, the researchers from the University of Rome La Sapienza and the University of California, San Diego decided to take a different view of longevity.

They focussed on a cluster of villages in Italys mountainous Cilento region on the coast of the Tyrrhenian Sea where 29 nonagenarians and centenarians and 51 family members aged 5175 years, lived a long and healthy existence. No diet study, no genetics study, for this study, the researchers focused on participants character traits.

This group was now a part of a larger study called CIAO (Cilento Initiative on Aging Outcomes) and they titled this study as "Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits".When the Cambridge University Press published this study online on 12 December 2017 in International Psychogeriatrics, this is what they declared they had found.

Participants age 90 years had worse physical health but better mental well-being than their younger family members. Mental well-being correlated negatively with levels of depression and anxiety in both the group Researchers graded the elderly persons on issues like mental and physical well-being, resilience, optimism, anxiety, depression, and perceived stress. Several of them had been through life's upheavals... migrations, traumatic events, wars etc.Their lives were a picture of resilience and optimism, working hard, and bond with family and religion, but also a need for control and love of the land.

Ability to handle stress with positivity:"Older people are much better able to brush off lifes small stressors and accumulate a valuable thing called wisdom: being emotionally stable and compassionate, knowing yourself and being able to make smart social decisions," Dr Dilip V Jeste, senior associate dean for the Center of Healthy Aging at UC San Diego School of Medicine, told TIME. https://time.com/4464811/aging-happiness-stress-anxiety-depression/

Self-confidence and decision-making:In a piece CNBC carried on the study's findings, it noted that when the researchers compared the participants to their younger relatives between the ages of 51 and 75, they were surprised to find that, although the older generation had worse physical health, they scored higher on measures of self-confidence, decision-making and mental well-being, meaning they were generally less anxious and depressed.

Adaptability and resilience:This shows that there are certain attributes that are very important, including resilience, strong social support and engagement and having confidence in yourself, Jeste said. They exuded a sense of pride in their personal histories, beliefs and the trials theyve had to overcome throughout their lives.

Love of their land and people:The groups love of their land is a common theme and gives them a purpose in life. Most of them are still working in their homes and on the land. They think, This is my life and Im not going to give it up, said Anna Scelzo of the Department of Mental Health and Substance Abuse in Chiavarese, Italy, in a press release, as per the CNBC report.

A bond with family and religion:This seemed to give the elderly a sense of grounding. This paradox of ageing supports the notion that well-being and wisdom increase with ageing even though physical health is failing, said Jeste. As he told TIME, it shows that getting older is not all gloom and doom.

Exceptional longevity was characterized by a balance between acceptance of and grit to overcome adversities along with a positive attitude and close ties to family, religion, and land, providing purpose in life.

Disclaimer: Tips and suggestions mentioned in the article are for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a professional healthcare provider if you have any specific questions about any medical matter.

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Secret to longevity: Common personality traits of people who live to be 100 years old - Times Now

Adventist announces major hospital expansions in downtown Bakersfield and Tehachapi, as well as new focus on longevity and wellness – KGET 17

Posted: at 1:49 am


BAKERSFIELD, Calif. (KGET) The coronavirus pandemic wreaked havoc on the nations economy and exposed logistical shortcomings in a multitude of areas, both public and private.

But it also provided many institutions, healthcare organizations chief among them, with the chance to reevaluate the way they operate and, perhaps more important, develop new and better strategies for the future.

That appears to be the case with Adventist Health, which on Friday announced a range of initiatives, some weve heard about before and some we havent. Namely, longevity.

Adventist didnt wait for the last coronavirus case to be resolved. Leaders of the three-state, 24-hospital nonprofit healthcare system were still neck deep in the pandemic when, four months ago, they decided to put their new, hard-won knowledge to work deciding where they want to be as a healthcare institution by the end of this decade.

Daniel Wolcott, president of Adventist Health of Kern County, convened a small press conference Friday morning to announce some key initiatives. First, Adventists primary, 20-acre Bakersfield campus on Chester Avenue, will be getting a third tower.

22 percent of our population in poverty and that means they dont have access to the resources necessary to live long and healthy lives, Woloctt said. So what is Adventist health going to do about it? Here at our downtown campus were planning to add a third patient care tower and that patient care tower will house additional acute and surgical room space On the third floor we would be adding (resources for) maternal and child care. And we would be reserving the fourth and fifth floors for future expansion.

Adventist will also make some significant additions at its Tehachapi hospital a 10 thousand square foot facility for primary and specialty care.

The biggest initiative is not brick and mortar, however, but philosophical. Adventist will advance further into the science of longevity by turning its still-undeveloped Bakersfield Commons campus into, essentially, a Blue Zone project a place where Bakersfield can explore the lifestyle characteristics that enable people in certain so-called Blue Zones around the world to live to 100 years old.

Adventist has partnered with Dan Buettner, author of The Blue Zones, to help the cities where it has a presence to put those lifestyle characteristics to work.

Put it all together and you have an ambitious plan to improve communities health and well-being and polish up the Adventist brand in an increasingly competitive healthcare industry that has already sought to put aside its sterile, antiseptic image in favor of Thrive and Hello Human Kindness.

Look for some changes at Adventist Health in the next five to seven years.

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Adventist announces major hospital expansions in downtown Bakersfield and Tehachapi, as well as new focus on longevity and wellness - KGET 17

Ageing process is unstoppable, finds unprecedented study – The Guardian

Posted: at 1:49 am


Immortality and everlasting youth are the stuff of myths, according to new research which may finally end the eternal debate about whether we can live for ever.

Backed by governments, business, academics and investors in an industry worth $110bn (82.5bn) and estimated to be worth $610bn by 2025 scientists have spent decades attempting to harness the power of genomics and artificial intelligence to find a way to prevent or even reverse ageing.

But an unprecedented study has now confirmed that we probably cannot slow the rate at which we get older because of biological constraints.

The study, by an international collaboration of scientists from 14 countries and including experts from the University of Oxford, set out to test the invariant rate of ageing hypothesis, which says that a species has a relatively fixed rate of ageing from adulthood.

Our findings support the theory that, rather than slowing down death, more people are living much longer due to a reduction in mortality at younger ages, said Jos Manuel Aburto from Oxfords Leverhulme Centre for Demographic Science, who analysed age-specific birth and death data spanning centuries and continents.

We compared birth and death data from humans and non-human primates and found this general pattern of mortality was the same in all of them, said Aburto. This suggests that biological, rather than environmental factors, ultimately control longevity.

The statistics confirmed, individuals live longer as health and living conditions improve which leads to increasing longevity across an entire population. Nevertheless, a steep rise in death rates, as years advance into old age, is clear to see in all species.

The debate over how much longer we can live has divided the academic community for decades, with the search for extended life and health particularly active in the UK, where at least 260 companies, 250 investors, 10 non-profits, and 10 research labs are using the most advanced technologies.

The UK government has even prioritised the separate sectors of AI and longevity by including both of them in the four industrial strategy grand challenges, which aim to put Britain at the forefront of the industries of the future.

But what has been missing from the debate is research comparing lifespans of multiple animal populations with humans, to work out what is driving mortality.

This study plugs that gap, said Aburto. This extraordinarily diverse collection of data enabled us to compare mortality differences both within and between species.

David Gems, a professor of biogerontology at UCLs Institute of Healthy Ageing, said that the summary of the report suggested the research was a very high-powered study proving something contentious and surely right.

All the datasets examined by Aburtos teams revealed the same general pattern of mortality: a high risk of death in infancy which rapidly declines in the immature and teenage years, remains low until early adulthood, and then continually rises in advancing age.

Our findings confirm that, in historical populations, life expectancy was low because many people died young, said Aburto. But as medical, social, and environmental improvements continued, life expectancy increased.

More and more people get to live much longer now. However, the trajectory towards death in old age has not changed, he added. This study suggests evolutionary biology trumps everything and, so far, medical advances have been unable to beat these biological constraints.

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Ageing process is unstoppable, finds unprecedented study - The Guardian

New study says humans cannot slow the process of aging | TheHill – The Hill

Posted: at 1:49 am


A new study suggests that stopping or even reversing the aging process is impossible.

In a collaborative effort from scientists worldwide, including experts from the University of Oxford, it was concluded that aging is inevitable due to biological constraints, The Guardian reported.

Our findings support the theory that, rather than slowing down death, more people are living much longer due to a reduction in mortality at younger ages, Jos Manuel Aburto, Oxfords Newton International Fellow, said.

America is changing faster than ever! Add Changing America to your Facebook or Twitter feed to stay on top of the news.

Aburto was part of the Leverhulme Centre for Demographic Science project that analyzed age-specific birth and death data spanning centuries and continents.

We compared birth and death data from humans and non-human primates and found this general pattern of mortality was the same in all of them, Aburto said. This suggests that biological, rather than environmental factors, ultimately control longevity."

The statistics confirmed, individuals live longer as health and living conditions improve which leads to increasing longevity across an entire population. Nevertheless, a steep rise in death rates, as years advance into old age, is clear to see in all species," he added.

For some, the news means one will never regain his or her youthfulness again. For others, whether it is a government, business, institute or a group of investors, the $110-billion anti-aging industry is a lost cause,even thoughsome estimates say it will be worth $610 billion by 2025.

In perspective, in the U.K., there are at least 260 companies, 250 investors, 10 nonprofits and 10 research labs dedicated to finding "eternal youth," accompanied by decades of academic research and advanced technology.

As The Guardian previously reported, the U.K. has prioritizedartificial intelligencetech to help doctors diagnose medical conditions more effectively to allow people to influence their lifespans.

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New study says humans cannot slow the process of aging | TheHill - The Hill

How LifeQ Biometrics Improves Your Health and Longevity – Longevity LIVE – Longevity LIVE

Posted: at 1:49 am


If we measured your body, what would we find? Biometrics refers to body measurements and calculations related to human characteristics. An example of biometrics is voice recognition and fingerprint scanning. Now, this information is often used to guard our secrets. However, what if we could use the information to uncover the secret to longevity?

In a series called The Business of Health, hosted on the Nielsen Network, Longevity Live spoke to Laurence Olivier, the CEO ofLifeQ, the leading provider of biometrics and health information derived from wearable devices, helping people live healthier lives. LifeQ, recently secured a $47 million from top investors around the world.

Laurence Olivier

The company has assembled a valuable shareholder base to assist with business expansion. The impressive list of institutions and strategic investors includes Invenfin, 4Di Capital, Allectus Capital, Mogul Capital, Tenhong Holdings, Analog Devices, Hannover Re, Convergence Partners, Stellar Capital Partners, Nedbank Corporate and Investment Bank, Delos, OneBio Seed Investment Fund, Virgin Group, Lireas, Allen & Co, and Acequia Capital. LifeQ has also drawn the backing of experienced entrepreneurs and family offices such as Rachel Diamond, Halls Investments, Bremer Investments, Errol Damelin, Dietco, among others.

We discussed the importance of biometrics and how the health information derived from wearable devices can help us live healthier lives.

What intrigued me was the fact that you could actually almost transcribe human physiology in the form of computer equations.

According to Olivier, he had the idea of developing an electronic interface between human and digital programs and software. The purpose of this would be to take it to the next level in terms of efficiency in terms of power.

How easy would it be to live a healthy life if you could understand your health better? Thats exactly the purpose behind LifeQs technology. The company was founded in South Africa after Olivier met his two Ph.D. co-founders at a biotechnology business planning competition. Now while his co-founders didnt win the competition, Olivier, who was a judge at the competition, was intrigued. What would follow is LifeQ, a fast growing global biometric business.

LifeQ has two key value propositions: enabling wearable devices to provide business-grade and near clinical-grade health information streams; and using this data to generate health and wellness solutions for consumer, business and clinical applications. LifeQ is rapidly becoming the preferred health enabler and benchmark for the worlds top consumer electronics companies. This has already had significant, life-changing and even life-saving impact on real users lives.

Lets look at sleep. We all understand that sleep is important for our health, but unfortunately, a lot of us arent getting enough of it.

This technology provides insight. Sleep apnea is a sleep-breathing disorder which demonstrates itself by oxygen saturation in your body, explains Olivier. He adds that thanks to the technology, you can monitor your sleep apnea and therefore try to change your behavior for the better. He added that if you are on any treatment, the information provided can also help your sleep clinician better monitor the success of the treatment.

Its important to remember that your body is an interlinked system, and all the different elements involved can influence it. However, thanks to the technology provided by Olivier, one can look at the total system and find connections between different health issues,

I think thats one of the things that sets LifeQ apart is the fact that we look at the total system, we look at all the different elements, explains Olivier, You actually have to give a person a total view on a lot of moving parts, because you have to think about the total system which needs to be solved.

In another first, LifeQ, 1Life and Samsung South Africa recently launched a Covid-19 screening app which is only available on the Samsung Galaxy Watch Active 2 device. The app uses unique models derived from the users biometric data to give them an indication of changes in their health. This enables consumers to take proactive precautions in the event of potential Covid-19 onset.

Olivier says the technology on your wrists can work as a small brain, helping to alert you to health issues before you even notice them. In fact, the technology could help alert you to one of the biggest health issues in recent months.

Solutions can actually help detect covid 19 infections earlier. says Olivier, Usually your brain detects the infection when you start to feel unwell, you have a temperature and you feel the symptoms. However, the COVID virus affects your body much earlier than that. In fact, there are already small immune responses in your body, your immune response, and you would not sense that yet as a symptom. Thankfully, being equipped with smart technology, we can pick it up much earlier.

Olivier adds that this is a good example of the power of digital capability because, during those 48 hours of viral shedding, which is the most dangerous part of COVID, they can alert the person and say that they may have COVID, and thus need to get tested and self-isolate.

Its great that LifeQ uses the information it collects to help support your health. However, its hard not to worry about what they could potentially be doing with the data. Thankfully, you dont have to worry about them misusing the information it collects.

LifeQ regards data, the same way as the organ of the body you own your organs, and you have all the rights and all the decisions. To us, your health data is just another organ of yours, says Olivier.

Olivier adds that LifeQs data policies are extremely rigorous. Whatever has to be done to process the collected data is done with your consent, and for your benefit.

Dont miss this interview with Laurence Olivier, co-founder of LifeQ.

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How LifeQ Biometrics Improves Your Health and Longevity - Longevity LIVE - Longevity LIVE

How to live longer: Three teas shown to reduce cancer, heart attack and stroke risk – Express

Posted: at 1:49 am


Rooibos tea

The tea, which is grown exclusively in the Western Cape province of South Africa, is not only delicious but boasts an array of health benefits helping to extend ones longevity.

Rooibos teas health benefits include supporting a healthy heart, preventing cancer, managing and preventing diabetes, supporting healthy digestion, fighting inflammation, promoting stronger bones, supporting weight loss, slowing down the ageing process, treating blood pressure, supporting healthy skin, fighting dandruff and supporting kidney health.

The main nutritional benefit of rooibos tea lies in its rich antioxidant content and it being a source of some unique polyphenols, including aspalathin.

These protective plant compounds may help protect against the free radical damage that leads to conditions like diabetes, heart disease and potentially cancer.

READ MORE:Arthritis diet: Three of the best spices to avoid arthritis symptoms and joint pain

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How to live longer: Three teas shown to reduce cancer, heart attack and stroke risk - Express

Cleveland Clinic Finds Link Between Gut Microbes and Stroke – Longevity LIVE – Longevity LIVE

Posted: at 1:49 am


According to the World Stroke Organization, globally,1 in 4 adults over the age of 25will have a stroke in their lifetime.So, how exactly can we reduce our risk?Well, according to a recent study fromCleveland Clinic, focusing on our gut health can help to protect us from severe strokes.

The state of our gut can influence our health in a number of ways, from our immune system to our mental health. That said, a recent study suggests that certain gut microbes can cause a profound change in stroke severity.

The study, published in Cell Host & Microbe, Recently,was done bya group of researchers from the Cleveland Clinic. For the purpose of the study, the researcherstransplanted various microbial communities into multiple murine stroke models in an effort to better understand the causal role of gut microorganisms in stroke.

SizeSquares/Shutterstock

The theme of the study isnt a new one for study author Dr. Hazen, who also happens to be chair of the Department of Cardiovascular & Metabolic Sciences and director of Cleveland Clinics Center for Microbiome & Human Health.

For him and his team, the study builds on more than a decade of research related to the gut microbiomes role in cardiovascular health and disease, including the adverse effects of TMAO (trimethylamine N-oxide) a byproduct produced when gut bacteria digest certain nutrients abundant in red meat and other animal products.

For the study, Dr. Hazen and his team compared brain damage in preclinical stroke models between those with elevated or reduced TMAO levels.

Functionality after a stroke which occurs when blood flow to the brain is blocked is a major concern for patients, said Dr. Hazen, who is also co-section head of Preventive Cardiology & Cardiac Rehabilitation in Cleveland Clinics Miller Heart, Vascular & Thoracic Institute. To understand if choline and TMAO affect post-stroke functionality, in addition to stroke severity, we compared performance on various tasks pre-stroke, and then both in the short- and long-term following stroke.

It appears that those with higher levels of TMAO not only had more extensive brain damage but also faced a greater degree of motor and cognitive functional deficits following stroke.

In this study, we found that dietary choline and TMAO produced greater stroke size and severity, and poorer outcomes in animal models, said Dr. Hazen, Remarkably, simply transplanting gut microbes capable of making TMAO was enough to cause a profound change in stroke severityThis new studyfor the first time provides proof that gut microbes in general and through TMAO specifically can directly impact stroke severity or post-stroke functional impairment,

The study also revealed that CutC, a gut microbe enzyme critical to TMAO production, drove heightened stroke severity and worsened outcomes.

Simple: focus on your gut.

Dr. Weifei Zhu, Ph.D. has also led the study. She believes that targeting the CutC gut microbe enzyme may help prevent stroke.

When we genetically silenced the gut microbe gene that encodesCutC, stroke severity significantly diminished, she said.

Ongoing research is exploring this treatment approach, as well as the potential for dietary interventions to help reduce TMAO levels and stroke risk, since both a Western diet and a diet rich in red meat are known to elevate TMAO levels. Switching to plant-based protein sources helps to lower TMAO.

Switching to plant-based protein sources wont only help to lower TMAO levels, but it could also have amazing benefits for your health.

Zhu, W., Romano, K. A., Li, L., Buffa, J. A.,et al. (2021). Gut microbes impact stroke severity via the trimethylamine N-oxide pathway.Cell host & microbe, S1931-3128(21)00230-4. Advance online publication. ttps://doi.org/10.1016/j.chom.2021.05.002

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Cleveland Clinic Finds Link Between Gut Microbes and Stroke - Longevity LIVE - Longevity LIVE

How to live longer: One of the healthiest drinks to reduce cancer and heart disease risk – Daily Express

Posted: at 1:49 am


Reduces diabetes risk

In a study published in the US National Library of Medicine National Institutes of Health, the effects of green tea on type 2 Diabetes was analysed.

Obesity and type 2 diabetes are major public health issues worldwide, contributing to increased cardiovascular morbidity and mortality, noted the study.

It continued: Green tea is one of the world's most popular beverages, especially in Asian countries including Korea, China, and Japan.

Because of the high rate of green tea consumption in these populations, even small effects on an individual basis could have a large public health impact.

Various studies have shown the beneficial effects of green tea, not only on cardiovascular diseases but also on obesity and type 2 diabetes itself.

In a retrospective cohort study performed in Japan, a 33 percent risk reduction of developing type 2 diabetes was found in subjects consuming six or more cups of green tea daily.

The study concluded that evidence from epidemiological studies suggest the possibility of green tea being a novel strategy for treatment or prevention of obesity and diabetes.

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How to live longer: One of the healthiest drinks to reduce cancer and heart disease risk - Daily Express

Quote Of The Week: Neuroscientist Matthew Walker On Sleep – Longevity LIVE – Longevity LIVE

Posted: at 1:49 am


Neuroscientist Matthew Walker Ph.D is a world renowned expert on sleep. He hosts a MasterClass on the science of better sleep and his TED Talk, Sleep is your superpower has over 20 million views. Matthew Walker is also the author of an international smash bestselling book Why We Sleep. Its a must-read for anyone and everyone looking to live and feel better.

We should be serious about our sleep. Walker himself is dead serious about the dangers of sleep deprivation. Now more than ever, perhaps, as bedrooms everywhere glow from the screens of round-the-clock technology consumption.

The silent sleep loss epidemic is one of the greatest public health challenges we face in the 21st century, says Walker, who has served as a sleep consultant to the NBA, NFL and Pixar Animation Studios, among other Fortune 500 enterprises.

He was recently quoted on the Rich Roll podcast saying:

Dr. Matthew Walkeris a specialist in the study of slumber and the founder-director of the Center for Human Sleep Science at the University of California, Berkeley. The influential British neuroscientist is the author of the international bestsellerWhy We Sleep (2017). It was recommended by The New York Timesfor night-table reading in the most pragmatic sense and endorsed by Bill Gates. In addition to examining how sleep affects the brain and body,Matthew has analyzed everything from its role in Alzheimers disease and depression to how it can facilitate learning and, potentially, extend our life expectancy.

Matthew Walker received his Ph.D. from the Medical Research Council at Nottingham University in London in 1996, eventually becoming an assistant professor of psychiatry at Harvard Medical School in 2004. As a certified sleep scientist, Matthew has conducted extensive research and studies into the impact of sleep and how it affects our physical and mental health.

You can join his sleep masterclass here: Matthew Walker Masterclass

Watch his TED talk here: Matthew Walker on TED

Buy his book here: Why We Sleep

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Quote Of The Week: Neuroscientist Matthew Walker On Sleep - Longevity LIVE - Longevity LIVE

Successful Results in Integrating NEO’s Silicon into Graphite-Based Anodes for Improved Longevity, Stability, and Capacity Retention – Yahoo Finance

Posted: at 1:49 am


Vancouver, British Columbia--(Newsfile Corp. - June 18, 2021) - Dr. Jong Hyeok Park, Chief Scientific Advisor and Director of NEO Battery Materials Ltd. (TSXV: NBM) (OTC Pink: NBMFF) ("NEO" or the "Company"), is pleased to announce that NEO's silicon (Si) nanocoating technology is highly effective in conventional graphite/Si mixture anodes, overcoming a major barrier to the commercialization of Si anodes in graphite anode systems. For this past week, this test was conducted and validated by a well-established third-party laboratory in South Korea. More detailed experiment conditions are as below.

Loading mass: 6.5mg/cm2

Electrode density: 1.1g/ cm3

Natural graphite/Si ratio: 9:1

Charging condition: 0.5C with CC/CV mode (NOT CC mode)

Voltage: 0.01V ~ 1.5V

NEO's previous 100% Si nanoparticle-based durability test results had confirmed that NEO's proprietary nanocoating technology stabilizes the Si material at long-term operating times required for electric vehicles (EV) and various energy storage applications. These new results further demonstrate the longevity and stability of NEO's Si anode when it is mixed with a conventional graphite-based anode. Introducing 10% of NEO's nanocoated silicon in a natural graphite anode allows a more uniform solid-electrolyte interface (SEI) layer formation with minimal volume expansion during cycling, and thus, more than two-times higher capacity retention is obtained.

Dr. Park added, "NEO's Si anode innovation breaks through the barriers that have hindered the commercialization of Si anode materials in conventional graphite-based batteries. Initially, we questioned if the nanocoating layer on Si nanoparticles could be sustainable in conventional graphite powder, but this test provides us a highly positive signal for the commercialization of our patented nanocoating technology in silicon-graphite anodes. This indicates that we may increase the Si contents in graphite systems without serious performance degradation."

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Strategic Developments & Activities

Additionally, for the past two weeks, NEO has signed several non-disclosure agreements with some established players in the battery metals and materials industry. Discussions pertain to the advancement of NEO's silicon production and proprietary nanocoating technology for silicon anodes. Due to reasons of confidentiality and the competitive nature of the industry, all parties will remain unidentified at this point in time.

Spencer Huh, President and CEO, commented, "This is extremely welcome news as we are on an accelerated process to push our corporate initiatives. NEO's robust portfolio of properties, patents, and personnel are currently producing considerable synergy, and we look forward and are enthusiastic to advance to the next stage of our plans."

At this time, no further deal terms have been reached, nor has the Company entered into any letters of intent, partnerships, advisory agreements, or any other form of definitive agreement with these parties. As the Company's discussions remain at preliminary stages, there can be no assurance or guarantee that the Company will enter into binding agreements.

Upon the request of the Exchange, NEO clarifies its relationship with 321Gold as advertisers. NEO has solely paid for banner advertisements for a six-month period. 321Gold was not paid for investor relations, promotional, nor market-making services. The article written by 321Gold on June 04, 2021, was independently written and was not paid by NEO. NEO disassociates itself with the article and neither sponsors nor endorses the article.

About NEO Battery Materials Ltd.

NEO Battery Materials Ltd. is a Vancouver-based resource company focused on battery metals exploration. The Company has staked new mining claims in Golden, BC, along a strike with a quartzite bed, targeting silica in the quartzites for a total of 467 hectares. NEO is also focusing on developing silicon anodes, which provide improvements in capacity and efficiency over lithium-ion batteries using graphite in their anode materials. The Company intends to become an integrated silicon producer and anode materials supplier to the electric vehicle industry. For more information, please visit the Company's website at: https://www.neobatterymaterials.com/.

On behalf of the Board of Directors

Spencer HuhPresident and CEO604-697-2408shuh@neobatterymaterials.com

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Successful Results in Integrating NEO's Silicon into Graphite-Based Anodes for Improved Longevity, Stability, and Capacity Retention - Yahoo Finance

California to pay unpaid rent accumulated over course of COVID-19 pandemic | TheHill – The Hill

Posted: at 1:49 am


California will pay off the past-due rent thats accrued for residents in the state during the COVID-19 pandemic as officials consider whether to extend the eviction moratorium set to expire at the end of this month, The Associated Press (AP) reports.

Several aid packages approved by the U.S. Congress have left California with more than $5 billion to pay off the accumulated unpaid rent.

Senior counselor to Gov. Gavin Newsom (D-Calif.) on housing on homelessness told the news outlet the $5.2 billion should be enough to help landlords break even and give renters in the state much-needed relief.

The AP notes, however, that California has moved slow in dishing out those funds. A report from the California Department of Housing and Community Development showed the state has received $490 million in rental aid requests through May 31, but has only paid out $32 million, not including the 12 cities and 10 counties that run independent rental assistance programs.

Our country is in a historic fight against the Coronavirus. Add Changing America to your Facebook or Twitter feed to stay on top of the news.

Lawmakers are mulling over whether to extend the eviction moratorium passed June 30, and if so, how long the eviction protections should continue. Doing so would give the state time to distribute the funds to pay off unpaid rents, which seems unlikely to do by the end of the month.

Newsom told Univision earlier this month that he does indeed want to extend the protections.

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California to pay unpaid rent accumulated over course of COVID-19 pandemic | TheHill - The Hill

Does Religious Belief Help People Think in a More Complex Way? – Walter Bradley Center for Natural and Artificial Intelligence

Posted: at 1:49 am


University of South Florida psychologist Jay L. Michaels, who has a background in experimental social psychology and quantitative psychology, designed a study to test that proposition:

In the study, 630 adults from from 48 countries completed a cognitive assessment in which they were asked to pick a phrase that best described a given behavior. They had the choice of picking a high-level description (which focused on why the action was performed) or a low-level description (which focused on mechanistic aspects of the action.) For example, one item asked whether reading was better described as Gaining knowledge or Following lines of print.

They were also asked about their religious beliefs.

participants who agreed with statements such as I have often had a strong sense of Gods presence (intrinsic religiosity) and Prayer is for peace and happiness (extrinsic-personal religiosity) were more likely to describe reading as Gaining knowledge, and this relationship was mediated by the strength of spiritual beliefs, such as the belief that God is an all-pervading presence.

But extrinsic-social religiosity (I go to church mainly because I enjoy seeing people I know there) was unrelated to these patterns of thought. Moreover, among non-religious participants, there was no link between religious motivations and higher-order thought patterns.

These results may be accounted for in part by the fact that deeply religious people might interact with Big Ideas more commonly (Is there free will? Is there life after death? Do miracles occur?) And they may be aware of more complex arguments around these issues.

Michaels first became interested in the question because many studies have associated religious belief with better health outcomes, including better surgical outcomes and greater longevity.

He is cautious about his conclusions because his teams study demonstrated only correlation, not causation:

The main takeaway from this study is that people who are motivated to pursue religion or spirituality and integrate it fully into their life while finding it contributing to what they experience tend to think in more meaningful ways, Michaels told PsyPost

As with any research, my study has flaws, Michaels explained. It used a survey method, which means we cannot conclude religion and spirituality cause people to think in a more meaningful way. Its merely a relationship. Future work that uses experimental techniques are needed to identify if there is a cause-effect relationship.

Thats an important qualification. To take religion and longevity as an example, the fact that religious people live longer is well established. But is the cause of greater longevity the content of beliefs? Or is it the lifestyle associated with the beliefs?

Thats tricky. Religious groups tend to form communities in which lifestyle rules are common. Aged people who have the support of such a community will probably live longer. And if the groups beliefs also forbid smoking, that alone would improve longevity over a broad population. On that view, the content of the beliefs is important only insofar as they are acted on and are relevant to health.

Michaels teams study is one of many to challenge the view that religious belief harms the mind in some way.

The paper, Michaels, J.L., Petrino, J. and Pitre-Zampol, T. (2021), Individual Differences in Religious Motivation Influence How People Think. Journal for the Scientific Study of Religion, 60: 64-82, https://doi.org/10.1111/jssr.12696, is open access.

You may also wish to read:

How did one man gain the strength to turn away from nihilism? Chambers was quite willing to accept that he had joined, essentially, a terrorist organization, so long as he could see it as for the greater good. The first crack in a worldview that accommodated terror came when he began to see nature not as a happenstance but an immense design. (Eric Holloway)and

Can religion improve a persons mental health? Thats a big claim but there is considerable evidence for it. The question is, what does the evidence mean? Religious groups are communities. Belonging to a community, absent obvious exploitation, is better for mental health than isolation.

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Does Religious Belief Help People Think in a More Complex Way? - Walter Bradley Center for Natural and Artificial Intelligence

B.C. public health officials prepare to manage COVID-19 differently in the future – Vancouver Sun

Posted: at 1:49 am


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Dr. Reka Gustafson said its hard to speculate on the longevity of COVID-19 but public health officials are preparing for a shift to more typical communicable disease management based on the characteristics and behaviour of the virus.

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The future of COVID-19 could look a lot like seasonal flus or other common illnesses like measles or pneumonia, B.C.s deputy provincial health officer says.

Dr. Rka Gustafson said its hard to speculate on the longevity of COVID-19 but public health officials are preparing for a shift to more typical communicable disease management based on the characteristics and behaviour of the virus.

We certainly wouldnt be surprised if this virus turns into one of the circulating coronaviruses in the population. That would be our best bet at this point, she said.

British Columbia entered the second stage of its reopening plan Tuesday after surpassing target rates for first-dose vaccinations amid a sharp decline in new cases. More restrictions are scheduled to be lifted on July 1 and the fourth and final stage of the reopening plan is slated to go into effect on Sept. 7, if that trajectory continues.

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For the public, life should return to pre-pandemic norms of interaction in September if all goes as planned, Gustafson said, adding that she believes the plan is very cautious and sensible.

Behind the scenes, public health officials are anticipating a shift away from emergency pandemic management toward communicable disease control, she said. However, even as a more routine strategy replaces the all-hands-on-deck approach, Gustafson said it will involve many of the same tools: testing, surveillance, case and contact management, and immunization strategies.

Those are actually things that happen in the background for a number of communicable diseases in the population, she said.

Under communicable disease control, local officials monitor reportable diseases for trends and respond to what are typically isolated outbreaks.

An example from Gustafsons experience includes a significant outbreak of pneumonia in 2006 in Vancouvers Downtown Eastside. Public health teams brought the infections under control with detailed epidemiological investigations and vaccination clinics, she said.

The difference between that outbreak and the pandemic was the vulnerability of the entire population to COVID-19 before vaccines were available and how little was known about the behaviour of the new coronavirus early on, which meant the size of the outbreak had the potential, of course, to be enormous, she said.

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With the majority of Canadians expected to have had two vaccine doses by the end of summer, scientists have a baseline for monitoring changes in the virus over the next season, Gustafson said.

We definitely can see the time where were not dealing with COVID-19 as a global emergency because everyone is susceptible but rather, as we do with other communicable diseases, well monitor it, well protect against local resurgences, well respond to those, well change the vaccine as necessary.

Health officials are also prepared to adapt their response as they learn more about the viruss behaviour and the level of immunity among the population over time, she said. That happened with the measles, where second doses of vaccine were rolled out only after they were identified as necessary for long-term protection, Gustafson said.

Depending on how COVID-19 evolves, it could mean vaccines are reformulated every year like the seasonal flu shot, or boosters are necessary every five or 10 years, she said.

Potential resurgences may also occur, but they shouldnt be anything like the outbreaks that happened over the past year, she said.

Its a very, very different context. Its not the same as the pandemic because the pandemic requires everybody to be susceptible at the same time and that is not a state we expect to go back to.

Of course, another pandemic is always possible as virologists monitor for new viruses. But the proven effectiveness of vaccines against COVID-19 is a very powerful tool, Gustafson said.

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She said she could not predict when the shift to communicable disease control would occur.

Last week, Yukons chief medical health officer also said its hard to predict the end of the pandemic but he doesnt believe the disease itself is going away.

We are definitely well positioned for future openings and the ability to live our life close to normal, but definitely COVID will become part of our lives, Dr. Brendan Hanley said.

Hanley said he expects repeat vaccinations similar to the flu vaccine, but added its too early to be certain as it will take time to determine how long the current vaccines remain effective, how new variants respond and what new vaccines are developed.

(Theres) lots to know and learn, especially as new variants come on the scene and new vaccines as well, and new studies.

Start your day with a roundup of B.C.-focused news and opinion delivered straight to your inbox at 7 a.m., Monday to Friday by subscribing to our Sunrise newsletter here.

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B.C. public health officials prepare to manage COVID-19 differently in the future - Vancouver Sun

Antengene Announces Fifteen Clinical Studies and Results of Selinexor to be Presented at ASCO 2021 – PRNewswire

Posted: June 6, 2021 at 1:51 am


SHANGHAI and HONG KONG, June 1, 2021 /PRNewswire/ -- Antengene Corporation Limited ("Antengene", SEHK: 6996.HK), a leading innovative biopharmaceutical company dedicated to discovering, developing and commercializing global first-in-class and/or best-in-class therapeutics in hematology and oncology, announced that fifteen studies and results of selinexor, the world's first approved oral selective inhibitor of nuclear export (SINE), will be presented at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place in a virtual format on June 4 to 8.

Selected Abstracts:

Effects of weekly selinexor, bortezomib, dexamethasone (XVd) versus standard twice weekly bortezomib and dexamethasone (Vd) on RAS-mutated previously treated multiple myeloma (MM).

Abstract #: 8027

Effects of refractory status to lenalidomide on safety and efficacy of selinexor, bortezomib, and dexamethasone (XVd) versus bortezomib and dexamethasone (Vd) in patients with previously treated multiple myeloma.

Abstract #: 8024

Survival among older patients with previously treated multiple myeloma treated with selinexor, bortezomib, and dexamethasone (XVd) in the BOSTON study.

Abstract #: 8019

Updated overall survival of eltanexor for the treatment of patients with hypomethylating agent refractory myelodysplastic syndrome.

Abstract #: e19037

Results of the phase 2 MARCH Study: Oral ATG-010 (Selinexor) plus low dosedexamethasone in Chinese patients with relapsed/refractory multiple myeloma (RRMM) previously treated with an immunomodulatory agent (IMiD) and a proteasome inhibitor (PI).

Abstract #: e20002

Oral selinexor, pomalidomide, and dexamethasone (XPd) at recommended phase 2 dose in relapsed refractory multiple myeloma (MM).

Abstract #: 8018

SIENDO/ENGOT-EN5/GOG-3055: A randomized phase 3 trial of maintenance selinexor versus placebo after combination platinum-based chemotherapy in advanced or recurrent endometrial cancer.

Abstract #: TPS5610

Open-label phase 1 study evaluating the tolerability and anti-tumor activity of selinexor and pembrolizumab in colorectal cancer.

Abstract #: e15579

A phase 1/2 study of selinexor in combination with standard of care therapy for newly diagnosed or recurrent glioblastoma.

Abstract #: TPS2071

A phase Ib/II study of selinexor in combination with imatinib in patients with advanced gastrointestinal stromal tumor (GIST): SeliGIST/GEIS-41 trial.

Abstract #: 11534

Selinexor in combination with weekly paclitaxel in patients with advanced or metastatic solid tumors: Results of an open label, single-center, multiarm phase 1b study.

Abstract #: 5565

Once weekly selinexor, carfilzomib, and dexamethasone (XKd) in carfilzomib nonrefractory multiple myeloma (MM) patients.

Abstract #: 8038

A randomized, open-label, phase 3 study of low-dose selinexor and lenalidomide (Len) versus len maintenance post autologous stem cell transplant (ASCT) for newly diagnosed multiple myeloma (NDMM): ALLG MM23, Sealand.

Abstract #: TPS8055

Molecular predictors of response to selinexor in advanced unresectable de-differentiated liposarcoma (DDLS).

Abstract #: 11509

Selinexor containing regimens in patients with multiple myeloma (MM) previously treated with anti-CD38 monoclonal antibodies (CD38 mAbs).

Abstract #: e20020

About Antengene

Antengene Corporation Limited ("Antengene", SEHK: 6996.HK) is a leading clinical-stage R&D driven biopharmaceutical company focused on innovative medicines for oncology and other life-threatening diseases. Antengene aims to provide the most advanced anti-cancer drugs to patients in the Asia Pacific Region and around the world. Since its establishment in 2017, Antengene has built a broad and expanding pipeline of clinical and pre-clinical stage assets through partnerships as well as in-house drug discovery, and obtained 15 investigational new drug (IND) approvals and submitted 5 new drug applications (NDAs) in multiple markets in Asia Pacific. Antengene's vision is to "Treat Patients Beyond Borders". Antengene is focused on and committed to addressing significant unmet medical needs by discovering, developing and commercializing first-in-class/best-in-class therapeutics.

SOURCE Antengene Corporation Limited

http://www.antengene.com

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Antengene Announces Fifteen Clinical Studies and Results of Selinexor to be Presented at ASCO 2021 - PRNewswire

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