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How to live longer: Four habits to reduce cancer and heart disease risk boosting longevity – Express

Posted: August 29, 2021 at 1:47 am


World leading longevity expert, Dr David Sinclair and author of Lifespan: Why We Age and Why We Dont Have To, shared his tips on how one can boost their longevity. Dr Sinclair is an Australian biologist with a PHD from Harvard University and shares four of his daily habit secrets which pertain to longevity. His acclaimed scientific studies have proven age reversal is possible and by incorporating certain habits into your life you could turn back the ageing clock.

Sugar and carbohydrate-rich diets have a negative impact on health independent of obesity.

Researchers discovered that the shortened survival of fruit flies fed a sugar and carbohydrate-rich diet were more prone to an early death.

Low carbohydrate dietary patterns favouring animal-derived protein and fat sources, from sources such as lamb, beef, pork, and chicken, were associated with higher mortality.

High sugar diets positively correlate with age-related diseases including diabetes and heart disease, so reducing sugar in the diet may delay ageing in humans by preventing metabolic diseases and improving general health.

Dr Sinclair advises on taking 1,000mg of Resveratrol which is an antioxidant found in red wine and certain foods.

Resveratrol has been touted as a natural way to help slow the ageing process whilst fighting cancer, obesity, heart disease and diabetes.

Dr Sinclair and colleaguesdiscovered in 2003that resveratrol could increase cell survival and slow aging in yeast (and later in mice) by activating a longevity gene known as SIRT1.

Other health benefits from resveratrol include protecting against high blood pressure, heart disease, obesity and improved insulin sensitivity.

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How to live longer: Four habits to reduce cancer and heart disease risk boosting longevity - Express

Creating snacks to combat the age-old longevity challenge and other health issues – BakeryAndSnacks.com

Posted: at 1:47 am


The pandemic has drastically changed the way consumers view their health and the impact of what they consume. As a result, the functional food market will continue its trajectory growth, estimated to burst through the $260b barrier by 2027.

Glanbia Nutritionals recent snacking habit survey conducted among 2,001 consumers in the UK by Opinion Matters in June 2021 found that 51% of over 55-year-olds will be more conscious of what they eat to stay healthy following the pandemic.

With the global population over the age of 60 reaching 22% by 2020 double what it was in 2015 according to the World Health Organisation, that is a very large target group looking for something specific. Ageing brings with it a multitude of health conditions, requiring additional supplements to help address deficiencies or prevent health problems.

Functional and fortified foods have typically been more popular with older generations, particularly products that support heart, bone, eye and brain health, said Tara Bane, marketing manager, EMEA at Glanbia Nutritionals.

However, ingredients that provide consumers with energy, focus or have calming benefits should all now be considered when producing new snack products, as the functional trend is now popular with all age groups. Research shows that food with calming health properties is especially appealing to Gen Z and Millennials.

Bane added that younger generations (in particular, 25-34-year-olds) also turn to protein as an important aspect of a healthy snack. In fact, Glanbias research found that high protein snacks are sought after by 23% of German Millennials, alongside 18% of those in the UK and 15% in France.

For brands looking create products in line with this demand, snack bars are an obvious choice, with nearly one in three snack bar launches in 2020 featuring a high protein claim, she added.

But while functional snacks should be packed with the nutritional ingredients that will bring something to the party, consumers are also looking for labels to remain as clean as possible. Again, Glanbias research found that 43% of Baby Boomers prefer foods to be made with simple, real ingredients, while 43% of Gen Z prefer to have something labelled as no preservatives, artificial ingredients, high fructose corn syrup, or trans fats .

It is also important that functional snacks tap into the conscious indulgence trend as increasingly, consumers want to feel good about their snack choices without compromising on flavour, said Bane, noting that 64% of global consumers believe that indulgent snacking is acceptable as part of a healthy diet.

Chocolate fudge brownie and peanut butter cup are the top two preferred flavours, she added.

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Creating snacks to combat the age-old longevity challenge and other health issues - BakeryAndSnacks.com

Celebrating the longevity of Louisa May Alcott’s ‘Little Women’ at her Orchard House in Concord, Massachusetts – WCVB Boston

Posted: at 1:47 am


Celebrating the longevity of Louisa May Alcott's 'Little Women' at her Orchard House in Concord, Massachusetts

Visit the house where Louisa May Alcott wrote 'Little Women' 150 years ago

Updated: 4:55 PM EDT Aug 26, 2021

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QUIETER SPOT THAT'S TRIED AND TRUE. SHAYNA: WE'LL TAKE YOU ONINE CONCD.OR ANTHONY: A GRAND CELEBRATION CALLS FOR A FRESH COAT OF PNTAI AT THE LUISA MAY HOUSEN I CONCORD. 2018 MARKED THE PUBLICATIONF O "LITTLE WOMEN." >> I'M CURRENTLY REREADING IT WITH MY FRIEND. IT'S NEAT TO COME AND SEE T HE HISTORICAL HOUSE. ANTHONY: WRITTEN HERE 150 YEARS AGO, NEVER OUTF O PRINT, TRANSLATED INTO 50 LANGUAGES. SO TRIED AND TRUE, HOLLYWOOD HAS DEMA YET ANOTHER MOVIE OF THE CLASSIC. IS OTHNE, DIRECTED B OSCAR-NOMINATED GRETA GERWICK. >> GRETA AND THE ACTRESSES HAVE COME THROUGH MULTIPLE TIMES ASKING QUESTIONS, WANTING TO SORT OF ABSORB THE HOU.SE THEY WANTED THE EXACT PAINT COLOR. THEY HAVE BEENAS PSIONATE ABOUT GETTING IT RIGHT. ANTHONY: THERE ISO N SHORTAGE OF PASSION FOR ORCHARD HOUSE SAYS EXECUTIVE DIRECTOR JAN TURNKWIS. VISITORS- - TURNQUIST. >> IT SPEAKS TO THE HEART OF SO MANY READERS NO MATTER WHAT THEIR CULTURE. THE FACT THAT YOU CAN COME RIGHT INTO THE ROOMS AND FEEL AS IF THE FAMILYAS H JUST LEFT A MOMENT AGO IS AS CLOSE AS THEY CAN COME TO MEETINGHE T AUTHOR. ANTHONY: MOST NOTABLE AND ACCESSIBLE IS LUISA'S -- LOUISA'S WRINGTI DESK. >> TYHE FELT THEIR DAUGHTERS SHOULD FULFILL THEIR OWN DESTINY. A DESK OF HER OWN IN ANOTHER FAMILY WOULD HAVE BEEN CONSIDERED ABSOLUTELY FORBIDEN AND PHYSICIANS -- FORBIDDEN AND PHYSICIANS SAID BRAIN WORK SUCH AS WRITING THOUGHT THAT IS BAD FOR HIS HEALTH. THEY THOUGHT IT WAS RIDICULOUS. THEY GAVE HER A PEN WITH A LITTLE NOTE THAT SAID, MAY THIS PEN YOUR MUSE INSPIRED WHEN WRAPPED IN PURE POETIC FIRE. ANTHY:ON ALCOTT, AN EDUCAR,TO FOUNDED THE CONCORD SCHOOL OF PHILOSOPHY AND LITERATURE HERE p ONE YEAR LATER HE BUILT A LECTURE HALL OUTSIDE. IT IS SLATED FOR THE HOLLYODWO DEBUT. >> THE MAKERS OF THIS PARTICULAR MOVIE WANTED SO MUCH TO DO SOME OF THE FILMING HERE AT THE SCHOOLF O PHILOSOPHY WAS GOING TO WORK, THEY THOUGHT,OR F THE SCHOOL SCENE WHEN AMY MARCH BRINGS PICKLED LINES TO SCHOOL. >> 150 YEARS AND STILL GOING STRONG. WHATOU WLD LOUISA MAKE OF ALL THE FUSS? >> SHE REALLY, I THIS I, WOULD BE COMPLETELY ASTONISHED THAT COULD CONTINUE LONG AFTER THE PUBLICATION OF THE BOOK, 150 YEARS, I THINK SHE WOULD BE AMUSED, PLEASED, AND MOSTLY AMAZED. SHAYNA: JUST AWESOME. AND THE FILM "LITTLE WOMEN" WAS RELEASEDN I 2019 AND GOT SIX OSCAR NOMINATIO.NS ANTHONY: ONE FOR BEST COSTUME DESIGN. IT'S OPENED ON WEEKENDS AND SATU SA TURDAYS BUT YOU HAVE TO SIGN UP FOR A TIMED RESERVATION. LAL RIGHT, EVERYONE, THAT'S IT

Celebrating the longevity of Louisa May Alcott's 'Little Women' at her Orchard House in Concord, Massachusetts

Visit the house where Louisa May Alcott wrote 'Little Women' 150 years ago

Updated: 4:55 PM EDT Aug 26, 2021

The year 2018 marked the sesquicentennial of the publication of "Little Women." Written in Concord at Orchard House 150 years ago, it never went out of print and has been translated into 50 languages. It is so tried and true, Hollywood has made yet another movie of the classic, this one directed by Oscar-nominated Greta Gerwig.

The year 2018 marked the sesquicentennial of the publication of "Little Women." Written in Concord at Orchard House 150 years ago, it never went out of print and has been translated into 50 languages. It is so tried and true, Hollywood has made yet another movie of the classic, this one directed by Oscar-nominated Greta Gerwig.

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Celebrating the longevity of Louisa May Alcott's 'Little Women' at her Orchard House in Concord, Massachusetts - WCVB Boston

Regular walnut consumption linked to greater longevity, reduced death risk: Harvard-led study – The Indian Express

Posted: at 1:47 am


Consuming walnuts regularly may be associated with a lower risk of death and an increase in life expectancy among older adults compared to those who do not eat the nuts, according to a Harvard-led study.

The research, published in the journal Nutrients, found five or more servings of walnuts per week may provide the greatest benefit for reducing mortality risk and increasing life expectancy.

What we have learned from this study is that even a few handfuls of walnuts per week may help promote longevity, especially among those whose diet quality isnt great, to begin with, said Yanping Li, senior research scientist at Harvard T.H. Chan School of Public Health in the US.

Its a practical tip that can be feasible for a number of people who are looking to improve their health, which is top of mind for many people, said Li, lead investigator of the study.

The research found that eating five or more servings per week was associated with a 14 per cent lower risk of death from any cause, 25 per cent lower risk of dying from cardiovascular diseases (CVD), and a gain in about 1.3 years of life expectancy, compared to those who didnt consume walnuts.

Consuming walnuts two to four times per week could have its benefits, too, with the researchers finding a 13 per cent lower risk of death overall, 14 per cent lower risk of dying from cardiovascular diseases, and a gain in about one year of life, compared to non-walnut consumers, the researchers said.

Even among people with a suboptimal diet, just a half serving per day increase in walnut consumption was associated with benefits, including 12 per cent reduced risk of death and 26 per cent lower risk of death from cardiovascular diseases, specifically, they said.

For this study, the researchers examined data from 67,014 women of the Nurses Health Study with an average age of 63.6 years and 26,326 men from the Health Professionals Follow-up Study aged 63.3 years in 1986.

Participants were relatively healthy when they joined the studies, and were followed for about 20 years (1998-2018).

Dietary intake was assessed every four years in which participants reported on their overall dietary intake, including how often they consumed walnuts, other tree nuts, and peanuts, as well as lifestyle factors like exercise and smoking status.

Based on this data, the researchers were able to identify associations between walnut consumption at varying levels and different health indicators related to longevity.

We observed that participants with higher amounts of walnut consumption, as well as the frequency, had a lower risk for all-cause mortality and CVD mortality compared with non-consumers, the authors of the study wrote.

The researchers noted that as an observational study, these results do not prove cause and effect, but they do shed light on how walnuts may support an overall healthy lifestyle that promotes longevity.

Participants who consumed greater amounts of walnuts tended to be more physically active, have a healthier diet, lower alcohol consumption, and take multivitamins, they said.

All of these factors could influence life expectancy, however, the researchers adjusted for these aspects in their analysis.

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Regular walnut consumption linked to greater longevity, reduced death risk: Harvard-led study - The Indian Express

Charlie Watts Is a Jazz Drummer: The Lost Rolling Stone Interview – Rolling Stone

Posted: at 1:47 am


In 2013, I interviewed the Rolling Stones for this magazine as the band prepared for the next leg of their 50th anniversary tour. Id talked to Mick Jagger, Keith Richards, and Ron Wood before, but never Charlie Watts. I was excited by the prospect: For more years than I could count, I had wanted to be able to sit in a room and talk with him about jazz. I got to do that, but the section I wrote about him didnt make the final story.

After I learned Watts would not be joining the Stones on tour this fall due to a health issue, I went back and reread the section, expanded it with some more passages from the interview. Now, on the heels of Watts death at age 80, I offer it in full. The piece raises a question: Are the Rolling Stones still the Rolling Stones without Charlie Watts? There can be no doubt that Mick Jagger and Keith Richards feel this demise immensely, since they have loved the man and have appreciated for well over half a century what he meant to their sound and history. They have carried indelible ghosts before, but Watts passing is a crushing loss. He was absolutely central to the Rolling Stones history, sound, and identity. Mikal Gilmore

Charlie Watts is a jazz drummer. When he joined the Rolling Stones in 1963, in his early twenties, he had doubts about casting his lot with an outfit that though a self-described blues ensemble would quickly be identified as a teen-adored rock band, like the Beatles. He had drummed with bandleader Alexis Korner in Londons blues scene which the Stones emerged from but he always saw himself playing jazz. In 1965, he would publish an illustrated childrens book about bebop alto-saxophonist Charlie Parker, Ode to a High Flying Bird. (Much later, in 1992, he would record an album devoted to the late alto saxophonist, A Tribute to Charlie Parker With Strings.) Keith Richards has said he considers the Stones a jazz band at least onstage because of Watts.

It was Richards, Watts tells me, who taught him new ways to hear rock & roll: While they were all going on about John Lee Hooker and all these other marvelous people [like] Muddy Waters, Id be putting Charlie Parker and Sonny Rollins in. Thats what I was into when I joined the Rolling Stones, thats what I used to listen to. Keith taught me to listen to Elvis Presley, because Elvis was someone I never bloody liked or listened to. Obviously, Id heard Hound Dog and all that, but to listen to him properly, Keith was the one who taught me.

Watts also began listening to New Orleans musicians who played rock & roll and R&B as well as jazz. Like Earl Phillips, Jimmy Reeds drummer. Earl Phillips kind of played like a jazz drummer, he says. Another New Orleans drummer, Earl Palmer [who played with Dave Bartholomew, Fats Domino, Professor Longhair, and Little Richard, among others], always thought of himself as a jazz player and, in fact, he was; he played for King Pleasure.

Watts came to see how jazz and rock & roll emerged from similar backgrounds, sometimes played by the same players: Its quite a normal mixture in New Orleans for the drummers somebody like Zigaboo [Joseph Modeliste, drummer for the Meters]. He could play bebop but also could play second-line rhythms. Ed Blackwell was a revolutionary drummer with Ornette Colemans quartet, and he was what we would call a jazz player, thats what he did, thats what he was. But he could play a New Orleans second line because he was from New Orleans.

Watts has recorded 10 jazz albums on his own, in a wide variety of styles, starting in 1986 with Live at Fulham Town Hall, by the Charlie Watts Orchestra an oversized orchestra that included seven trumpeters, four trombones, three altoists, six tenors, a baritonist, a clarinetist, two vibraphonists, piano, two basses, Jack Bruce on cello, and three drummers. It was abundantly arranged, and some of it Lester Leaps In, with a massive tenor conflagration was played at breakneck clips. In addition, he has issued recordings with a tentet, a quintet, plus a big band (which played versions of You Cant Always Get What You Want and Paint It, Black); has recorded two Charlie Parker tributes; and has released two luxuriantly scored sets of American Songbook standards Warm & Tender and Long Ago & Far Away, both featuring longtime Rolling Stones backing vocalist Bernard Fowler. On the vocal albums, Watts muted his rhythms into a faded heartbeat, guiding songs of longing and loss. His most adventurous work, though, was a sweeping tribute to jazz drummers, in collaboration with drummer Jim Keltner who has played with Eric Clapton, Ry Cooder, Delaney & Bonnie, Bob Dylan, George Harrison, John Lennon, Ringo Starr, and Gbor Szab, among numerous others.

When I meet Watts in a Beverly Hills hotels small, comfortable conference room, he is dressed in a fine gray suit, a couple shades darker than his swept back hair. He sits with his legs crossed, and his hands crossed at his wrists above them. I tell him I especially like the sprawling and ambitious Charlie Watts-Jim Keltner Project, on which the two played a series of nine tributes with such titles as Kenny Clarke, Roy Haynes, Max Roach, and The Elvin Suite. They didnt attempt to emulate the drummers they were recognizing though in the case of Airto, they fairly reconstructed the sound that the Brazilian percussionist evoked in Miles Davis 1970s ensembles.

For the most part, though, Watts and Keltners dedications were impressionistic constructions that caught something of the essence of the nine drummers they paid homage to, utilizing unusual instrumentation as well as occasional loops and electronics, plus West African-sounding rhythmic undertows. I tell Watts I especially liked the tracks named after Art Blakey and Tony Williams, and he seems surprised and grateful that an interviewer knows the album.

For me, Watts jazz recordings stand on their own yet also deepen an understanding of his place in the Rolling Stones. When you hear Watts drum with his stunning tentet on Watts at Scotts, its as if all the beats withheld over the years from his work in an electric-blues and pop band have suddenly fallen into place. You can imagine superimposing one perspective over the other, and there you have it: A full picture of the history of drumming emerges in these recordings, as it developed in the blues-based formations of Blakey, Max Roach, and a major touchstone for Watts Elvin Jones, and finally informed the razor-edged swing that Watts instilled in the Rolling Stones, then winds up some place altogether different in his epic with Keltner.

Watts talks about seeing Tony Williams in the young drummers early years with Miles Davis. He was so unlike anybody else, he says. I mention that during an interview with Williams he once told me that the single influence who opened him to drumming so wide was Keith Moon. Watts eyes grow wide, and he leans his head rearward as if taken aback: Blimey.

When I thought about it, I say, it made sense. Not to me, says Watts. Keith Moon, there was a character. Loved him. Theres only one of him. I miss him a lot. He was a very charming bloke, a lovely guy, really, but quite

Watts pauses to make a whew sound. But he could be a difficult guy, really. Actually, there wasnt only one of him. He was more like three people in one. He used to live here in Los Angeles for a while, in some of his madder days. God, I remember being here once with him when he tried to turn me on to chocolate ants; he was walking about with tins of chocolate ants. Thats what I mean. He was not your regular guy, in that way, but he was, in his heart, a nice guy. I always got on well with him.

Keith Moon, there was a character. Loved him. Theres only one of him. I miss him a lot. He was a very charming bloke, a lovely guy, really, but quite

Watts shakes his head and smiles at the memory. He was an amazing drummer with Pete [Townshend]. I dont know if he was a very good drummer outside of Pete, he adds, laughing. A lot of guys, I dont think, would have liked playing with him. He didnt play real time or anything. He wasnt funky or anything. He was a whole other thing. He was on top of everything, and maybe thats what Tony liked, but youd never think that Tony was like I would have thought Roy Haynes was his big influence.

Tony Williams was a lovely man, too, and he was writing some great stuff at the time he died. He was getting out, writing more than just playing. Brilliantly, he was writing brilliantly. He was very young when he joined Miles and became this iconic figure. I saw him when he was 18, I think, in London, the first time, when he had the black kit, and nobody played like that. Years later, when he died, I saw the brilliant Roy Haynes do his gig at Catalinas, and I suddenly thought of Tony as an extension of Roy, which I never realized before. When Tony came to London in the Sixties with Miles, like I said before, he completely blew everybody away, because nobody played like that. They didnt ride that way or do things like that. Then I saw his band Lifetime, of course, with Larry Young and John McLaughlin. I went with Mick Taylor to see that. It was fantastic. The three of them were incredible.

Mainly what Watts talks about that afternoon is durability. I tell him that Im not aware of any other drummer at least not a well-known one who has played with a musical unit for 50 years. For that matter, the only other band I can think of that ran that long was the Duke Ellington Band, from 1924 to 1974. Watts seems a little surprised as he pores over the thought of being the single longest-lasting band drummer in history. Many guys have drummed 50 years, he says, but I guess its true, what you say. When we were going along through the years and people would say, God, youve been going for 20 years, or something, my stock answer in those days was, Yeah, but Duke Ellington has been going 40-something years. Of course, he never had the same band, really. He had a lot of the same guys in and out. The wonderful Sonny Greer was with him for, blimey, from when he was in his twenties; he must have been 30 years with him, easy, up to the 1950s. Then Ellington swapped a lot of drummers around. So, no, there havent been I dont know what that means, actually, 50 years with one band.

It must mean that you really like it.

Well, yeah. Also, I prefer bands to Im not Buddy Rich, Ive never been a jazz musician thats in a book that you ring up to do a gig. That would worry the life out of me, turning up and playing with people for the first time. Ive never had that virtuosity. It takes about three or four gigs before I feel comfortable. Most of the drummers I love, really, are band guys, like Sonny. Theyve been in units for a while. It doesnt happen so much nowadays. Roy Haynes, hes been in so many great, great bands. Or the bands have been great with him in them, under great leaders Lester Young, Charlie Parker, Gary Burton. Stan Getz had one of the great bands with him. Theres also a great record with Monk that he did, I think its one of the Five Spots. Its amazing, really. Theres a great album he did with Coltrane called To the Beat of a Different Drum. Roy is an amazing guy who plays now as well as hes ever played. If any young person asked me who they should follow in ones life, Id say Roy Haynes. Hes eternally young theres absolutely nothing wayward about him. Hes at an age where most guys are not even bothering with it, really. But you put your arm around him, hes solid. Hes a fantastic man, and a very, very charming guy, beautiful man.

When the Rolling Stones started, all those other bands were obviously going they were big and now weve gone past them in years, in longevity. This is nothing to do with fame and fortune or greatness. Its just longevity, actually, and suddenly weve gone past them.

I point out that probably nobody has drummed so hard, so relentlessly and fiercely as Watts over a lifetime. Thats a drummers lot, he says. When youd see Otis Redding, that band live, those tempos. He was entertaining, doing it all, but he could stop during a sax solo or something. That drummer, though, was going the whole bloody time. Its what you do. The drummer is the engine. Its worse when you get tired and have a lot of the show still to do.

Theres nothing worse than being out of breath or your hands are killing you, and you still have a quarter of the show to go. Thats the worst one. When you were young, youd have a drink to get through that, but now I couldnt do that. I like to be over-ready for things. Thats really one of the reasons why I started to play jazz the love of it was another but it was to do other things while we werent on the road, because wed work for two years, and youd be great at the end of it, and you wouldnt work for another year or so. I like to do something to keep my hands going, really.

The Beatles were fabulous in a studio, getting their songs together, but we were much better at entertaining we were more raucous.

There had been reports about tensions between Mick Jagger and Keith Richards. Were there any doubts about the 50th-anniversary tour happening?

Not to me, but to many people there was a doubt. The two big offenders of that virtually lived together when they were kids, didnt they? They lived down the road from each other. It comes from all that. Theyre like brothers, arguing about the rent, and then if you get between it, forget it. They leave you high and dry. I think its part of being together for 50 years. Keith couldnt say things in his book without knowing Mick that well. I havent read it, actually. I just heard things hed said, and its what he felt.

I always thought we should do something for the 50th year, which Bill Wyman informed me actually is this year it wasnt last year. I was very in favor of doing a show, or a few of them. Its all right to do three numbers, but by the time youve rehearsed, paid for everybody, its like a juggernaut, our thing. Its not just me and Keith turning up and having fun, although that really is what it is, but the whole thing of it turns into a production, so you generally have to do two or three shows to pay for thinking about getting it together.

The shows in London and New York were good, and sort of spurred this on. I hope this is as comfortable as that was, because that was really comfortable to do. I like it when you can see the end of it. When you have an endless list of dates 50 shows in America or something you just look at it and go, Oh, Christ. But its very tempting to carry on, once youve started that. As Keith would say, Why dont we do more? Its logically the thing to do, because the start-up is the hard thing on your body. So obviously, nonstop is the best thing. Well see.

Are the Rolling Stones the best at being the Rolling Stones when theyre on tour or onstage?

Yeah. Yeah. Yeah. Yeah, we are a live band. We always have been, even in the early days. The Beatles were fabulous in a studio, getting their songs together, but we were much better at entertaining we were more raucous. I think were a better live band than a lot. For your ego, theres nothing nicer than driving down Santa Monica and hearing yourself on the radio, especially if its a new record. But the real fun is on the stage.

Keith [Richards] is very much like playing with a jazz guy, very loose. He can go anywhere, and if you follow him and its right, its something special. Its very easy to play with him.

Thats why I like jazz and why I prefer playing in clubs, because its more immediate. Its just what I like. And I think everybody does, probably apart from Mick, whos more about songwriting, that sort of thing. Im sure Keith prefers playing live to the other stuff. Watts laughs. People would look at us and hear the music and think, God, why do you bother to rehearse for that? But we always do, and we always have.

Every night, I offer, it seems like theres breathing room, theres a chance for something a little different.

A lot of that comes from Keith, really. Keiths very much like playing with a jazz guy, very loose. He can go anywhere, and if you follow him and its right, its something special, which is kind of what happens with jazz in its moments, really. Hes very much like that. Its very easy to play with him. You can go anywhere, really, sometimes. Roy Haynes told me you had to be quick with Bird [Charlie Parker], because he was so quick thinking, his little inflections and that. Keiths kind of like that. I dont mean Keiths like Charlie Parker, but its the same feeling. It can go somewhere quick, and if you go with it where he thinks it should go, its a lot of fun. Thats why its loose. Sometimes we dont go with it, and it falls apart.

Is going with it more difficult on large stages in arenas?

You can hear better, obviously, in a smaller room, except now the stage equipment is so advanced. In the early days, Keith used to have his Vox amplifier on a chair, tilted up so I could hear him. He still does, actually he has it right by my hi-hat, so I can hear him. In the early days, when it was what I call the Beatle period, which was all screaming girls, you couldnt hear a bloody thing, but I had to really hear him to know where the song is, because in those days, you didnt have very good PA. I couldnt hear what Mick was singing, really. Now, its quite sophisticated, but also its incredibly loud. When a band like ours goes into a small club, it carries half of that with it, and its miles too loud for me in a club. We never used to be like that. Its very difficult to suddenly jump from that huge stage down to that. Its pretty hard.

Keith Richards tells me, more than once, that Watts is essentially the reason that he still plays with Mick Jagger, and the reason the Rolling Stones endure so well and renew so effectively. Jagger, too, has said he cant imagine the band continuing without Watts. The Rolling Stones could survive the loss of guitarists Brian Jones and Mick Taylor, and the departure of bassist Bill Wyman. They can withstand years of a worlds distance apart from one another. But they cant imagine truly being the Rolling Stones without Charlie Watts. Watts is similar-minded: They are the only people I want to play rock & roll with.

Much of this is to say that when the Rolling Stones play music together, when they walk onstage together, they are an interesting coalition of history, musicianship, personality, pain, loss, joy, daring, change, and most important roughhewn fellowship.

By this time, the longevity of the Rolling Stones has become as distinguishing a characteristic of the bands history as their blues-indebtedness and all the notoriety and rebelliousness that put them on the map in the first place. That longevity, of course, has taken its toll at moments their union seemed strained beyond any hope of repair. Yet they know theres an alchemy at work between them, a collective mystery that is beyond their individual talents or reputations.

Past that, none of the three original members Watts, Jagger, Richards is at ease offering insight into why their legend and appeal survive so potently, but they realize that it endures when they are together, especially in the presence of an audience.

Were very, very fortunate, says Watts. Ive always felt that folks have liked this combination of people. Mick, Keith, Brian, and Bill: People turned up to see them. First it was 100 attending, then it was 200, then its a lot. People love looking at Mick Jagger and watching what Keiths doing. I dont know why, but they do. I mean, I do know, I know how good Keith is, and I know Mick is the best frontman going now that James Brown and Michael Jackson have gone. Being out there, hes the best. He takes it deadly seriously, as well; he keeps himself together. He looks great everything you could want. You wouldnt expect them to turn up to see me its, like, 200 people but the Rolling Stones say theyre doing something, and we get more people standing outside, listening to our rehearsals, than I do in a club listening to me do a set. Its something that Ive got no idea why.

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Charlie Watts Is a Jazz Drummer: The Lost Rolling Stone Interview - Rolling Stone

India vs England: Legendary James Anderson reveals the secret of longevity! – The New Indian Express

Posted: at 1:47 am


By PTI

LEEDS: Ageless English pacer James Anderson says the secret to his longevity in Test cricket lies in cutting down on his time at the nets to save it for the matches.

Anderson's masterclass was full on display in an awe-inspiring spell of 8-5-6-3 with the new ball as England bowled India out for 78 after Virat Kohli opted to bat in the first Test here on Wednesday.

"As I get older, I feel like I have to work that little bit harder in the gym.

I feel like I bowl less in the nets, and try to save it for when it matters in the middle," the 39-year-old said after the first day's play.

"The biggest test in Test cricket is mentally getting yourself up for bowling big spells and playing in big games. It's about keeping yourself switch on through games and switch off when you are not bowling -- that's something I've always had."

Just a week ago during the Lord's Test, Anderson, having grabbed a five-for in the first innings, was over-bowled in the second as the Indian tail frustrated the hosts with its remarkable resilience and invaluable runs.

"Walking off the pitch during the second Test at Lord's, pretty much everything hurt, but that gives so much satisfaction knowing that I have put a shift in for the team."

Asked about his problematic right shoulder, he said: "It still hurts. You just find a way of putting up with it. It's just part and parcel of the job."

Anderson said that after all the talk during the Lord's Test, the aim here was to "shut the noise" and focus on the job.

India took a 1-0 lead at Lord's riding on the tail-enders' brave display with the bat followed by their excellent bowling.

"We have made a conscious effort of trying to just focus on us, on what we do well and try and ignore everything else, the outside noise or wherever there might be going on, and make sure there's a real focus on what we do well," Anderson said.

He did admit that they had a chat in the dressing room.

"Yeah, I think there was a bit of chat about that. We were just making a point of trying to focus on what we do well.

"I think that you know the first three or four days at Lord's, we probably played brilliantly and maybe until day three, and then after that, just at times it did affect a little bit.

"We're individuals, at the end of it. We have made a conscious effort to try and focus only on us, what we do well: try and ignore everything else, the outside noise, or whatever that might be, going on."

At Headingley, Anderson took off by dismissing KL Rahul with the fifth ball and then deceived Cheteshwar Pujara with an incoming delivery that swung away, but the biggest breakthrough came when he won his mini battle with Indian skipper Virat Kohli.

"I think so (it was special). We have had some great battles over the years. He is someone you want to keep quiet. Especially, in a five-match series, if he gets going he can be very disruptive," Anderson said of Kohli after dismissing him for the seventh time in Tests.

"I think the way we have bowled to him throughout the series has been very good. We just got to keep doing that and keep him quiet as often as we can."

In reply, England openers Haseeb Hameed (60) and Rory Burn (52) remained unbeaten as the scorecard read 120 for no loss with a lead of 42 runs after day one.

Rating England's show as one of the best, Anderson drew parallel with their famous Boxing Day Test in 2010 when they had skittled out Australia for 98 before Andrew Strauss and Alastair Cook put on a 157-run opening stand.

"It doesn't get much better than that. These days don't come around very often, so you just have to be happy when they do.

"The only difference with Melbourne is that I was keen to bowl there and I wasn't today for some reason. I was trying to tempt Joe into batting.

"But losing the toss, being asked to bowl and then putting in a performance like that, it doesn't get much better. We've talked about trying to bowl as a unit, as a group, and we just absolutely nailed it. With both ball and bat we've displayed exactly what we wanted to do."

Showering praise on their opening duo, he said: "It was outstanding batting and exactly what we have been asking for."

"When you bowl someone out for less than 100 you're never quite sure whether you've bowled well or if the wicket is not as good as you think it might be. So to see the way they both went about their business, just felt so calm in the dressing room.

"The way they were so measured, they were solid in defence, left well and put away the bad ball when they got one. I just thought it was brilliant Test match batting."

Anderson was particularly happy for his former Lancashire teammate Hameed who shrugged off his Lord's disappointment with a half century.

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India vs England: Legendary James Anderson reveals the secret of longevity! - The New Indian Express

NBA: Who are the greatest NBA players to fall short in the playoffs? – Hoops Habit

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NBA (ROBERT SULLIVAN/AFP via Getty Images)

Among team sports, the NBA is the most individualistic, where one superstar player can come in and take over the game. Sometimes however even the greatest NBA stars cant win it all.

Each of the players on this list is highly accomplished but met a barrier that they simply couldnt cross in the playoffs. To avoid choosing talented young players who havent made it very far yet, I only looked at players who were retired or have played at least 10 years in the NBA. For some of them, its surprising to see that they never made a deep run despite their immense star power.

To determine the greatest players who fell short at each juncture, I prioritized MVPs, All-Stars and All-NBA selections. Beyond that, I looked at their playoff success and general longevity rather than focusing on their peaks. Raw stats didnt factor as much because its hard to compare players from different eras going solely by it. I did use it as a tie-breaker as appropriate.

For example, when choosing the best player to not win a championship, it came down to Karl Malone, Charles Barkley and Elgin Baylor. Malone was selected because he had more longevity than both players and more MVPs.

Lets take a trip down memory lane and look back at some of the legends who fell just short.

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NBA: Who are the greatest NBA players to fall short in the playoffs? - Hoops Habit

100-Year-Olds Have Superior Gut Health. Here’s How You Can Too – Longevity LIVE – Longevity LIVE

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Asnicar, F., Berry, S. E., Valdes, A. M., Nguyen, L. H., et al. (2021). Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.Nature medicine,27(2), 321332. https://doi.org/10.1038/s41591-020-01183-8

Bressa, C., Bailn-Andrino, M., Prez-Santiago, J., Gonzlez-Soltero, R., Prez, M., Montalvo-Lominchar, M. G., Mat-Muoz, J. L., Domnguez, R., Moreno, D., & Larrosa, M. (2017). Differences in gut microbiota profile between women with active lifestyle and sedentary women.PloS one,12(2), e0171352. https://doi.org/10.1371/journal.pone.0171352

Bridgewater, L.C., Zhang, C., Wu, Y.et al.Gender-based differences in host behavior and gut microbiota composition in response to high fat diet and stress in a mouse model.Sci Rep7,10776 (2017). https://doi.org/10.1038/s41598-017-11069-4

Sato, Y., Atarashi, K., Plichta, D.R.et al.Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians.Nature(2021). https://doi.org/10.1038/s41586-021-03832-5

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100-Year-Olds Have Superior Gut Health. Here's How You Can Too - Longevity LIVE - Longevity LIVE

The Inflammation Clock Is a Key To Unlock Longer Lifespans – Well+Good

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New research published in July by Nature shows that the latest feature to boost longevity might be a handy tool known as the inflammation clock.

The clock measures your biological age, which may be higher or lower than your chronological age. A 25-year-old, for example, could have an inflammation clock that resembles that of a 50-year-old. And theyd never know unless there were a way (like an inflammation clock) to reveal it at a younger age to help prepare for the future.

The study analyzed blood protein markers from 1,001 people aged between eight and 96 years old and identified protein markers, which signal age-related systemicinflammation.

The inflammation clock, iAge, works with protein markers to monitor risk of age-related diseases, which could compromise someones lifespan, says Chris Airey, MD, medical director at Optimale and practicing physician with the NHS.

These markers together would form iAge, and theres one indicator in particular, CXCL9, which is a chemokine linked to cardiac aging and a more probable development of heart disease later in life.

Researchers also found that when they silenced the expression of the gene that encodes CXCL9, the cells that became dysfunctional due to those higher levels of CXCL9 then regained some of their function, says Dr. Airey. And this in turn leads to hopes of a longer lifespan and a reversal in the damage thats been done.

The iAge uses certain protein markers in the blood that signal inflammation to establish a person's risk of developing age-related disorders, and this is based on the theory that a person's body experiences more systemic inflammation as they get older and as cells become damaged, says Dr. Airey.

While the study doesnt give us the whole picture into how these protein markers are related to risk of age-related disease and longevity, it definitely has the potential to provide more knowledge about inflammation and how it works within the body.

This research has the potential to help people understand the level ofinflammationin their body, so those at a higher risk of age-related disorders can then take steps to lowerinflammationearlier, he says.

Think of it as a warning when youre youngerif you know you are predisposed for certain complications that will lead to a reduction in longevity, you can take action steps to prevent such damage and increase your life span through healthy, daily measures, while limiting adverse habits as well.

More studies need to be done to verify the practical use of iAge, but it has the potential to be used as part of more health checkups to identify people with higher risks of age-related diseases earlier so they can take steps to reduce inflammation in the body, says Dr. Airey.

Using this feature in a doctors visit as a regular check-in could surely be beneficial for people as they age so that theyre aware of any biological factors working against their favor.

While more research is needed, you can keep inflammation at bay and lower your iAge by living a balanced lifestyle with healthy, daily habits, such as clean eating, exercising regularly and getting enough shut-eye, which would be about seven to nine hours a night.

In fact, when tested, those who are known to live healthier lives, like centenarians, had a younger age inflammation clock than their actual age. On average the centenarians had an iAge that was 40 years lower than their actual age,according to a press release. And this makes sense, since they are known to have greater longevity due to their lifestyles and diet.

Beyond diet and exercise, keeping stress levels low is key, since more stress will raise cortisol levels and create more inflammation. Chill out through soothing activities, such as meditation, yoga, journaling, exercise, napping and spending time outdoors.

Reduce the amount of refined carbohydrates, soda, fried foods and trans fats in your diet, says Dr. Airey, as these foods increase inflammation.

Get at least 1.5 hours of moderate-intensity exercise every week, he says. Go for varietycycling, walking, running, boxing, HIIT, and dance are all great forms of cardio. Include weight training 3-4 days a week as well to keep your bones and muscles strong.

Lastly, quit any smoking habits, says Dr. Airey, since smoking will directly raise your risk of age-related diseases and shorten your lifespan. Its a real nasty habit and tough to break, but itll be worth it.

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He Hasnt Had Longevity- Paddy Pimblett Details Why Khabib Nurmagomedov Couldnt be Placed in the GOAT List – EssentiallySports

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Former Cage Warriors champion and new UFC recruit, Paddy Pimblett, detailed why he wont put Khabib Nurmagomedov on the list of GOAT. The Scouser, who will make his debut for the promotion against Brazilian Luigi Vendramini on September 04, recently spoke with Submission Radios Kacper Rosolowski and Denis Shkuratov.

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The Liverpool native spoke on different topics, including his comparisons with Conor McGregor, his opponent Vendraminis record, and other things related to his debut. But the one major thing that will cause some stir is his opinion on the former lightweight champion, Khabib Nurmagomedov.

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Recently, in an interview with ace MMA reporter, James Lynch, The Baddy had named his GOAT list and surprisingly kept Khabib out of it. The former Cage Warriors featherweight champ received a lot of flak from Khabibs fans around the world.

Pimblett addressed the fans issues with him over not putting Khabib on the GOAT list. According to him, no one can stop him from giving out his opinions.

Dont care what anyone says, Pimblett told Kacper and Denis. He (Khabib) is not the GOAT level. You gotta have longevity in this sport to be the GOAT. He hasnt had longevity and had 3 title defenses. Jon Jones is at what, 12?

Khabib retired from MMA altogether after successfully defending his title against Justin Gaethje at UFC 254. He had defended his title 3 times. After winning it at UFC 223, his first title defense came against Conor at UFC 229. After beating The Notorious one, Khabib defeated Dustin Poirier at UFC 242.

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When asked if he can lure Khabib out of retirement, The Baddy said, I would love that but I cant see him coming back at all.

Khabib recently appeared in Hotboxin with Mike Tyson. The Eagle said many things in the show, including his rivalries from his MMA days. He also did some actions that didnt really amuse The Baddy.

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Hes become the Karen of the MMA scene. On the podcast with Mike Tyson the other day lad hes going, Oh can you put this fast food away, and this weed? No, lad! Its his podcast, hell do what he wants. Shut up! Youve been invited on as a guest, lad. Do as youre told you, di**y, Pimblett added.

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It will be interesting to see if Khabib has an answer in store for The Baddy as thats the only way Paddy could face Khabib. If at all Khabib appears in the octagon, Paddys name would be on the bottom of the list of opponents.

What did you make of Paddys comments on Khabib? Let us know.

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He Hasnt Had Longevity- Paddy Pimblett Details Why Khabib Nurmagomedov Couldnt be Placed in the GOAT List - EssentiallySports

How to live longer: The diet linked to a disease-free life expectancy past the age of 50 – Express

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A study published in The American Journal of Clinical Nutrition aimed to investigate the association of diet quality with cardiometabolic diseasefree life expectancy between ages 50 and 85.

Researchers assessed the relationship between the health outcomes of 8041 participants of the Whitehall II cohort study (an interdisciplinary study of ageing) and adherence to the Alternative Healthy Eating Index 2010 (AHEI-2010).

The AHEI-2010 is based on 11 components: six components for which the highest intakes were supposed to be ideal (vegetables, fruit, whole grains, nuts and legumes and polyunsaturated fats), one component for which only moderate intake was supposed to be ideal (alcohol), and four components for which avoidance or lowest intake were supposed to be ideal (sugar-sweetened drinks and fruit juice, red and processed meat, trans-fats, and sodium).

Each component was given a minimal score of 0 and a maximal score of 10.

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A higher score represented a healthier diet.

Cardiometabolic diseasefree life expectancy was defined based on the years without these chronic diseases.

The number of cardiometabolic diseasefree life-years after age 50 was 23.9 years for participants with the healthiest diet, that is, a higher score on the AHEI-2010, and 21.4 years for participants with the unhealthiest diet.

The association between diet quality and cardiometabolic diseasefree life expectancy followed a doseresponse pattern, meaning the more participants adhered to the dietary pattern, the greater the benefits.

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What's more, the finding was consistent across occupational position, body mass index (BMI), physical activity level, and smoking habit.

"Healthier dietary habits are associated with cardiometabolic diseasefree life expectancy between ages 50 and 85," the researchers concluded.

Cutting back on saturated fat is key to living a long life.

Saturated fat is the kind of fat found in butter, lard, ghee, fatty meats and cheese.

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"Eating a diet high in saturated fat is associated with raised levels of non-HDL (bad) cholesterol," warns the British Heart Foundation.

This fatty substance is linked to an increased risk of heart and circulatory disease.

Sitting down too much can also put your health at risk.

Studies have linked being inactive with being overweight and obese, type 2 diabetes, some types of cancer, and early death.

"To reduce our risk of ill health from inactivity, we are advised to exercise regularly, at least 150 minutes a week, and reduce sitting time," advises the NHS.

According to the health body, sitting for long periods is thought to slow the metabolism, which affects the body's ability to regulate blood sugar, blood pressure and break down body fat.

"Many adults in the UK spend around nine hours a day sitting," it adds.

"This includes watching TV, using a computer, reading, doing homework, travelling by car, bus or train but does not include sleeping."

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How to live longer: The diet linked to a disease-free life expectancy past the age of 50 - Express

A longevity expert on how to live longer and better – Vogue India

Posted: at 1:47 am


Aug 26, 2021 | 14:42:25 IST Age is not just a number, but it tends to add to your list of problems. If you'relooking to 'cheat' your body clock, longevity expert Dr Gil Blander may have some answers to living longer and better.

Last November, six-odd months into #WFH in Mumbai (a city in lockdown on and off since early 2020), I came across a clip of Jennifer Lopezs incredibly powerful performance at the American Music Awards. At 51, the singer and actor looked strong, showing off dance moves only someone immensely fit could pull off. Lopez is not a rare exceptionacross professions, be it business, sport or entertainment, several men and women are redefining the perception of age and living their best lives no matter how old or young they may be.

And while our prospects of living well into our eighties and nineties may have increased over time-thanks to advancements in medicine, science and technologythere has never been a more critical time in modern history to re-evaluate our lifestyles. Ageing is a complex, multifactorial process that starts in our cells, resulting in a gradual decline of the larger systems in the body. Its a time in life defined by declining mental faculties, rising disease risk and loss of vigour. According to Dr Gil Blander, founder and chief scientific officer of the personalised health performance analytics company Inside Tracker, we can slow down the fundamental ageing process and lessen its impact. The first step is to know what you are working with. This includes your blood biomarkers and DNA data. Here, Blander explains further.

Why are blood biomarkers key to increasing longevity?

There are many biomarkers related to the ageing process. Our research and data show a strong correlation between blood glucose and agea lower glucose level is associated with younger age and vice versa. Its also well established that lower cholesterol levels, particularly LDL (low-density lipoproteins or bad) cholesterol, can predict healthy ageing. Additionally, research shows high inflammation levels, measured by the biomarker hs-CRP (high sensitivity C-reactive protein), relate to age-related conditions such as metabolic syndrome and diabetes. Optimal vitamin D levels are also essential as it has many functions in the body, including a role in modulating inflammation, a mechanism that may protect telomeres, a hallmark of ageing.

Can we boost our immune system with a certain kind of diet?

A single food wont solely impact the immune system, but a balanced and varied diet, daily movement, adequate sleep and stress management will contribute to optimal immune function. Commonly under consumed nutrients include calcium, vitamin D, potassium and dietary fibre. So you must include fruits, vegetables, whole grains, dairy and legumes in your daily diet as they contain these essential nutrients. Also incorporate lean protein sources like chicken, fish, yoghurt and eggs into your diet daily. These foods provide necessary vitamins and minerals like vitamin D, vitamin E, vitamin C and zinc, to keep your immune system running smoothly.

Are there any specific hormones we should focus on as we grow older?

Well-established research illustrates that DHEAS in women decreases with age, and maintaining higher levels is protective against age-related diseases because of its anti-clotting and anti-proliferative properties. It also helps improve energy, immune function, and bone and muscle health. In men, optimised free testosterone is vital for muscle building, strength and prevent ing age-related bone loss. They can increase free testosterone by focusing on restful sleep and reducing stress when possible.

Do you believe in a mind-body connection?

The body is constantly reacting to stressors, both physical and emotional. Regard less of the source, cortisol is released to trigger the fight or flight response. Elevated cortisol signals the body to reallocate energy away from processes that are not vital to survival, and prolonged high cortisol levels can impair bodily processes like immune function and digestion. So yes, there is a large body of scientific evidence that connects the minds health to the bodys.

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A longevity expert on how to live longer and better - Vogue India

These 4 tech breakthroughs could help end aging – Fast Company

Posted: at 1:46 am


We live in a unique time when for the first time in human history there is a real opportunity to extend our lives dramatically. Recent scientific discoveries and technological breakthroughs that soon will translate into affordable and accessible life-extending tools will let us break the sound barrier of the current known record of 122 years. I am talking about breakthroughs in genetic engineering, regenerative medicine, healthcare hardware, and health data.

Very soon, slowing, reversing, or even ending aging will become a universally accepted ambition within the healthcare community. Technology is converging to make this a certainty. Developments in the understanding and manipulation of our genes and cells, in the development of small-scale health diagnostics, and in the leveraging of data for everything from drug discovery to precision treatment of disease are radically changing how we think about healthcare and aging.

When I speak of the Longevity Revolution, what I really mean is the cumulative effect of multiple breakthroughs currently underway across several fields of science and technology. Together, these parallel developments are forming the beginning of a hockey-stick growth curve that will deliver world-changing outcomes.

Completed in 2003, the Human Genome Project successfully sequenced the entire human genomeall 3 billion nucleotide base pairs representing some 25,000 individual genes. The project, arguably one of the most ambitious scientific undertakings in history, cost billions of dollars and took 13 years to complete. Today, your own genome can be sequenced in as little time as a single afternoon, at a laboratory cost of as little as $200.

The consequences of this feat are nothing short of revolutionary. Gene sequencing allows us to predict many hereditary diseases and the probability of getting cancer. This early benefit of gene sequencing became widely known when Angelina Jolie famously had a preventative double mastectomy after her personal genome sequencing indicated a high vulnerability to breast cancer. Genome sequencing helps scientists and doctors understand and develop treatments for scores of common and rare diseases. Along with advances in artificial intelligence, it helps determine medical treatments precisely tailored to the individual patient.

Longevity scientists have even identified a number of so-called longevity genes that can promise long and healthy lives to those who possess them. Scientists now understand far better than ever before the relationship between genes and aging. And while our genes do not significantly change from birth to death, our epigenomethe system of chemical modifications around our genes that determine how our genes are expresseddoes. The date on your birth certificate, it turns out, is but a single way to determine age. The biological age of your epigenome, many longevity scientists now believe, is far more important.

Best of all, however, science is beginning to offer ways to alter both your genome and epigenome for a healthier, longer life. New technologies like CRISPR-Cas9 and other gene-editing tools are empowering doctors with the extraordinary ability to actually insert, delete, or alter an individuals genes. In the not terribly distant future, we will be able to remove or suppress genes responsible for diseases and insert or amplify genes responsible for long life and health.

Gene editing is just one of the emerging technologies of the genetic revolution: Gene therapy works by effectively providing cells with genes that produce necessary proteins in patients whose own genes cannot produce them. This process is already being applied to a few rare diseases, but it will soon become a common and incredibly effective medical approach. The FDA expects to approve 10 to 20 such therapies by the year 2025.

Another major transformation driving the Longevity Revolution is the field of regenerative medicine. During aging, the bodys systems and tissues break down, as does the bodys ability to repair and replenish itself. For that reason, even those who live very long and healthy lives ultimately succumb to heart failure, immune system decline, muscle atrophy, and other degenerative conditions. In order to achieve our ambition of living to 200, we need a way to restore the body in the same way we repair a car or refurbish a home.

Several promising technologies are now pointing the way to doing just that. While it is still quite early, there are already a few FDA-approved stem cell therapies in the United States targeting very specific conditions. Stem cellscells whose job it is to generate all the cells, tissues, and organs of your bodygradually lose their ability to create new cells as we age. But new therapies, using patients own stem cells, are working to extend the bodys ability to regenerate itself. These therapies hold promise for preserving our vision, cardiac function, joint flexibility, and kidney and liver health; they can also be used to repair spinal injuries and help treat a range of conditions from diabetes to Alzheimers disease. The FDA has approved 10 stem cell treatments, with more likely on the way.

Its one thing to replenish or restore existing tissues and organs using stem cells, but how about growing entirely new organs? As futuristic as that sounds, it is already beginning to happen. Millions of people around the world who are waiting for a new heart, kidney, lung, pancreas, or liver will soon have their own replacement organs made to order through 3D bio-printing, internal bioreactors, or new methods of xenotransplantation, such as using collagen scaffoldings from pig lungs and hearts that are populated with the recipients own human cells.

Even if this generation of new biological organs fails, mechanical solutions will not. Modern bioengineering has successfully restored lost vision and hearing in humans using computer sensors and electrode arrays that send visual and auditory information directly to the brain. A prosthetic arm developed at Johns Hopkins is one of a number of mechanical limbs that not only closely replicate the strength and dexterity of a real arm but also can be controlled directly by the wearers mindjust by thinking about the desired movement. Today, mechanical exoskeletons allow paraplegics to run marathons, while artificial kidneys and mechanical hearts let those with organ failure live on for years beyond what was ever previously thought possible!

The third development underpinning the Longevity Revolution will look more familiar to most: connected devices. You are perhaps already familiar with common wearable health-monitoring devices like the Fitbit, Apple Watch, and ura Ring. These devices empower users to quickly obtain data on ones own health. At the moment, most of these insights are relatively trivial. But the world of small-scale health diagnostics is advancing rapidly. Very soon, wearable, portable, and embeddable devices will radically reduce premature death from diseases like cancer and cardiovascular disease, and in doing so, add years, if not decades, to global life expectancy.

[Photo: BenBella Books]The key to this part of the revolution is early diagnosis. Of the nearly 60 million lives lost around the globe each year, more than 30 million are attributed to conditions that are reversible if caught early. Most of those are noncommunicable diseases like coronary heart disease, stroke, and chronic obstructive pulmonary disease (bronchitis and emphysema). At the moment, once you have gone for your yearly physical exams, stopped smoking, started eating healthy, and refrained from having unprotected sex, avoiding life-threatening disease is a matter that is largely out of your hands. We live in a world of reactive medicine. Most people do not have advanced batteries of diagnostic tests unless theyre experiencing problems. And for a large percentage of the worlds population, who live in poor, rural, and remote areas with little to no access to diagnostic resources, early diagnosis of medical conditions simply isnt an option.

But not for long. Soon, healthcare will move from being reactive to being proactive. The key to this shift will be low-cost, ubiquitous, connected devices that constantly monitor your health. While some of these devices will remain external or wearable, others will be embedded under your skin, swallowed with your breakfast, or remain swimming through your bloodstream at all times. They will constantly monitor your heart rate, your respiration, your temperature, your skin secretions, the contents of your urine and feces, free-floating DNA in your blood that may indicate cancer or other disease, and even the organic contents of your breath. These devices will be connected to each other, to apps that you and your healthcare provider can monitor, and to massive global databases of health knowledge. Before any type of disease has a chance to take a foothold within your body, this armory of diagnostic devices will identify exactly what is going on and provide a precise, custom-made remedy that is ideal just for you.

As a result, the chance of your disease being diagnosed early will become radically unshackled from the limitations of cost, convenience, and medical knowledge. The condition of your body will be maintained as immaculately as a five-star hotel, and almost nobody will die prematurely of preventable disease.

There is one final seismic shift underpinning the Longevity Revolution, and its a real game-changer. Pouring forth from all of these digital diagnostic devices, together with conventional medical records and digitized research results, is a torrent of data so large it is hard for the human mind to even fathom it. This data will soon become grist for the mill of powerful artificial intelligence that will radically reshape every aspect of healthcare as we know it.

Take drug discovery, for instance. In the present day, it takes about 12 years and $2 billion to develop a new pharmaceutical. Researchers must painstakingly test various organic and chemical substances, in myriad combinations, to try to determine the material candidates that have the best chance of executing the desired medical effect. The drugs must be considered for the widest range of possible disease presentations, genetic makeup, and diets of targeted patients, side effects, and drug interactions. There are so many variables that it is little short of miraculous that our scientists have done so much in the field of pharmaceutical development on their own. But developing drugs and obtaining regulatory approval is a long and cash-intensive process. The result is expensive drugs that largely ignore rarer conditions.

AI and data change that reality. Computer models now look at massive databases of patient genes, symptoms, disease species, and millions of eligible compounds to quickly determine which material candidates have the greatest chance of success, for which conditions, and according to what dose and administration. In addition to major investments by Big Pharma, there are currently hundreds of startups working to implement the use of AI to radically reshape drug discovery, just as we saw happen in the race to develop COVID-19 vaccines. The impact that this use of AI and data will have on treating or even eliminating life-threatening diseases cannot be overstated.

But that is not the only way that artificial intelligence is set to disrupt healthcare and help set the Longevity Revolution in motion. It will also form the foundation of precision medicinethe practice of custom-tailoring health treatments to the specific, personal characteristics of the individual.

Today, healthcare largely follows a one-size-fits-all practice. But each of us has a very unique set of personal characteristics, including our genes, microbiome, blood type, age, gender, size, and so on. AI will soon be able to access and analyze enormous aggregations of patient data pulled together from medical records, personal diagnostic devices, research studies, and other sources to deliver highly accurate predictions, diagnoses, and treatments, custom-tailored to the individual. As a result, healthcare will increasingly penetrate remote areas, becoming accessible to billions of people who today lack adequate access to medical care.

I predict that the development of AI in healthcare will change how we live longer, healthier lives as radically as the introduction of personal computers and the internet changed how we work, shop, and interact. Artificial intelligence will eliminate misdiagnosis; detect cancer, blood disease, diabetes, and other killers as early as possible; radically accelerate researchers understanding of aging and disease; and reestablish doctors as holistic care providers who actually have time for their patients. In as little as 10 years time, we will look back at the treatment of aging and disease today as quite naive.

The Longevity Revolution lives not in the realm of science fiction but in the reality of academic research laboratories and commercial technology R&D centers. The idea of aging as a fixed and immutable quality of life that we have no influence upon is ready to be tossed into the dustbin of history.

Sergey Young is a renowned VC, longevity visionary, and founder of the $100 million Longevity Vision Fund. This is an adapted excerpt from The Science and Technology of Growing Young, with permission by BenBella Books.

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These 4 tech breakthroughs could help end aging - Fast Company

Delta-driven COVID-19 surge in the south has likely peaked, expert says | TheHill – The Hill

Posted: at 1:46 am


The worst of the delta variant outbreaks for southern U.S. states may be over, according to former U.S Food and Drug Administration (FDA) director Scott Gottlieb.

Speaking as a CNBC contributor on Squawk Box, Gottlieb referenced decreasing rates of transmission in hotspot states.

On a day-to-day basis, new infections are being reported nationwide, especially in comparison to the early summer months. The peak of the most recent outbreak, however, may have recently reached its peak as new cases come in at a lower rate.

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I think its pretty clear right now the South has peaked, he said on Monday. Theres very clear evidence...you look at states like Arkansas and Louisiana, you see the cases coming down.

He added that the rate of transmission for other southern states hit hard by the delta variant, namely Florida, is finally beginning to decline. This trend is apparent for all age groups, except for younger children, who are driving new cases.

Gottlieb attributes this to schools restarting in an in-person setting. He also noted that the delta variant is far more contagious than other COVID-19 strains.

This outbreak is probably infecting more kids than what weve seen in the past epidemic surges, he said.

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Gottlieb noted that it isnt evident yet that the delta variant is more dangerous than older COVID-19 strains despite the resurgence of hospitalizations.

He referenced the state rates of transmission on covidestim.org, which shows lower rate of virus transmission than seen in weeks prior. Missouri, for instance, was one of the states dealing with a surge in delta-driven infections, represented by a rate of transmission at 1.30 in early July a unit of measurement that describes the average number of people who will be infected by another individual.

Now, as of Aug. 22, the rate has fallen to 0.79.

National data analyzed by the New York Times also suggests a slowly declining rate of transmission. New cases are up by 36 percent over the last two weeks, much lower than the 140-percent increases seen in mid-July.

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Delta-driven COVID-19 surge in the south has likely peaked, expert says | TheHill - The Hill

Alarming new study finds number of people with high blood pressure has doubled over three decades | TheHill – The Hill

Posted: at 1:46 am


The number of people with high blood pressure across the globe has almost doubled over the last 30 years, and nearly half were unaware they had the condition.

A new studyconducted by researchers at Imperial College London and scientists from The World Health Organization found that the number of people aged 30 to 79 years with high blood pressure has increased from 650 million to 1.28 billion between 1990 and 2019.

The study, which was published in The Lancet on Tuesday, analyzed blood pressure measurement and treatment data frommore than100 million people in 184 countries. High blood pressure, or hypertension, is diagnosed when the top number on a reading reaches 140 and the bottom number hits 90 on two separate readings on different days.

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The research shows that nearly 580 million people were unaware they had the condition, and roughly 720 million people were not receiving treatment from medicines designed to lower their blood pressure. The condition can cause significant damage to vital organs and is one of the major causes of death worldwide,according to the World Health Organization.

Nearly half a century after we started treating hypertension, which is easy to diagnose and treat with low-cost medicines, it is a public health failure that so many of the people with high blood pressure in the world are still not getting the treatment they need, Majid Ezzati, senior author of the study and Professor of Global Environmental Health at the School of Public Health at Imperial College London, said in a release.

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Researchers also concluded the study highlights health care equity concerns given the disparity between wealthier nations and certain low-income regions. Meanwhile, the researchers note that although the overall case rate has remained largely unchanged, there has been a shift in burden to lower income countries.

Although hypertension treatment and control rates have improved in most countries since 1990, there has been little change in much of sub-Saharan Africa and Pacific Island nations. International funders and national governments need to prioritise global treatment equity for this major global health risk, Bin Zhou, a research fellow in the School of Public Health at Imperial College London, who led the analysis, said in the release.

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Alarming new study finds number of people with high blood pressure has doubled over three decades | TheHill - The Hill

Akero Therapeutics Reports Second Quarter 2021 Financial Results and Provides Business Update

Posted: August 15, 2021 at 1:51 am


SOUTH SAN FRANCISCO, Calif., Aug. 13, 2021 (GLOBE NEWSWIRE) -- Akero Therapeutics, Inc. (Nasdaq: AKRO), a cardio-metabolic biotechnology company developing transformational treatments for non-alcoholic steatohepatitis (NASH), today reported second quarter financial results for the period ending June 30, 2021.

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Akero Therapeutics Reports Second Quarter 2021 Financial Results and Provides Business Update

POINT Biopharma Reports Second Quarter 2021 Financial Results and Provides Business Update

Posted: at 1:51 am


Strengthened the Company’s balance sheet by completing the business combination with Therapeutics Acquisition Corp (“RACA”), with gross proceeds from the transaction totaling approximately $286.7 million

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POINT Biopharma Reports Second Quarter 2021 Financial Results and Provides Business Update

HCW Biologics Reports Second Quarter Financial Results and Recent Business Highlights

Posted: at 1:51 am


MIRAMAR, Fla., Aug. 13, 2021 (GLOBE NEWSWIRE) -- HCW Biologics Inc. (the “Company”) (NASDAQ: HCWB), an innovative, biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between chronic, low-grade inflammation and age-related diseases, today reported financial results and recent business highlights for its second quarter ended June 30, 2021.

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HCW Biologics Reports Second Quarter Financial Results and Recent Business Highlights

ContraFect Reports Second Quarter 2021 Financial Results and Provides Business Update

Posted: at 1:51 am


Multiple peer-reviewed journal publications and presentations at scientific forums drive value and recognition across the Company’s DLA portfolio

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ContraFect Reports Second Quarter 2021 Financial Results and Provides Business Update

Alpha Healthcare and Humacyte Announce Nominees for Election to Post-Merger Public Company Board of Directors

Posted: at 1:51 am


NEW YORK and DURHAM, N.C., Aug. 13, 2021 (GLOBE NEWSWIRE) -- Alpha Healthcare Acquisition Corp. (Nasdaq: AHAC) (“AHAC”), a special purpose acquisition company, today announced the nominees who will stand for election/reelection to its Board of Directors during the August 24, 2021, AHAC special shareholder’s meeting to vote on the proposed business combination with Humacyte, Inc., a clinical-stage biotechnology platform company developing universally implantable bioengineered human tissue at commercial scale.

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Alpha Healthcare and Humacyte Announce Nominees for Election to Post-Merger Public Company Board of Directors

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