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Grand Traverse Co. Health Department Seeks Volunteers for Hagerty Center Vaccination Clinics – 9&10 News

Posted: January 20, 2021 at 7:53 pm

The mass COVID-19 vaccination clinic is well underway at the Hagerty Center in Traverse City, but theyre looking for a little extra help.

The health department has partnered with United Way to bring in more volunteers.

With the opening of a second vaccination clinic in February at the Civic Center, theyre looking for people to help with non-healthcare related tasks.

That includes anything from greeting people at the door to helping with registration.

Having United Way assist us with finding these volunteers and having volunteers give up their time to assist in these mass vaccination clinics, its just going to get us through this process faster and it feels really good on our end when we see people kind of staffing up and raising their hand to assist the local health department, said Emmy Schumacher, Grand Traverse County Health Department.

You must be 18 or older to volunteer and pass a background check, follow CDC guidelines, and complete a COVID-19 waiver.

Click here for more information.

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Grand Traverse Co. Health Department Seeks Volunteers for Hagerty Center Vaccination Clinics - 9&10 News

How to live longer: Should you skip breakfast to promote longevity? Doctor weighs in – Express

Posted: December 28, 2020 at 10:00 am

Loose Women: Dr Hilary discusses how to live longer

Attempts to lead a long and healthy life are often stymied by conflicting advice, particularly when it comes to nutrition. A new fault line has opened up in recent years around not so much what you should eat but when you should eat. Whether to eat or avoid breakfast has proven to be a particular flashpoint.

Having breakfast has been shown to decrease the risk of heart disease, obesity and cholesterol in some studies.

Despite these findings, Babylon GP Dr Sinan Mir tends not to promote breakfast in his dealings with clients.

Speaking to Express.co.uk, he says: "I often encourage my clients, if they are breakfast neutral, to consider skipping it."

Dr Mir outlines six key reasons for this:

READ MORE:How to live longer: Sex may reduce heart disease risk - how often you should have it

Dr Mir does quality his advice, however. "We dont know enough to categorically recommend that people should have or skip breakfast."

He adds: "The most important thing is to not be dogmatic and remember, neither approach is inherently bad or harmful, but form part of a wider approach to nutrition and your health."

Studies offer conflicting results. A study published in the Journal of the American College of Cardiology found skipping breakfast was significantly associated with an increased risk of cardiovascular-related death, especially stroke-related death.

After a person's age, sex, race, socioeconomic status, diet, lifestyle, body mass index and disease status were taken into account, the study found that those who never had breakfast had a 87 percent higher risk of cardiovascular mortality compared with people who had breakfast every day, said Dr. Wei Bao, an assistant professor of epidemiology at the University of Iowa in Iowa City and senior author of the study.

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However, as Harvard Health explains, a "plethora of intermittent fasting studies" suggest that extending the overnight fast is indeed associated with weight loss, but also more importantly, with improved metabolism.

"Overnight fasting of at least 16 hours (which really isnt that extended) allows blood sugar and insulin levels to decrease, so that fat stores can be used for energy," reports the health body.

This is significant because high blood sugar levels and poor insulin production is a feature of type 2 diabetes - a precursor to heart disease.

What's more, researchers from Melbourne, Australia reviewed seven studies looking at the effects of breakfast on weight change, and after an average study length of seven weeks, participants who ate breakfast gained 1.2 pounds compared to those who didnt.

The researchers also reviewed ten studies investigating the effects of breakfast on total daily calorie intake, and after an average study length of two weeks, participants who ate breakfast consumed 260 calories more than those who didnt.

These results fly in the face of the notion that skipping breakfast will cause people to binge later.

Combining a healthy diet with regular exercise is the best way of maintaining a healthy weight - a key preventative measure against heart disease.

"Having a healthy weight reduces your chances of developing high blood pressure," notes the NHS.

What's more, regular exercise will make your heart and blood circulatory system more efficient, lower your cholesterol level, and also keep your blood pressure at a healthy level, says the health body.

Exercising regularly also reduces your risk of having a heart attack.

"The heart is a muscle and, like any other muscle, benefits from exercise," explains the NHS.

Any aerobic exercise, such as walking, swimming and dancing, makes your heart work harder and keeps it healthy.

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How to live longer: Should you skip breakfast to promote longevity? Doctor weighs in - Express

China Long Avoided Talking About Mental Health. Then Covid Hit. – The New York Times

Posted: December 22, 2020 at 11:01 am

Chinas fight against the coronavirus was mostly over, but Zhang Xiaochun, a doctor in Wuhan, was sinking into depression, convinced she had failed as a daughter and mother. She agonized over her decision to keep working even after her father fell critically ill. She worried about her young daughter, whom she had frequently left alone at home.

But rather than hide those feelings, as would have been common just a few years ago in a country where mental illness has long been stigmatized, Dr. Zhang consulted therapists. When friends and colleagues checked in on her, she openly acknowledged that she was struggling.

If we can face such a huge disaster as this outbreak, then how could we not dare to talk about something so small as some mental health problems? said Dr. Zhang, an imaging specialist.

The coronavirus pandemic, which started in China, has forced the country to confront the issue of mental health, a topic long ignored because of scarce resources and widespread social stigmas. In the Mao era, mental illness was declared a bourgeois delusion and the countrys psychiatric system was dismantled. Even today, discrimination persists, and many people with mental illnesses are shunned, hidden at home or confined in institutions.

But after the coronavirus outbreak, that kind of neglect has become increasingly untenable. The uncertainty of the pandemics early days has combined with the grief and terror of the subsequent weeks to leave a trauma both personal and collective.

At the height of Chinas outbreak, more than a third of people around the country experienced symptoms of depression, anxiety, insomnia or acute stress, according to a nationwide survey by a Shanghai university. An expert in Beijing recently warned that the effects could linger for 10 to 20 years.

Because of the Chinese governments top-down leadership, officials have mobilized quickly to provide help. Local governments have set up hotlines. Psychological associations have rolled out apps and held online seminars. Schools are screening students for insomnia and depression, and universities are establishing new counseling centers.

But the country also faces serious challenges. There is a dearth of therapists for the countrys 1.4 billion people, with fewer than nine mental health professionals for every 100,000 residents as of 2017, according to the World Health Organization.

Chinas centralized political system, for all its strengths in mobilizing resources, may also create problems of its own. The government has curbed public mourning and suppressed calls for accountability over early missteps, pushing a simplified narrative of Chinas triumph over the virus.

Still, the hope is that the pandemic could propel a long-term shift in the conversation around mental health in China, with advocates pointing in part to high-level government orders to improve treatment.

Because of the pandemic, they are braver in coming to ask for help, Du Mingjun, a psychologist in Wuhan, said of the influx of people she had seen seeking treatment this year. More and more people are accepting this. That is new.

Ms. Du was one of the first witnesses to the crisiss mental health toll. On Jan. 23, the day Wuhan locked down, she and her colleagues at the provincial psychologists association helped launch a government-backed 24-hour hotline, placing ads in newspapers and posting on WeChat to reach a city suddenly convulsed by fear.

Immediately, they were inundated. A woman called because her parents were in separate hospitals, and trying to run between the two had left her on the verge of collapse. A man was taking his temperature every 30 minutes, terrified of falling ill. A 12-year-old boy dialed on behalf of his mother, explaining that he was worried about her. At the peak, the hotline managed between 200 and 300 calls each day, Ms. Du said.

Dec. 22, 2020, 5:18 a.m. ET

As the situation improved, the calls tapered off. By late October, there were around 10 a day. Some callers were still seeking help for trauma related to the outbreak, brought back by news reports, or old photos glimpsed on cellphones. But others have come looking for help with more mundane issues, such as academic pressure or arguments with family.

I think this change is here now, and theres no way to stop it, Ms. Du said. We all lived through this together, and it was continuously unfolding around us. So the collective consciousness of our community is very deep.

Around the country, schools have expanded mental health counseling and encouraged students to take time to unwind, as the Ministry of Education has warned of post-epidemic syndrome. Officials have said that after months of stressful lockdowns, students might be more likely to have conflicts with parents and teachers.

Even before the pandemic, the trends in students mental health were worrying. A Shanghai official said in May that suicides among K-12 students were on the rise, with stress arising from academic pressure and domestic disputes.

While the rollout of services has been spotty, educators and students say the campaign has helped break stereotypes about mental health. In the northern province of Hebei, officials have produced cartoons to help students understand trauma. In the southern city of Guangzhou, students are writing letters about anxiety and practicing breathing exercises.

Xiao Zelin, a junior at Sun Yat-sen University in Guangzhou, said he suffered anxiety and insomnia when he returned to campus this fall. After months of being cooped up at home, he struggled adjusting to crowds of people. His appetite was poor and he couldnt seem to relax.

Mr. Xiao had never visited a therapist before, but he spoke with a counselor provided by his university. The counselor, he said, helped him understand what he was going through and to be patient with himself. Mr. Xiao suggested his classmates sign up as well.

In the beginning I was lost, he said. Now Im feeling much better.

Liang Lingyan, a psychologist in Shanghai, said the government there had also arranged more community services, such as home visits for seniors who live alone.

After the epidemic, people are paying much more attention to health, especially mental health, she said. This will be a long-term change.

Despite the efforts, cracks in the system remain.

There are signs that those who need help have difficulty finding it. One survey by Chinese researchers found that only 7 percent of patients with mental disorders had sought online help during the pandemic, despite the introduction of apps and websites by the government.

There are also too few high-quality training programs for mental health professionals, said Yu Lingna, a psychologist from China who is now based in Tokyo. Even if those were expanded, training people would take time.

I expect we will be in a state of inadequacy for our lifetimes, she said.

For Dr. Zhang, the imaging specialist who worked in Wuhan, the feeling that she had betrayed her family lingered, even as state media feted frontline doctors for their contributions. Her father recovered but her parents treated her coldly.

Studies suggest that medical staff may be particularly vulnerable to the pandemics aftershocks, with one study finding that over half of Chinese health care workers surveyed showed symptoms of depression. While many of those symptoms faded as the epidemic ebbed, others, such as a sense of guilt over losing patients, could persist, experts said.

Dr. Zhang said she found therapy unhelpful, but she eventually found other sources of comfort. She immersed herself in the writings of Wang Yangming, a Ming dynasty philosopher. It is easy to catch the thief that lives in the mountain, but hard to catch the thief that lives in the heart, he wrote.

She also eventually left her job at the Wuhan hospital and is now living in Chengdu, in the countrys southwest, spending time with her husband and daughter. She is hopeful that one day her parents will understand her decisions.

Dr. Zhang has often emphasized that her experience is not unique. Many of her former colleagues are also still grappling with the scars of the outbreak, she said, and she was heartened that many of them had also turned to friends or therapists.

Any big crisis like this is bound to leave people with some sort of pain, she said. Theres nothing shameful about it.

Albee Zhang and Liu Yi contributed research.

The Substance Abuse and Mental Health Services Administration National Helpline offers free and confidential information on mental health treatment and services, 24 hours a day. Call (800) 662-4357 or TTY: (800) 487-4889.

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China Long Avoided Talking About Mental Health. Then Covid Hit. - The New York Times

With fitness centers shut down due to COVID-19, home gyms are on the rise – SW News Media

Posted: December 10, 2020 at 8:55 pm

Peter Hartman's home gym was set up before the COVID-19 pandemic hit.

Hartman doesn't have a crystal ball. He also doesn't sell used fitness equipment, an industry that's booming now with gyms and fitness centers forced to shut down twice since April in Minnesota.

Hartman is a social studies teacher and assistant football coach at Prior Lake High School. He's also a coach for Laker Performance, a weight and fitness training program for Prior Lake athletes.

"I got lucky with the timing of COVID-19," Hartman said. "We moved over a year ago (to Lakeville), and outfitting a home gym was part of the negotiation with my wife about the move. In other words, the home gym was setup before COVID-19.

Hartman said the home gym has become "invaluable" for his family. His wife Heather was a regular Life Time Fitness class-goer before the pandemic and has still not returned to her usual routine. She gets in workouts via online classes with friends in each other's garages and has started using her husband's home gym equipment.

"Ive used COVID-19 as an excuse to get some additional equipment recently," Hartman said.

Rising sales

Hartman is not the only one bulking up their basement gyms. The used fitness equipment industry has benefited from the pandemic, even more so now that the winter months are coming.

Jay Fotso, manager at the Johnson Fitness & Wellness in Burnsville said there's been a lot of foot traffic in his store and sales have been way up since the summer. Johnson Fitness & Wellness is one of the largest specialty fitness retailers in the U.S. with 12 stores in Minnesota, including locations in Chanhassen and Edina.

"There's definitely been more demand," Fotso said. "Winter sales are usually good and could be even better this year."

According to the NDP Group, a market research company, sales of fitness equipment has risen by 130% since the pandemic began compared to last year. Stackline, an e-commerce data company, recorded a 307% jump in online sales of weight-training equipment back in the spring.

"It's been a good time for people to try something new," Fotso said.

According to the International Health, Racquet & Sportsclub Association, the health club industry lost roughly $14 billion in revenue since the pandemic began, and an estimated one-fourth of the country's 40,000 fitness facilities could close without financial relief by the end of the year.

For Hartman, the home gym has also allowed his two young children to stay active during the pandemic.

"Fitness has truly been a saving grace for me and my family throughout this pandemic," he said. "It provides a healthy outlet that I can control. So much going on throughout the world recently has been out of our control. It's comforting to know that I can head down to my basement and get a solid workout in anytime my schedule allows.

Hartman said he regularly sets up routines for his kids and others in the neighborhood.

Laker Performance

Staying fit has also been a challenge for high school athletes. Spring sports in the Minnesota State High School League were canceled last April.

Summer activities were played but were limited, and this fall the MSHSL had abbreviated seasons for high school teams. Winter sports have also been paused.

Hartman said the Prior Lake football and track coaches got together to give athletes some direction with their fitness needs and goals, as well to bring a sense of community.

The coaches posted CrossFit-style workouts for all teams. There was video direction and workout strategies on the team's Schoology pages. Athletes could post their results along with doing a video and share ideas on the discussion board.

And many of these workouts were done in home gyms.

"Our athletes are pretty self-motivated and dedicated," Hartman said. "This was a fantastic way for athletes to compete with one another, hold each other accountable, and most importantly, connect with one another."

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With fitness centers shut down due to COVID-19, home gyms are on the rise - SW News Media

Review: Equinox Takes Luxe Fitness Into The Wild at Their First Outdoor Gym in LA – InsideHook

Posted: September 30, 2020 at 4:59 pm

Theres something calming about the Century City mall. Already a hot-spot for luxury-ticket items like Next Healths trendy Cryotherapy and Vitamin IVs, or, at the other end of the spectrum, Eatalys multi-story Italian decadence, the shopping center has recently become home to another one-of-a-kind offering: Equinoxs first ever completely outdoor fitness club. Officially opening its doors to the public in late September, the club was already bustling when I visited late last week.

Dubbed Equinox+ In The Wild, the 27,000-square-foot outdoor gym is equipped with the same level of hospitality and attention to detail that the indoor clubs offered in a pre-pandemic world, and it might be the solution for staying in shape and preserving community while indoor fitness remains risky. Between views of the L.A. skyline and the added bonus of working out in the sunshine, this new club is a win-win at least for Angelenos. An outdoor option is less tenable for cities like New York, Toronto or London, especially as winter approaches, but here in L.A., where indoor-outdoor living has always been part of the culture, embracing In The Wild is a no-brainer.

When people come up here to do their first workout, theyre like, Oh my God, this is awesome! laughed Jack Gannon, Equinoxs Senior Vice President for the West Coast. Theyre so excited to be outside with the views, and the air, and to just not be in their own apartment. This has been an adventure and we put this together in about three weeks so from an operations standpoint it was challenging. Weve even rearranged the club four or five times as we learned member behavior.

Working out in the open air.


Gannon is right: the new outdoor club is not only impressive, its completely unexpected. On the top floor of the malls parking structure, a back corner lot has been completely re-imagined from drab gray concrete into a sleek, turf-covered paradise, complete with a full selection of cardio machines, weights, dedicated class space and plenty of room for distanced free weights, TRX, yoga, stretching and more. For destination members who are already familiar with this Equinox location, the shift is fairly easy: simply head up two more floors from the regular third-floor entrance to the fifth floor, then turn left to find the new outdoor space.

Entering the terrace build-out feels like an event itself, with temporary silver rails and a logo-covered backdrop to direct visitors to the gyms check-in desk, where all guests have their temperature taken and sign a waiver indicating theyve had no known contact with anyone with symptoms of COVID-19. Masks are required to enter, but per Californias guidelines, as long as there are eight feet or more of distance, people can safely remove their masks while working out. To that end, all cardio machines are safely spaced eight feet apart to allow for non-masked use, and as long as social distance is in place, weight lifting and other strength-building workouts can also be performed without masks.

Visiting the gym on a particularly sunny day last week, I was pleasantly surprised by just how much space there was to workout freely. Soldiering my way through a 45-minute workout curated by Equinoxs Regional Personal Training Manager, Annie Blackford, I squatted, planked and lunged my way through multiple sets without anyone outside our group coming within 10 feet of us and the gym was plenty full when I was there, too. Even during my brief visit, I saw equipment being sanitized and wiped down all throughout the space, and since opening the space, Equinox has begun using medical-grade disinfectant on everything. As the Regional Director of Group Fitness for Equinox, Stephanie Vitorino is confident that bringing people together at the outdoor club is safe not only for guests taking classes, but also for herself and her coworkers in their workplace. And there is something special about coming back together after six months of isolation.

Weve worked with health experts and created a task force that implemented guidelines for cleaning, social-distancing and safety protocols as well as mandatory health screenings, Vitorino explained. Im extremely confident in how our brand is protecting the safety of our members and teams. And since Into The Wild is centrally located in the heart of Los Angeles, were seeing members come together from many different clubs. Reuniting with people they havent seen in months is bringing so much joy and a sense of belonging.

When I was visiting, even members who had clearly come to workout together were respectfully holding space from each other, and the overall setup of the gym made that easy. Divided into several different sections, there was no chance that a speed workout would run over into the cardio section, or that a midday class might crowd out strength training. And as much as there is room to be separate at the outdoor club, Gannon reiterates that the companys core focus on community remains the same.

We are definitely community-based, and the company has evolved so much around that over the last several years, Gannon said. Weve been open under a week here, and so much of the community hasnt seen each other in six months. Its so interesting to see people run into each other and watch this reunion take place and then two days later theyre showing up together. So that community is starting to build again as weve opened this opportunity. Especially in the times were in, people need that more than ever before.

All the space you might need for a great workout.


Joining Equinox can be a spendy endeavor, but like plenty of other brands, the company has shifted with the times to increase accessibility when it comes to budget. Currently, membership tiers all range in the $200-$300/month range, with single-club memberships in Los Angeles on average around $220, a regional Southern California option at $245, and global club access at $305 per month. Right now, the pricey $300 initiation fee has also been waived, and the month of October is free. That offer is good through September 30, so if an outdoor gym is calling your name for the fall, now is the time to act.

Like most gyms, all of the Equinox indoor club spaces have been closed since the Mayors office gave an order for shut down in early March. After six months, Gannon said a massive wave of the community has opted to try out the outdoor space and resume membership. The overwhelming positive response from our members that have come, visited, and rejoined has been incredible, he said. Its off the charts beyond our expectations both from a business and that were meeting our members needs. Were very proud of it, and were still learning, but were proud of the experience weve built.

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Review: Equinox Takes Luxe Fitness Into The Wild at Their First Outdoor Gym in LA - InsideHook

Colorados fitness industry starting to reawaken, but some studios will never reopen – Loveland Reporter-Herald

Posted: June 16, 2020 at 2:51 pm

Buying Barre Forte in LoHi was the realization of a dream years in the making for Sage Fennig. She had longed to own a business that empowers people and makes them feel good about themselves, but only 15 days after she took ownership in March, her dream took a nightmare turn when Colorados fitness industry was shut down due to the coronavirus.

I live right down the street, Fennig said. Ive lived in downtown Denver for the past 16 years, so I really know the area. I know the clientele really well. If I had a dream situation, this was it. Then COVID-19 happened.

Twelve weeks after being shut down, Fennig reopened this past Monday. According to state guidelines, she can only operate at 25% of capacity, which for her studio means five students with one instructor. For Monday evenings class, five came to the studio while eight more participated online.

In the studio, it felt like a reunion.

Its kind of like family to me, member Sherry Ewing said. Im just really excited to be back and see everyone. I think its a good step to start moving forward. Its all about the community, just being together, seeing each other, having those conversations. Its just wonderful.

Ewing felt relatively safe, too.

I feel more safe coming to the studio than I do grocery shopping, she said.

Gyms, fitness studios and rec centers across Colorado are beginning to reopen in limited fashion under strict guidelines, but many are not. Gyms and rec centers managed by the cities of Denver and Lakewood remain closed until further notice, while Englewoods two rec centers will reopen next week. In Arvada, the Apex Recreation District has begun staged reopenings of its facilities.

Denver recreation centers remain closed due to the public gathering limitations, physical distancing, and cleaning and disinfecting requirements, according to Cyndi Karvaski, a public information officer for Denver Parks and Recreation.

But the Englewood Rec Center will reopen on Monday, by reservation only, for hour-long workout blocks. Each block will be followed by 15 minutes of cleaning with spray sanitizers by workers, according to Englewood senior recreation supervisor Allison Boyd, and the facility will be closed from 1 to 4 p.m. for deeper cleaning. A similar plan will be followed at Englewoods Malley Rec Center, a facility for people 55 and over.

The new state guidelines allow gyms to operate at up to 25% capacity or 50 people, whichever is fewer. Complicating matters is that some counties have received variances with different sets of rules. In Lakewood, officials are still trying to determine whether they can open any rec centers before August.

The city is working to balance the ability to operate safely under the limitations, recall employees from furloughs to open the facilities, and pay the cost of operating the facilities with limited users at a time when the citys revenues have dropped significantly, said Stacie Oulton, a public information officer for the city of Lakewood.

Planet Fitness gyms inCastle Rock, Loveland, Parker and Greeley have reopened, and all but one Denver location will open next week. Fourteen metro-area 24 Hour Fitness gyms are scheduled to reopen June 22, according to the corporate website.

Kindness Yoga will begin a phased reopening on July 1 with only one location operating at first, the South Broadway studio. Members received an email this week from Kindness conceding that we face the reality that not all nine studios will be reopening, but founder Patrick Harrington said no decisions have been made on which ones will close permanently.

Evo Rock + Fitness in Louisville will reopen on Monday, June 15..G1 Climbing + Fitness, a new facility in Broomfield that had been open for a month when gyms were closed by the state, reopened June 4 the day the new state guidelines went into effect. Earth Treks climbing gyms will reopen June 22.

Some studios will never reopen, though, and their owners are devastated.

Before the pandemic, Andora Freedom owned three Samadhi Yoga locations that she said were thriving. But after 18 years in business, she is shutting the businesses down.

It was much more than a yoga center, Freedom said. It was a spiritual center. It was peoples church, it was peoples sacred space. If your life was falling apart, you could go, you could just cry. You would be held in the energy of the space. Those people now are giving me the hope that one day Im going to get a life back, because now my life is destroyed. Ive got nothing left, and I dont know how the hell Im going to get through this.

She says she has been through a hellish experience and blames government officials state and federal for lack of support.

Its deeply upsetting to me because I find that my greatest responsibility is creating a sense of community for people, and I find that to be vital for peoples thriving, Freedom said. Knowing that I can no longer be that for people, thats pretty devastating.

Another studio that will not come back is Flex Yoga + Barre. Co-owner Sarah Mellick said the financial numbers just really werent there to operate within the severely limited capacity restrictions mandated by the state.

It was not an easy decision, Mellick said. So much has been put into the space and the community, and theres a lot of emotion behind it. Its hard to go out on terms that werent necessarily yours. When we closed doors on March 16, never in a million years did I imagine that it would be for good. We all thought it was just going to be a few weeks and we would be back up and running.

Freedom said she would be surprised if any yoga studios make it through this transition, and long-term financial viability is still a worry for Fennig despite the excitement of reopening her Barre Forte location on Monday. She has spent $1,000 to enhance her online streaming equipment in hopes of generating more revenue.

Were not going to cut it moving forward if we have to maintain at 25% and are not able to make up some lost revenue through live streaming and on demand-services or outdoor classes, Fennig said. I dont know if were ever going to truly make it, and if I am going to be able to fully see out my dream, no matter how hard I work.

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Colorados fitness industry starting to reawaken, but some studios will never reopen - Loveland Reporter-Herald

In sickness and in health: North Spokane couple weds in front yard during pandemic – The Spokesman-Review

Posted: May 18, 2020 at 2:54 pm

Nothing was going to stop Tony and Nikki Barbee from getting married on Sunday not a worldwide pandemic and certainly not a little bit of rain.

The couple tied the knot Sunday afternoon in their front yard as friends and family watched from the sidewalk.

The couple met about 5 years ago when Tony started working at Costco in Kirkland and Nikki helped train him.

I started working there and she taught me how to do the book table at Costco, Tony said with a chuckle.

The pair had great banter and often quoted Monty Python and the Holy Grail to each other.

Nikki made the first move by buying a copy of the movie for Tony.

They quickly began falling for each other. In fact, their first dance was to the classic Tom Petty tune, Free Fallin.

Tony has three kids, Aadin, 15, Evelynne, 10 and Tony Jr., 9. Nikki has a 12-year-old son, Brayden Webster.

Nikki has swooped in and loved Tonys kids like theyre hers, and Tony does the same, said Dallas Hoy, a bridesmaid and sister-in-law, Dallas Hoy. Its just really sweet to watch.

Nikki said she knew Tony was the one their first Mothers Day as a couple. Despite their constant banter, Tony found a moment to be sincere.

The pair were joking around and Tony said, Yeah, its cause I love you, Nikki recounted.

It just made my heart melt obviously and I was like, this guy is a keeper, Nikki said.

Nikkis mother agreed.

Hes just always been really attentive, even with her son, said Nadine Webster. They feed on each others craziness. Its just fun.

A few years later, Tony couldnt stand being away from Spokane anymore and decided he needed to move back.

She stood by me through everything, ups, downs, moving, Tony said.

Last year, Tony planned a vacation to Mexico to propose.

I planned the whole trip just to ask her to marry me, Tony said.

Nikki had noticed Tony mentioning marriage a bit more in the months before the vacation and had an inkling a proposal was coming, but wasnt quite sure when.

But when Tony got down on one knee on the beach, Nikki was overjoyed.

The couple came back to Spokane and started planning their wedding.

We had everything already paid for and paid off, Tony said. We were going to have Veraci Pizza cater and we had a spot on the South Hill.

They planned on having about 160 people attend, but at the beginning of April it was obvious they would have to cancel the gathering. The couple decided the nuptials just couldnt be postponed.

Nothing was going to stop her from being my wife today, Tony said. Thats what we had planned and I wasnt going to wait any longer than that.

So, they decided on a front yard wedding at their North Spokane home.

Nikki wore a strapless white dress with red pumps and a red ribbon at the end of her braided hair. The dress was a steal for $50 at Goodwill.

I hope the rain goes away, Nikki said while she was getting dressed. I dont want to get my dress wet.

It rained all afternoon, but moments before the ceremony began at 5 p.m. the clouds cleared.

Tony stood nervously waiting under a canopy.

Honestly, I couldt wait, Nikki said. Just looking and seeing his face was probably the best moment of it right there.

Tony described the moment as just happy, just all happy.

The ceremony was short, but sentimental, with a few jokes and lots of laughs.

Moments after Kenny Carlson, the pastor, pronounced them husband and wife, the couples 3-year-old nephew Presley screamed, They did it! eliciting cheers from the family.

Its better than we could have ever thought, Tony said.

That statement sums up not only the wedding day but the couples relationship, according to Tonys brother Matt.

From the first time Tony ever mentioned her he has never talked about any girl like that, Matt said.The first time I ever met her, I finally felt like I had a sister.

Matts wife, Hoy, agreed.

When I first met Nikki it just made sense, Hoy said. She and him, theyre both complete absolute weirdos, which is why theyre perfect together.

Tonys parents, Kim and Jeri Barbee, couldnt agree more.

We call her the Energizer bunny, Kim said.

Shes just a light, a positive light, Jeri added.

Despite all that energy and positivity, it has been a tough season for the couple, who were set to open their business, Vintage Slice Pizza Co., before the pandemic put things on hold.

The couple both worked for the food truck when they lived in Western Washington, and told the former owner if he ever wanted to sell the 1953 blue GMC pickup with a wood fire pizza oven in the back, that they would buy it.

We fell in love with making pizzas, and each other, Tony said.

Now, the pair has to wait until Washington reopens to get the rest of their permits.

Even with the setbacks and change of plans, the couple is excited for married life.

Weve lived together for four years and are raising our kids together, and I mean its just another day but were married now, Nikki said.

The couple danced to Tom Petty in the middle of the street as friends and family tearfully looked on.

Some even drove across the state to be there.

The fact that they were here made me realize how special and loved both of us are, Nikki said.

While their wedding wasnt quite what they expected, it was not only a celebration of love but indicative of the positive and resilient people the Barbees are.

This wedding is such a good representation of them as a couple, Hoy said. The two of them together will take any poor, negative situation and make the best out of it.

Originally posted here:
In sickness and in health: North Spokane couple weds in front yard during pandemic - The Spokesman-Review

Furry Friends Provide Big Benefits

Posted: June 20, 2018 at 4:48 pm

Photo credit: Pixabay

The first feelings of puppy love are probably distant memories for many older adults, but that doesn’t mean they can’t experience those same sentiments -- although the expression may be more literal than figurative this time around if their object of affection actually happens to be a furry friend.

And, if they consider animals an important part of their lives, they are far from alone. Indeed, 84.6 American households, or 68 percent, included a pet according to the 2017-2018 American Pet Products Association National Pet Owners Survey, up from 56 percent in 1998 in the poll’s first year.

Given the mental and physical perks pets offer, it’s no surprise those numbers are on the rise. Owning a pet can help your heart health, and not just because some pet owners are more physically active. In fact, simply sitting quietly and stroking a pet lowers people’s blood pressure and pulse rate. Along those same lines, interacting with animals can also reduce stress and anxiety levels.

Walking the Dog

And the benefits increase when your factor movement into the mix. A small study that focused on adults age 65 and older found dog owners walked about 23 minutes longer each day than non-dog owners and took an additional 2,760 steps. Dog owners also had eight fewer continuous periods of sitting down, according to the research cited in a story from Health magazine.

And other research shows the extra activity can translate directly into better health. According to a study cited by U.S. News & World Report, seniors who owned dogs and took them on regular walks were found to have lower body mass indexes, fewer visits to the doctor, and spent less time sedentary than those who did not have a dog or those who had dogs, but did not walk them.

But owning a dog doesn’t always equate to higher activity levels. If you are considering a canine companion, it’s important to find one that’s well-suited to your habits and abilities. For instance, if you really want an exercise partner, you should find a dog who enjoys walks and isn’t too large for you to manage safely.

Part-Time Pet Care

Also, keep in mind that you don’t have to be a dog owner to find a furry workout buddy. For instance, you can sign up as a service provider for a pet sitting and dog walking service. Joining such a network will not only encourage you to get some exercise outdoors, it will give you your dose of dog cuddles without the responsibilities and costs that can come with full-time pet ownership, which can be especially appealing if you like to travel or live in a space that doesn’t allow dogs. Pet sitting and dog walking can also be a great way to expand your social circle to include other animal lovers in your area.

In addition, animals themselves can play an important role in social support systems. In fact, studies have shown pet owners tend to have higher self-esteem and more extroverted than non-owners. And you don’t have to share a home with a pet to reap some of the same benefits. Animals are increasingly being used in a variety of settings, including hospitals and schools to help humans heal faster, adopt healthy habits, or overcome anxieties.

While you may not need formal animal therapy, working as a dog walker and pet sitter may provide many of the same benefits. You’ll be forced to become more of an entrepreneurial extrovert because you’ll be introduced to new people and challenges -- such as setting your own rates and schedule. And you’ll be getting more exercise all while earning extra money and enjoying the physical and mental benefits that come with animal interaction.

So, whether you own and care for your own pet or spend time doting over other people’s dogs, you can be sure your labor of love won’t go unrewarded.

CT Nutrition Consultants – Registered Dietitian

Posted: July 12, 2017 at 7:45 pm

CT Nutrition Consultants are a group of registered dietitians dedicated to helping you improve your health and prevent or reverse disease through nutrition. Our goal is to educate and empower people to move toward better food choices. Our services are geared towards YOU! Our counseling is specific to meet your individual needs.

CT Nutrition Consultants is owned and operated by Mary Ellen Campbell, M.S., R.D., CD-N who has been a registered dietitian for twenty years plus. She has spent many years as a clinical dietitian in hospitals and has counseled patients with coronary artery disease, diabetes, high blood pressure, obesity celiac disease, irritable bowel and bariatric surgery.

Nutrition Services

You realize the importance of making informed food choices and developing sound eating and fitness habits. Registered dietitian nutritionists . . . are the food and nutrition experts. We are here to help you find accurate information to support your healthy lifestyle.

What is a Registered Dietitian?

Registered dietitians, or RDs, are the food and nutrition experts, translating the science of nutrition into practical solutions for healthy living. When you need food and nutrition information based on fact or need to know how a healthy diet improves health and fights disease a registered dietitian can provide you with sound, easy-to-follow nutrition advice. In addition to holding a bachelor's degree, a RD must fulfill a specially designed, accredited nutrition curriculum, pass a rigorous registration exam; and complete 1200 hours of supervised practice through an accredited program.

Registered dietitians play a vital role in the management of your health. As nutrition experts, dietitians must remain abreast of the current literature to provide accurate, medically appropriate information.

Original post:
CT Nutrition Consultants - Registered Dietitian

Channel Update – Fitness & Football Videos Only! – Video

Posted: August 10, 2014 at 9:44 pm

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Measuring the Impact of Cytomegalovirus in Younger People

Posted: September 1, 2013 at 2:49 am

Cytomegalovirus (CMV) is one of the less immediately harmful members of the family of herpesviruses. It is very prevalent: most people have it in their system by the time they are old, but probably never even noticed, as the symptoms for a healthy individual are essentially nonexistent. Nonetheless like all herpesviruses CMV is very successful at remaining within the body after initial exposure, establishing a life-long infection despite the best efforts of the immune system to get rid of it. The recurring campaigns waged against CMV by your immune cells appear to have a long-term cost: we have evolved to support a given number of immune cells as adults, and as ever more of those immune cells become specialized to a specific pathogen, such as CMV, there is ever less space left in the inventory for cells that can tackle new threats or keep up with all the other jobs of the immune system, such as destroying precancerous and senescent cells.

If you eye the publications of an open access journal like Immunity and Ageing, you'll see a steady flow of papers looking at the role of CMV in age-related immune system decline, a fair-sized component of the frailty of old age. There are a range of possible approaches to this problem, but the most direct and potentially effective don't actually involve doing anything about CMV itself. Instead there are proposals to either add large numbers of new, fresh, and capable immune cells to the body or eliminate the CMV-specialized cells to free up space. Both of these approaches are quite near-term: only a a couple of years would be needed to develop a viable prototype therapy from where we are now, were a research group fully funded and tasked with the effort. Both the ability to culture immune cells and the ability to destroy specific cells in the body based on their surface markers are progressing rapidly.

Some research groups are working on a vaccine for CMV - but a successful vaccine won't do much good for those high percentage of adults in much of the world who have been infected for a long time. Their immune systems are already badly misconfigured as a result of the extended exposure. So tackling CMV isn't a good enough approach on its own, as it only stops the very slow pace of ongoing harm.

Here is a paper to suggest that the progressive disarray in the immune system caused by CMV starts early, even while young.

Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults

Ageing is associated with a decline in immune competence termed immunosenescence. In the elderly, this process results in an accumulation of differentiated 'effector' phenotype memory T cells, predominantly driven by Cytomegalovirus (CMV) infection.

Here, we asked whether CMV also drives immunity towards a senescent profile in healthy young adults. One hundred and fifty-eight individuals (age 21?±?3 years, body mass index 22.7?±?2.7) were assessed for CMV serostatus, the numbers/proportions of CD4+ and CD8+ late differentiated/effector memory cells, plasma interleukin-6 (IL-6) and antibody responses to an in vivo antigen challenge (half-dose influenza vaccine). Thirty percent (48/158) of participants were CMV+.

A higher lymphocyte and CD8+ count and a lower CD4/CD8 ratio were observed in CMV+ people. Eight percent (4/58) of CMV+ individuals exhibited a CD4/CD8 ratio of less than 1.0, whereas no CMV- donor showed an inverted ratio. The numbers of late differentiated/effector memory cells were?~fourfold higher in CMV+ people. Plasma IL-6 was higher in CMV+ donors and showed a positive association with the numbers of CD8+CD28- cells. Finally, there was a significant negative correlation between [vaccine response and the levels of CMV particles present]. This reduced vaccination response was associated with greater numbers of total late differentiated/effector memory cells.

This study observed marked changes in the immune profile of young adults infected with CMV, suggesting that this virus may underlie rudimentary aspects of immunosenescence even in a chronologically young population.


Decreased mTOR Expression Provides 20% Mean Life Span Extension in Mice

Posted: at 2:49 am

Mammalian (or mechanistic, depending on who you ask) target of rapamycin (mTOR) is the most likely candidate for the next round of billion-dollar research funding devoted to the search for drugs that can slow aging. It will be a repeat of the overhyped and ultimately largely futile interest in sirtuin research, which generated knowledge but nothing of real practical application, except that this time there is far more compelling evidence that manipulation of mTOR actually extends life in laboratory animals. Though as always, there are those who believe that this is not in fact the case - that mTOR alteration only reduces cancer risk, rather than impacting the processes of aging per se. Just as resveratrol and resveratrol-derivatives are the compounds of choice for those investigating sirtuin biology, so rapamycin and rapamycin-derivatives are the compounds of choice for research groups focused on manipulating mTOR and its related signaling networks. I would imagine that we're in for another decade or so of overhyped claims and public and research community interest in what is in fact an inefficient, expensive, and time-consuming path towards only slightly extending healthy life.

Drugs to slow aging through alterations to metabolism are not the path to radical life extension. Slowing aging does nothing for people already old. The research community should focus instead on rejuvenation through therapies that repair and remove the cellular damage that causes aging, an approach that can actually meaningfully help the aged when realized. For all that rejuvenation is the obviously superior research strategy, however, it's taking time to convince the world of that truth. Time spent on trying to slow aging is little different in outcome to time spent investigating the details of aging but choosing to do nothing about it: a few years here and there, and nothing that is as effective as simple exercise and calorie restriction. There's no such thing as useless knowledge in the long term, but we already know enough to work effectively on human rejuvenation.

The new study quoted below will no doubt bolster the prospects of those groups presently raising funds for attempts to slow aging or further develop drug candidates derived from rapamycin. While looking at the results, however, you might compare them with plain old calorie restriction in mice, something that can produce twice the extension of healthy life shown here.

Mutant Mice Live Longer

MTOR is a kinase involved in myriad cellular processes, from autophagy to protein synthesis. Genetic studies of TOR in other organisms, such as yeast and flies, have implicated a role for the enzyme in lifespan. In mammals, however, mTOR is required for survival, making a knockout mouse model unfeasible. So the National Heart, Lung and Blood Institute's Toren Finkel and his colleagues decided to use a mouse in which transcription was only partially disrupted, reducing the levels of mTOR to about 25 percent of the normal amount.

All else being equal, the researchers found that normal mice typically lived 26 months, while those with less mTOR survived around 30 months. Finkel said the increase in lifespan was greater than other researchers have seen using the immunosuppressant rapamycin to inhibit mTOR. It's possible that having mTOR reduced beginning in the womb, rather than at middle age, could explain the disparity. Additionally, this new mutant affected the levels of both forms of mTOR - mTORC1 and mTORC2 complexes - rather than preferentially impacting one, as rapamycin would.

The paper on this research is open access, so head on over and take a look. I think you'll find it interesting. In particular note the author's cautions regarding the size of the life extension effect and the life span of the control mice in the discussion section: the number of mice used isn't large, and it's possible that the controls were just randomly a slightly short-lived group.

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

We analyzed aging parameters using a mechanistic target of rapamycin (mTOR) hypomorphic mouse model. Mice with two hypomorphic (mTOR?/?) alleles are viable but express mTOR at approximately 25% of wild-type levels. These animals demonstrate reduced mTORC1 and mTORC2 activity and exhibit an approximately 20% increase in median survival. While mTOR?/? mice are smaller than wild-type mice, these animals do not demonstrate any alterations in normalized food intake, glucose homeostasis, or metabolic rate. Consistent with their increased lifespan, mTOR?/? mice exhibited a reduction in a number of aging tissue biomarkers. Functional assessment suggested that, as mTOR?/? mice age, they exhibit a marked functional preservation in many, but not all, organ systems. Thus, in a mammalian model, while reducing mTOR expression markedly increases overall lifespan, it affects the age-dependent decline in tissue and organ function in a segmental fashion.


A Collagen Patch to Spur Heart Tissue Repair

Posted: at 2:49 am

Building patches for damaged hearts is a popular implementation in tissue engineering at the moment: it's an achievable stepping stone on the way to more complex goals, such as the creation of entire organs starting from only a patient's stem cells, something that still lies in the future. Progress towards a long-term goal in any field requires useful intermediary products, as they help pull in the greater support and funding needed for the next phase of research and development.

When heart cells die from lack of blood flow during a heart attack, replacing those dead cells is vital to the heart muscle's recovery. But muscle tissue in the adult human heart has a limited capacity to heal, which has spurred researchers to try to give the healing process a boost. Various methods of transplanting healthy cells into a damaged heart have been tried, but have yet to yield consistent success in promoting healing.

Now, [researchers] have developed a patch composed of structurally modified collagen that can be grafted onto damaged heart tissue. Their studies in mice have demonstrated that the patch not only speeds generation of new cells and blood vessels in the damaged area, it also limits the degree of tissue damage resulting from the original trauma. The key [is] that the patch doesn't seek to replace the dead heart-muscle cells. Instead, it replaces the epicardium, the outer layer of heart tissue, which is not muscle tissue, but which protects and supports the heart muscle, or myocardium.

The epicardium - or its artificial replacement - has to allow the cell migration and proliferation needed to rebuild damaged tissue, as well as be sufficiently permeable to allow nutrients and cellular waste to pass through the network of blood vessels that weaves through it. The mesh-like structure of collagen fibers in the patch has those attributes, serving to support and guide new growth. Because the patch is made of acellular collagen, meaning it contains no cells, recipient animals do not need to be immunosuppressed to avoid rejection. With time, the collagen gets absorbed into the organ.

Link: http://www.eurekalert.org/pub_releases/2013-08/sumc-scp082613.php


Statin Use Correlates With Higher Telomerase Activity

Posted: at 2:49 am

There has been interest in extending increasing telomerase expression as a means to slow aging for some years. The available tools other than gene therapy are sparse on the ground, however. Telomerase extends telomere length, the caps of repeating DNA sequences at the ends of chromosomes that shorten with each cell division. Telomerase may have other roles that more directly impact aging, however, such as an influence on mitochondrial function.

Shorter telomeres in at least some tissues correlate with stress and ill health and aging, but this is a very dynamic system - average telomere length can change in either direction on a short time scale. It is far from clear that progressively shorter telomere length is a cause of aging rather than just a reflection of other changes and damage, and the same goes for natural variations in levels of telomerase in the body. While increasing expression of telomerase is shown to extend life in mice, that may or may not have anything to do with telomere length, and mouse telomerase biology is quite different from that of humans.

So all this said, it was only a matter of time before researchers evaluated all the existing approved drugs for treatment of age-related conditions to see if any of them altered telomerase activity. There are regulatory incentives to beware of here, however, in that it is much cheaper for research institutions to try to find marginal new uses of already approved drugs than to work on new and radically better medical technologies that would then have to go through the exceedingly and unnecessarily expensive approval process. So don't expect anything of great practical use to result from this:

Not only do statins extend lives by lowering cholesterol levels and reducing the risks of cardiovascular disease, but new research [suggests] that they may extend lifespans as well. Specifically, statins may reduce the rate at which telomeres shorten, a key factor in the natural aging process. This opens the door for using statins, or derivatives of statins, as an anti-aging therapy. "By telomerase activation, statins may represent a new molecular switch able to slow down senescent cells in our tissues and be able to lead healthy lifespan extension."

To make this discovery, Paolisso and colleagues worked with two groups of subjects. The first group was under chronic statin therapy, and the second group (control), did not use statins. When researchers measured telomerase activity in both groups, those undergoing statin treatment had higher telomerase activity in their white blood cells, which was associated with lower telomeres shortening along with aging as compared to the control group. This strongly highlights the role of telomerase activation in preventing the excessive accumulation of short telomeres.

"The great thing about statins is that they reduce risks for cardiovascular disease significantly and are generally safe for most people. The bad thing is that statins do have side effects, like muscle injury. But if it is confirmed that statins might actually slow aging itself - and not just the symptoms of aging - then statins are much more powerful drugs than we ever thought."

Link: http://www.eurekalert.org/pub_releases/2013-08/foas-sms082913.php


Children of Long-Lived Parents Have Better Immune Systems

Posted: at 2:49 am

The immune system declines greatly with aging, and poor immune response is an important component of age-related frailty: old people become vulnerable to infections that the young can shrug off with ease. So we might expect to see that long-lived people have better immune systems, and that whatever underlying mechanisms cause that difference are to some degree inherited.

People may reach the upper limits of the human life span at least partly because they have maintained more appropriate immune function, avoiding changes to immunity termed "immunosenescence." Exceptionally long-lived people may be enriched for genes that contribute to their longevity, some of which may bear on immune function. Centenarian offspring would be expected to inherit some of these, which might be reflected in their resistance to immunosenescence, and contribute to their potential longevity. We have tested this hypothesis by comparing centenarian offspring with age-matched controls. We report differences in the numbers and proportions of both CD4+ and CD8+ early- and late-differentiated T cells, as well as potentially senescent CD8+ T cells, suggesting that the adaptive T-cell arm of the immune system is more "youthful" in centenarian offspring than controls. This might reflect a superior ability to mount effective responses against newly encountered antigens and thus contribute to better protection against infection and to greater longevity.

The goal of future medicine is to make inherited differences of this nature irrelevant. There are a number of promising approaches that may remove much of the age-related decline of immune function: regrow the atrophied thymus, where immune cells are cultured; create new immune cells in the clinic and infuse them regularly into older people; destroy the population of over-specialized memory cells that exist in the elderly, thus freeing up space for effective immune cells that can combat new threats.

Link: http://www.ncbi.nlm.nih.gov/pubmed/23974207


A Two-Part Report on Global Futures 2045

Posted: August 25, 2013 at 2:53 am

The 2045 Initiative is a fairly young but comparatively well-backed effort to generate more support for and technological progress towards non-biological means of human life extension: artificial bodies, and ultimately artificial brains, built to be far more resilient and maintainable than our present evolved equipment. There is some debate over whether this is an efficient course in comparison to medical research, but that end of the futurist community already primarily interested in strong artificial intelligence seem to like where this is going.

There is a lot of fascinating groundwork in reverse-engineering the human brain presently under way, and it's clear that neuroscience is going to become an interesting place to be over the next few decades. However, I remain unconvinced that any of this is going to help us get over the initial hurdles to extending human longevity, meaning the frailty and short life span of the human body and physical structures that support the mind, soon enough to matter. Artificial intelligence and human minds running on machinery will certainly come to pass, and I will be surprised if the latter fails to happen in the laboratory prior to 2050 given the pace at which available processing power is growing. However, and this is important, over that time scale most of us doing the writing and the reading here and now are dead without some means of medical treatment for aging. This is one of the reasons why I pay less attention to neuroscience and mind-machine interface development than I do to repair biotechnologies for the causes of aging.

The Global Futures 2045 conference series is a part of the 2045 Initiative advocacy, and the most recent event took place a couple of months ago. I noted some of the media reports at the time. A two part report published earlier this month is quoted below and focuses more on the presentations than did past articles in the popular press, which I think is a good thing.

The world according to Itskov: Futurists convene at GF2045 (Part 1)

The development of brain-computer interfaces (BCIs) to allow paralyzed individuals to control various external prosthetic devices, such as a remote robotic arm, was another key topic at GF2045. A very recent example of the BCI research Carmena and Maharbiz discussed is Neural Dust: An Ultrasonic, Low Power Solution for Chronic Brain-Machine Interfaces. The theoretical pre-print paper proposes neural dust - thousands of ultra-miniaturized, free-floating, independent sensor nodes that detect and report local extracellular electrophysiological data - with neural dust power and communication links established through a subcranial interrogator. With the purpose being to enable "massive scaling in the number of neural recordings from the brain while providing a path towards truly chronic BMI," the researchers' goal is "an implantable neural interface system that remains viable for a lifetime."

In Making Minds Morally: the Research Ethics of Brain Emulation, Dr. Anders Sandberg - a Computational Neuroscientist, and James Martin Research Fellow at the Future of Humanity Institute at Oxford University, and Research Associate at the Oxford Neuroethics Center - addressed the social and ethical impact of cognitive enhancement and whole brain emulation. "We want to get to the future," Sandberg said in his talk, "but that implies that the future had better be a good place. Otherwise, there wouldn't be a point in getting there - but that would mean in turn that the methods we're going to use to get to the future had better be good as well."

The world according to Itskov: Futurists convene at GF2045 (Part 2)

Dr. Theodore Berger gave the most groundbreaking presentation of the Congress - one that also received a standing ovation. In Engineering Memories: A Cognitive Neural Prosthesis for Restoring and Enhancing Memory Function, Berger discussed his extraordinary research in the development of biomimetic models of hippocampus to serve as neural prostheses for restoring and enhancing memory and other cognitive functions. Berger and his colleagues have successfully replaced the hippocampus - a component of the cortex found in humans and other vertebrates that transforms short-term memory into long-term memory - with a biomimetic VLSI (Very Large-Scale Integrated circuit) device programmed with the mathematical transformations performed by the biological hippocampus.

Dr. Randal Koene, neuroscientist, neuroengineer and science director of the 2045 Initiative, has been focusing on the functional reconstruction of neural tissue since 1994. In his Whole Brain Emulation: Reverse Engineering A Mind presentation and soon-to-be published book with the same title, Koene describes the process of progressing from our current condition to a possible substrate-independent mind achieved by whole brain emulation and cites a wide range of research, including the work of fellow GF2045 presenters.


The Next Few Years of Research Into Alzheimer’s Disease

Posted: at 2:53 am

A conservative view of what lies ahead for Alzheimer's disease (AD) research sees incremental progress resulting from new and better investigative biotechnologies:

In the recently published work "The Biology of Alzheimer Disease" (2012), most of what is known about AD today is described in detail. The book culminates in a chapter called Alzheimer Disease in 2020, where the editors extol "the remarkable advances in unraveling the biological underpinnings of Alzheimer disease...during the last 25 years," and yet also recognize that "we have made only the smallest of dents in the development of truly disease modifying treatments." So what can we reasonably expect over the course of the next 7 years or so? Will we bang our heads against the wall of discovery, or will there be enormous breakthroughs in identification and treatment of AD?

Though a definitive diagnosis of AD is only possible upon postmortem histopathological examination of the brain, a thorough review of the book leads me to believe that the greatest progress currently being made is in developing assays to diagnose AD at earlier stages. It is now known that neuropathological changes associated with AD may begin decades before symptoms manifest. This, coupled with the uncertainty inherent in a clinical diagnosis of AD, has driven a search for diagnostic markers. Two particular approaches have shown the most promise: brain imaging and the identification of fluid biomarkers of AD.

The authors anticipate that advances in whole-genome and exome sequencing will lead to a better understanding of all of the genes that contribute to overall genetic risk of AD. Additionally, improved ability to sense and detect the proteins that aggregate in AD and to distinguish these different assembly forms and to correlate the various conformations with cellular, synaptic, and brain network dysfunction should be forthcoming in the next few years. Lastly, we will continue to improve our understanding of the cell biology of neurodegeneration as well as cell-cell interactions and inflammation, providing new insights into what is important and what is not in AD pathogenesis and how it differs across individuals, which will lead, in turn, to improved clinical trials and treatment strategies.

Link: http://www.alcor.org/magazine/2013/08/21/alzheimer-disease-in-2020/


A Look Back at Some of the Roots of Modern Thought on Radical Life Extension

Posted: at 2:53 am

The modern movements of transhumanism and support for longevity science have deep roots: you can find early expressions of the ideas of human enhancement and overcoming natural limits on our biology in a range of writings from past centuries. These ideas became more commonplace and more complex over time as the prospects for technology caught up with our desires:

Immanuel Kant (1724-1804) was an 18th century philosopher, one of the earliest philosophers belonging to the enlightenment tradition, and often considered the father of German Idealism. Kant is remembered today more for his moral philosophy than his contributions to metaphysics and epistemology (Rohlf 2010). His contributions to the field of life-extension, however, remain almost completely unexplored, despite the fact that certain claims made in his Theory of Ethics arguably qualify him as a historical antecedent of the contemporary social movement and academic discipline of life-extension.

Marquis du Condorcet (1743-1794), another historical antecedent the modern longevity movement, appears to have originated the "idea of progress" in the context of the enlightenment, which became an ideological cornerstone of the enlightenment tradition. In Sketch for a Historical Picture of the Progress of the Human Mind, Condorcet not only conceives of the idea of progress in perhaps the first form it would take within the enlightenment tradition, but also explicates its link to indefinite life-extension, which was not an existing movement or academic discipline at the time of his writing:

"Would it be absurd now to suppose that the improvement of the human race should be regarded as capable of unlimited progress? That a time will come when death would result only from extraordinary accidents or the more and more gradual wearing out of vitality, and that, finally, the duration of the average interval between birth and wearing out has itself no specific limit whatsoever? No doubt man will not become immortal, but cannot the span constantly increase between the moment he begins to live and the time when naturally, without illness or accident, he finds life a burden?"

It is this very notion of infinite progress towards endlessly-perfectible states, carried forward after Condorcet by Kant and other members of the enlightenment tradition, that also underlies Kant's own ties to the contemporary field of life-extension. Kant's claim, made in his Theory of Ethics, that to retain morality we must have comprehensively unending lives - that is, we must never, ever die - I will argue qualifies him as a historical antecedent of the contemporary life-extension movement.

Link: http://hplusmagazine.com/2013/08/21/immanuel-kant-morality-necessitates-immortality/


Damaging the Biology of Mice to Make them Age More Rapidly Often Tells Us Little of Use

Posted: at 2:53 am

Aging is damage: it is the accumulation of broken and obstructed protein machinery and nanoscale structures inside and around our cells. Living beings come with many varied repair systems, so the processes by which damage grows and eventually overwhelms those repair systems is far from straightforward. In that sense aging isn't like the wearing of stone by the weather, or the failure of a non-repairing mechanical system like a car - but it's still all about damage. At the highest level the same mathematical models of damage and component loss that work just fine as aids to understanding failure in complex non-repairing systems like electronics also work just fine for aging.

Every so often a research group feels the need to publicize work in which they damage mice or other laboratory species in ways that cause them to live shorter lives. There are many very subtle ways to alter genes, such as those involved in DNA repair, that produce what is arguably accelerated aging. (Though not everyone thinks that these forms of life span reduction are in fact accelerated aging, but that's a debate for another time and place). The point here is that I think you have to beware of taking it at face value that these research results are relevant to normal aging, or relevant to extending healthy life. You can damage mice with a hammer if you so choose, and it will certainly shorten their life spans, but examining the results won't tell you anything about aging. Similarly, it's the case that near all of the possible ways of interfering in mouse biology via genes and metabolic operation in order to reduce life span are just as irrelevant.

Here is an example of this sort of thing: researchers are producing mice with additional damage in their mitochondria, a component of cellular biology known to be important in all sorts of metabolic processes, and considered to be important in aging, and showing that these mice don't live as long. I don't think that the authors can show that they've proved much of relevance to aging with this study as constructed, however, for the reasons noted above.

Mutations of mitochondrial DNA can hasten offspring's ageing process

In ageing research, mitochondria have been scrutinized by researchers for a long time already. The mitochondria in a cell contain thousand of copies of a circular DNA genome. These encode, for instance, proteins that are important for the enzymes of the respiratory chain. Whereas the DNA within the nucleus comes from both parents, the mitochondrial DNA (mtDNA) only includes maternal genes, as mitochondria are transmitted to offspring via the oocyte and not via sperm cells. As the numerous DNA molecules within a cell's mitochondria mutate independently from each other, normal and damaged mtDNA molecules are passed to the next generation.

To examine which effects mtDNA damage exerts on offspring, researchers used a mouse model. Mice that inherited mutations of mtDNA from their mother not only died quicker compared to those without inherited defects, but also showed premature ageing effects like reduced body mass or a decrease in male's fertility. Moreover, these rodents were prone to heart muscle disease.

As the researchers discovered, mutations of mtDNA not only can accelerate ageing but also impair development: In mice that, in addition to their inherited defects, accumulated mutations of mtDNA during their lifetime, researchers found disturbances of brain development. They conclude that defects of mtDNA that are inherited and those that are acquired later in life add up and finally reach a critical number.

To show relevance, you really need to demonstrate life extension - meaning repair mechanisms for mitochondrial DNA rather than damage mechanisms should be the focus. To shorten life spans through various forms of damage is unlikely to provide anything more than hints and inference when it comes to ways to extend life.


Calorie Restriction as a Means to Augment Cancer Therapies

Posted: at 2:53 am

Long term calorie restriction lowers the risk of cancer in addition to extending life in laboratory animals. Here researchers show that short term calorie restriction appears to augment the effectiveness of treatments for an existing cancer:

While previous studies suggest a connection between caloric intake and the development of cancer, scientific evidence about the effect of caloric intake on the efficacy of cancer treatment has been rather limited to date. When humans and animals consume calories, the body metabolizes food to produce energy and assist in the building of proteins. When fewer calories are consumed, the amount of nutrients available to the body's cells is reduced, slowing the metabolic process and limiting the function of some proteins. These characteristics of calorie restriction have led researchers to hypothesize that reducing caloric intake could potentially help inhibit the overexpression of the protein Mcl-1, an alteration associated with several cancers.

Researchers conducted a series of experiments in mice developing lymphoma resembling Burkitt's lymphoma and diffuse large B-cell lymphoma, two human cancers of the white blood cells. The team began by separating the mice into two categories: those who would receive a regular diet and those who would receive a reduced-calorie diet (75 percent of normal intake) for the duration of the experiment. After the mice consumed either a regular or a reduced-calorie diet for one week, researchers then further divided the mice into four groups according to the treatment they would receive for the following 10 days. Of the two groups of mice that received a normal diet, one (the control group) did not receive treatment and the other received treatment with an experimental targeted therapy, ABT-737, designed to induce cancer cell death. Of the two groups of mice who received a reduced-calorie diet, one did not receive treatment and the other received ABT-737. On day 17 of the experiment, both treatment and calorie restriction ended, and mice had access to as much food as they desired.

Investigators observed that neither treatment with ABT-737 nor calorie restriction alone increased the survival of mice over that of the other mice; however, the combination of ABT-737 and calorie restriction did. Median survival was 30 days in the control group that received a regular diet and no treatment, 33 days in mice that received a regular diet and treatment with ABT-737, 30 days in mice that received a reduced-calorie diet without treatment, and 41 days in mice that received a reduced-calorie diet and treatment with ABT-737. Shortly after this experimental period, investigators also observed that the combination of calorie restriction and ABT-737 reduced the number of circulating lymphoma cells in the mice, suggesting that the combination sensitized the lymphoma cells to treatment.

Link: http://hematology.org/News/2013/10958.aspx


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