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22 Purported Resveratrol Benefits – SelfHacked

Posted: April 16, 2021 at 1:52 am


Resveratrol, a polyphenol abundant in red wine, has some antioxidant and heart-protective properties. However, its bioavailability is poor and most of its purported benefits have not been confirmed in humans. Read this science-based review to learn more.

Resveratrol is a small polyphenol that came to scientific attention during the 1990s. Since then, it has been hyped by supplement manufacturers and news outlets alike.

Resveratrol is high in grape skin, as grapes produce resveratrol in defense against toxins and parasites. It is also found in various berries, peanuts, soy, and Itadori tea made from Japanese Knotweed [1].

Limited studies have explored its antioxidant, anti-inflammatory, anti-aging, and phytoestrogen activity. Resveratrol does hold some potential for improving chronic diseases. Researchers are also exploring its ability to mimic the effects of caloric restriction in animals, which might affect lifespan [2, 3].

According to some clinical trials, resveratrol nose sprays may improve symptoms of hay fever or allergic rhinitis. Scientists came up with nose sprays as a great way to bypass resveratrols poor bioavailability and get it straight to localized, problematic body areas.

In one study of 100 people, an intranasal spray containing resveratrol 0.1% reduced nasal symptoms and improved quality of life in adults with hay fever used three times daily for 4 weeks [4].

In another trial of 68 children with pollen-induced hay fever, an intranasal spray with resveratrol 0.05% and one other ingredient (beta-glucan 0.33%) improved itching, sneezing, runny nose, and nasal blockage. It was given three times daily for 2 months [5].

Limited evidence suggests that red wine, in moderation, supports heart health.

On the other hand, resveratrol supplements probably dont aid in heart disease prevention.

Therefore, scientists think that other compounds in red wine may be more important, while resveratrol may or may not contribute to this effect.

Additional, large-scale studies are needed to determine the specific effects of different components in red wine, especially in people with blood pressure and heart problems.

In 67 men at high heart disease risk, alcohol-free red wine reduced blood pressure (both diastolic and systolic) after 4 weeks. It increased nitric oxide, which relaxes blood vessels. Regular red wine (9 oz glass/day) also slightly reduced blood pressure and increased nitric oxide, but less so than dealcoholized wine. A control group that only drank gin didnt see any benefits [6].

One analysis of 19 studies concluded that drinking 1 2 glasses of wine daily (150 300 ml) reduces heart disease risk [7].

Interestingly, based on the first study, the alcohol in red wine may actually reduce the beneficial effect of resveratrol and other polyphenols. This especially holds true for people who already have high blood pressure or those at high risk.

In healthy people, though, moderate intake of red wine may indeed improve heart health.

In a study of 80 healthy, young people, a smaller amount of red wine (100 ml/day) over 3 weeks boosted blood vessel health, nitric oxide, and the number of cells that regenerate blood vessels (endothelial progenitor cells). Drinking water, beer, or vodka didnt achieve these effects [8].

In cells, resveratrol increased the enzyme that makes nitric oxide (NO synthase) [9].

According to animal and cellular studies, resveratrol also reduces the formation of plaques in arteries, known as atherosclerosis. It also reduces the clumping of platelets, reduces blood lipids, and lowers inflammatory substances that increase risk of atherosclerosis [10].

In cells, resveratrol increases the expression of the PON1 gene, which reduces inflammation and helps detox pesticides and drugs [11].

Clinical studies suggest that drinking small amounts of red wine daily might support heart healthbut resveratrol supplements probably dont.

Researchers are investigating the effects of resveratrol on liver disease and bile flow.

Most clinical research suggests that resveratrol is not beneficial for non-alcoholic fatty liver disease (NAFLD). According to one analyses of four small clinical studies, resveratrol (300-3000 mg daily) taken for 3 months does not affect liver enzymes, insulin resistance, or weight in patients with NAFLD [12].

In animals, it prevented and improved conditions of obstructed bile flow (by blocking MMP-2 and MMP-9). It also prevented liver damage in animals with sepsis, or blood poisoning from serious infections. These effects remain to be explored in clinical studies [13, 14, 15].

Resveratrol likely doesnt improve non-alcoholic liver disease. Its oher purported effects on the liver remain unexplored in humans.

The following purported benefits are only supported by limited, low-quality clinical studies.

There is insufficient evidence to support the use of resveratrol for any of the below-listed uses.

Remember to speak with a doctor before taking resveratrol supplements. Resveratrol should never be used as a replacement for approved medical therapies.

One study suggested that resveratrol helps with glucose metabolism. In 11 healthy but obese men, resveratrol (150 mg/day) increased insulin sensitivity and lowered blood sugar levels after 30 days [16].

However, additional clinical studies are lacking. Therefore, existing evidence does not support the use of resveratrol for lowering blood sugar.

It also raised SIRT1 and PGC-1a levels. SIRT is an enzyme crucial for turning off harmful genes that increase fat deposits, blood sugars, and inflammation in the body, while PGC-1a supports healthy mitochondria [16].

Resveratrol lowered blood sugars in studies on rats with diabetes. It prompts cells to take in more glucose, which reduces insulin resistance. Resveratrol also protects the insulin-secreting beta cells in the pancreas, which helps increase insulin when its low and decrease it when its too high [17].

Scientists have yet to explore resveratrols effects on insulin resistance and diabetes in humans.

Despite some promising early findings, its still uncertain whether resveratrol supports healthy blood sugar control in people at risk of type 2 diabetes.

According to one research team, resveratrol may help balance the response to estrogen, which affects reproductive health in both men and women.

In male rats, resveratrol increased testosterone and sperm count without any adverse effects. Scientists think it may activate the HPG hypothalamic-pituitary-gonadal axis that controls sex hormone release from the hypothalamus via the pituitary in the brain [18].

In women, resveratrol may act in a somewhat different way. In one trial of 40 postmenopausal women, resveratrol (1g/day for 12 weeks) didnt affect estrogen or testosterone but increased the protein that binds sex hormones and carries them through the blood (SHBG) by 10%. It also improved estrogen metabolism, which may lower the risk of breast cancer [19].

In animals, it blocks the enzyme that makes estrogen (aromatase) and mildly activates estrogen receptors. Resveratrol binds to estrogen receptors much weaker than estrogen does, which has a balancing effect: it may help increase estrogen-like activity when this female sex hormone is low (as after menopause) or decrease it when its too high. More human studies are needed [20, 21].

Based on limited evidence, reveratrol may affect some hormonal and metabolic markers in postmenopausal women. Data are still inconslusive.

In a clinical trial of 20 people with acne, a gel with resveratrol showed positive results over 2 months. It reduced acne severity by almost 70% and improved overall skin health by over 50% with no adverse effects. The team discovered that cosmetic products with resveratrol are stable and dont degrade when kept in the fridge (at 4C/40F) [22].

No clinical evidence supports the use of resveratrol for any of the conditions listed in this section.

Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.

Scientists believe resveratrol may have dual antioxidant activity: as a direct antioxidant and as a compound that may increase other antioxidant enzymes, genes, and pathways.

Antioxidant claims underlie many of its purported health benefits. Based on this theory, oxidative stress and inflammation trigger or worsen numerous diseases from heart disease and diabetes to cancer and cognitive decline [3].

Resveratrol increased antioxidant enzymes in cellular and animal studies, including the following:

At the same time, limited studies suggest that resveratrol reduces free radicals and inflammatory substances (including iNOS, Myeloperoxidase, NADPH oxidase) [23].

Scientists are investigating whether resveratrol activates antioxidant enzymes in cells and animals, but human data are not available.

Aside from its indirect antioxidant effects on inflammation, resveratrol is theorized to affect specific inflammatory processes.

For one, it may block inflammatory COX enzymes, which are also the main target of commonly used painkillers and anti-inflammatory drugs (NSAIDs like Motrin). However, resveratrols mechanism and anti-inflammatory potential hasnt been clinically confirmed [25].

Some scientists suspect that resveratrol also blocks the following inflammatory players (in animals or cells):

Researchers propose that resveratrol acts on several anti-inflammatory pathways, but this hasnt been proven in humans.

Resveratrol may not be the philosophers stone that will confer you immortality, but scientists are looking to see if it can beneficially impact some important aging-related disease pathways.

Based on animal and cellular research, they hypothesize that resveratrol may combat some age-related disorders by [28, 29]:

Well present some interesting aging-related resveratrol research and hypotheses below. Nonetheless, the whole anti-aging theory of resveratrol remains unproven.

One of the theories scientists use to explain aging involves so-called cellular senescence. With aging, cells become senescent and less resilient to stress, they lose their function and start producing inflammatory substances [30].

This loss of function and inflammation on a cellular level then extends to organs and tissues: the brain, heart, muscles, skin, and gut and the body as a whole also start to degenerate and lose function, especially if the body cannot or does not eliminate the dysfunctional cells through a process called autophagy [30].

SIRT1 is an enzyme that can turn off genes that trigger cellular senescence. Scientists are wondering if, by activating SIRT1, resveratrol may epigenetically hinder the aging process, at least based on cellular studies [3, 31].

Autophagy is a normal process that triggers the destruction of damaged cells, recycling the products of broken-down cells to make new and healthy ones. Autophagy is our bodys main Quality Control Officer.

Some theories have linked aging and age-related diseases to impaired autophagy. Though these theories are still a topic of research, they have yet to be confirmed or rejected.

Autophagy theories also led to the recent boom in caloric-restriction practices. Caloric restriction is said to promote longevity and healthy aging by activating autophagy [32].

However, caloric restriction is not safe for everyone. It may be especially tricky for older or thin people who struggle to get enough nutrients in their daily diet.

In animal studies, resveratrol confers similar benefits to caloric restriction and increases autophagy induction without the need to reduce daily calorie intake. These effects have not been investigated in humans yet [32].

Clinical studies are needed to determine whether or not resveratrol can extend lifespan in humans.

Some scientsts hypothesize that reveratrol turns on anti-aging pathways like SIRT1 and autophagy, but theyve only tested their theories in cells and animals so far.

Glial cells, specifically astrocytes, provide support and protection to neurons and their damage or dysfunction is linked to many brain-related diseases [33].

One of the ways in which astrocytes protect neurons is by removing excess glutamate (a neurotransmitter) from synapses and the extracellular space that surrounds neurons. Excess glutamate in the brain can lead to excitotoxicity and ultimately neuronal damage or even death [33].

In a cellular study, resveratrol increased their glutamate uptake. Theoretically, this is linked to better protection from brain degeneration and stroke. However, we cant draw this conclusion from a cell-based study [33].

In animal studies, resveratrol reduced seizures and protected the hippocampus, the brains main memory hub. It also increases IGF-1 in the hippocampus, which may improve cognition [34, 35].

One research group suggested that resveratrol may protect the brain by acting on the gut-brain axis [36].

According to this unproven theory, resveratrols potential benefits may not even depend on it being absorbed and passing the blood-brain barrier. In mice, resveratrol stimulated gut nerves, which passed the signal on to the hippocampus. Resveratrol was undetectable in the hippocampus, it improved cognition only by activating nerves in the gut [36].

In a study on brain cells, resveratrol increased the activity of the antioxidant gene heme-oxygenase 1, which protects the brain from damage. The effect was enhanced by melatonin [24].

In mice with late-onset Alzheimers disease, long-term resveratrol supplementation reduced cognitive impairment and disease biomarkers. It could also activate AMPK, which maintains energy balance in the brain under challenging conditions [37, 38].

Nonetheless, clinical studies have not yet examined the effects of resveratrol on brain health. Thus, this purported benefit remains unproven.

Animal experiments point to resveratrols brain-protective potential, but clinical studies are still lacking.

Some scientists believe that the gut microbiome can protect against diseases of the arteries [39].

In one study, resveratrol protected blood vessels in mice without APOE, stopped harmful bacteria in their gut from secreting harmful oxidative substances (like TMAO), and balanced their microbiome. It increased beneficial gut bacteria (such as Lactobacillus and Bifidobacterium), which raised the production of bile acids [39].

According to some, resveratrol may counter lower bile acid production and the weaker ability to eliminate cholesterol in people with heart disease. However, clinical trials are lacking to support such claims [40].

No clinical evidence supports the use of resveratrol in people who struggle with obesity. The existing animal research should guide future human studies.

In mice fed a high-fat diet, resveratrol reduced oxidative stress and prevented the death of protective immune cells called Tregs [41].

Resveratrol stopped fat cells from making new fats and triggered their death, in cell-based studies. It accomplishes this by turning off genes that cause weight gain (such as PPAR gamma) while activating genes that enhance energy use and mitochondrial health (SIRT3, UCP1) [42, 43].

Additionally, resveratrol may boost weight loss by blocking several key fat-creating enzymes (called fatty acid synthase, lipoprotein lipase, and hormone-sensitive lipase) [42].

This purported benefit remains unproven.

Stem cells in the connective tissue are presented with several possibilities: to develop into fat cells, bone-building cells, joint, or muscle cells. Resveratrol activates the fat-burning pathway (SIRT1), which blocks genes that increase fat storage (PPAR gamma). This epigenetic shift causes stem cells to develop into bone-building cells, which may boost bone health [44].

According to some, resveratrol may synergize with Vitamin D and vitamin K2 to protect the bones and increase their mineralization [45].

Evidence is lacking to support the use of reveratrol for bone health, weight control, and microbiome or bile imbalances.

The effects of resveratrol on cancer prevention in humans are unknown.

Scientists are investigating resveratrol for its potential to prevent cancer, especially liver cancer and some other cancer cell types [46, 47, 48].

In mice, resveratrol applied to the skin before UVB exposure prevented skin cancers. Given orally, it was active against esophageal cancer in rats [49, 50].

Since resveratrol is an antioxidant phytoestrogen, some scientists are investigating its effects on breast cancer. In cells, it blocks the enzyme aromatase, which makes estrogen. High activity of this enzyme and high estrogen levels worsens a common type of breast cancer that has receptors for estrogen (receptor-positive or ER+) [51, 52].

In animal studies, resveratrol prevented and reduced the growth of breast cancer. Clinical studies have not yet determined its efficacy and safety in breast cancer patients [51].

Aside from its hormonal effects, scientists are wondering whether resveratrol can regulate another cancer enzyme called topoisomerase II. In cells from a deadly brain tumor (glioblastoma), resveratrol blocked the activity of this cancer enzyme, which should guide further research efforts [53].

There is no evidence that resveratrol can help prevent cancer in humans.

According to some unproven theories, resveratrol may increase muscle-building pathways and block processes that degrade proteins (proteolysis). For example, it increased the size of fish and enhanced their muscle growth in one study [54].

In another study, resveratrol supplementation enhanced the exercise training response, upper muscle strength, and aerobic performance in rats [55].

Scientists are questioning if its effects stem from epigenetic changes like activating fat- and sugar-burning sirtuins (SIRT1) and other molecules that heighten energy levels (AMPK and PGC-a). Future studies might give us some answers [55].

In mice, high-dose resveratrol had a good anti-radiation effect. It prevented the decline in bone marrow and white blood cells from radiation, helping to maintain proper immune function. It also increased the antioxidant and detox enzyme SOD without causing adverse effects. These effects remain completely unproven in humans, though [56].

Scientists found that noise increases free radicals, which can cause ear damage and hearing loss. In mice exposed to damaging noise, resveratrol protected against hearing loss by neutralizing free radicals and improving blood flow in the ears [57].

In a different rat study, resveratrol prevented ear damage from the toxic chemotherapy drug cisplatin [58].

Clinical research is needed.

The impact of resveratrol on muscle growth, radiation, and hearing loss in humans is still unknown.

Resveratrol has some virus-fighting action, according to cell-based or animal studies. It was effective against:

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22 Purported Resveratrol Benefits - SelfHacked

What Is the Difference Between Resveratrol & Grape Seed …

Posted: at 1:52 am


Unlike grape seed extract, resveratrol comes from grape skins.

Both resveratrol and grape seed extract are derived from grapes, but unlike grape seed, resveratrol is extracted from grape skins like those used to make red wine. Although both substances have similar actions in the body, they each have some individual recommended medicinal uses. You might take grape seed extract for different health benefits than resveratrol. Before you begin taking either alternative remedy, consult your doctor to discuss the correct dosage and possible drug interactions.

Identification

Resveratrol is also found in peanuts and purple grape juice. Because resveratrol is found in the highest concentrations in red wine, wine is considered the main dietary source of resveratrol. Grape seed extract is taken from the seeds or from whole grapes. Grape seed extract contains substantial amounts of flavonoids, vitamin E and linoleic acid, among other important constituents.

Function

Both resveratrol and grape seed extract act as powerful antioxidants in the body. Antioxidants combat free radicals, which can attack and kill your body's cells, as well as damage cell DNA. Antioxidants also play a role in certain medical conditions like heart disease and cancer, as well as in aging. The antioxidant actions in grape seed extract are attributed to the constituents known as oligomerica proanthocyanidin complexes, or OPCs, while resveratrol itself is a constituent of grape skins that bears the antioxidant effects. Additionally, resveratrol is considered a phytoestrogen, which is a plant-based substance that acts in a similar way to the estrogen hormone in your body.

Effects

Due to its antioxidant and estrogen-like actions in the body, resveratrol is sometimes used to treat heart disease and prevent cancer. Grape seed extract's antioxidant actions account for its potential use in treating chronic venous insufficiency, high cholesterol, edema and hypertension, as well as in preventing cancer, according to the University of Maryland Medical Center. Grape seed extract is also sometimes recommended for treating diabetes, hemorrhoids and poor night vision, and for skin anti-aging purposes. Additionally, grape seed may help treat burns, atherosclerosis, constipation and other gastrointestinal conditions, as well as promote wound healing, according to the Memorial Sloan-Kettering Cancer Center. No widely accepted, conclusive scientific research supports the use of resveratrol or grape seed extract to prevent or treat any medical condition, however.

Dosages

A typical dose of resveratrol is 500 mg per day, according to the University of Pittsburgh Medical Center. For grape seed extract, a daily dosage of 200 to 400 mg is used to treat edema and 150 to 300 mg to treat chronic venous insufficiency, notes the University of Maryland Medical Center. You could take 25 to 150 mg of grape seed extract up to three times daily for general antioxidant effects. Grape seed extract is usually standardized to contain 40 to 80 percent proanthocyanidins. Ask your physician about the dosage that's right for you before taking grape seed extract or resveratrol.

Warning

Resveratrol's estrogenic effects could potentially increase the growth of breast cancer cells, making the remedy unsafe for women who have or are at risk of having estrogen-sensitive types of cancer, warns the University of Pittsburgh Medical Center. Grape seed extract may offer blood-thinning effects, making the remedy possibly unsafe if you're also taking anticoagulant drugs like Coumadin, warns the Memorial Sloan-Kettering Cancer Center. The same is true if you have a bleeding disorder like hemophilia, notes the University of Maryland Medical Center.

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What Is the Difference Between Resveratrol & Grape Seed ...

8 Reasons To Love Red Wine | Prevention

Posted: at 1:52 am


Beneficial Booze

Any hardworking gal knows that kicking back with a girlfriend and a glass of red wine is a fabulous way to de-stress. The best part? Your red-wine habit also happens to come with some happy health benefits, such as protecting your ticker and even slimming your waistline. Check out these eight reasons why winding down with a glass of vino is a good call all around.

MORE: 9 Very Best Solutions To Solve Your Snoring (Prevention Premium)

1. Lower your cholesterol

High-fiber Tempranillo red grapeswhich are used to make certain red wines, like Riojamay actually have a significant effect on cholesterol levels,according to a study from the Universidad Complutense de Madrid in Spain.

Healthy study participants who consumed the same grape supplement found in red wine saw their LDL, or "bad cholesterol," levels decrease by 9% among healthy. Participants withhigh cholesterol experienced a drop of 12%. What's the big deal? Excess LDL ends up getting deposited in arterial walls and forming plaque, which causes arteries to stiffen and blood pressure to rise, ultimately leading to heart attacks, says Arthur Agatson, MD, an associate professor of medicine at the University of Miami and author ofThe South Beach Heart Program.

MORE: 12 Foods That Lower Cholesterol Naturally

2. Protect your heart

On top of lowering bad cholesterol, polyphenolsthe antioxidants in red winecan help keep blood vessels flexible and reduce the risk of unwanted clotting, saysJohn Folts, PhD, a professor of cardiovascular medicine and nutrition at the University of WisconsinMadison.

"They're nearly as effective as aspirin," says Folts. But be careful: Chronic heavy drinking damages the heart, so, as with most things, moderation is key.(If you prefer an aspirin to protect your ticker, be sure to follow these3 aspirin safety tips.)

MORE: 28 Days To A Healthier Heart

3. Control blood sugar

The skin of red grapesa rich source of red wine's natural compound resveratrolmay actually help diabetics regulate their blood sugar, finds recentresearch published in the journalNutrition. Study participants who took a250 mg resveratrol supplement once a day for three months had lower blood glucose levels than those who didn't take the pill. Plus, resveratrol-takers also had significant decreases in total cholesterol and systolic blood pressure. Researchers suspect that resveratrol may help stimulate insulin secretion or activate a protein that helps regulate glucose and insulin sensitivity.

4. Boost your brain

Resveratrol may also be the key to keeping your memory sharp, says Philippe Marambaud, PhD, a senior research scientist at New York's Litwin-Zucker Research Center for the Study of Alzheimer's Disease and Memory Disorders. The compound has been shown to hamper the formation of beta-amyloid protein, a key ingredient in the plaque found in the brains of people with Alzheimer's.Marambaud suggests flexing your noodle by doing crossword puzzles and brain teasers for an hour then cooling down with a glass of wine. New to brain teasers? We've got you covered with 7 Brain Games That Make You Smarter.

5. Fight off a cold

If you hate getting sick (and who doesn't?), the antioxidants in red wine may help keep you healthy.A 2010 study in the American Journal of Epidemiology found that among 4,000 faculty members at five Spanish universities,those who drank more than 14 weekly glasses of wine for a year were 40% less likely to come down with a common cold.Why? According to the National Institutes of Health, antioxidants are believed to fight infection and protect cells against the effects of free radicals, which may play role in cancer and other diseases.

Another antioxidant boost? They may also lower sex hormone levels to protect against breast cancer,says a study from Cedars-Sinai Medical Center in Los Angeles.(Stay up to date on the latest breast cancer news with ourBreast Cancer Center.)

6. Stop cancer

According to researchers at the University of Virginia, the resveratrol you get from drinking one glass of red wine three or four times a week may be enough to starve any nascent cancer cells. The scientists dosed human cancer cells with resveratrol and found that the compound inhibited the key action of a cancer-feeding protein.

MORE: The Ultimate Anti-Cancer Diet

7. Get slim

Clearly, resveratrol is a bit of a limelight hog when it comes to the healthful compounds in vino. But research in the Journal of Biological Chemistry suggests piceatannol, the chemical compound our bodies convert from resveratrol, deserves some credit. This compound was shown to actually prevent the growth of fat cells in a series of lab tests. How? Researchers say that piceatannol binds to the insulin receptors of fat cells, essentially blocking the pathways necessary for immature fat cells to mature and grow.

8. Jazz up dinner

Who said your red wine consumption had to be limited to the glass? You can include the drink in your dinner, either as a sauce (in which case we suggest our yummy DIY red wine sauce) or complimentary ingredient, and still reap its benefits.

Need inspiration? We love these four recipes:

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8 Reasons To Love Red Wine | Prevention

Caudalie unlocks a centuries-old secret of youthful skin with its bestselling resveratrol line – CNN

Posted: at 1:52 am


(CNN)

Youre not alone in feeling like you aged a decade in the last year. And youre also not the only one who secretly partially dreads the idea of seeing your co-workers, friends and family after such a long time away from face-to-face contact after all, cucumber peels and exfoliating brushes werent exactly on the top of anyones daily to-do list.

So whats the answer to washing away all the extra years you psychically packed into your skin while you kept the world from crumbling all around you for over a year? Caudalie has a suggestion: Hit the wine bottle. Just not quite in the way you think.

For centuries, in the heart of wine country in France, wine grapes were the secret to the glowing, spot-free skin of the women who worked the vineyards making some of the finest vintages the world has ever seen. But it wasnt until the mid-1990s in Bordeaux that Mathilde and Bertrand Thomas, working with Professor Joseph Vercauteren, finally pinpointed the actual science behind the beauty secrets local women had known for so long. The result was Caudalie, a beauty company that harnessed the unsurpassed power of the anti-aging polyphenols found in the grape seeds that most wineries simply let go to waste. And in the last year, Caudalies resveratrol collection has skyrocketed in popularity with good reason.

Working with a Harvard University genetics professor, Caudalie patented a combination of resveratrol, a natural phenol found in grapevines to help regenerate healthy cells after damage, and hyaluronic acid, a substance found naturally in your body whose function is to keep your skin and eyes well lubricated. That elixir has been found to be twice as effective as retinol in keeping skin visibly firm. And thats the mixture that Caudalie has used as the key to its line of resveratrol skin and beauty products.

Its the reason why Resveratrol-Lift Instant Firming Serum has become such a hit, with users swearing by it. Theyve gone on record saying theyre getting noticeable results within weeks, with Caudalies resveratrol serum leaving them feeling fresh and not oily or overly scented but still keeping the skin smooth and hydrated. Look it up for yourself: Its earned over 100 5-star reviews.

In keeping with Mathilde Thomas philosophy, all resveratrol products are at least 97% natural and follow the universal Caudalie rule of no parabens, phenoxyethanol, phthalates, mineral oils, PEGs, silicones or animal-derived ingredients. In addition, Caudalie has committed to zero-waste packaging by 2022, meaning all packaging will soon be completely recycled, recyclable or refillable, using less paper and no plastic film. That means a reduction in Caudalies carbon footprint of a whopping 40%. So when you buy Caudalie, youre not just restoring your own beauty; youre helping preserve our planets.

As we all start to finally return to our daily regimens of self-care, Caudalies resveratrol line should be part of your go-to skin care products when you wake up and when you go to bed. Because the secret to glowing, youthful skin is out and this is one vintage you dont want to pass up.

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Caudalie unlocks a centuries-old secret of youthful skin with its bestselling resveratrol line - CNN

Resveratrol in red wine could help to treat endometriosis – The Drinks Business

Posted: at 1:52 am


Researches at the Iran University of Medical Sciences have found that the anti-inflammatory properties of resveratrol in red wine could help to treat endometriosis.

As reported by Wine Spectator, the study was published in the online journalNature.

Endometriosisis a condition where tissue similar to the lining of the womb starts to grow in other places, such as the ovaries and fallopian tubes. It can affect women of any age and can cause chronic pain, irregular bleeding and infertility.

There is no cure for endometriosis, which is treated with anti-inflammatory medication.

The Iran study aimed to find out how effective resveratrol an antioxidant-rich compound found in red wine was in treating the symptoms of endometriosis.

The researches tested the antioxidant in the lab on endometrial cells, collecting endometrial cells from 40 patients suffering from stage 3 or 4 endometriosis, along with 15 patients without the condition.

After isolating the cells, the scientists treated them with varying amounts of resveratrol.

As reported by Wine Spectator, three genes and the proteins they produce cause endometrial cells growing outside the uterus.

The researchers found that resveratrol suppressed all three of the offending genes, controlling inflammation and keeping the condition under control.

According to the findings, resveratrol may ameliorate endometriosis progression through reducing the expression of these genes in endometrial cells, the researchers reported, adding that further research was needed.

The findings give hope to women suffering from the condition, who may benefit from the anti-inflammatory effects of a daily glass of red wine.

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Resveratrol in red wine could help to treat endometriosis - The Drinks Business

Why Pinot Noir May Be The Best Wine For Your Health – Forbes

Posted: at 1:52 am


Glass of red wine and electrocardiogram

The benefits of drinking red wine have long been debated. Numerous studies have suggested that there is a link between moderate red wine consumption and heart health, but the issue has yet to be definitively settled.

According to the Mayo Clinic:

Red wine, in moderation, has long been thought of as hearthealthy. Thealcoholand certain substances inred winecalled antioxidants may help prevent coronary artery disease, the condition that leads to heart attacks. Any links betweenred wineand fewer heart attacks, (however) aren't completely understood.

The health benefits associated with drinking red wines are mainly associated with a powerful antioxidant called resveratrol. The Mayo Clinic has suggested that:

Resveratrol might help prevent damage to blood vessels, reduce low-density lipoprotein (LDL) cholesterol (the "bad" cholesterol) and prevent blood clots.

It also notes, however, that other studies found no benefits from resveratrol in preventing heart disease and that more research is needed.

Before you rush off to buy another bottle of your favorite red wine, however, you should note that the level of resveratrol in red wines can vary widely.

According to Jim Bernau, the president of Willamette Valley Vineyards, one of Oregons leading Pinot Noir producers, cool climate Pinot Noir, especially whole cluster fermented wines, are more likely to deliver high levels of resveratrol than other varietal red wines.

Jim Bernau, President, Willamette Valley Vineyards

Bernau notes that resveratrol is a fungicide, a polyphenolic compound an antimicrobial deterrent and repellant that is naturally produced by grape plants to protect grapes from molds. Its found in the skin of the grapes.

Red grape varieties grown in cool regions that are prone to high levels of humidity during harvest time, and more prone to mold damage, will produce higher levels of resveratrol than red grapes grown in drier regions.

Thin skinned grapes are even more vulnerable to being attacked by molds, so those varieties of grapes, he believes, also tend to produce even higher levels of resveratrol. According to Bernau, local climatic conditions post veraison, regardless of where the thin-skinned grapes are grown, is the determining factor.

There are many thin-skinned red grape varietals. Sangiovese, Tuscanys main grape varietal, is famously thin skinned, although Sangiovese Grosso, the Sangiovese clone used to make Brunello di Montalcino, is much thicker skinned.

In addition to Pinot Noir, other thin skinned red grape varietals include Grenache, Cabernet Franc, Merlot, Nebbiolo and Gamay. Grenache and Merlot are typically grown in drier, Mediterranean like climates, Bordeaux being something of an exception, and are less prone to mold outbreaks.

Cabernet Franc, Gamay and Nebbiolo can thrive in cooler climates in regions that can be prone to rainy weather during harvest season. They are good candidates to produce resveratrol rich wines.

Pinot Noir, however, is usually the northernmost planted red grape varietal, and typically reaches its most complex expression when grown in cool climates. Combined with its notoriously thin skins makes it the ideal candidate for producing wines with elevated levels of resveratrol.

Thats why Bernau, believes the defense response is greatest in the Pinot Noir variety He notes, however, that the impact of grape varieties on resveratrol levels needs more extensive study.

Resveratrol is a powerful antioxidant. That means it will combine readily with oxygen. In the body antioxidants inhibit oxidation, hence the name, by combining and neutralizing potentially damaging oxidizing agents.

To maximize the level of resveratrol in a wine, Bernau argues, its necessary to minimize the wines contact with oxygen.

As a general rule, winemakers want to limit oxygen contact with grapes, especially the grape must during fermentation.

Whole cluster Pinot noir grapes being emptied from a fermentation tank prior to being crushed.

Oxygen combines with phenolic compounds in wine or fermenting grape must and causes them to oxidize, resulting in a loss of fruity flavors and diminishing aroma. Oxidation can also lead to browning in a wine and the creation of aldehydic, nut like, flavors.

Oxidation is an inevitable consequence of aging wines. Thats why older wines tend to lose the purple and crimson coloration of their youth and become browner, more brick like in color, and often exhibit less intense fruit aromas and flavors. Presumably that means that older wines are likely to contain less resveratrol.

Whole cluster fermentation, a popular technique among Pinot Noir producers and the signature style of Beaujolais, is especially suited, Bernau believes, for maximizing resveratrol levels in wine.

Grapes that are vinified as whole clusters are not destemmed or crushed prior to vinification. Instead, they are placed as whole bunches in a fermenter. Typically, the grapes at the bottom of the fermenter are split open by the weight of the grapes on top of them, and some juice is released, but the majority of the grapes remain whole.

Once the fermenter is filled, carbon dioxide is pumped into the tank to flush out any oxygen; creating an anaerobic environment. The technique is called carbonic maceration. In this wine making process most of the actual fermentation occurs within the grape itself, thus limiting even more the fermenting grape juices exposure to oxygen. After the fermentation is over, the grapes are gently crushed to release the juice.

Carbonic maceration is used to produce light bodied, fresh and fruit forward red and ros wines. One of the characteristics of such wines is that they have a distinctive bubble gum flavor note. If you detect a bubble gum flavor in a wine, then the odds are that at least a portion of that wine was produced using carbonic maceration.

Since contact with oxygen reduces resveratrol levels, Bernau believes that you should not decant a wine if you are looking to preserve the resveratrol level.

He also notes that there is no relationship between a wines appearance and the level of resveratrol it contains. Since resveratrol is found in the skins of grapes, extended contact should theoretically increase resveratrol levels.

Deeply hued wines, presumably an indication of extended skin contact, do not, however, necessarily have higher resveratrol levels argues Bernau, the issue is extraction at lower levels of oxygen thats why clusters fermented whole result in more resveratrol content than those macerated through punch downs or pump overs.

There are still a lot of questions about resveratrol that remain to be answered. Its health benefits have not been definitively settled. How to maximize resveratrol levels in wine production, the impact of vineyard management techniques, the effect of different grape varietals, the consequences of different closures during bottling, all await further study.

For now, however, if you are looking to maximize the health benefits of drinking red wine, reaching for a bottle of whole cluster fermented, cool climate Pinot Noir, like the kind produced in Oregons Willamette Valley, would be a good place to start!

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Why Pinot Noir May Be The Best Wine For Your Health - Forbes

Resveratrol Market to Witness Robust Expansion throughout the Forecast 2021-2031 Future Market Insighgts – NewsMaker

Posted: at 1:51 am


A recent market study published by Future Market Insights on theResveratrol market offers global industry analysis for 2016-2020& opportunity assessment for 20212031s. The study offers a comprehensive assessment of the most important market dynamics. After conducting a thorough research on the historical, as well as current growth parameters of theResveratrol market, the growth prospects of the market are obtained with maximum precision.

To Get Sample Copy of Report Visit @ https://www.futuremarketinsights.com/reports/sample/rep-gb-2744

Product type

Form

Isomer

End Use

Region

The global Resveratrol market is segmented in detail to cover every aspect of the market and presentComplete market intelligence to readers.

For More Details, Ask Analyst @ https://www.futuremarketinsights.com/ask-question/rep-gb-2744

Report Chapters

Chapter 01Executive Summary

The executive summary of theResveratrol market includes the market proprietaryGlobal Market Outlook, Demand-side Trends, Supply-side Trends, Technology Roadmap Analysis, Analysis and Recommendationson the globalResveratrolmarket.

Chapter 02 Market Overview

Readers can find the detailed segmentation and definition of theResveratrol market in this chapter, which will help them understand basic information about theResveratrol market. This section also highlights the inclusions and exclusions, which help the reader understand the scope of theResveratrol market report.

Chapter 03Key Market Trends

The key market trend is assessed in this chapter which gives brief idea about Key Trends Impacting the Market, Product Innovation / Development Trends. Which help in understand the market trends in resveratrol market.

Chapter 04Key Success Factors

In this chapter readers will find about these key success factors: Product Adoption / Usage Analysis, Product USPs / Features, Strategic Promotional Strategies of resveratrol market.

Chapter 05 Global Resveratrol market Demand Analysis and Forecast 2016-2031

This chapter includes detailed analysis of the historical Resveratrol market (2016-2020), along with an opportunity analysis for the forecast period (2021-2031). Readers can also find the absolute $ opportunity for the current year (2020 2021) and incremental opportunity for the forecast period (2021-2031).

Chapter 06 Global Resveratrol market - Pricing Analysis

This chapter includes global as well as regional pricing analysis by source. The pricing influencing factors are also explained in this chapter. The readers can understand the manufacturer level, distributor level as well as retail level pricing analysis for 2021 and 2031.

Chapter 07Global Resveratrol Market Demand (in Value or Size in US$ Mn) Analysis 2016- 2020 and Forecast, 2021-2031

In this chapter Historical Market Value (US$ Mn) Analysis, 2016-2020, Current and Future Market Value (US$ Mn) Projections, 2021-2031 in which Y-o-Y Growth Trend Analysis and Absolute $ Opportunity Analysis are given according to the resveratrol market.

Chapter 08 Market Background

The associated industry assessment of theResveratrol market is carried out in this section. The macroeconomic factors affecting growth of theResveratrol market are provided in this section and the impact of these macroeconomic indicators on theResveratrol market is analyzed. The processing overview and technological advancements in theResveratrol market is also provided.

Chapter 08(a)GlobalResveratrol market Value Chain

Profit margins at each level of theResveratrol market are analyzed and readers can find detailed information on top importers and exporters as well as the value chain of theResveratrol market.

Chapter 08(b) Market Dynamics

The drivers and restraints impacting the growth of theResveratrol market are explained in this chapter. Opportunities and ongoing trends in theResveratrol market are also comprehensively discussed.

Chapter 09 GlobalResveratrol market Analysis 2016-2020& Forecast2021-2031by Product Type

Based on Product Type, theResveratrol market is segmented intoExtract (Plant-based), Fermentation (Yeast-based), and Synthetic (Chemical Synthesis).In this chapter, readers can find information about key trends and developments in theResveratrol market and market attractiveness analysis based on Product Type.

So On

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Resveratrol Market to Witness Robust Expansion throughout the Forecast 2021-2031 Future Market Insighgts - NewsMaker

How a glass of wine could ease the agony of endometriosis for millions… – The Sun

Posted: at 1:51 am


DRINKING a glass of wine a day could ease the agony of endometriosis for millions of sufferers, experts have revealed.

Researchers at the Iran University of Medical Sciences found that compounds included in red wine could help treat common symptoms of the illness.

1

One in ten women are thought to be plagued by endometriosis and it takes around seven and a half years from the onset of symptoms for a woman to be diagnosed with the condition.

Endometriosis is where tissue that is similar to the lining of the womb grows in other places.

This can be the ovaries and fallopian tubes.

It can affect women of any age and can cause chronic pain, irregular bleeding and infertility.

At present, there is no cure for endometriosis and many cases are treated with anti-inflammatory medication.

THE SYMPTOMS OF ENDOMETRIOSIS

THE main symptoms associated with endometriosis are:

This is where compounds found in red wine can help.

The study published in Nature journal, conducted by experts in Iran looked at an ingredient called resveratrol.

This is an antioxidant-rich compound that is found in red wine.

Experts looked at how effective this would be in treating patients with endometriosis and found that the ingredient was able to suppress the condition, controlling inflammation.

Researchers tested the ingredient in a lab on endometriosis cells.

They collected the cells from 40 patients who were suffering from stage 3 and 4 endometriosis.

They also tested the ingredient on 15 patients who did not suffer with the condition.

The cells were isolated before being treated with resveratrol.

The experts said there were three genes and proteins that caused cells to grow outside the uterus and that resveratrol suppressed them all.

The researchers added: According to the findings, resveratrol may ameliorate endometriosis progression through reducing the expression of these genes in endometrial cells.

They said further research was needed to see how the ingredient could be used.

It comes after it was last month revealed that a drug that is currently used to treat rare metabolic conditions in children is now being trialled on endometriosis patients.

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MOP THE HELLBritain's most extreme cleaners - including woman who PAINTS floor twice daily

Dichloroacetate helps to control lactate levels, which have found to be at high levels in patients suffering with endometriosis.

Experts at the University of Edinburgh are currently conducting a trial with 30 women as the search continues for an effective endometriosis treatment.

When testing the drug the experts found that the pelvic walls of women with the condition differ from those without the disease.

When the cells were treated with dichloroacetate they returned to normal behavioural patterns.

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How a glass of wine could ease the agony of endometriosis for millions... - The Sun

Global Resveratrol Market 2021 Trending Technologies, Competitors Analysis, and Industry Insights SoccerNurds – SoccerNurds

Posted: at 1:51 am


The Resveratrol market offers an extensive analysis of the crucial industry aspects including drivers, restraints, limitations, growth prospects and opportunities, threats, and macro and micro-economic factors. The study offers decision-makers all the crucial statistical data to help them gain maximum returns on their investments and capitalize on the emerging growth prospects. The Resveratrol Market research report draws focus on the strengths and weaknesses of the key players of the market through a comprehensive SWOT analysis and Porters Five Forces analysis to project the growth rate.

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The report contains a serious examination of the key players working in the Resveratrol market and covers inside and out information identified with the serious scene of the market and the ongoing methodologies and items that will help or influence the market in the coming years.

The global Resveratrol market report further segments the market based on product types offered by the market, applications, and key geographies of the market. The research study assesses the market in terms of market size, volume, revenue, and share.

Global Resveratrol Market Segmentation By Type:

Global Resveratrol Market Segmentation By Applications:

Global Resveratrol Market Segmentation By Regions:

Get Updated COVID19 Impact Analysis on Resveratrol Market @ https://www.in4research.com/impactC19-request/31245

This report provides a critical analysis of the global Resveratrol market in respect to the COVID-19 pandemic and its adverse impact on the manufacturing and global sales of the product. It provides an extensive study on the impact of the COVID-19 pandemic on the global Resveratrol market and explains how it would affect the business operations of the industry soon.

Global Resveratrol market report client gets detailed and verified data about the business. Likewise, this report covers the top to bottom factual investigation and the market elements and requests which give an entire situation of the business. The report gives the distinctive business challenges which are affecting business sector development a positive and negative way.

Chapters Define in TOC (Table of Content) of the Report:

Chapter 1: Resveratrol Market Overview, Drivers, Restraints and Opportunities, Segmentation overview

Chapter 2: Market Competition by Manufacturers

Chapter 3: Production by Regions

Chapter 4: Consumption by Regions

Chapter 5: Production, By Types, Revenue, and Market share by Types

Chapter 6: Consumption, By Applications, Market share (%) and Growth Rate by Applications

Chapter 7: Complete profiling and analysis of Manufacturers

Chapter 8: Manufacturing cost analysis, Raw materials analysis, Region-wise manufacturing expenses.

Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10: Resveratrol Marketing Strategy Analysis, Distributors/Traders

Chapter 11: Market Effect Factors Analysis

Chapter 12: Market Forecast

Chapter 13: Resveratrol Market Research Findings and Conclusion, Appendix, methodology and data source.

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Global Resveratrol Market 2021 Trending Technologies, Competitors Analysis, and Industry Insights SoccerNurds - SoccerNurds

Leaders in Cannabis Formulations: Part 2 – Cannabis Industry Journal

Posted: at 1:51 am


Editors Note: In Part 1 of this series, green sat down with Drew Hathaway, senior food scientist at Stillwater Brands. Click here to see Part 1.

Natural cannabinoid distillates and isolates are hydrophobic oils and solids, meaning that they do not mix well with water and are poorly absorbed in the human body after consumption. By formulating these ingredients using a patented delivery system technology, trademarked VESIsorb, Geocann has overcome common obstacles associated with fat-soluble active ingredients, including poor stability, bioavailability, absorption, and solubility. In addition, Geocann has peer-reviewed, published evidence of the dramatic improvements in Cmax, AUC, and Tmax(time to peak absorption directly related to fast-acting benefits).

Geocann is a cannabis formulation company with its headquarters in Fort Collins, Colorado, and additional offices in Chicago, Illinois and Zurich, Switzerland. The company is led by an impressive leadership team of scientists, pharmacists, researchers and natural product industry leaders. Geocanns technology platform has been successfully applied to a wide range of cannabis product applications, including soft gel and hard-shell capsules, functional foods (e.g. gummies) and beverages, powder systems, tinctures, sublingual sprays and topically applied formulations. Brand partners in the U.S. utilizing Geocanns technology for hemp applications include Nestl Health Science, Cannaray and Onnit, and brand partners for medical and adult-use cannabis applications include Curaleaf, Sunderstorm and CannaCraft, among others.

We spoke with Jesse Lopez, CEO and Founder of Geocann, about their product formulation technology in cannabis and how they work with brand partners in the U.S and internationally. Lopez started Geocann in 2018 alongside the success hes experienced at SourceOne Global Partners (founded in 2003 by Lopez), a leading formulation company in the nutraceuticals space with a reputation for pioneering innovative products that combine science-backed ingredients with patented drug delivery system technologies to address the most pressing consumer health concerns, such as heart health, cognitive function, inflammatory response, metabolic syndrome and type II diabetes, among others.

Aaron Green: Jesse, first off, how did you get involved in the cannabis industry?

Jesse Lopez: Our focus at SourceOne Global Partners has been on natural products for nearly two decades. Some of the folks involved with our natural products business decided that they would get involved in the cannabis business and they asked for my support at the Advisory Board level. I agreed to serve and figured I better learn about the cannabis industry! We realized that there was a tremendous opportunity for utilizing our drug delivery system technology to enhance the value of these cannabis-based products. Due to the regulatory environment, strategic legal counsel and new investments necessary to take an immediate leadership position in the cannabis industry we launched Geocann in 2018 with an office in a fully legal state at the time, Colorado.

Green: How do you select the natural products you work with at SourceOne?

Lopez: We really focus on science-backed natural product ingredients that may require high doses to reach therapeutic blood levels. By combining these science-backed ingredients with patented technologies which we own the global rights to these products offer desirable differentiation for leading brands, such as dramatically improved absorption and bioavailability, patent protection and trademarked intel inside branding.

Green: What are some of the other natural products you have experience with?

Lopez: We work with a range of some of the most popular nutraceuticals such as coenzyme Q10 and omega-3 fish oil to the more innovative natural products like resveratrol. We also work with vitamin D, and other immunity-based ingredients that can be enhanced using our delivery system technology to deliver greater benefits to the people that are taking those products.

Green: What is the technology and how does it work?

Lopez: I think its important to recognize our technology partner, Vesifact, in Zurich, Switzerland, who is the inventor of the VESIsorb technology platform and serves as the scientific research, technical support, production, and product development arm of SourceOne and Geocann. We are very proud of this symbiotic relationship where our role at Geocann and SourceOne is to provide the commercial development, sales, marketing and strategic distribution infrastructure. We promote our partnership openly on our website and in our marketing materials because of their unrivaled leadership position in the global marketplace.

They have consistently been recognized as a top 10 global organization for health-related nanotechnology patent activity, ahead of many of the most well-known pharmaceutical companies in the world. It is an intellectual property portfolio that has been used to provide solutions to the most difficult product formulation challenges over the yearsin pharmaceuticals, medical devices, nutraceuticals, cosmetics, and now cannabis applications. Together, our focus has been on delivering novel solutions in these diverse fields of use and product applications based upon VESIsorb formulation technology.

Each active compound identified with its own set of formulation, absorption and bioavailability challenges requires a customized solution that allows the full potential health benefits to be realized from success in the lab to commercial scale up. This is the process and we have successfully delivered unmatched solutions for close to twenty years from coenzyme Q10 to now both psychoactive and non-psychoactive cannabinoid product formulations in a wide range of product applications.

We saw the exploding interest in CBD with our nutraceutical partners and demanding consumers worldwide but chose to start Geocann to keep the markets served separate. We were confident that the VESIsorb technology would provide much needed solutions for CBD as a wellness product, but also adult-use and medical cannabis products regarding fast acting and product stability needs.

Green: Whats the problem in cannabinoid bioavailability that Geocanns technology helps to solve?

Lopez: It is well-recognized in the scientific literature that CBD, THC and other cannabinoids, in general, show limited bioavailability due to their lipophilicity, poor aqueous solubility and extensive first-pass metabolism.

OurVESIsorb technology was designed to address the poor bioavailability of drugs and natural bioactives like cannabinoids exhibiting poor water solubility but high membrane permeability (Biopharmaceutical Classification System: Class II compounds). The VESIsorb technology is a lipid-based formulation that self-assembles on contact with an aqueous phase into a colloidal delivery system. This colloidal solubilization improves the transport of the cannabinoids through the aqueous phase of the GI-lumen to the absorptive epithelium, dramatically improving bioavailability.

VESIsorb is typically characterized as a SEDDS (self-emulsifying drug delivery system). Whats unique about our VESIsorb SEDDS is the long history of safe and effective use worldwide and the large number of products that, over the years, weve successfully developed. With decades of experience delivering novel formulation solutions, there is significant and valuable know how that we bring to each formulation challenge. This know how allows us, for example, to develop cannabinoid formulationsthatprovide lymphatic absorption pathway advantages in addition to standard gastrointestinal absorption, therefore optimizing therapeutic blood levels for maximum benefits.

Needless to say, there are various methods that attempt to address the poor cannabinoid bioavailability.Unfortunately, too often, companies make claims that they have water soluble cannabinoids but offer little evidence to validate their claims.The popular misconception is that some degree of water solubility will consistently translate to improved bioavailability. This is clearly not accurate.We know scientifically that pharmacokinetic performance is highly variable. A review paper I read recently comparing water soluble delivery system formulation types illustrated this fact. There was greater than an eight-fold difference in bioavailabilityamongst the various water-soluble formulations.

Green: Can you tell me some details about your global license with Vesifact?

Lopez: Our technology exclusivity is based upon given categories. So, when we say we have global exclusivity for nutraceuticals, that can be as Ive already mentioned, omega-3, coenzyme Q10, or resveratrol as examples, and this business is managed by SourceOne. With regards to our global exclusivity for cannabinoids and terpenes whether we formulate these ingredients to create a functional drink, or were creating a gummy, or creating a softgel capsule or powder-filled hard-shell capsule, or sublingual, or topical all of those product applications are covered by ourexclusivity for the technology and is managed by Geocann.

The beauty of our technology is that weve already achieved success with all of those product applications. Thats one of the big advantages of our technology versus some other approaches trying to address the challenges of cannabinoid bioavailability.

Green: What kind of validation and clinical studies have you done so far in the cannabinoid space?

Lopez: We were the first to have stability data with creating our formulation in a soft gel capsule with CBD. We recently submitted to the European market for novel food application. We invested hundreds of thousands of dollars in proprietary safety studies that are required to achieve novel food status in Europe and FDA GRAS in the U.S. We have proprietary stability data as well as proprietary toxicology data from multiple, self-funded clinical studies. Many companies that submit for the EU novel food application are only referencing the existing scientific literature about the pharmacokinetics of cannabinoids, whereas we have our own peer-reviewed, published study. In our study, we compared our VESIsorb-CBD formulation to the industry standard MCT Oil-CBD formulation in a crossover design where we were able to demonstrate how we could dramatically improve the bioavailability of CBD.

Green: Can you talk about the benefits of your technology with regards to bioavailability and onset time?

Lopez: When you start talking about onset time we move into a broader discussion relative to cannabinoids. Weve been very successful with marijuana, especially as it relates to THC, because of the dramatic improvement in time to Tmax, and how much faster we reach Tmax than a standard THC formula. Our formulation is generally four times faster compared to standard formulations.

When it comes to area under the curve and Cmax, we show improvements of four to six times a standard THC or CBD product. Further, when we start looking at the differences between other studies that have been published, we show an even greater improvement based upon study comparisons to what other people have done, even compared to products like GW Pharmaceuticals Sativex Oromucosal Spray.

Green: Can you address the SEDDS formulation and liver metabolism?

Lopez: Weve dramatically overcome challenges with the first-pass effect. We have also formulated our products to address lymphatic absorption. So, were coming at it from a number of different angles.

We disagree with people who talk about water solubility as an end-all be-all solution. When you look at the range of published studies, whether its nanoparticles or liposomal systems or micro-emulsions, they all are water soluble systems, but yet the data shows theres dramatic differences in the real efficacy of those approaches, and what the actual improvement in blood levels are. Ultimately, those blood levels represent the efficacious nature of the products whether were talking about CBD, or talking about THC.

Green: As a Colorado-based company you work with cannabis partners across the US. Can you tell me about your relationship with marijuana product formulators and brands and how you structure your licensing agreements across state boundaries?

Lopez: In a recent article aboutthe leading fast acting gummies, the two companiesthey focused on were Sunderstorm with the Kanha Nano gummies and Curaleaf with their Select Fast Acting Nano gummies. Both of those companies use our VESIsorb technology. Were very proud of our relationship and the success theyre having as leaders in most dominant states with that particular product application.

Onset time has always been a challenge with gummies. And weve dramatically improved onset. Actually, weveshown statistically significant improvements for all measured pharmacokineticparameters in a recent peer-reviewed published study. We demonstratedmuch higher total absorption in maximum plasma concentration (Cmax), total exposure [area under the curve (AUC)]) and the time to reach the peak concentration (Tmax).

We say powered by VESIsorb technology the product is faster, stronger, longer.

Green: How does the experience differ from a standard oil- or isolate-based formulation?

Lopez: The only way that I can answer that question is weve had 100% success with the companies we work with in their initial trials. When someone tells me that a group of employees are going to try the product and theyre heavy users of cannabis and they are smokers, I think, wow, you know, gummies have to be really successfully formulated for someone like that to be pleased with the high. Then they come back and say, thats the best that Ive had in four years! and theyre totally blown away. Thats completely different than a peer reviewed published study, but for sure, thats the kind of feedback and anecdotal evidence that we get. I think thats why that application is growing so much faster now because weve overcome this onset issue.

Green: Do you give exclusive rights on a state-by-state basis?

Lopez: Were very selective about who we work with. Exclusivity is always part of the discussion. But at the same time, its really more about protecting the investment in the people that we partner with and not cannibalizing a given market. So, there are some exclusive relationships in the U.S. and internationally, like Heritage Cannabis and Pathway Health Corp in Canada, but for the most part, I would say simply, we were very selective about who we do business with and open to new partnerships.

Green: What kind of support do you provide to your licensing partners?

Lopez: We provide 100% formulation and technical support. We provide the SEDDS and then they use their own legal, licensed cannabis and their own equipment. Our system requires no special equipment or investment in changes to their process. So, not only do we provide formulation expertise, but our system is really easy to use both in a lab environment as well as producing large scale commercial productions.

Green: What geographies are you in currently with the cannabinoid formulations?

Lopez: We are global in scope. Weve been very fortunate to have success not only in the US and Canada, but Europe, Brazil and Australia as well. Our level of participation will vary whether were talking about medical marijuana, adult-use or hemp extract and CBD.

Green: If somebody is interested in learning more about your product or potentially becoming a license partner, how would they how would they reach out to you to set that up?

Lopez: If they went to our website, http://www.geocann.com, its pretty easy to reach us and I am grateful that so many companies are doing that.

Green: Great, thanks Jesse that concludes the interview!

More:
Leaders in Cannabis Formulations: Part 2 - Cannabis Industry Journal

Beverage brand bets on pterostilbene, unique turmeric constituent to boost health benefits – NutraIngredients-usa.com

Posted: at 1:51 am


The brand, called Happy Being, is the work of two recent Williams College grads, Dutch Buckley and Josemaria Silvestrini. The pair said they became interested in a health promoting beverage when sharing each other experiences with health challenges faced by various family members. Was there a product they would recommend their family members use that would improve their overall health on day-to-day basis?

The pair teamed with another co-founder, Chris Conway, a seasoned health products entrepreneur. One of his previous startups is called Everyday Throat Spray, an immune support product that combines various herbs with colloidal silver. Conway also operates a personalized nutrition service called Solutions 4 Health and is a former owner of standalone vitamin store.

We analyzed the marketplace and felt there really wasnt a lot out there what we would consider to be a true health promoting functional beverage, Conway said.

Buckley said his and Silvestrinis conversations with Conway opened their eyes to how much control individuals have over their own health.

We learned from talking with Chris about the role that epigenetics play, Buckley said. We wanted to create products that had not just a high perceived value but a high actual value.

One of the key ingredients in the product, which is being sold as a dietary supplement, is a 50 mg dose of pterostilbene. Conway said the research on this polyphenol, found in blueberries and other botanicals, was persuasive. The ingredient is similar to resveratrol in its anti oxidant and healthy aging effects, but its slightly different chemical structure imparts a greater bioavailability, Conway said.

In the research we have access to pterostilbene came up over and over, Conway said.

One recent issue with the ingredient has been an assertion that it raised LDL cholesterol levels in some subjects. Conway said the brand took that seriously and had its advisers had looked into the question.

We had our medical team take a look at that research very aggressively and they determined that that study was not something to really to be concerned about, he said.

In keeping with a theme of maximum bioavailability, the company chose a turmeric ingredient devoid of curcuminoids, which are usually though to be the powerhouse constituents of this popular botanical. The ingredient, branded as Turmacin, is manufactured by Indian ingredient developer Natural Remedies. It is a water soluble ingredient rich in the tumerosaccharides of the turmeric plant, which the developer claims have powerful health properties of their own. Natural Remedies markets the ingredient for joint support, but in the Happy Being formulation it is included for over inflammation control.

Silvestrini said the choice came down to one that would easily work in a beverage application. There are turmeric beverages on the market, but many suffer from the insoluble turmeric particles settling out of the solution. The traditional benefits of turmeric as part of a curry-based diet came from ingesting high amounts of the botanical on a daily basis and in the context of a fat-containing meal, so the poor unit absorption of the turmeric was less of an issue. Neither a large dose or a big slug of fat fits into a functional beverage value proposition.

The company had a lot of data on its ingredient in terms of its reduction of inflammatory makers. We really wanted to go with an option with a high bioavailability, Silvestrini said.

The products also include a green tea extract supplying 35 mg of EGCG per serving. Rounding out the ingredients list is a 1 gram dose of elderberry fruit powder for immune support.

The formulation rests on a base of organic white tea flavored in three options: peach rose, blueberry raspberry and lemongrass min. The product is positioned as a low calorie beverage at 25 calories per bottle, sweetened with a blend of cane sugar and monk fruit extract.

The co-founders faced the same conundrum many product developers using branded ingredients do: How much good stuff can you include and still keep costs under control? At the moment the product is in the premium price category at about $5 per bottle which is in line with a few other functional beverage competitors that pack in the functional ingredients. But the companys executives hope that as distribution scales up (the company is only a few weeks beyond its formal launch) those costs can come down with economies of scale. And in any case, Silvestrini said, the product is competing in a marketplace where many consumers think nothing of dropping $5 on a drink at a Starbucks.

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Beverage brand bets on pterostilbene, unique turmeric constituent to boost health benefits - NutraIngredients-usa.com

Chocolates are fun, but your heart needs better help than that – pentictonherald.ca

Posted: February 14, 2021 at 4:55 pm


Valentines Day, the largest chocolate and flower day of the year happens tomorrow. Youre welcome to all the gents reading this, you've still got time to pick up something for your sweetheart.

In addition to flowers, chocolate, wine and heart-shaped pizzas, paradoxically February is also heart-health month. As much as wed like to believe consuming a box of dark chocolates and a bottle of red wine after dinner can be good for the heart, the palette is by far the body part experiencing the greatest benefits.

Now, before you all go labelling me as anti-chocolate and no fun, I am a chocolate lover. In fact Ive created several chocolate recipes that are not only delicious, but healthy. Something Ive been able to share and help my clients stay on track with their health goals and not feel deprived. And on the rare occasion, Ill have a glass of red wine.

Dark chocolate and red wine both contain resveratrol, a component that does promote heart health. What most people dont know however, is that the amount of resveratrol youd ingest over dessert with your sweetheart, isnt enough to make a significant difference in your health.

As youve heard (or read) me say before, we can get all the nutrients our body needs from food. Theres no question God gave us great stuff here on this planet. The question is, do we? An article published by the Kressler Institute in 2018 reported, More than half the calories Americans consume, come from nutrient-depleted, ultra-processed foods... and went on to say that Nearly one-third (31%) of the U.S. population is at risk for at least one vitamin deficiency or anemia.

United States stats are always easier to dig up, but trust me, Canadians are right there too.

Since were smack dab in the middle of heart month, let's look at three supplements that are known for building and supporting a healthy heart. Ive already mentioned resveratrol. Coenzyme Q10 or CoQ10, and Omega 3.

As with any nutrient, taking a supplement should not be considered a replacement for the healthy foods that also contain the same nutrients. Supplements are to come alongside and fill the gaps, not provide a get-out-of-eating-your-veggies free card.

Of these three, if you take supplements at all, you're most likely using, or at least have heart of, omega 3s. Several types of fish including salmon, lake trout, sardines, herring, anchovies, as well as nuts, seeds, flaxseed, and chia all contain omega 3 fatty acids. Great for supporting brain function, alleviating rheumatoid arthritis, and joint pain, omega 3s also help to lower blood fat levels.

In other words, omega 3s help bring down elevated triglycerides and lowers cholesterol, which also brings down your risk of heart disease and stroke. And unless youre eating fish daily, supplementing is definitely a good idea.

Resveratrol, found in red grapes and cocoa beans red wine and dark chocolate is known for its antioxidant properties and a 2015 review posted on PubMed concluded high doses may help reduce the pressure exerted on artery walls when the heart beats, bringing down blood pressure.

Of course, consuming high doses of red wine or chocolate for that matter would produce the opposite effect, creating inflammation. So, supplementing is the way to go.

Researchers also found supplementing with resveratrol had a positive impact on overall cholesterol levels and may also help decrease plaque buildup inside

Unlike resveratrol and omega 3, Coenzyme Q10, or CoQ10, is something our bodies produce naturally.

According to a June 2019 article by Dr. Josh Axe, CoQ10 helps cells produce energy and neutralize free radicals, the damaged cells that cause illness and aging, improve heart health.

It offsets negative effects of statin drugs, slows down DNA damage due to aging, helps maintain ph balance, may slow or reverse the spread of some cancers, supports cognitive function, may improve male infertility, treats symptoms of fibromyalgia.

The amount of CoQ10 our bodies produce reduces with age. And although consuming foods that contain CoQ10 such as meats, poultry, fish, eggs, beans and nuts is something everyone should be doing, Dr. Axe goes on to say that for people who, struggle with certain health conditions, such as heart disease having chronic diseases, high levels of stress, deficient in vitamin B, mitochondria diseases, taking statin drugs, food alone may not be enough as these conditions further impede CoQ10 production.

And as the heart is just one of many areas CoQ10 is needed for optimal health, it's in our best interest to keep those levels up.

As with anything you put in your body, quality matters. Like your car, the better quality fuel you put in, the better performance youre going to get. Whether its food or supplements, same goes for your body. And in case there was any doubt, that old adage you get what you pay for, is true.

Februarys the perfect time to give your heart and yourself some love. Youre worth it.

Tania Gustafson is a nutritionist and fitness coach.

On the web: fuelignitethrive.com.

Email: tania@fuelignitethrive.com. Find healthy chocolate recipes at the 8 Weeks is All it Takes group on Facebook.

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Chocolates are fun, but your heart needs better help than that - pentictonherald.ca

Does Red Wine Have Any Effect on Weight Loss? – Healthline

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Red wine is the alcoholic drink of choice for many people, and its gotten a lot of buzz for its potential health benefits.

The drink, made from fermented red grapes, is loaded with antioxidants, but it can also be full of calories and sugar.

If youre trying to lose weight, you may be wondering if red wine could help you or if it would just be a hindrance.

This article reviews red wines nutrient content, what the evidence says about red wine and weight control, and how you can enjoy red wine while still losing weight.

A 5-ounce (148-mL) serving of red wine contains (1):

Most of the calories in red wine come from alcohol, which provides seven calories per gram, and the remainder comes from carbs (2).

Keep in mind that there are several different types of red wine, all with varying amounts of alcohol and sugar content, which will affect their total calorie count. Additionally, there will be some variation among brands.

A 5-ounce (148-mL) serving of red wine contains 125 calories, mostly from alcohol and carbs. There will be some variation among types and brands of red wine.

Several studies have assessed the link between alcoholic beverages and weight.

When it comes to weight management, there appear to be both pros and cons to drinking red wine.

Red wine is rich in resveratrol and other antioxidants that may benefit blood sugar control, heart health, and inflammation. Additionally, moderate wine consumption may help protect against excess weight gain (2, 3).

Red wine and other flavonoid-rich foods like olive oil, nuts, fruits, and legumes are considered staple foods in the Mediterranean-style diet, which has been associated with better weight control than a standard American diet (4, 5).

Unfortunately, evidence on the effects of red wine itself is fairly mixed. Some animal studies have found that red wine consumption decreases body weight and body fat levels, but others have found the opposite (6, 7, 8).

Additionally, a study in 29 people with obesity found that red wine antioxidants appeared to not affect blood sugar control (9).

However, other human studies have noted that moderate alcohol consumption may help improve blood sugar control potentially making it easier to manage weight (10, 11).

More research is needed before the effects of red wine on weight control are fully understood.

Several studies have noted that excess alcohol consumption is linked to weight gain especially in men (2, 12, 13).

Alcohol contains more calories per gram than carbs and protein, and many alcoholic beverages like beer, wine, and mixed drinks may also be loaded with sugar.

Because of this, it can be easier to consume more calories than you intend to when drinking alcohol (2, 14, 15).

Additionally, overconsumption of alcohol may lead to insulin resistance and blood sugar control problems, which may be a precursor to weight gain and type 2 diabetes (16).

Note that 5 ounces (148 mL) of wine is considered 1 serving, and moderate drinking is defined as no more than 2 servings of alcohol per day for men and 1 serving of alcohol per day for women (15).

Red wine is rich in the antioxidant resveratrol, but research is mixed regarding its positive weight effects. Excess alcohol consumption including red wine may lead to weight gain.

Luckily, you dont have to completely avoid drinking red wine if youre trying to lose weight.

Here are some ways that you can enjoy red wine without hindering your weight loss efforts:

As long as youre watching your portion sizes and drinking in moderation, wine shouldnt have a huge effect on your weight.

Additionally, if you notice that your weight loss is slowing down and nothing has changed except the amount or frequency of your red wine intake, try cutting back to see if that helps.

You can drink red wine and still lose weight as long as you limit how much you drink and track your calories.

Red wine is rich in antioxidants, but its also full of calories from alcohol and carbs. This makes it a mixed bag when it comes to weight loss.

Too much red wine, or any alcoholic drink, may hinder weight loss and contribute to weight gain. That said, red wine in moderation may provide some protective effects against weight gain.

To enjoy red wine while losing weight, make sure to stick to a single serving, avoid sugary dessert wines, and track your calories.

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Does Red Wine Have Any Effect on Weight Loss? - Healthline

What Happens To Your Body When You Eat Grapes | Eat This Not That – Eat This, Not That

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As far as healthy snacks go, it doesn't get much better than grapes. They're super convenient to pack and take with youand they taste good, to boot. Best of all, they're about 84% water. Simple, meaning you get an instant dose of hydration from munching on them. Grapes come in literally thousands of different varieties and colors, all of them delicious in their own unique way. But what happens to your body when you eat grapes? Well, a lot of things. While grapes offer a bevy of health benefits, they can also do more harm than good if you go overboard with your snackingwhich, let's be honest, is pretty easy to do with this fruit.

A 1-cup serving of red or green grapes contains 28% of your daily recommended intake for vitamin K, a nutrient that's essential for bone and heart health. Not only that, but they're extremely low in fat, sodium, and cholesterol, and an excellent source of vitamin C. Studies have shown that eating grapes doesn't just support your physical health, but also your cognitive health, too: One 2017 studyfound that when adults took a grape supplement daily, they improved their test scores for attention, memory, and language. That said, grapes are also high in sugar and carbs, and low in protein.

Grapes are incredibly versatileyou can snack on them right off the vine, incorporate them into smoothies, toss them into salads, or even freeze them for a popsicle-like treat. Now, if you're curious about what happens to your body when you eat grapes, read on. And for more healthy tips, be sure to check out our list of The 7 Healthiest Foods to Eat Right Now.

Grapes pack a whopping 23 grams of sugar per cup.However, certified nutritionist Paul Claybrook, MS, notes that this fruit is relatively low on the glycemic index, meaning they shouldn't cause your blood sugar to spike too much if you eat them in moderation.

"Your blood sugar will increase but not as significantly as something like soda would cause," he explains. "Part of the reason for this is that grapes contain some fiber, which slows down the speed at which your body can absorb nutrients, including sugar. There isn't a whole lot of fiber (just under a gram per cup) but it's enough to keep your blood sugar in a reasonable range as long as you aren't pigging out on them."

Grapes also contain a compound called resveratrol, which research has shown may increase insulin sensitivity, thus having a beneficial effect on your blood sugar levels.

Studies even say that Controlling This Hormone May Help Lower Blood Sugar.

You've heard of antioxidants, right? Those powerful substances that defend your body from free radical damage? Well, grapes are chock-full of them, and they can help protect and repair your cells from oxidative stresswhich is linked to the development of chronic diseases like cancer, heart disease, and diabetes.

"Oxidative stress simply means that there are too many free radicals (waste products) and not enough antioxidants (waste neutralizers) in your body to mop them up," explains Claybrook. "The result is damage to tissues that can lead to disease. Fortunately, grapes contain tons of antioxidants including flavonoids, phenolics, vitamin C, quercetin lutein, beta carotene, and resveratrol."

Research has revealed that grapes contain over 1,600 beneficial plant compounds, and since the highest concentration of antioxidants is in the seeds and the skin, it's better to eat them whole than simply drink grape juice. Additionally, it's also worth noting that red grapes are higher in antioxidants than green ones because they contain anthocyanins, a type of flavanoid that's responsible for their color.

Get even more healthy tips straight to your inbox by signing up for our newsletter!

Chronic inflammation can cause a number of long-term symptoms and health issues, including muscle aches and joint pain, weight gain, headaches, fatigue, and gastrointestinal problems. It's also been linked to cancer, heart disease, Alzheimer's, type 2 diabetes, arthritis, and other serious conditions.

Luckily, according to Claybrook, the diversity of powerful antioxidants found in grapes can help to reduce inflammation in the body. Specifically, resveratrol is known to have anti-inflammatory properties. Multiple studieshave found that taking grape powder extract can increase the levels of anti-inflammatory compounds in your blood.

Here are Instant Ways to Reduce Your Inflammation, According to a Doctor.

"While grapes are very healthy, too much of a good thing can still be a problem," says Claybrook.

If you were to eat, say, 2 cups of grapes, you'd be getting almost 47 grams of sugarthat's almost the equivalent of two candy bars.

"Sugar causes weight gain, so you don't want to eat grapes by the pound," adds Claybrook. "Grapes could also cause gas, bloating, diarrhea, and an upset stomach if you overdo it."

One serving is about 1/2 cup or 16 grapeswhich may seem small, but controlling your portion sizes of this fruit will allow you to reap the benefits without the risks of digestive issues and weight gain.

One cup of grapes contains an impressive 288 milligrams of potassium, which plays a key role in lowering blood pressure. Not only that but studies have shown that red grapes contain compounds that may help to reduce total and "bad" LDL cholesterol.

"The polyphenols in grapes have been shown to lower the risk of atherosclerosis (hardening of the arteries)," adds Claybrook. "They do this of course by eliminating free radicals but also improve the function of the tissues and help avoid LDL cholesterol from being damaged and sticking to blood vessel walls. They also help maintain the elasticity of blood vessels, thus reducing blood pressure and keep platelets from sticking together and creating clogs."

Here are 17 Foods That Lower Cholesterol.

Grapes are a stellar source of vitamin C, packing 27% of the RDI in 1 cup. As you may or may not know, vitamin C is an essential nutrient that benefits your immune system, which may explain why test-tube studies have shown that grape skin extract can protect against the flu virus.

In fact, 2013 research that compared the immune-boosting effects of hundreds of foods found that red grapes stood outmainly due to the resveratrol, which works with vitamin D to raise the expression of a specific gene involved in immune function.

Here are 8 Ways to Support a Healthy Immune System, According to Harvard.

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What Happens To Your Body When You Eat Grapes | Eat This Not That - Eat This, Not That

Global Resveratrol Market Report 2020 Industry Trends, Share and Size, Expected CAGR, Top Manufacturers and Consumer Analysis across the Region and…

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Resveratrol Market Overview

The report study researched by Adroit Market Research gives comprehensive knowledge and valuable insights about the Resveratrol Market. Also, the study attempts to deliver significant and detailed insights into the current market prospect and emerging growth scenarios. The report on the Resveratrol Market also emphasizes on market players as well as the new entrants in the market landscape.

The Resveratrol Market report is a precise and deep-dive study on the current state that aims at the major drivers, market strategies, and imposing growth of the key players. Worldwide Resveratrol Industry also offers a granular study of the dynamics, segmentation, revenue, share forecasts, and allows you to make superior business decisions. The report serves imperative statistics on the market stature of the prominent manufacturers and is an important source of guidance and advice for companies and individuals involved in the Resveratrol industry.

Get Sample PDF Brochure (including full TOC, Tables, & Figures) of Resveratrol Market @ https://www.adroitmarketresearch.com/contacts/request-sample/503?utm_source=bh

By Geographical Regions

Asia Pacific: China, Japan, India, and Rest of Asia Pacific Europe: Germany, the UK, France, and Rest of Europe North America: The US, Mexico, and Canada Latin America: Brazil and Rest of Latin America Middle East & Africa: GCC Countries and Rest of Middle East & Africa

Highlights of the Report:

Accurate market size and CAGR forecasts for the period 2019-2026 Identification and in-depth assessment of growth opportunities in key segments and regions Detailed company profiling of top players of the global Resveratrol Market Status and Trend Analysis 2019-2026 (COVID-19 Version) Exhaustive research on innovation and other trends of the global Resveratrol Market Status and Trend Analysis 2019-2026 (COVID-19 Version) Reliable industry value chain and supply chain analysis Comprehensive analysis of important growth drivers, restraints, challenges, and growth prospects

Competitive Analysis:

The Resveratrol industry company profile section of the report includes their basic information like website, legal name, market position, and headquarters, top competitors by market revenue or capitalization, and past background together with contact information.

The competitive evaluation of the application market brings monitoring into the product usage types of the current top players. Also, the study focusses on characteristic features & Resveratrol price, valuable reviews on the crucial products in the global market. The report offers key facts and figures on the Resveratrol market statistics, key competitors and is a significant source of guidance and business direction and an individuals interests in the Resveratrol industry.

Some of the Important and Key Players of the Global Resveratrol Market:

Jeunesse Global, DSM Nutritionals, Sirtris Pharmaceuticals Inc., Ltd., Resveratrol Enhanced Pty Ltd, Hill Pharmaceutical Co., Andorra Life, Terraternal, ResVitale LLC, Endurance Products Company, ASN Pharmaceutical LLC, Xieli Pharmaceutical, RevGenetics, GlaxoSmithKline and Evolva among others.

Complete Summary with TOC Available @ https://www.adroitmarketresearch.com/industry-reports/resveratrol-market?utm_source=bh

The report provides market size with 2019 as the base year in consideration and a yearly forecast until 2025 in terms of Revenue (USD Million). The estimates for all segments including type and application have been provided on a regional basis for the forecast period mentioned above. We have implemented a mix of top-down and bottom-up approaches for market sizing, analysing the key regional markets, dynamics, and trends for various applications.

The report of Resveratrol Market studies the key players present in the market. The chapter includes the competitive landscape section which provides the full and in-depth analysis of the current market trends, changing technologies, and developments that will be beneficial for the companies, which are competing in the market. The report offers an overview of revenue, demand, and supply of data, futuristic cost, and growth analysis during the projected year. In addition to a brief overview of the company, analysts shed light on their valuation and evolution. It also discusses the list of important products and the ones in the pipeline. The competitive landscape is analysed by understanding the approaches of the companies and the initiatives they have taken in recent years to triumph over the intensive competition.

Resveratrol Market Segmentation

Type Analysis of Resveratrol Market:

Form Segment, (Liquid supplements,Powdered form,Red wine pill), Type Segment, (Grape seed extract,Natural resveratrol,Japanese knotweed extract), Distribution channel Segment, (Drug stores,Departmental stores,Hypermarket/supermarket,Online stores,Others)

Applications Analysis of Resveratrol Market:

Application Segment, (Cosmetics,Pharmaceuticals,Dietary supplements,Others)

Reasons for Purchasing Resveratrol Market Report:

This report provides pin-point evaluation for changing competitive dynamics of Resveratrol market It supplies a forward-looking viewpoint on Various factors driving or restraining keyword market growth It supplies an eight-year forecast assessed based on the way the Resveratrol market is predicted to increase This will help in knowing the key product segments along with their future It provides pin point evaluation of altering competition dynamics and keeps you ahead of competitors This will help in making informed business decisions by having complete insights of Resveratrol market and by making in-depth evaluation of Resveratrol market segments

Key benefits to buy this report: What are the key market trends? What are the market dynamics? What are the constraints on category growth? What are the category growth drivers? What are the demand-supply shifts? Who are the suppliers in this market?

Table of Contents: Resveratrol MarketChapter 1. Resveratrol Market OverviewChapter 2: State of the World Market and Forecasts by RegionChapter 3: State of the World Market and Forecast by TypeChapter 4: Global Market State and Prospects for the Downstream SectorsChapter 5: Analyzing Market DriversChapter 6: The State of Market Competition of Major ProducersChapter 7: Major Producers and Market DataChapter 8: Exploration and Production Market AnalysisChapter 9: Cost and Gross Profit AnalysisChapter 10: Analyzing Marketing Status

For any queries get in touch with Industry Expert @ https://www.adroitmarketresearch.com/contacts/enquiry-before-buying/503?utm_source=bh

About Us :

Adroit Market Research is an India-based business analytics and consulting company incorporated in 2018. Our target audience is a wide range of corporations, manufacturing companies, product/technology development institutions and industry associations that require understanding of a Markets size, key trends, participants and future outlook of an industry. We intend to become our clients knowledge partner and provide them with valuable Market insights to help create opportunities that increase their revenues. We follow a code- Explore, Learn and Transform. At our core, we are curious people who love to identify and understand industry patterns, create an insightful study around our findings and churn out money-making roadmaps.

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Global Resveratrol Market Report 2020 Industry Trends, Share and Size, Expected CAGR, Top Manufacturers and Consumer Analysis across the Region and...

I Live in the Mountains, and This $30 Hyaluronic Acid Moisturizer Is the Only Thing That Hydrates My Skin – Yahoo Lifestyle

Posted: at 4:55 pm


Winky Lux Cream

Courtesy/InStyle

I've been spending the winter in the mountains of New Hampshire, which is wonderful for my mental health and terrible for my skin. While I thought subjecting my skin to Boston's city pollution was bad, it's apparently much more adverse to harsh, sub-zero winds and frequent snowstorms. I'd slather expensive cream on my red, chapped cheeks only to wake up with a sprinkling of acne and an oily complexion. Thankfully, I discovered the newly formulated Winky Lux Dream Gele Moisturizer, and my skin is finally at peace.

If I'm being honest, I was initially skeptical because this cream is only $30. If my $100 celebrity-touted products weren't doing the trick, why would a budget-friendly option? Desperation and curiosity led me to try it anyways. Plus, my New Year's resolution was to clean up my skincare a bit, so I liked that it's vegan, cruelty-free, phthalate-free, sulfate-free, and paraben-free.

Shop now: $30; winkylux.com

When I tried the cream, I was impressed that it not only felt lightweight, but that it also melted in, almost like my parched skin was finally taking a long drink of water. The formula was cooling and gave my irritated skin the same sort of relief aloe vera gives a sunburn which makes sense, because aloe vera is one of the key ingredients. I also liked that the formula contained salicylic acid so I'd avoid the dreaded post-moisturizer breakouts.

I let the cream melt into my skin overnight and assessed the results in the morning. Like any good cream containing hyaluronic acid and glycerin, the moisturizer helped to soften and hydrate my dry, flaky patches overnight. Unlike any other cream I'd tried, though, I woke up with a clearer, brighter complexion than the night before. Not only was I free of acne, but the moisturizer appeared to have this plumping effect (thank you, caffeine) that made me look downright dewy. Honestly, I was a little embarrassed to go into the kitchen looking so glowy when the rest of my household was nursing mild winter-induced wind burns.

The cream's newly enhanced formula also contains resveratrol, an ingredient that helps to protect the skin's natural moisture barriers from environmental aggressors, so now I'm proactive against the elements by blending the cream with my sunscreen for my morning walks. Tip: This also makes for a great primer if you're wearing makeup during the day.

Going forward, I'll be saving myself the trouble of purchasing overly priced creams and sticking to Winky Lux's Dream Gele Moisturizer. Shop the top-rated cream now and glow later.

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I Live in the Mountains, and This $30 Hyaluronic Acid Moisturizer Is the Only Thing That Hydrates My Skin - Yahoo Lifestyle

[Full text] Application of Radiosensitizers in Cancer Radiotherapy | IJN – Dove Medical Press

Posted: at 4:55 pm


Introduction

Cancer remains one of the greatest challenges to human health. World Health Organization (WHO) reported that about 8.8 million deaths worldwide were due to cancer in 2015, and the deaths are expected to break through 13 million in 2030 according to the report by the International Agency for Research on Cancer (IARC). To reduce the deaths from cancer, several strategies have been developed in recent years to improve cancer therapy including surgery, radiotherapy, chemotherapy, immunotherapy, targeted therapy, hormone therapy, stem cell transplant and precision medicine.1 Among them, radiotherapy (RT) is considered as one important and effective modality to kill or control tumors since Marie Curie, the Nobel Prize winner, discovered radioactivity.2 Typically, RT is a treatment modality to cancer cells by using high-energy photon radiation such as X-rays, gamma ()-rays, and others. RT can take effect via direct and indirect mechanisms to destroy cancer cells and tumor tissue (Figure 1).

Figure 1 Schematic of the mechanism of ionizing radiation (IR) in RT. In the case of direct effect, IR directly damages the DNA, which, if unrepaired, results in cell death or permanent growth arrest. In the case of indirect effect, ROS are formed by the radiolysis of a large amount of water and oxygen, and then the ROS damage the DNA. There are many types of DNA damage, such as base change, SSB, DSB, cross-linkage with protein or with other DNA molecules.

In the direct action, radiation directly induces single-strand breaks (SSB) and double-strand breaks (DSB) in DNA, resulting in the termination of cell division and proliferation, or even cell necrosis and apoptosis. In the case of indirect action, radiation induces the generation of ROS, which can induce cellular stress in, and injure biomolecules, and and ultimately alter cellular signaling pathways. Clinical studies have shown that more than half (about 70%) of patients need to receive RT, and in some cases RT is the only kind of cancer treatment.3 Therefore, there is a great need to develop approaches to improve radiosensitivity.

Innovative technologies can provide alternative strategies to improve RT efficiency. For example, image-guided radiation therapy (IGRT) is the use of imaging during radiation therapy to improve the precision and accuracy of treatment delivery. IGRT can be used to treat tumors in areas of the body that move, such as the lungs. RT machines are equipped with imaging technology to allow your doctor to image the tumor before and during treatment. By comparing these images to the reference images taken during simulation, the patients position and/or the radiation beams may be adjusted to more precisely target the radiation dose to the tumor. To help align and target the radiation equipment, some IGRT procedures may use fiducial markers, ultrasound, MRI, X-ray images of bone structure, CT scan, 3D body surface mapping, electromagnetic transponders or colored ink tattoos on the skin.4 Intensity-modulated radiation therapy (IMRT) is an advanced mode of high-precision RT that uses computer-controlled linear accelerators to deliver precise radiation doses to a malignant tumor or specific areas within the tumor.5 Although the abovementioned innovative technologies greatly improve the therapeutic effect, there are still obstacles such as cancer stem cells and tumor heterogeneity making it difficult to use RT alone to cure tumors. Radiosensitizers with the ability to increase the radiosensitivity of tumor tissue and pharmacologically decrease normal tissue toxicity are expected to be an efficient way to improve RT.6

Radiosensitizers are compounds that, when combined with radiation, achieve greater tumor inactivation than would have been expected from the additive effect of each modality. G E Adams, a pioneer in the field of RT, classified radiosensitizers into five categories: (1) suppression of intracellular thiols or other endogenous radioprotective substances; (2) formation of cytotoxic substances by radiolysis of the radiosensitizer; (3) inhibitors of repair of biomolecules; (4) thymine analogs that can incorporate into DNA; and (5) oxygen mimics that have electrophilic activity.7,8 This classification was based on the mechanism of DNA damage and repair and indicated the direction for radiosensitizers at the early stage. However, with the continuous technological innovation, more and more materials and drugs with radiotherapy sensitization have been defined as radiosensitizers. In addition, some in-depth mechanisms for radiosensitization have also been discovered.9,10 According to the latest research, radiosensitizers can be classified into three categories based on their structures: small molecules (Figure 2), macromolecules (Table 1), and nanomaterials (Table 2).11 In the following part, the applications, the main role, and influencing factors of these three types of radiosensitizers are first summarized, especially those have currently entered clinical trials. Second, the development status and the mechanism of action of the radiosensitizer are also summarized. Third, the future development and application of the radiosensitizer was presented.

Figure 2 Molecular structures of some representative small-molecule radiosensitizers discussed in this paper.

Table 1 Some Macromolecule Radiosensitizers Discussed in This Paper

Table 2 The List of Nanomaterials Used for Radiosensitization

Hypoxia in tumor microenvironment is one of the major limitations to radiotherapy. Tumor cells in the hypoxic microenvironment are much more resistant to radiation than in the normal oxygen microenvironment.1214 Oxygen enhancement ratio (OER) or oxygen enhancement effect in radiobiology refers to the enhancement of the therapeutic or detrimental effect of ionizing radiation due to the presence of oxygen. This so-called oxygen effect is most notable when cells are exposed to an ionizing radiation dose.15,16 Oxygen, a potent radiosensitizer, promotes free radical formation through its unique electronic configuration. As the most electrophilic cellular molecule, oxygen is easily reduced by electrons formed from the incident radiation. After oxygenated tumor irradiation, energy transfer results in the radiolysis of water with the initial formation of an ion radical that then forms the highly reactive hydroxyl radical after reaction with another water molecule. Oxygen leads to the formation of peroxide after reaction with the hydroxyl radical. Then, the peroxide results in permanent cellular and DNA damage.13

Accompanied with solid tumor growth, the surrounding vasculatures are not in sufficient quantities to supply oxygen to the new cells, the cancer cell mass becomes heterogeneous gradually, and necrosis occurs following ischemia. Normally, cancer cells undergo apoptosis through the p53 pathway, while those heterogeneous cells adapt to the hypoxic environment efficiently by activation of additional signaling pathways, especially the hypoxia-inducible factor (HIF) pathway.1719 Studies showed that HIF-1 was associated with vascular endothelial growth factor (VEGF) signaling pathway, glucose transport, and glycolysis pathway, which could help the tumor to build vasculature.1921 Under hypoxia, the cancer cells are more aggressive and resisted radiotherapy significantly. Thus, hypoxia often occurs in most solid tumors and leads to radioresistance both through increasing free radical scavenging and changing patterns of gene expression.22,23

More and more research has been devoted to overcoming hypoxia problems, from using high-pressure oxygen tanks and blood substitutes that carried oxygen, to using intricate, accurate approaches that proportionated differences in partial pressure of oxygen (PO2) between tumors and healthy tissue.24,25 Hyperbaric oxygen is the most direct method to ameliorate hypoxia in tumor cells, while this method is inconvenient and may increase complications sometimes.26,27 A new radiosensitizer, Kochi oxydol-radiation therapy for unresectable carcinomas (KORTUC), is being evaluated by a Phase I/II clinical trial (NCT02757651) for the treatment of malignant tumors that contain numerous hypoxic cancer cells and/or large quantities of antioxidative enzymes.28

Oxygen mimetics, using the chemical properties of molecular oxygen as a template, have higher electron affinity and better diffusion properties to anoxic tissue than oxygen. As oxygen mimetics can theoretically substitute for oxygen in fixing radiation-induced damage of DNA, making it nonrepairable and hence lethal. Therefore, oxygen mimetics are considered as true radiosensitizers. The most representative oxygen mimetics are nitro-containing compounds and nitric oxide (NO).13

The prototype of electron-affinity radiosensitizers is nitrobenzene, and then researchers focus on nitroimidazole and its derivatives.2931 Nitroimidazoles, which undergo enzymatic and radiation-induced redox reactions. These agents are intrinsic inactive, their effect becomes evident only in the presence of ionizing radiation to fix or stabilize DNA radical lesions in oxygen-deficient cells.32 Misonidazole, a 2-nitroimidazole, is one of the earliest developed nitroimidazoles. In preclinical studies, misonidazole showed better radiosensitizing effect than 5-nitro imidazole or metronidazole (Flagyl) in the majority of solid murine tumors.3335 However, the results were unsatisfactory in clinical trials, since severe neurotoxicity was caused by misonidazole.3639 Metronidazole, a 5-substituted nitroimidazole, which has less electron-affinic was proven as an inferior radiosensitizer.40,41 In conclusion, because of the dose-limiting toxicity at clinically tolerable doses, misonidazole and metronidazole are not the ideal candidates in radiotherapy.42

In view of the issues discussed above, further efforts have been made to improve the pharmacokinetic properties of nitroimidazoles. Second-generation nitroimidazole radiosensitizers, such as etanidazole or nimorazole, are designed to increase the hydrophilicity of the reagents and thereby reduce neurotoxicity. For example, etanidazole has better hydrophilicity than misonidazole because its side chain is modified by hydroxyl.43 Although etanidazole presents lower preclinical toxicity and higher efficacy, it shows no obvious benefit for head and neck cancer patients in randomized studies.44 Nimorazole, a 5-nitroimidazole, is recommended for the treatment of head and neck cancers in Denmark since its beneficial effects in several clinical trials. Moreover, it has been further explored in an EORTC international trial.4551 Notably, the DAHANCA 28 trial demonstrated that hyperfractionated, accelerated radiotherapy with concomitant cisplatin and nimorazole (HART-CN) for patients was feasible and yielded favorable tumor control.52 Other nitro compounds have also been exploited for hypoxia radiosensitization. Dinitroazetidine, RRx-001, has been evidenced as an effective radiosensitizer with low toxicity and is now being evaluated in the NCT02871843 clinic trial.53

Nitrogen oxides, in particular, NO, act as radiosensitizers through many direct and indirect mechanisms. Similar to the oxidative stress induced by oxygen, NO can fix or stabilize radiation-induced DNA damage through nitrosative stress pathways.54 Oxidative and nitrosative stress pathways involve the generation of reactive species. For example, nitrous acid, peroxynitrite (ONOO), and nitric acid produce cytotoxic effects through mechanisms including DNA cross-linking, protein nitrosylation, glutathione depletion, and inhibition of mitochondrial respiration.5558 As an uncharged free radical, NO can diffuse across cell membranes freely and bind to soluble guanylate cyclase (sGC) to induce cyclic GMP production, thereby regulating vascular physiology.5961 Researchers have reported that 5-nitroimidazoles and sanazole can release NO.62,63

A phase I study of non-small-cell lung cancer (NSCLC) patients suggested that NO donation increased tumor perfusion and, therefore, promoted tumor growth.64 However, a phase II study of prostate cancer patients claimed that low-dose NO had no direct cytotoxic effect, but could decrease hypoxia through improving blood flow in tumor tissue.65 Some anticancer drugs approved by US Food and Drug Administration (FDA), such as bevacizumab, sorafenib, and etaracizumab played their roles by blocking the VEGF pathway to some extent.66 VEGF is overexpressed in anoxia environment, which leads to endothelial cell proliferation and neovascularization. In angiogenesis, there is a positive and negative feedback regulation relationship between VEGF and NO, which maintains vascular homeostasis precisely.67 In addition, Liebmann et al proved that pretreatment with NO improved the survival of mice after irradiation.68

In recent years, more and more researchers reported that active compounds from Chinese herbs such as curcumin,6971 resveratrol,7274 dihydroartemisinin7577 and paclitaxel,7880 could enhance tumor radiotherapy sensitivity (Figure 2). Curcumin is a polyphenolic active compound extracted from turmeric. Curcumin exerts anti-inflammatory effect by inhibiting the transcription factor NF-B, which is involved in both tumorigenesis and radioresistance.81 In a preclinical study, Chendil et al reported that when treated with RT and curcumin together, the human prostate cancer cell line, PC3 presented threefold fewer surviving and the mechanism was supposed to have a relationship with NF-B.82 In addition, nanocurcumin as a radiosensitizer is being evaluated by a Phase II clinical trial (NCT02724618). Other relevant research on mutant p53 Ewings sarcoma cells proved that radiosensitivity of curcumin was associated with other p53-response genes.83

Resveratrol is an active compound extracted from grapes, knotweed, peanuts, mulberry and other plants. Tan et al proved that resveratrol enhanced the radiosensitivity in nasopharyngeal carcinoma cells by downregulating E2F1.73 Liao et al found that resveratrol enhanced radiosensitivity in human NSCLC NCI-H838 cells by inhibiting NF-B activation.84 Dihydroartemisinin is a derivative of artemisinin, which can shorten the G2/M phase, while increases the G0/G1 and S phase, thereby reducing the radiation resistance.85 Although the relevant clinical research has not yet been carried out, researchers have demonstrated that resveratrol8689 and dihydroartemisinin9092 possessed radiosensitization on cancer cells in vitro.

Paclitaxel is widely known as a very good natural anticancer drug.93,94 As a new type of antimicrotubule drug, paclitaxel can inhibit the microtubule networks formation and prevent the tumor cells proliferation to achieve radiosensitization.95 Results showed that paclitaxel could obviously enhance the radiosensitivity of inoperable patients with locally advanced esophageal cancer and improve the prognosis of patients with acceptable therapeutic effect.96 A three-arm randomized Phase III trial (NCT02459457)comparison of paclitaxel-based three regimens concurrent with radiotherapy for patients with local advanced esophageal cancer and a Phase III study (NCT01591135) of comparing paclitaxel plus 5-fluorouracil vs cisplatin plus 5-fluorouracil in chemoradiotherapy for locally advanced esophageal carcinoma are underevaluated.

Some bioreductive agents, such as aromatic N-oxides, transition metal complexes, quinones, aliphatic N-oxides and nitro compounds, have radiosensitization effects by virtue of their preferential cytotoxicity toward hypoxic cells.11 Tirapazamine (TPZ), a hypoxia-selective radiosensitizer, has shown promising results in clinical trials.97,98 Under hypoxic environments, TPZ can be reduced by reductase in cells to a metabolite that produces free radical and then leads to SSB, DSB, and base damage on DNA.99 A Phase I clinical trial of TPZ with cisplatin and radiotherapy in small cell lung cancer showed prolonged survival of patients.100 A Phase II study of TPZ with chemoradiotherapy in locally advanced head and neck cancer reported improvements in failure-free survival and response of patients.101 However, further phase III trials of TPZ with chemoradiotherapy in locally advanced head and neck cancer concluded that there was no obvious improvement in patient survival.102 In addition, SN30000 (previously known as CEN-209), an analog of TPZ, with more favorable diffusion property that provides greater toxicity in hypoxic cancer cells than TPZ, is currently under development by the Drug Development Office of Cancer Research UK.103

AQ4N, a representative to aliphatic N-oxide, can be reduced to AQ4 by cytochrome P450 isoenzymes or nitric oxide synthase 2A.104 In vivo experiments showed that combined utilization of AQ4N with radiotherapy resulted in increased antitumor efficacy, as well as negligible toxicity to normal tissue compared with radiation alone.105 Positive results were also evidenced in Phase I clinical trials.106 A Phase I clinical trial in glioblastoma and head and neck tumor patients proved that AQ4N could be specifically activated in hypoxic regions of solid tumors.107 Unfortunately, a Phase II clinical trial of AQ4N with radiotherapy and temozolomide in glioblastoma began in 2006, was in a pending status (NCT00394628).

TH-302 (evofosafamide), a similar compound that can be reduced to bromo-isophosphoramide mustard in hypoxic conditions, has radiosensitization activity, especially in hypoxic cells.108,109 In preclinical models of rhabdomyosarcoma (skeletal muscle) and NSCLC, TH-302 combined with radiotherapy treatment resulted in significant tumor growth delay.110 In addition, in a study in patient-derived xenograft models of pancreatic cancer, combination treatment of TH-302 and radiotherapy was more efficient than either treatment alone.111 TH-302 can specifically target the hypoxic tumor cells and induce DNA damage simultaneously in adjacent tumor tissue of the hypoxic zone, and thus holds potential radiosensitization effects in solid tumor treatment.112 However, on the database of US National Institutes of Health clinical trials, only one of the 26 trials listed proposed combination treatment of TH-302 with radiotherapy (NCT02598687), and it was withdrawn because two phase III trials did not meet their primary endpoint.113

Mitomycin C, a quinone-based anticancer therapeutic, can be activated via DNA cross-linking. In preclinical study, mitomycin C showed only slight toxicity in hypoxic cells, which promotes the development of other hypoxia-sensitive quinones selection.114 Among them, porfiromycin (POR) and apaziquone (EO9) are bioreductive prodrugs, represent the leading candidates.104 Preclinical studies concluded that POR held higher hypoxic selectivity than mitomycin C.115 Although preclinical trials proved POR had acceptable toxicity, the following Phase 3 trial demonstrated that POR had a poorer therapeutic effect than mitomycin C.116 Preclinical studies indicated that EO9 had greater antitumor property than mitomycin C, indicating EO9 can be a ideal radiosensitizer.117

Other types of chemical radiosensitizers have also seen some progress and some of them are in preclinical evaluations. For example, chemicals that influence cell signaling, suppress radioprotective substances, pseudosubstrates and targeted delivery systems are exploited. With the development of research on radioresistance mechanism, it has been found that multiple signal pathways are related to radioresistance, providing more targets for radiosensitization, such as PI3KAktmTOR,118 Wnt,119 MAPK,120 MDM2121 and c-METPI3KAkt.122 For example, BKM120, the oral PI3K inhibitor, can inhibit the activity of PI3K/Akt by targeting the PI3K-Akt pathway, thereby increasing cell apoptosis and inhibiting DNA double-strand break repair in liver cancer cells.123 BEZ235, a dual PI3KmTOR inhibitor, can improve the radiosensitivity of colorectal cancer cells.124 AMG 232, a picomolar affinity piperidinone inhibitor of MDM2, can suppress tumor growth on a mouse model.121

Suppression of radioprotective substances, such as glutathione (GSH), is another strategy of radiosensitization. Inhibition of GSH can prevent DNA damage repair and lead to increased damage in tumor cells, which improves the efficacy of radiotherapy in turn.125 In addition, pseudosubstrates lead cells undergoing DNA synthesis unable to distinguish thymidine and its halogenated analogs efficiently. It is a new area of clinical research to use halogenated pyrimidine analogs, like bromodeoxyuridine (BrdUrd) and iododeoxyuridine (IdUrd), as potential clinical radiosensitizers.126 One study demonstrated that electron affinities of 5-halogenated deoxyuridine led to enough ability to bind a radiation-produced secondary electron, thereby increasing the sensitivity of radiotherapy.127

In addition, research on new indications for existing drugs provides a new paradigm for the development of radiosensitizers. For instance, papaverine, an ergot alkaloid first isolated from Papaver somniferum in 1848, has been used for treatment of vasospasm, cerebral thrombosis, pulmonary embolism and erectile dysfunction.128 Denko et al identified papaverine as an inhibitor of mitochondrial complex I and proved that papaverine could increase oxygenation and enhance radiation response.128 A phase I trial (NCT03824327) study on papaverine and stereotactic body radiotherapy (SBRT) for NSCLC or lung metastases is under evaluation. In summary, small-molecule chemicals as radiosensitizers initiated in the past five years under clinical trials are summarized in Table 3.

Proteins and peptides, such as antibodies and short peptides, have high affinity with antigens and receptors overexpressed on the surface of tumor cells, making them usable as radiosensitizers.129 For instance, HER3-ADC, a maytansine-based antibody-drug conjugate targeting HER3, which induces cell arrest in the G2/M phase to inhibit DNA damage repair and thereby improves radiosensitivity of HER3-positive pancreatic cancer cells.130 SYM004, a epidermal growth factor receptor targeting antibody, can inhibit DNA double strand breaks repair and induces apoptosis via downregulating MAPK signaling, and thereby improves radiosensitivity in tumor cells.120 Cetuximab and nimotuzumab, binding the epidermal growth factor receptor (EGFR), can increase radiation-induced apoptosis and DNA damage, and thereby improve the radiosensitivity of human epidermal-like A431 cells.131 The hepatocyte growth factor (HGF)/Met signaling pathway which mediates DNA double-strand break repair is upregulated in the majority of cancers. AMG102, a monoclonal antibody against HGF, can inhibit DNA damage repair and increase radiosensitivity of glioblastoma multiforme.132 In addition, proteins and peptides in serum, such as C-reactive peptide,133 HSP134 and paraoxonase-2135 contribute to radioresistance and can be used as radiotherapy targets. ECI301, a mutant derivative of macrophage inhibitory protein-1a, can be assisted by HSP-70 and HMGB1, thereby enhancing the effect of radiotherapy.134 Other proteins, like DNAzyme (DZ1)136 and NKTR-214,137 can also improve the effect of radiotherapy.

MicroRNAs (miRNAs), which encode by endogenous genes are noncoding single-stranded RNA molecules containing about 22 nucleotides. Studies have shown that some specific miRNAs can be used to improve radiotherapy efficacy138,139 and some miRNAs can be used as radiotherapy sensitization targets.140 For example, miR-621 targets SETDB1 in hepatocellular carcinoma can be used as a tumor radiosensitizer directly.141 miR-205 targets zinc finger E-box binding homeobox 1 (ZEB1) and the ubiquitin-conjugating enzyme Ubc13 to enhance the radiosensitivity of breast cancer cells.142 miR-144-5p targets ATF2 to enhance radiosensitivity of NSCLC.143 miR-146a-5p enhances radiosensitivity in hepatocellular carcinoma through activation of DNA repair pathway.144 miR-150 modulates AKT pathway in NK/T cell lymphoma to enhance radiosensitivity.145 miR-99a targets mTOR pathway to enhance the radiosensitivity of NSCLC.146 miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense.147 Transcriptional activation of miR-320a induces cancer cell apoptosis under ionizing radiation conditions.148 However, inhibition of miR-21-5p promotes the radiation sensitivity of NSCLC.149 Inhibition of miR-630 enhances radiotherapy resistance in human glioma by directly targeting CDC14A.150 Furthermore, a clinical study included 55 atypical meningioma patients found in seven upregulated miRNAs (miR-4286, miR-4695-5p, miR-6732-5p, miR-6855-5p, miR-7977, miR-6765-3p, miR-6787-5p) and seven downregulated miRNAs (miR-1275, miR-30c-1-3p, miR-4449, miR-4539, miR-4684-3p, miR-6129, miR-6891-5p) in patients. Those miRNAs may induce radioresistant and radiosensitive, respectively.

siRNA, known as short interfering RNA or silencing RNA, is a class of double-stranded RNA, noncoding RNA molecules, typically 2027 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway.151 HuR is a protein related to radiotherapy resistance, knockdown of HuR by siRNA resulting DNA damage and enhanced radiosensitivity.152 S100A4, a member of the S100 family of transcription factors, modulates various activities of malignant tumor cells through different mechanisms. A short siRNA against S100A4 enhances the radiosensitivity of human A549 cells.153 NBS1 plays an important role in the radiation-induced DNA double-strand breaks reparation, siRNA targets NBS1 can increase radiation sensitivity of cancer cells.154 Survivin, a member of the inhibitor of apoptosis (IAP) protein family, is overexpressed in most cancers resulting in aggressive behavior of tumor and therapy resistance. Downregulation of survivin by siRNA can enhance radiosensitivity in head and neck squamous cell carcinoma.155 Therefore, numerous siRNAs can be used as radiosensitizers by silencing genes related to radioresistance.

Similar to siRNAs, oligonucleotides also play important roles in gene expression regulation. Since they are easy to design and synthesize, antisense oligonucleotides have great potential to develop as radiosensitizers.11 Telomerase expresses in many kinds of tumors (>85%), while the expression of telomerase is restricted in normal tissues. A study indicated that expression of telomerase could be inhibited by radiolabeled oligonucleotides, which targeted the RNA subunit of telomerase, thereby inducing DNA damage in telomerase-positive tumor cells.156 In addition, the phosphorothioate-modified antisense oligonucleotides (PS-ASODN) against human telomerase reverse transcriptase were reported to promote radiotherapy effect in liver cancer.157 Furthermore, Park et al reported that inhibition of cyclic AMP response element-directed transcription using decoy oligonucleotides enhanced tumor-specific radiosensitivity.158 Yu et al demonstrated that antisense oligonucleotides targeted human telomerase RNA (hTR ASODN) could improve the radiosensitivity of nasopharyngeal carcinoma cells.159 The radiosensitization mechanism of macromolecules was summarized in Figure 3.

Figure 3 Radiosensitization mechanism of macromolecules. (A) Proteins and peptides. (a1) Direct interaction of key proteins. (a2) Loading of radioactive seeds. (a3) Radiosensitizers delivery. (a4) Conjugation with nanomaterials. (B) miRNAs can then bind with mRNAs to implement radiosensitization. (b1) Downregulation by inhibitors. (b2) Upregulation. (C) siRNAs can improve radiosensitivity by binding and degrading complementary mRNAs. (D) Oligonucleotides improve the radiosensitivity by complementary binding with DNAs.

The X-ray absorption coefficient () represents the relationship between the X-ray absorption phenomenon (E) and atomic number (Z), =Z4/(AE3), where is the density and A is the atomic mass of the element.160 Therefore, the change of atomic number (Z) causes a significant change of X-ray absorption coefficient (). Noble metal nanomaterials, such as gold (Au, Z=79), silver (Ag, Z=47) and platinum (Pt, Z=78) can effectively absorb X-ray energy and interact with radiation in tumor cells, and then emit photoelectrons, auger electrons, compton electrons and other secondary electrons. These secondary electrons not only interact with DNA directly, but also react with water to increase the production of ROS and further increase the sensitivity of tumor cells to radiation. This process is a physical sensitization mechanism.161 Furthermore, functionalized noble metal nanomaterials promote the generation of ROS, transfer the cell cycle into a radiosensitive state, and inhibit p53 signaling pathway to induce cell autophagy and lysozyme body function disorder, thereby increasing radiotherapy sensitivity. This process is a biochemical sensitization mechanism.162,163

Gold nanoparticles with good chemical stability, easy preparation, controllable size and shape, easy surface functionalization, high biocompatibility, and low toxicity have proven satisfactory radiosensitizing effects in various tumors.164167 Silver nanoparticles and platinum nanoparticles are also commonly used in biomedicine.168,169 Research found that silver nanoparticles combined with radiotherapy could enhance the radiosensitivity of human glioma cells in vitro and extended the survival time of glioma mice.170,171 Liu et al demonstrated that silver nanoparticles could induce apoptosis of cancer cells through G2/M phase arrest after radiation, and they suggested that silver nanoparticles could be used as a nanoradiosensitizer for hypoxic glioma radiotherapy.172 Recently, Fathy reported that thymoquinone-capping silver nanoparticles represented a promising engineered nanoformulation for enhancing cancer radiosensitivity.173 Li et al demonstrated that platinum nanoparticles could enhance radiosensitivity through increasing DNA damage, ROS stress, and cell cycle arrest.163 They also proved that platinum nanoparticles could convert endogenic H2O2 to O2 in cancer cells, thus significantly improving radiosensitivity without apparent toxicity to animals in vivo.163

Similar to noble metal nanomaterials, gadolinium (Gd, Z=64), hafnium (Hf, Z=72), tantalum (Ta, Z=73), tungsten (W, Z=74), and bismuth (Bi, Z=83) are also metal elements with large atomic coefficients and have a great X-ray attenuation capability.174176 Based on this, numerous studies have focused on these heavy metal nanomaterials to investigate their radiotherapy sensitization. However, they usually cause damage to healthy tissues with direct contact.177 Therefore, their stable forms such as oxides, sulfides, and selenides are explored as the radiosensitizers.178180

Gadolinium-based nanoparticles are usually known as magnetic resonance imaging (MRI) contrast agents. It should be noted that researchers discovered a family of gadolinium-based nanoparticles called AGuIX for combined MRI and radiosensitization.181 Results showed that AGuIX could interact with X-rays and -rays at a certain concentration. After internalization through the enhanced permeability and retention (EPR) effect, AGuIX could be resident in the tumor for a long time before being cleared by the kidneys.182 Preclinical animal experiments proved that AGuIX held obvious radiosensitization effects in several tumor models without obvious toxicity.183 A Phase I clinical trial (NCT03308604) to evaluate the optimal dose of AGuIX combined with chemoradiation in patients with locally advanced cervical cancer; a Phase II clinical trial (NCT03818386) using AGuIX gadolinium-chelated polysiloxane based nanoparticles and whole brain radiotherapy in patients with multiple brain metastases; and a single-arm phase II trial (NCT04094077) aiming to evaluate the efficacy of AGuIX during fractionated stereotactic radiotherapy of brain metastasis are being evaluated.

Hafnium, in the same family as titanium and zirconium, is chemical inertness. The oxidation state of hafnium, hafnium dioxide (HfO), was usually used in radioactive protective coatings, biosensors, and X-ray contrast agents.184,185 Jayaraman et al demonstrated that HfO2 nanoparticles had excellent biocompatibility.185 Researchers from France discovered that HfO can be used as a radiosensitizer with low cytotoxicity.186 A Phase I trial (NCT03589339) combining hafnium oxide nanoparticles (NBTXR3) with anti-PD-1 therapy in microsatellite instability-high solid malignant tumour and a Phase III clinical trial (NCT02805894) of NBTXR3 in prostate adenocarcinoma are under evaluation.

Tantalum is a nontoxic, biologically inert element with good biocompatibility.187 Studies found that TaOx and Ta2O5 could be used as CT imaging contrast agents.188190 Brown et al found Ta2O5 nanoparticles showed a radiasentizition effect on radioresistant glioma cells.191 Song et al showed hollow shell tantalum oxide (HTaOx) had a large X-ray attenuation capability and could enhance radiation therapy effects by Compton scattering and Auger effect.192 In addition, TaOx can be used as functional group carrier to load drugs, thereby improving tumor hypoxic environment. For example, HTaOx loaded with catalase, which reacted with H2O2 in the tumor microenvironment, then improved the oxygen content and overcame the radiotherapy tolerance of hypoxic tumor cells, thereby improving the radiotherapy effect.193

Tungsten and bismuth also have significative applications in medicine.194,195 Hossain et al concluded that bismuth nanoparticles had stronger radiosensitizing effect than gold and platinum nanoparticles at the same physical and chemical conditions.196 Yu et al found that the ultra-small semi-metallic Bi nanoparticles with LyP-1 peptide modified at 3.6 nm showed obvious radiosensitization effect.197 Recently, a large number of studies shown that some nanomaterials of tungsten and bismuth had excellent photothermal absorption conversion performance and strong X-ray absorption capacity, therefore they can be used for tumor radiosensitization as well as synergistic therapy of hyperthermia and radiotherapy.198201

In addition, research about several high Z metal elements combined together to further improve the radiosensitization effect were also explored. For example, SiBiGdNP chelated Bi and Gd in organosilane to improve the sensitivity of radiotherapy.202 GdW10O36 contained both W and Gd to expect they had better radiotherapy sensitization effect.203

Ferrite-based nanomaterials can catalyze the generation of free radicals through Fentons reaction (1) and HaberWeiss reaction (2) to enhance the effect of radiosensitization.204

Fe2+ + H2O2 Fe3+ + OH + OH

Fe3+ + H2O2 Fe2+ + OOH + H+ (1)

Fe3+ + O2 Fe2+ + O2

Fe2+ + H2O2 Fe3+ + OH + OH (2)

Studies proved that Fe3O4 had a dose-enhancing effect for radiotherapy, especially superparamagnetic Fe3O4 nanoparticles (SPIONS) possessing MRI imaging property had good application prospects in image-guided tumor radiotherapy.205

The composition of the spinel structure ferrite is usually stated as MFe2O4, where M=Fe, Zn, Co, Mn, Ni.206 Among them, ZnFe2O4, MnFe2O4, CoFe2O4 nanoparticles were widely investigated.207 For example, Meidanchi et al confirmed that ZnFe2O4 nanoparticles interacted with -rays to produce photoelectric effect resulting in a higher release level of electron in radioresistant cells.208 Studies also indicated that ZnFe2O4 nanoparticles could be used as radiosensitizers.208,209 Salunkhe et al demonstrated that MnFe2O4 and CoFe2O4 nanoparticles could improve the therapeutic efficacy of cancer through multimodal image-guided combination therapy.210

Semiconductor quantum dots have unique properties, such as quantum dimension effect, surface effect, and quantum confinement effect, making them great candidates in biomedicine applications.211 Until now, numerous studies focused on using semiconductor quantum dots as photosensitizers and radiosensitizers for tumor treatment have been reported.212214 When the electronic energy levels are in the range of 15 eV, the semiconductor nanomaterials can absorb the photon energy and perform as photosensitizers, showing photocatalytic properties. When the electronic energy levels are at keV and MeV (X-rays and -rays), semiconductor nanomaterials can enhance absorption of high-energy photons acting as radiosensitizers and causing damage to cancer cells.212 Nakayama et al synthesized a semiconductor nanomaterial PAA-TiOx to generate hydroxyl radicals under the irradiation of X-rays, which increased DNA damage and inhibited tumor growth significantly.215 Morita et al clarified the radiosensitization mechanism of PAA-TiOx nanoparticles by releasing H2O2 to relieve hypoxia in tumor cells.216 TiO2 nanotubes have been reported to enhance the radiosensitization effect through regulating G2/M cycle arrest and reducing DNA repair of tumor cells.177 The mechanism of radiosensitization of metal-based nanomaterials is shown in Figure 4.

Figure 4 Radiosensitization mechanism of metal-based nanomaterials. The process contains physical and biochemical sensitization mechanism.

Many nonmetallic nanomaterials also possess the function of radiosensitization.217 For example, C60, fullerene, has potent anticancer activities, however, the potential toxicity to normal tissues limits its further use. Therefore, nanocrystals of C60 (Nano-C60) with negligible toxicity to normal cells have been developed as a radiosensitizer.218 In addition, nanodiamonds and carbon nanotubes can reduce radioresistance of tumor cells by promoting ROS generation, destroying DNA double-strands, and regulating the cell cycle.219,220 Selenium (Se) nanoparticles not only work as chemotherapeutic drugs, but also improve the antitumor effect of X-rays by activating ROS to induce DNA damage in cancer cells.221

Nano-based delivery systems are efficient approaches for drug targeted transportation, which can deliver radiosensitizers, such as chemicals, oxygen carriers, siRNAs and catalases to the tumor sites and have attracted wide interest of researchers recently.222 More importantly, nanobased delivery systems can precisely deliver radioactive particles like223 Ac (releasing a-particles), 131I, and 125I to tumor sites.223 With the development of nanotechnology, nanobased delivery systems have great potential for radiosensitizer delivery.

However, there is still a challenge to achieve clinical translation of nanobased delivery systems, factors like physicochemical properties of the nanoformulations, radiation sources, and indications block their clinical translation.223 In addition, long circulation lifetime of nanodelivery systems may increase the risk of long-term toxicity.224 Another critical factor is stability in body fluid of nanodelivery systems. Because the aggregation of nanoparticles in body fluid will influence the pharmacokinetics and the cellular response and generate serious side effects such as blocking the blood vessels.222 Therefore, attention should be paid to these factors when designing the nanodelivery systems. Size is also an important factor, small size and high Z nanoparticles often hold better radiosensitizing effect than larger-size ones.223 In particular, the small size nanoparticles with positive charge can bind to negative charged DNA and can be eliminated by renal clearance conveniently. In addition, functional modification of nanostructures using biocompatible materials can improve their stability and targeting.225

Radiosensitizers have been developed for decades from the earliest free radical damage and fixation strategies to gene regulation, from chemicals to biological macromolecules and nanomaterials. Although each radiosensitizer has dialectical advantages and limitations, the mechanisms of sensitization are similar. The main mechanisms include: (I) inhibiting radiation-induced repair of DNA damage, increasing the degree of DNA damage; (II) disturbing the cell cycle and organelle function to improve cytotoxicity; and (III) inhibiting the expression of radiation resistance genes or promoting the expression of radiation sensitive genes.

Although small molecules, macromolecules, and nanomaterial radiosensitizers are being developed, and some nanoradiosensitizers have been used for clinical research (Table 4), the result still cannot meet clinical translation needs. Therefore, there is an urgent need to find new targets of radiotherapy and new mechanisms of sensitization, and after that to develop more effective radiosensitizing drugs. First of all, multitarget radiosensitizers often have more obvious efficacy than single target, researchers can focus on screening multitarget radiosensitizers or drug combinations. New approaches, in particular, nanotechnology based as radiosensitizers have shown promise. Nanomaterials with low cytotoxicity, good biocompatibility, and ease of functionalization need to be explored. In addition, other technologies, such as molecular structure analysis, molecular cloning technology, and bioinformatics analysis can accelerate the development of new radiosensitizers. Moreover, development of new drug delivery systems can also improve radiosensitization efficacy. Finally, the application of artificial intelligence and machine learning in new drug discovery and clinical trials, may guide development of new radiosensitizers and optimization of existing radiosensitizers.

Table 4 Clinical Translation of Some Nanoradiosensitizers

This work was supported by Innovation Capacity Support Plan of Shaanxi Province (2018TD-002), the National Natural Science Foundation of China (No. 82000523), the Natural Science Foundation of Shaanxi province (Grant No. 2020JQ-087, 2020JQ-095), the Young Talent Support Plan of Xian Jiaotong University (YX6J001), the Fundamental Research Funds for the Central Universities (xzy012019070).

The authors report no conflicts of interest in this work.

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[Full text] Application of Radiosensitizers in Cancer Radiotherapy | IJN - Dove Medical Press

Trans Resveratrol Market Expected to Witness the Highest Growth – The Courier

Posted: February 9, 2021 at 6:52 pm


The latest report on Trans Resveratrol Market provides an overall assessment of the world market Trans Resveratrol by classifying it into terminal applications, types, and regions. The report presents a comprehensive analysis of the competitive landscape and strategies that have positively influenced the market. Furthermore, the report provides an overview of current market dynamics by looking at different key segments based on product, types, applications, end-to-end industries, and market scenario.

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Leading Essential Players of Trans Resveratrol Market Report:

Trans Resveratrol Market segments by product type taking into account output, turnover (value), price trends:

Market segment by applications that take consumption growth rate and market share into consideration:

Scope/Extent of the Trans Resveratrol Market Report:

The Trans Resveratrol market research report concentrates on the analysis of demand and supply at the regional and national global level. From a global perspective, the report presents Trans Resveratrol markets per size, analyzing historical data and future perspectives. The report focuses on a number of key areas, including North America, Europe, Asia-Pacific and the West.

2019 has been considered the base year and the report provides a market estimate for 2020-2026. The report looks at the world market for the Trans Resveratrol (size, capacity, production, and consumption) in key regions.

Do not hesitate to consult our analyst prior to purchasing the report at https://www.regalintelligence.com/enquiry/207288

Additionally, in the Trans Resveratrol market research reports, the following points are included with an in-depth review of each point:

Table of Contents

Chapter 1: An overview of the market includes the definition, specifications, and classification of the market Trans Resveratrol, characteristics, scope, and applications.Chapter 2: Analysis of product costs and prices: structure of manufacturing costs, cost of raw materials and suppliers, manufacturing process, the structure of the industrial chain.Chapter 3: Market demand and supply analysis which includes commercial production capacity and date, distribution of manufacturing plants, R&D status, and technology source, analysis of raw material sources.Chapter 4: Forces that keep the marketplace going.Chapter 5 and 6: Regional Market Analysis that includes North America, Europe, China, Japan, Southeast Asia, and India, Trans Resveratrol Market Analysis (by Type).Chapter 7 and 8: Industrial structure, Demand, and Supply Gap Analysis.Chapter 9: Market Trend Analysis, Regional Market Trend, Market Trend according to Product Type.Chapter 10: Trans Resveratrol Turnover Channels, Distributors, Retailers, Dealers, Research Findings and Conclusion, Appendix along with Data Source.

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Trans Resveratrol Market Expected to Witness the Highest Growth - The Courier

Resveratrol Market Healthy Pace throughout the Forecast during 2018-2028 Jumbo News – Jumbo News

Posted: at 6:51 pm


FMI has compiled a study on resveratrol, which offers an analysis and forecast of theresveratrol market in its publication titled Resveratrol Market: Global Industry Analysis 2013 2017 and Opportunity Assessment 2018 2028. This report on resveratrol market covers some of the vital facets which are key influencing factors on the demand and supply for various resveratrol products over the next several years. An in-depth review of growth drivers, potential challenges, unique trends, and opportunities for market participants equip readers to fully comprehend the overall landscape of the resveratrol market. The report on resveratrol market also covers analysis of key regions and countries of particular interest which are anticipated to become frontrunners or remain laggards over the forecast period. The report covers a historical analysis of the market from 2013 to 2017 and provides forecasts from 2018 to 2028 in terms of volume in metric tons and revenue in US$.

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Resveratrol is polyphenolic compound and an antioxidant agent that is extracted from fruits (grapes, blueberry, and others), and plants. The presence of resveratrol as a key compound in red wine was established in the early 1990s, theorizing that moderate consumption of red wine could help explain the relatively low incidence of cardiovascular disease. Resveratrol has since been a part of several research studies supporting its varied health benefits, ranging from prevention and/or treatment of neurodegenerative diseases, cancer, cardiovascular disease, metabolic disorders, among others, prompting its utilization infunctionalfoods,dietary supplements, pharmaceutical products, cosmetics and personal care, among others.

This report on resveratrol market has been broken down into different chapters to enhance clarity and provide context. A brief executive summary at the beginning of the report consists of some of the key findings of the study on resveratrol market, as well as market estimates and growth rates for important segments. The following chapter presents the definitions and scope of the study, as well as the coverage in terms of the way the resveratrol market is structured. Subsequently, the chapter on market background presents the evolution of resveratrol, relevant economic indicators such as GDP and per capita food consumption, including an assessment of the supply chain, policy developments and regulatory scenario, dynamics impacting the resveratrol market as well as an explanation of the factors considered important to develop forecasts and estimates. The report on resveratrol market also includes a chapter on pricing analysis, highlighting price point variations between different regions and products, including pricing forecasts. The following chapters dive deep into the global resveratrol market, covering detailed information based on product categories, end use, and sales channel. The next set of chapters provide region-wise analysis and forecasts of the resveratrol market, covering vital aspects of the market in North America, Latin America, Europe, East Asia, South Asia, Oceania, and the Middle East and Africa.

A dashboard view of some of the key companies operating in the resveratrol market in terms of their offerings, regional presence, and other metrics is a precursor to detailed profiles of these participants including financial information, strategy overview, and SWOT analysis, market share, as well as analyst commentary. Some of the key players analyzed in the resveratrol market report include DSM Nutritionals, Sabinsa Corporation, InterHealth, MAYPRO INDUSTRIES, Evolva, LAURUS LABS Limited, Resvitale LLC, Endurance Products Company, Chongqing Kerui Nanhai Pharmaceutical Co., Ltd., Jiaxing Taixin Pharmaceutical Chemical Co., Ltd., Shanghai Natural Bio-engineering Co., Ltd, Chengdu Yazhong Bio-Pharmaceutical Co., Ltd., and Xieli Pharmaceutical.

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To develop the market estimates for resveratrol, the overall production of resveratrol from different methods such as natural and synthetic was estimated, followed by identifying the utilization of resveratrol in volume terms by analysing permissible limits and review of ingredient labels in different regions and countries. This information was then validated by understanding the revenue generated from sales of resveratrol by key producers for top countries globally. Prices of resveratrol products have been obtained from manufacturers, distributors, and wholesalers for bulk quantities at a country-level.

Our team of analysts reviews and interpret data from a variety of sources. Data attributed to FMI are derived by using a combination of various approaches, which are then consolidated, interpreted, and extrapolated by FMI analysts. Data is sourced from government statistics, trade associations, company annual reports and investor presentations, press articles and directories, technical publications, and online databases which are cross-referenced with FMIs reports and internal repository of data to filter and validate the collected information. Intelligence gathered from desk research is supplemented by extensive interviews with selected key expert participants across the value chain not only to gain information specific to their role and operations but also to obtain their perspective and insights of the issues impacting the resveratrol market.

Global Resveratrol Market: Segmentation

Analysis by Product Type

Analysis by Form

Analysis by End Use

Analysis by Region

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Resveratrol Market Healthy Pace throughout the Forecast during 2018-2028 Jumbo News - Jumbo News

Absorbable Tissue Spacer Market to reach US $145.0 million by 2028 – Global Insights on Trends, Key Growth Drivers, Restraints, Challenge, Recent…

Posted: at 6:51 pm


Dallas, Texas, Feb. 08, 2021 (GLOBE NEWSWIRE) -- The Global Absorbable Tissue Spacer Market Size 2019, by Product (Hydrogel Based Spacers and Biodegradable Balloon Spacers), by Application (Radiotherapy and Infection Management), by End User (Hospitals, Ambulatory Surgical Centers, and Others), by Region and Forecast 2018 to 2028 study provides an elaborative view of historic, present and forecasted market estimates.

The global absorbable tissue spacer market is growing at a CAGR of over 4.0%. Increasing incidence of cancer in male population is one of the major factors for market development across the globe. Rapid increase in number of cases diagnosed with prostate cancer in likely to fuel the market growth in coming years.

Request for Sample Report: https://www.adroitmarketresearch.com/contacts/request-sample/1851

Global Absorbable Tissue Spacer Devices Market, 2018-2028 (USD Million) Adroit Market Research report on global absorbable tissue spacer market gives a holistic view of the market from 2018 to 2028, which includes factors such as market drivers, restraints, opportunities, challenges and regulatory scenario. The market has been studied for historic years from 2018 to 2019, with the base year of estimation as 2019 and forecast from 2020 to 2028. The report covers the current status and future traits of the market at global as well as country level. In addition, the study also assesses the market competition with Porter's five forces analysis and positions the key players based on their product portfolio, geographic footprint, strategic initiatives and overall revenue. Prominent players operating in the global market have been studied in detail.

The global market is segmented on the basis of product, end user and application. The product segment is further broken down to hydrogel based spacers and biodegradable balloon spacers). In terms of application, the market is bifurcated into radiotherapy and infection management). On the basis of end user the market is segmented into hospitals, ambulatory surgical centers, and others. Hydrogel-based absorbable tissue spacers accounted for more than 60% of the market in 2019.

Read the complete report: https://www.adroitmarketresearch.com/industry-reports/absorbable-tissue-spacer-market

Key players in the market include Biocomposites, Bioprotect Ltd, Boston Scientific, BD, Palette Life Sciences and many more. Key players are replacing non-absorbent materials with bio-absorbent materials due to their advantages and high number of product approvals from regulatory bodies. Such trend is likely to bring more bio-based spacers in the market.

Based on segmentation global absorbable tissue spacer market is fragmented into product, application, end user and regional industry. By product, global absorbable tissue spacer market is splintered into hydrogel based spacers, biodegradable balloon spacers. Based on application the market is classified into radiotherapy, infection management. Based on end user the market is classified into hospitals, ambulatory surgical centers & others. Further, absorbable tissue spacer market is also fragmented on the basis of regional diversification, identifying Europe, North and South America, MEA and APAC as major growth spots in absorbable tissue spacer market.

Table of Content:

1. Introduction

2. Research Methodology

3. Market Outlook

4. Absorbable Tissue Spacer Market by Product, 2018-2028 (USD Million)

5. Absorbable Tissue Spacer Market by End use, 2018-2028 (USD Million)

6. Absorbable Tissue Spacer Market by End-User, 2018-2028 (USD Million)

7. Absorbable Tissue Spacer Market by Region 2018-2028 (USD Million)

8. Competitive Landscape

9. Company Profiles

10. Appendix

Interested to Procure The Data? Inquire here at: https://www.adroitmarketresearch.com/contacts/enquiry-before-buying/1851

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Global Thoracic Drainage Devices Market Size 2019, by Product (Thoracic Drainage Systems, Thoracic Drainage Kits, Pleural Drainage Catheters, Trocar Drains, Others), by Application (Cardiac Surgery, Oncology & Pain Management, Thoracic Surgery & Pulmonology, General Intensive Care Emergency Medicine, Others), by Region and Forecast 2018 to 2028

Global Resveratrol Market by Product (Natural Resveratrol {Grape seed extracted, Knotweed extracted}, Synthetic Resveratrol), By Application (Cosmetics, Dietary Supplements, Pharmaceutical, and Others), By Form (Liquid, Solid/Powder, Pill), By Distribution Channel (Retail Stores, Online Stores, Others), By Region (North America, Europe, Asia Pacific, Latin America, Middle East and Africa), Global Forecast 2018 to 2028

Global Wound Debridement Market Size 2019, by Product (Gels, Ointment & creams, Surgical devices, Medical gauzes, Ultrasonic devices, Others), by Method (Autolytic, Enzymatic, Surgical, Mechanical, Others), by Wound Type (Pressure ulcers, Diabetic foot ulcers, Venous leg ulcers, Burn wound, Others), by Region and Forecast 2018 to 2028

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