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How many calories are in a glass of wine? – Medical News Today

Posted: August 2, 2021 at 1:51 am


The number of calories in a glass of wine can range from around 120165, depending on the type of wine.

Wine is one of the oldest beverages and has been popular for centuries. Even today, it continues to be one of the most consumed drinks in the world. According to the Wine Institute, people in the United States drink more than 3 gallons of this fermented grape juice each year.

Wine has an alcohol content that creates a feel-good effect in the brain, and many of the chemicals in wine can have beneficial health effects.

Experts associate wine drinking with reduced inflammation and lower blood pressure A daily glass of wine may also help prevent heart disease and stroke.

This article compares the calorie content in different types of wine and the source of these calories. It also contrasts wine with other alcoholic beverages, and explores some of the health benefits of wine.

The following chart lists the number of calories in some popular glasses of wine, typically five fluid ounces.

Wine is an alcoholic beverage that manufacturers create by fermenting grape juice. It is the alcohol concentration of carbohydrates that provides the calories in wine.

As the name suggests, sweet wines are often sweeter than dry wines. Manufacturers may add more sugar to these wines, contributing to a more significant number of calories than their dry counterparts.

A single glass of wine does not contribute many calories to someones daily energy intake. However, people may find it easy to overindulge. Most individuals have more than a single glass of wine in a sitting, leading to an overall increase in calorie intake.

Most glasses of wine contain around 120 calories, with sweet wine containing considerably more calories at 165 calories per glass.

When comparing the calorie content of wine and other popular alcoholic beverages, people must consider the serving size. Bars and restaurants may serve wine, spirits, and beer in different quantities.

Here are some example calories for popular alcoholic drinks:

The calorie content of wine falls in the middle of these standard alcoholic beverage options. However, wine, specifically red wine, offers health benefits that these other drinks do not.

The alcoholic and polyphonic components of wine have beneficial antioxidant, lipid regulating, and anti-inflammatory effects.

Past studies have found that moderate alcohol consumption can provide health benefits, including increasing the amount of good cholesterol in the body and decreasing the risk of diabetes.

There are no conclusive recommendations regarding wine consumption. But many studies have found that moderate consumption of red wine protects against:

Crushed grapes are the basis of wine. Grapes contain the natural antioxidant resveratrol, and this significant antioxidant concentration likely provides red wine with its many health benefits.

Additionally, resveratrol has anti-inflammatory characteristics. These anti-inflammatory properties help to protect the heart and nervous system and make also have antiaging effects.

Red wine also contains the compound proanthocyanidin. This bioactive chemical may contribute to heart health and protect against heart disease and other inflammatory conditions.

The antioxidants found in red wine are beneficial in reducing oxidative stress. The body naturally produces reactive oxygen and nitrogen species (RONS) through some natural processes, damaging cells and tissues.

To combat this, the body also has antioxidant defenses to neutralize any damage. However, if there are not enough antioxidants to combat RONS, oxidative stress can occur.

Oxidative stress plays a role in several conditions, including cardiovascular diseases, chronic kidney disease, chronic obstructive pulmonary disease, neurodegenerative diseases, and cancer.

So, while red wine may not cure these conditions, it may help prevent them by managing oxidative stress.

The alcohol in red wine, combined with its polyphenol content, can help to improve and maintain endothelial function.

Endothelial cells are crucial in keeping capillaries functional and bringing blood to all tissues of the body. Because of this, the endothelium plays a role in preventing conditions including:

Red wine helps maintain endothelial function, meaning that it also plays a role in protecting against various diseases and conditions.

Individuals should remember to drink in moderation. Instead of providing health benefits, excessive drinking may cause problems, such as obesity, liver damage, stroke, cancer, and a negative impact on heart health.

Learn more about the potential health benefits of wine here.

Wine comes from fermented, crushed grapes, and its calories come primarily from its alcohol and carbohydrate content.

There are many types of wine, including red, white, sweet, and rose. These wines have a calorie content ranging from 120165 calories for a single glass.

When compared to other alcoholic drinks, the calorie content for wine falls in the middle. However, red wine, in particular, offers many health benefits that other alcoholic beverages lack.

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How many calories are in a glass of wine? - Medical News Today

The One Supplement You Should Take Every Morning Over 50 To Take 10 YEARS Off Your Face – SheFinds

Posted: at 1:51 am


Supplements can seem a little bit like magic. Take one and all of your dietary needs can be addressed, right? Not quite. Maintaining a balanced diet with plenty of protein, carbs, and fats is the most important thing you can do for both your health and your skin. But if you are experiencing vitamin or mineral deficiencies and are looking for ways to boost your health and make your complexion glow, there are specific nutrients that can help. Lisa Moskovitz, RD, CDN and CEO of NY Nutrition Group, spoke with SHEFinds.com about the one supplement you should take every morning over 50 if you want to feel and look your best.

Beauty Experts Swear By This Collagen Powder For Younger Looking Skin

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Healthy, youthful skin never goes out of style - no matter how much you age, Moskovitz says. While we can't Benjamin Button our bodies, we can certainly take measures to slow down the aging process and enhance the tone and texture of our epidermis. The first step is to always practice healthy habitsincluding eating a balanced, nutrient-dense diet, staying hydrated, logging in enough sleep and participating in regular exercise. Outside of these health pillars, asupplementcan help fill in nutritional gaps ensuring a smoother skin surface.

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So, which supplement ingredient should you look to first? According to Moskovitz, the benefits of resveratrol can not be understated. If you're not familiar, resveratrol is a powerful polyphenol found in the skins of red grapes, red wine, blueberries and peanuts, Moskovitz says. It fights against oxidative stress that can accelerate the aging process, both internally and externally, and directly treats fine facial lines or wrinkles. One supplement that contains resveratrol and other effective vitamins that Moskovitz recommends is Oh Grape by Groove, which she calls a high-quality multivitamin that contains all the essentials to preserve your youthful appearance. The MVP of this concoction is 500mg of resveratrol.

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Aside from containing high amounts of resveratrol, Moskovitz credits Oh Grape for containing a hefty dose of vitamin C that directly improves collagen absorption. Collagen is a protein found naturally in our bodies, but it starts to deteriorate starting in our twenties, Moskovitz says. Collagen loss contributes to tarnished skin tone and texture. We can boost collagen by eating a well-balanced diet and by consuming enough vitamin C-rich foods,such as strawberries, oranges, red peppers, and broccoli, orsupplements.

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Finally, its important not to neglect vitamin D, as a deficiency in this vitamin can lead to red, itchy and dry skin - none of which translate to a youthful glow, Moskovitz says.

VItamin D is hard-to-come-by in your diet and limited to eggs,cod liver oil, bony fish, and fortified juices or milk products, Moskovitz says. That is why deficiencies are highly common.That said, I always recommend my clients adopt healthy behaviors andsupplementwhen necessary, especially if they want to be as proactive and preventive as possible. Thissupplementis taken once a day with, or without food.

And remember: always consult a doctor before you start any new supplement regimen.

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The One Supplement You Should Take Every Morning Over 50 To Take 10 YEARS Off Your Face - SheFinds

Detailed Analysis of Trans Resveratrol Market 2021-2026 with Top Company Profiles like DSM, Evolva, Sabinsa, InterHealth, Maypro, JF-NATURAL, and more…

Posted: at 1:51 am


The Trans Resveratrol market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, the impact of domestic and global market players like DSM, Evolva, Sabinsa, InterHealth, Maypro, JF-NATURAL, etc., value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.

The Key Areas That Have Been Focused in the Report:

Get Exclusive Sample of Report on Trans Resveratrol market @ https://www.affluencemarketreports.com/industry-analysis/request-sample/1669523/

Trans Resveratrol Market Segmentation:

Trans Resveratrol market is split by Type and by Application. For the period 2016-2026, the growth among segments provides accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.

Trans Resveratrol Market Report based on Product Type:

Trans Resveratrol Market Report based on Applications:

The key market players for global Trans Resveratrol market are listed below:

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Promising Regions & Countries Mentioned in Trans Resveratrol Market Report:

TABLE OF CONTENTS INCLUDE

Consumption Forecast, Market Opportunities & Challenges, Risks and Influences Factors Analysis, Market Size by Application, Market Size by Manufacturers, Market Size by Type, Trans Resveratrol Consumption by Regions, Trans Resveratrol Production by Regions, Production Forecasts, Value Chain and Sales Channels Analysis, Key Findings in the Global Trans Resveratrol Study, Manufacturers Profiles

Report Customization: Clients can request for customization of report as per their need for additional data.

CONTACT FOR ADDITIONAL CUSTOMIZATION @ https://www.affluencemarketreports.com/industry-analysis/request-inquiry/1669523/

Impact of COVID-19 on Trans Resveratrol Market

The report also contains the effect of the ongoing worldwide pandemic, i.e., COVID-19, on the Trans Resveratrol Market and what the future holds for it. It offers an analysis of the impacts of the epidemic on the international Market. The epidemic has immediately interrupted the requirement and supply series. The Trans Resveratrol Market report also assesses the economic effect on firms and monetary markets. Futuristic Reports has accumulated advice from several delegates of this business and has engaged from the secondary and primary research to extend the customers with strategies and data to combat industry struggles throughout and after the COVID-19 pandemic.

For More Details on Impact of COVID-19 on Trans Resveratrol Market https://www.affluencemarketreports.com/industry-analysis/covid19-request/1669523/

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Detailed Analysis of Trans Resveratrol Market 2021-2026 with Top Company Profiles like DSM, Evolva, Sabinsa, InterHealth, Maypro, JF-NATURAL, and more...

4 Paulas Choice Products That Would Get a Green Light From Your Derm – Well+Good

Posted: at 1:51 am


The ingredient(s) derms love: zinc oxide and resveratrol

Why they get the greenlight: Sunscreen plus antioxidants: a dream duo beloved by every derm in existence. (Slight exaggeration, but weve never met one who has said otherwise!). Simply put, these umbrella termsfound here in the form of zinc oxide and resveratrol, respectivelyoffer unparalleled protection against signs of premature aging. (ICYMI: UV rays and free radicals speed up sunspots, sagging, and other afflictions that make your skin appear older than it is.)

Because this formulas SPF component is zinc-based, it may warrant extra brownie points from certain skin pros. As per previous insight, zinc oxides benefits extend beyond sun protection. Specifically, it can help treat inflammation, and calm reactive skin, making it ideal for those with inflammatory skin conditions like acne and rosacea. Worried about a tell-tale zinc oxide white cast? This particular product creates a lightweight physical barrier that, when sheered out, blends seamlessly.

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4 Paulas Choice Products That Would Get a Green Light From Your Derm - Well+Good

Heart Healthy Foods: 25 Foods That Are Good for Your Heart – Parade Magazine

Posted: July 19, 2021 at 1:51 am


Every year, 647,000 Americans die from heart disease and heart-related conditions, according to the Centers for Disease Control and Prevention (CDC). In fact, its the leading cause of death in the United States.

In terms of prevention, living a healthy lifestyle is the best thing you can do. Some activities that can increase risk of developing heart disease include smoking, a lack of exercise, heavily drinking alcohol, and eating a diet high in cholesterol, fat, salt, and sugar. To stay as heart-healthy as possible, its best to avoid this activities and try to eat a diet that consists of heart healthy foods.

Wondering which foods are good for your heart? Weve got you covered.

Known as the fruit with the healthy fats, avocados are super nutritious thanks to their high concentration in dietary fiber, antioxidants, and other minerals. All of these things work together to keep your heart healthy, but a study from Penn State University also suggests that an avocado a day can lower LDL cholesterol levels.

Avocados contain heart healthy monounsaturated fatty acids, which can help lower LDL cholesterol (the bad kind), Laura Yautz, RDN, LDN, NBC-HWC, registered dietician and owner of Being Nutritious, tells Parade. In addition, avocados contain potassium and fiber, two essential components of heart health, which can work to lower blood pressure and cholesterol, respectively!

Sure, all fruits are relatively high in sugar, but the heart-healthy benefits of berriesstrawberries, blueberries, blackberries, cranberries, aa berries, bilberries, goji berries, raspberries, and even grapes!certainly outweigh the negatives of their natural sugar content.

Berries are a good source of polyphenols, especially anthocyanins, micronutrients, and fiber, explains Harland Adkins, a registered dietitian nutritionist and founder of Fast Food Menu Prices. In epidemiological and clinical studies, these constituents have been associated with improved cardiovascular risk profiles.

Adkins adds, Black raspberries and strawberries have been shown to help lower cholesterol in people who are obese or have metabolic syndrome.

Spinach is good for you in just about every way possiblenot solely for your heart. But besides the benefits it has for your eyes, reduced blood pressure, and even cancer prevention, spinachs high levels of omega-3 fatty acids, antioxidants, B vitamins, fiber, folate, calcium, and iron work wonders for your heart.

Spinach is most known for its folate content, but its also a great addition to heart healthy diets, Yautz explains. Spinach contains a healthy dose of vitamin K (ask your doctor if youre on a blood thinner!), vitamin A, iron, and fiber, all while being low in calories, so you can fill your plate up!

All dark leafy greens are heart-healthy foods, but kale in particular is a superfood. According to the American Heart Association (AHA), kale is high in potassium, which can reduce your risk of blood pressure and also heart disease.

Kale, like spinach, is very high in vitamin K, which is important to help your blood clot properly, Yautz says. Its also high in vitamins A and C. But unlike spinach, its a cruciferous vegetable (like broccoli and cauliflower), so it contains special compounds that may be particularly helpful in preventing clogged arteries.

Related: 125 Quotes About Heart Disease

Collard greens are another dark leafy green, cruciferous vegetable that works hard to keep your heart feeling strong. This superfood also can prevent cancer, features anti-inflammatory properties, and because theyre high in potassium, magnesium, and vitamin C, theyve been known to lower hypertension and support the heart.

Collard greens are an excellent source of vitamin A, vitamin C, and calcium, a rich source of vitamin K, and a good source of iron, vitamin B-6, and magnesium, Adkins explains. They also contain thiamin, niacin, pantothenic acid, and choline. Thanks to their many nutrients, collard greens have been associated with cancer prevention, detox support, anti-inflammatory properties, heart health, and digestive support.

Definitely dont underestimate the power of nuts when it comes to supporting your heart. As Yautz explains, Walnuts contain the highest amount of ALA (a plant-based form of Omega-3) of any of the tree nuts, making it an excellent heart healthy staple. They are also high in magnesium, which can help your heart maintain a normal rhythm.

Another nut thats great for your heart is the almond. Yautz explains, Almonds are a great source of vitamin E, a type of antioxidant that helps prevent cell damage. It can be particularly helpful for those who do or have smoked, and/or are exposed to air pollution, to help mitigate the effect.

Plus, they can be roasted, thrown into a salad, or eaten raw, and are known as a health, unsaturated fat that increases the bodys good cholesterol and decreases its bad cholesterol.

You know how that old adage goesbeans, beans, theyre good for your heart! We wont finish the rhyme here for the sake of being appropriate, but this kid-friendly diddy is true.

Beans are incredibly healthy, especially for your heart, high in both protein and fiber, and theyre amazingly versatile, Yautz says. Many studies have been conducted on their health benefits. They are known to help decrease blood cholesterol levels, and consuming 1/2 cup a day is associated with a lower risk of having a heart attack and heart disease in general.

Black beans are not only high in fiber, but they keep your blood sugar levels in check, control your cholesterol, and can even lower blood pressure.

Related: Can a Broken Heart Cause Actual Heart Damage? Heres What Doctors Say

Fatty fish is one of the best heart-healthy foods there is thanks to its high levels of Omega-3 fatty acids. In fact, the American Heart Association recommends eating salmon as much as twice a week.

Yautz adds, Salmon is well known for its healthy fat profile. The main type of fat is a polyunsaturated fat, known as omega-3. Eating fish high in Omega-3s has been linked to decreased coronary heart disease (CHD), including fatal CHD, myocardial infarction, and sudden cardiac death. Wild caught salmon is a better source than farmed.

High in lycopene, which can lower LDL levels and also blood pressure, eating tomatoes semi-frequently can reduce your risk of heart disease.

Tomatoes claim to fame is their lycopene content, which is widely known for its benefit to prostate health. But lycopene can also protect your heart! Studies have shown lycopene may lower your risk of stroke, and of having additional cardiac events, Yautz explains.

Chia seeds are also a superfood and theyre unique in that they contain the antioxidant quercetin. Quercetin reduces risk of heart disease, as well as other heart-related conditions as well.

Chia seeds are full of heart protecting antioxidants, as well as ALA Omega-3 fats, Yautz says. This tiny seed is also showing promise as being able to potentially lower triglycerides, inflammation, and blood pressure, as well as raising HDL (the good cholesterol).

Its the one youve been waiting foryes, its true! Dark chocolate is, in fact, good for your heart.

Dark chocolate is rich in flavanols, and a heart healthy addition with a caveat: all the added sugar, cream or milk, and cocoa butter tend to negate its effects, Yautz says. Choose the darkest chocolate you can to reap the benefits, such as lower total cholesterol, LDL cholesterol, and triglycerides.

Just like nuts, many seeds are considered to be heart-healthy food as well. Flax seeds are high in the Omega-3 fatty acids that hearts love and are even known to reduce the risk of stroke.

Flax, like chia, is high in Omega-3, and is particularly helpful in managing blood pressure and cholesterol, Yautz says.

Its a win-win!

Another heart-healthy seed is the hemp seed. These little-seeds-that-could regulate your heart beat, reduce bad cholesterol levels, and fight hard against coronary heart disease.

Hemp seeds are lower in both omega-3s and fiber then either chia or flax seeds, but they are high in protein a complete protein at that. They do have a high ratio of Omega-6 to Omega 3, which isnt problematic in the context of an otherwise healthy diet, but something to be aware of. They also contain iron and zinc, two minerals important for cardiac function, Yautz adds.

Cooking with oilespecially if its in place of butteris a meaningful decision for your heart. As Yautz explains, When it comes to oils for heart health, olive oil takes the cake. Studies have shown olive oil can help reduce cardiovascular disease and coronary artery disease. The benefit seems to cap out at about 1/2 tablespoon per day, though. Oils of all kinds are high in calories, so its preferable to replace fats like butter and margarine with olive oil instead of simply adding olive oil to the diet, to avoid unintentional weight gain.

As oranges are high in both fiber and potassium, this citrus fruit makes a great addition to any heart-healthy diet. After all, the more you eat of both, the less likely you are to develop a fatal heart disease.

Oranges are an excellent source of potassium, making them a good food for heart health. Potassium can help control blood pressure, because it acts opposite to sodium, Yautz says. While sodium attracts water and promotes retention, potassium helps the body release water, thereby reducing blood pressure.

Aside from their high levels of potassium, another heart-healthy benefit of oranges is their pectin.

Oranges have the cholesterol-fighting fiber pectin, Adkins says. In one study, two cups of OJ a day boosted blood vessel health. It also lowered blood pressure in men.

Just as fatty fish is good for the heart, fish oil is one of the best foods for the heart as well.

Fish oil is high in Omega-3s, and often recommended for its heart promoting benefits. While the omega-3s in flax, chia, and hemp are mostly in the form of ALA (alpha linolenic acid), the Omega-3s in fish oil are in the form of DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid), which are more usable by the body, Yautz explains. ALA must first be made into DHA and EPA.

Tuna is another fatty fish that has benefits for the heart because of its high levels of Omega-3 fatty acids. But, you should be wary of the tuna you choose.

Tuna is another great source of Omega-3 fats, Yautz says. Look for bluefin tuna, which is a better source of Omega-3s, and has a lower chance of being contaminated with heavy metals.

When you think heart-healthy food, you may not immediately envision garlic, but in reality, garlic has long been used as a medicinal herb, thanks to its health benefits.

Garlic and garlic supplements may have positive effects on heart health by preventing cell damage, regulating cholesterol, and lowering blood pressure, Adkins explains. Other research shows that garlic supplements may also reduce plaque build-up in the arteries. This is due to the presence of a compound called allicin, which is believed to have a multitude of therapeutic effects.

In addition to all those heart-healthy benefits, garlic may improve memory as well.

Fish and almonds arent the only significant source of heart-healthy proteins. As Yautz points out, Edamame is the most unprocessed form of soybeans, and incredibly nutritious. Its high in protein a complete proteinand also boasts tons of fiber and antioxidants. Studies show edamame may improve cholesterol and triglycerides, as well as reduce blood pressure. Other studies are being conducted on its ability to improve arterial stiffness, and improve markers of inflammation.

Sardines are jam-packed with Omega-3 fatty acids as well as fish oils that can regulate heart rhythms. Yautz adds, Unlike salmon and tuna, however, sardines are very low on the food chain. That means the likelihood of heavy metal contamination is very low. Just make sure to look for sardines without too much sodium.

Related: The Best and Worst Cooking Oils for Your Heart

Thank goodness! Of course, red wine has to be drank in moderation in order to reap its heart-healthy benefits, but some research shows that the antioxidants in red wines can prevent coronary artery disease and ultimately, decrease your risk of a heart attack.

If you drink alcohol, a little red wine maybe a heart-healthy choice, Adkins explains. Resveratrol and catechinstwo antioxidants in red winemay protect artery walls. Alcohol can also boost HDL, the good cholesterol [but] too much alcohol hurts the heart.

Yautz adds, Alcohol in excess can damage the heart, and contribute to high blood pressure. So, if you dont drink, dont start, but if you do, do so in moderation only (one or less 5-ounce glass of wine per day for women and two for men).

Another fatty fish rich in Omega-3 fatty acids, its recommended to eat mackerel at least once weekly in order to reduce your risk of a heart attack.

Mackerel are similar to sardines in their lower likelihood of heavy metal contamination, Yautz says. Eat it, and the other fatty fish on this list, at least once a week to help prevent heart attacks and other serious heart problems.

According to the Cleveland Heart Lab, herbs like cinnamon, cardamom, ginger, turmeric, and berberine can be used to prepare other foods for an added heart-healthy benefit.

Yautz adds, Herbs and spices are incredibly concentrated sources of antioxidants. Including a variety in liberal amounts on your food daily can contribute to lower inflammation, lower blood pressure, and lower cholesterol.

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Drinking tea could reduce risk of heart disease and stroke, but it should be done frequently in order to reap the benefits. In fact, the European Journal of Preventative Cardiology published research that found drinking green tea three or more times per week is ideal for improving the health of the heart.

Drinking green tea daily can also contribute to heart health! Studies show green tea may lower both LDL cholesterol and triglycerides, Yautz says. As long as youre careful about what you put in itadding sugar, creamer, etc. may offset those benefits!

Next up, important lifestyle changes to make for a healthy heart.

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Heart Healthy Foods: 25 Foods That Are Good for Your Heart - Parade Magazine

Food that can help ease stress – Jacaranda FM

Posted: at 1:51 am


Stress is defined as a stateof mental or emotional strain or tension resulting from adverse or demandingcircumstances.

It is caused by a variety of things including; anything that puts high demands on you, major life changes, financial problems, and relationship difficulties. The current state of events in South Africa is also leading to a lot of uncertainty.

Stress can lead to otherhealth complications including; depression,weight problems,anxiety, sleep problems, and thinking and memory problems.

All of us will deal with stressat some point in our lives and it is important that you seek help from a professionalwhen you feel overwhelmed and are struggling to cope.

READ:Three foods that can help you fight stress

Dietitian Sylven Masoga saysthere is no specific food that can reduce stress, but it's the ingredients containedin the food item that can help reduce stress.

You need food that containsVitamin C, such as grapes and oranges. That Vitamin C can destroy the freeradicals which are usually released when a person is suffering from stress related oxidation," says Masoga.

The dietitian recommendseating one orange a day or a bunch of grapes.

He also recommends eatingfoods that contain Vitamin A and Vitamin E.

READ: Expert tips on how to better manage stress

An example of these foods areyellow vegetables (pumpkin, carrots, gem squash etc.).

Vitamin A and Vitamin Econtaining foods will minimise the oxidation that will occur as a result ofstress in your blood, says the dietitian.

He adds: The intake ofVitamin A and Vitamin E protects the lining of the cells inside your body sothat they cannot be damaged by release of the free radicals.

The dietitian recommendseating foods that contain lycopene, phytochemical, and resveratrol.

Examples of such foods aretomatoes, guava, green vegetables, watermelon, papaya, pink grapefruit, and theskin of the grapes, peanuts, blueberries, cranberries, broccoli, pears, celery, and spinach.

The dietitian says such foods preventthe development of the free radicals.

He warns against eating foodsthat contain saturated fat and trans-fat.

READ: DrD on how to plan for a year-end holidays that bring more joy that stress

Image courtesy of iStock/ @Chinnapong

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Food that can help ease stress - Jacaranda FM

22 Purported Resveratrol Benefits – SelfHacked

Posted: April 16, 2021 at 1:52 am


Resveratrol, a polyphenol abundant in red wine, has some antioxidant and heart-protective properties. However, its bioavailability is poor and most of its purported benefits have not been confirmed in humans. Read this science-based review to learn more.

Resveratrol is a small polyphenol that came to scientific attention during the 1990s. Since then, it has been hyped by supplement manufacturers and news outlets alike.

Resveratrol is high in grape skin, as grapes produce resveratrol in defense against toxins and parasites. It is also found in various berries, peanuts, soy, and Itadori tea made from Japanese Knotweed [1].

Limited studies have explored its antioxidant, anti-inflammatory, anti-aging, and phytoestrogen activity. Resveratrol does hold some potential for improving chronic diseases. Researchers are also exploring its ability to mimic the effects of caloric restriction in animals, which might affect lifespan [2, 3].

According to some clinical trials, resveratrol nose sprays may improve symptoms of hay fever or allergic rhinitis. Scientists came up with nose sprays as a great way to bypass resveratrols poor bioavailability and get it straight to localized, problematic body areas.

In one study of 100 people, an intranasal spray containing resveratrol 0.1% reduced nasal symptoms and improved quality of life in adults with hay fever used three times daily for 4 weeks [4].

In another trial of 68 children with pollen-induced hay fever, an intranasal spray with resveratrol 0.05% and one other ingredient (beta-glucan 0.33%) improved itching, sneezing, runny nose, and nasal blockage. It was given three times daily for 2 months [5].

Limited evidence suggests that red wine, in moderation, supports heart health.

On the other hand, resveratrol supplements probably dont aid in heart disease prevention.

Therefore, scientists think that other compounds in red wine may be more important, while resveratrol may or may not contribute to this effect.

Additional, large-scale studies are needed to determine the specific effects of different components in red wine, especially in people with blood pressure and heart problems.

In 67 men at high heart disease risk, alcohol-free red wine reduced blood pressure (both diastolic and systolic) after 4 weeks. It increased nitric oxide, which relaxes blood vessels. Regular red wine (9 oz glass/day) also slightly reduced blood pressure and increased nitric oxide, but less so than dealcoholized wine. A control group that only drank gin didnt see any benefits [6].

One analysis of 19 studies concluded that drinking 1 2 glasses of wine daily (150 300 ml) reduces heart disease risk [7].

Interestingly, based on the first study, the alcohol in red wine may actually reduce the beneficial effect of resveratrol and other polyphenols. This especially holds true for people who already have high blood pressure or those at high risk.

In healthy people, though, moderate intake of red wine may indeed improve heart health.

In a study of 80 healthy, young people, a smaller amount of red wine (100 ml/day) over 3 weeks boosted blood vessel health, nitric oxide, and the number of cells that regenerate blood vessels (endothelial progenitor cells). Drinking water, beer, or vodka didnt achieve these effects [8].

In cells, resveratrol increased the enzyme that makes nitric oxide (NO synthase) [9].

According to animal and cellular studies, resveratrol also reduces the formation of plaques in arteries, known as atherosclerosis. It also reduces the clumping of platelets, reduces blood lipids, and lowers inflammatory substances that increase risk of atherosclerosis [10].

In cells, resveratrol increases the expression of the PON1 gene, which reduces inflammation and helps detox pesticides and drugs [11].

Clinical studies suggest that drinking small amounts of red wine daily might support heart healthbut resveratrol supplements probably dont.

Researchers are investigating the effects of resveratrol on liver disease and bile flow.

Most clinical research suggests that resveratrol is not beneficial for non-alcoholic fatty liver disease (NAFLD). According to one analyses of four small clinical studies, resveratrol (300-3000 mg daily) taken for 3 months does not affect liver enzymes, insulin resistance, or weight in patients with NAFLD [12].

In animals, it prevented and improved conditions of obstructed bile flow (by blocking MMP-2 and MMP-9). It also prevented liver damage in animals with sepsis, or blood poisoning from serious infections. These effects remain to be explored in clinical studies [13, 14, 15].

Resveratrol likely doesnt improve non-alcoholic liver disease. Its oher purported effects on the liver remain unexplored in humans.

The following purported benefits are only supported by limited, low-quality clinical studies.

There is insufficient evidence to support the use of resveratrol for any of the below-listed uses.

Remember to speak with a doctor before taking resveratrol supplements. Resveratrol should never be used as a replacement for approved medical therapies.

One study suggested that resveratrol helps with glucose metabolism. In 11 healthy but obese men, resveratrol (150 mg/day) increased insulin sensitivity and lowered blood sugar levels after 30 days [16].

However, additional clinical studies are lacking. Therefore, existing evidence does not support the use of resveratrol for lowering blood sugar.

It also raised SIRT1 and PGC-1a levels. SIRT is an enzyme crucial for turning off harmful genes that increase fat deposits, blood sugars, and inflammation in the body, while PGC-1a supports healthy mitochondria [16].

Resveratrol lowered blood sugars in studies on rats with diabetes. It prompts cells to take in more glucose, which reduces insulin resistance. Resveratrol also protects the insulin-secreting beta cells in the pancreas, which helps increase insulin when its low and decrease it when its too high [17].

Scientists have yet to explore resveratrols effects on insulin resistance and diabetes in humans.

Despite some promising early findings, its still uncertain whether resveratrol supports healthy blood sugar control in people at risk of type 2 diabetes.

According to one research team, resveratrol may help balance the response to estrogen, which affects reproductive health in both men and women.

In male rats, resveratrol increased testosterone and sperm count without any adverse effects. Scientists think it may activate the HPG hypothalamic-pituitary-gonadal axis that controls sex hormone release from the hypothalamus via the pituitary in the brain [18].

In women, resveratrol may act in a somewhat different way. In one trial of 40 postmenopausal women, resveratrol (1g/day for 12 weeks) didnt affect estrogen or testosterone but increased the protein that binds sex hormones and carries them through the blood (SHBG) by 10%. It also improved estrogen metabolism, which may lower the risk of breast cancer [19].

In animals, it blocks the enzyme that makes estrogen (aromatase) and mildly activates estrogen receptors. Resveratrol binds to estrogen receptors much weaker than estrogen does, which has a balancing effect: it may help increase estrogen-like activity when this female sex hormone is low (as after menopause) or decrease it when its too high. More human studies are needed [20, 21].

Based on limited evidence, reveratrol may affect some hormonal and metabolic markers in postmenopausal women. Data are still inconslusive.

In a clinical trial of 20 people with acne, a gel with resveratrol showed positive results over 2 months. It reduced acne severity by almost 70% and improved overall skin health by over 50% with no adverse effects. The team discovered that cosmetic products with resveratrol are stable and dont degrade when kept in the fridge (at 4C/40F) [22].

No clinical evidence supports the use of resveratrol for any of the conditions listed in this section.

Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.

Scientists believe resveratrol may have dual antioxidant activity: as a direct antioxidant and as a compound that may increase other antioxidant enzymes, genes, and pathways.

Antioxidant claims underlie many of its purported health benefits. Based on this theory, oxidative stress and inflammation trigger or worsen numerous diseases from heart disease and diabetes to cancer and cognitive decline [3].

Resveratrol increased antioxidant enzymes in cellular and animal studies, including the following:

At the same time, limited studies suggest that resveratrol reduces free radicals and inflammatory substances (including iNOS, Myeloperoxidase, NADPH oxidase) [23].

Scientists are investigating whether resveratrol activates antioxidant enzymes in cells and animals, but human data are not available.

Aside from its indirect antioxidant effects on inflammation, resveratrol is theorized to affect specific inflammatory processes.

For one, it may block inflammatory COX enzymes, which are also the main target of commonly used painkillers and anti-inflammatory drugs (NSAIDs like Motrin). However, resveratrols mechanism and anti-inflammatory potential hasnt been clinically confirmed [25].

Some scientists suspect that resveratrol also blocks the following inflammatory players (in animals or cells):

Researchers propose that resveratrol acts on several anti-inflammatory pathways, but this hasnt been proven in humans.

Resveratrol may not be the philosophers stone that will confer you immortality, but scientists are looking to see if it can beneficially impact some important aging-related disease pathways.

Based on animal and cellular research, they hypothesize that resveratrol may combat some age-related disorders by [28, 29]:

Well present some interesting aging-related resveratrol research and hypotheses below. Nonetheless, the whole anti-aging theory of resveratrol remains unproven.

One of the theories scientists use to explain aging involves so-called cellular senescence. With aging, cells become senescent and less resilient to stress, they lose their function and start producing inflammatory substances [30].

This loss of function and inflammation on a cellular level then extends to organs and tissues: the brain, heart, muscles, skin, and gut and the body as a whole also start to degenerate and lose function, especially if the body cannot or does not eliminate the dysfunctional cells through a process called autophagy [30].

SIRT1 is an enzyme that can turn off genes that trigger cellular senescence. Scientists are wondering if, by activating SIRT1, resveratrol may epigenetically hinder the aging process, at least based on cellular studies [3, 31].

Autophagy is a normal process that triggers the destruction of damaged cells, recycling the products of broken-down cells to make new and healthy ones. Autophagy is our bodys main Quality Control Officer.

Some theories have linked aging and age-related diseases to impaired autophagy. Though these theories are still a topic of research, they have yet to be confirmed or rejected.

Autophagy theories also led to the recent boom in caloric-restriction practices. Caloric restriction is said to promote longevity and healthy aging by activating autophagy [32].

However, caloric restriction is not safe for everyone. It may be especially tricky for older or thin people who struggle to get enough nutrients in their daily diet.

In animal studies, resveratrol confers similar benefits to caloric restriction and increases autophagy induction without the need to reduce daily calorie intake. These effects have not been investigated in humans yet [32].

Clinical studies are needed to determine whether or not resveratrol can extend lifespan in humans.

Some scientsts hypothesize that reveratrol turns on anti-aging pathways like SIRT1 and autophagy, but theyve only tested their theories in cells and animals so far.

Glial cells, specifically astrocytes, provide support and protection to neurons and their damage or dysfunction is linked to many brain-related diseases [33].

One of the ways in which astrocytes protect neurons is by removing excess glutamate (a neurotransmitter) from synapses and the extracellular space that surrounds neurons. Excess glutamate in the brain can lead to excitotoxicity and ultimately neuronal damage or even death [33].

In a cellular study, resveratrol increased their glutamate uptake. Theoretically, this is linked to better protection from brain degeneration and stroke. However, we cant draw this conclusion from a cell-based study [33].

In animal studies, resveratrol reduced seizures and protected the hippocampus, the brains main memory hub. It also increases IGF-1 in the hippocampus, which may improve cognition [34, 35].

One research group suggested that resveratrol may protect the brain by acting on the gut-brain axis [36].

According to this unproven theory, resveratrols potential benefits may not even depend on it being absorbed and passing the blood-brain barrier. In mice, resveratrol stimulated gut nerves, which passed the signal on to the hippocampus. Resveratrol was undetectable in the hippocampus, it improved cognition only by activating nerves in the gut [36].

In a study on brain cells, resveratrol increased the activity of the antioxidant gene heme-oxygenase 1, which protects the brain from damage. The effect was enhanced by melatonin [24].

In mice with late-onset Alzheimers disease, long-term resveratrol supplementation reduced cognitive impairment and disease biomarkers. It could also activate AMPK, which maintains energy balance in the brain under challenging conditions [37, 38].

Nonetheless, clinical studies have not yet examined the effects of resveratrol on brain health. Thus, this purported benefit remains unproven.

Animal experiments point to resveratrols brain-protective potential, but clinical studies are still lacking.

Some scientists believe that the gut microbiome can protect against diseases of the arteries [39].

In one study, resveratrol protected blood vessels in mice without APOE, stopped harmful bacteria in their gut from secreting harmful oxidative substances (like TMAO), and balanced their microbiome. It increased beneficial gut bacteria (such as Lactobacillus and Bifidobacterium), which raised the production of bile acids [39].

According to some, resveratrol may counter lower bile acid production and the weaker ability to eliminate cholesterol in people with heart disease. However, clinical trials are lacking to support such claims [40].

No clinical evidence supports the use of resveratrol in people who struggle with obesity. The existing animal research should guide future human studies.

In mice fed a high-fat diet, resveratrol reduced oxidative stress and prevented the death of protective immune cells called Tregs [41].

Resveratrol stopped fat cells from making new fats and triggered their death, in cell-based studies. It accomplishes this by turning off genes that cause weight gain (such as PPAR gamma) while activating genes that enhance energy use and mitochondrial health (SIRT3, UCP1) [42, 43].

Additionally, resveratrol may boost weight loss by blocking several key fat-creating enzymes (called fatty acid synthase, lipoprotein lipase, and hormone-sensitive lipase) [42].

This purported benefit remains unproven.

Stem cells in the connective tissue are presented with several possibilities: to develop into fat cells, bone-building cells, joint, or muscle cells. Resveratrol activates the fat-burning pathway (SIRT1), which blocks genes that increase fat storage (PPAR gamma). This epigenetic shift causes stem cells to develop into bone-building cells, which may boost bone health [44].

According to some, resveratrol may synergize with Vitamin D and vitamin K2 to protect the bones and increase their mineralization [45].

Evidence is lacking to support the use of reveratrol for bone health, weight control, and microbiome or bile imbalances.

The effects of resveratrol on cancer prevention in humans are unknown.

Scientists are investigating resveratrol for its potential to prevent cancer, especially liver cancer and some other cancer cell types [46, 47, 48].

In mice, resveratrol applied to the skin before UVB exposure prevented skin cancers. Given orally, it was active against esophageal cancer in rats [49, 50].

Since resveratrol is an antioxidant phytoestrogen, some scientists are investigating its effects on breast cancer. In cells, it blocks the enzyme aromatase, which makes estrogen. High activity of this enzyme and high estrogen levels worsens a common type of breast cancer that has receptors for estrogen (receptor-positive or ER+) [51, 52].

In animal studies, resveratrol prevented and reduced the growth of breast cancer. Clinical studies have not yet determined its efficacy and safety in breast cancer patients [51].

Aside from its hormonal effects, scientists are wondering whether resveratrol can regulate another cancer enzyme called topoisomerase II. In cells from a deadly brain tumor (glioblastoma), resveratrol blocked the activity of this cancer enzyme, which should guide further research efforts [53].

There is no evidence that resveratrol can help prevent cancer in humans.

According to some unproven theories, resveratrol may increase muscle-building pathways and block processes that degrade proteins (proteolysis). For example, it increased the size of fish and enhanced their muscle growth in one study [54].

In another study, resveratrol supplementation enhanced the exercise training response, upper muscle strength, and aerobic performance in rats [55].

Scientists are questioning if its effects stem from epigenetic changes like activating fat- and sugar-burning sirtuins (SIRT1) and other molecules that heighten energy levels (AMPK and PGC-a). Future studies might give us some answers [55].

In mice, high-dose resveratrol had a good anti-radiation effect. It prevented the decline in bone marrow and white blood cells from radiation, helping to maintain proper immune function. It also increased the antioxidant and detox enzyme SOD without causing adverse effects. These effects remain completely unproven in humans, though [56].

Scientists found that noise increases free radicals, which can cause ear damage and hearing loss. In mice exposed to damaging noise, resveratrol protected against hearing loss by neutralizing free radicals and improving blood flow in the ears [57].

In a different rat study, resveratrol prevented ear damage from the toxic chemotherapy drug cisplatin [58].

Clinical research is needed.

The impact of resveratrol on muscle growth, radiation, and hearing loss in humans is still unknown.

Resveratrol has some virus-fighting action, according to cell-based or animal studies. It was effective against:

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22 Purported Resveratrol Benefits - SelfHacked

What Is the Difference Between Resveratrol & Grape Seed …

Posted: at 1:52 am


Unlike grape seed extract, resveratrol comes from grape skins.

Both resveratrol and grape seed extract are derived from grapes, but unlike grape seed, resveratrol is extracted from grape skins like those used to make red wine. Although both substances have similar actions in the body, they each have some individual recommended medicinal uses. You might take grape seed extract for different health benefits than resveratrol. Before you begin taking either alternative remedy, consult your doctor to discuss the correct dosage and possible drug interactions.

Identification

Resveratrol is also found in peanuts and purple grape juice. Because resveratrol is found in the highest concentrations in red wine, wine is considered the main dietary source of resveratrol. Grape seed extract is taken from the seeds or from whole grapes. Grape seed extract contains substantial amounts of flavonoids, vitamin E and linoleic acid, among other important constituents.

Function

Both resveratrol and grape seed extract act as powerful antioxidants in the body. Antioxidants combat free radicals, which can attack and kill your body's cells, as well as damage cell DNA. Antioxidants also play a role in certain medical conditions like heart disease and cancer, as well as in aging. The antioxidant actions in grape seed extract are attributed to the constituents known as oligomerica proanthocyanidin complexes, or OPCs, while resveratrol itself is a constituent of grape skins that bears the antioxidant effects. Additionally, resveratrol is considered a phytoestrogen, which is a plant-based substance that acts in a similar way to the estrogen hormone in your body.

Effects

Due to its antioxidant and estrogen-like actions in the body, resveratrol is sometimes used to treat heart disease and prevent cancer. Grape seed extract's antioxidant actions account for its potential use in treating chronic venous insufficiency, high cholesterol, edema and hypertension, as well as in preventing cancer, according to the University of Maryland Medical Center. Grape seed extract is also sometimes recommended for treating diabetes, hemorrhoids and poor night vision, and for skin anti-aging purposes. Additionally, grape seed may help treat burns, atherosclerosis, constipation and other gastrointestinal conditions, as well as promote wound healing, according to the Memorial Sloan-Kettering Cancer Center. No widely accepted, conclusive scientific research supports the use of resveratrol or grape seed extract to prevent or treat any medical condition, however.

Dosages

A typical dose of resveratrol is 500 mg per day, according to the University of Pittsburgh Medical Center. For grape seed extract, a daily dosage of 200 to 400 mg is used to treat edema and 150 to 300 mg to treat chronic venous insufficiency, notes the University of Maryland Medical Center. You could take 25 to 150 mg of grape seed extract up to three times daily for general antioxidant effects. Grape seed extract is usually standardized to contain 40 to 80 percent proanthocyanidins. Ask your physician about the dosage that's right for you before taking grape seed extract or resveratrol.

Warning

Resveratrol's estrogenic effects could potentially increase the growth of breast cancer cells, making the remedy unsafe for women who have or are at risk of having estrogen-sensitive types of cancer, warns the University of Pittsburgh Medical Center. Grape seed extract may offer blood-thinning effects, making the remedy possibly unsafe if you're also taking anticoagulant drugs like Coumadin, warns the Memorial Sloan-Kettering Cancer Center. The same is true if you have a bleeding disorder like hemophilia, notes the University of Maryland Medical Center.

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What Is the Difference Between Resveratrol & Grape Seed ...

8 Reasons To Love Red Wine | Prevention

Posted: at 1:52 am


Beneficial Booze

Any hardworking gal knows that kicking back with a girlfriend and a glass of red wine is a fabulous way to de-stress. The best part? Your red-wine habit also happens to come with some happy health benefits, such as protecting your ticker and even slimming your waistline. Check out these eight reasons why winding down with a glass of vino is a good call all around.

MORE: 9 Very Best Solutions To Solve Your Snoring (Prevention Premium)

1. Lower your cholesterol

High-fiber Tempranillo red grapeswhich are used to make certain red wines, like Riojamay actually have a significant effect on cholesterol levels,according to a study from the Universidad Complutense de Madrid in Spain.

Healthy study participants who consumed the same grape supplement found in red wine saw their LDL, or "bad cholesterol," levels decrease by 9% among healthy. Participants withhigh cholesterol experienced a drop of 12%. What's the big deal? Excess LDL ends up getting deposited in arterial walls and forming plaque, which causes arteries to stiffen and blood pressure to rise, ultimately leading to heart attacks, says Arthur Agatson, MD, an associate professor of medicine at the University of Miami and author ofThe South Beach Heart Program.

MORE: 12 Foods That Lower Cholesterol Naturally

2. Protect your heart

On top of lowering bad cholesterol, polyphenolsthe antioxidants in red winecan help keep blood vessels flexible and reduce the risk of unwanted clotting, saysJohn Folts, PhD, a professor of cardiovascular medicine and nutrition at the University of WisconsinMadison.

"They're nearly as effective as aspirin," says Folts. But be careful: Chronic heavy drinking damages the heart, so, as with most things, moderation is key.(If you prefer an aspirin to protect your ticker, be sure to follow these3 aspirin safety tips.)

MORE: 28 Days To A Healthier Heart

3. Control blood sugar

The skin of red grapesa rich source of red wine's natural compound resveratrolmay actually help diabetics regulate their blood sugar, finds recentresearch published in the journalNutrition. Study participants who took a250 mg resveratrol supplement once a day for three months had lower blood glucose levels than those who didn't take the pill. Plus, resveratrol-takers also had significant decreases in total cholesterol and systolic blood pressure. Researchers suspect that resveratrol may help stimulate insulin secretion or activate a protein that helps regulate glucose and insulin sensitivity.

4. Boost your brain

Resveratrol may also be the key to keeping your memory sharp, says Philippe Marambaud, PhD, a senior research scientist at New York's Litwin-Zucker Research Center for the Study of Alzheimer's Disease and Memory Disorders. The compound has been shown to hamper the formation of beta-amyloid protein, a key ingredient in the plaque found in the brains of people with Alzheimer's.Marambaud suggests flexing your noodle by doing crossword puzzles and brain teasers for an hour then cooling down with a glass of wine. New to brain teasers? We've got you covered with 7 Brain Games That Make You Smarter.

5. Fight off a cold

If you hate getting sick (and who doesn't?), the antioxidants in red wine may help keep you healthy.A 2010 study in the American Journal of Epidemiology found that among 4,000 faculty members at five Spanish universities,those who drank more than 14 weekly glasses of wine for a year were 40% less likely to come down with a common cold.Why? According to the National Institutes of Health, antioxidants are believed to fight infection and protect cells against the effects of free radicals, which may play role in cancer and other diseases.

Another antioxidant boost? They may also lower sex hormone levels to protect against breast cancer,says a study from Cedars-Sinai Medical Center in Los Angeles.(Stay up to date on the latest breast cancer news with ourBreast Cancer Center.)

6. Stop cancer

According to researchers at the University of Virginia, the resveratrol you get from drinking one glass of red wine three or four times a week may be enough to starve any nascent cancer cells. The scientists dosed human cancer cells with resveratrol and found that the compound inhibited the key action of a cancer-feeding protein.

MORE: The Ultimate Anti-Cancer Diet

7. Get slim

Clearly, resveratrol is a bit of a limelight hog when it comes to the healthful compounds in vino. But research in the Journal of Biological Chemistry suggests piceatannol, the chemical compound our bodies convert from resveratrol, deserves some credit. This compound was shown to actually prevent the growth of fat cells in a series of lab tests. How? Researchers say that piceatannol binds to the insulin receptors of fat cells, essentially blocking the pathways necessary for immature fat cells to mature and grow.

8. Jazz up dinner

Who said your red wine consumption had to be limited to the glass? You can include the drink in your dinner, either as a sauce (in which case we suggest our yummy DIY red wine sauce) or complimentary ingredient, and still reap its benefits.

Need inspiration? We love these four recipes:

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8 Reasons To Love Red Wine | Prevention

Caudalie unlocks a centuries-old secret of youthful skin with its bestselling resveratrol line – CNN

Posted: at 1:52 am


(CNN)

Youre not alone in feeling like you aged a decade in the last year. And youre also not the only one who secretly partially dreads the idea of seeing your co-workers, friends and family after such a long time away from face-to-face contact after all, cucumber peels and exfoliating brushes werent exactly on the top of anyones daily to-do list.

So whats the answer to washing away all the extra years you psychically packed into your skin while you kept the world from crumbling all around you for over a year? Caudalie has a suggestion: Hit the wine bottle. Just not quite in the way you think.

For centuries, in the heart of wine country in France, wine grapes were the secret to the glowing, spot-free skin of the women who worked the vineyards making some of the finest vintages the world has ever seen. But it wasnt until the mid-1990s in Bordeaux that Mathilde and Bertrand Thomas, working with Professor Joseph Vercauteren, finally pinpointed the actual science behind the beauty secrets local women had known for so long. The result was Caudalie, a beauty company that harnessed the unsurpassed power of the anti-aging polyphenols found in the grape seeds that most wineries simply let go to waste. And in the last year, Caudalies resveratrol collection has skyrocketed in popularity with good reason.

Working with a Harvard University genetics professor, Caudalie patented a combination of resveratrol, a natural phenol found in grapevines to help regenerate healthy cells after damage, and hyaluronic acid, a substance found naturally in your body whose function is to keep your skin and eyes well lubricated. That elixir has been found to be twice as effective as retinol in keeping skin visibly firm. And thats the mixture that Caudalie has used as the key to its line of resveratrol skin and beauty products.

Its the reason why Resveratrol-Lift Instant Firming Serum has become such a hit, with users swearing by it. Theyve gone on record saying theyre getting noticeable results within weeks, with Caudalies resveratrol serum leaving them feeling fresh and not oily or overly scented but still keeping the skin smooth and hydrated. Look it up for yourself: Its earned over 100 5-star reviews.

In keeping with Mathilde Thomas philosophy, all resveratrol products are at least 97% natural and follow the universal Caudalie rule of no parabens, phenoxyethanol, phthalates, mineral oils, PEGs, silicones or animal-derived ingredients. In addition, Caudalie has committed to zero-waste packaging by 2022, meaning all packaging will soon be completely recycled, recyclable or refillable, using less paper and no plastic film. That means a reduction in Caudalies carbon footprint of a whopping 40%. So when you buy Caudalie, youre not just restoring your own beauty; youre helping preserve our planets.

As we all start to finally return to our daily regimens of self-care, Caudalies resveratrol line should be part of your go-to skin care products when you wake up and when you go to bed. Because the secret to glowing, youthful skin is out and this is one vintage you dont want to pass up.

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Caudalie unlocks a centuries-old secret of youthful skin with its bestselling resveratrol line - CNN

Resveratrol in red wine could help to treat endometriosis – The Drinks Business

Posted: at 1:52 am


Researches at the Iran University of Medical Sciences have found that the anti-inflammatory properties of resveratrol in red wine could help to treat endometriosis.

As reported by Wine Spectator, the study was published in the online journalNature.

Endometriosisis a condition where tissue similar to the lining of the womb starts to grow in other places, such as the ovaries and fallopian tubes. It can affect women of any age and can cause chronic pain, irregular bleeding and infertility.

There is no cure for endometriosis, which is treated with anti-inflammatory medication.

The Iran study aimed to find out how effective resveratrol an antioxidant-rich compound found in red wine was in treating the symptoms of endometriosis.

The researches tested the antioxidant in the lab on endometrial cells, collecting endometrial cells from 40 patients suffering from stage 3 or 4 endometriosis, along with 15 patients without the condition.

After isolating the cells, the scientists treated them with varying amounts of resveratrol.

As reported by Wine Spectator, three genes and the proteins they produce cause endometrial cells growing outside the uterus.

The researchers found that resveratrol suppressed all three of the offending genes, controlling inflammation and keeping the condition under control.

According to the findings, resveratrol may ameliorate endometriosis progression through reducing the expression of these genes in endometrial cells, the researchers reported, adding that further research was needed.

The findings give hope to women suffering from the condition, who may benefit from the anti-inflammatory effects of a daily glass of red wine.

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Resveratrol in red wine could help to treat endometriosis - The Drinks Business

Why Pinot Noir May Be The Best Wine For Your Health – Forbes

Posted: at 1:52 am


Glass of red wine and electrocardiogram

The benefits of drinking red wine have long been debated. Numerous studies have suggested that there is a link between moderate red wine consumption and heart health, but the issue has yet to be definitively settled.

According to the Mayo Clinic:

Red wine, in moderation, has long been thought of as hearthealthy. Thealcoholand certain substances inred winecalled antioxidants may help prevent coronary artery disease, the condition that leads to heart attacks. Any links betweenred wineand fewer heart attacks, (however) aren't completely understood.

The health benefits associated with drinking red wines are mainly associated with a powerful antioxidant called resveratrol. The Mayo Clinic has suggested that:

Resveratrol might help prevent damage to blood vessels, reduce low-density lipoprotein (LDL) cholesterol (the "bad" cholesterol) and prevent blood clots.

It also notes, however, that other studies found no benefits from resveratrol in preventing heart disease and that more research is needed.

Before you rush off to buy another bottle of your favorite red wine, however, you should note that the level of resveratrol in red wines can vary widely.

According to Jim Bernau, the president of Willamette Valley Vineyards, one of Oregons leading Pinot Noir producers, cool climate Pinot Noir, especially whole cluster fermented wines, are more likely to deliver high levels of resveratrol than other varietal red wines.

Jim Bernau, President, Willamette Valley Vineyards

Bernau notes that resveratrol is a fungicide, a polyphenolic compound an antimicrobial deterrent and repellant that is naturally produced by grape plants to protect grapes from molds. Its found in the skin of the grapes.

Red grape varieties grown in cool regions that are prone to high levels of humidity during harvest time, and more prone to mold damage, will produce higher levels of resveratrol than red grapes grown in drier regions.

Thin skinned grapes are even more vulnerable to being attacked by molds, so those varieties of grapes, he believes, also tend to produce even higher levels of resveratrol. According to Bernau, local climatic conditions post veraison, regardless of where the thin-skinned grapes are grown, is the determining factor.

There are many thin-skinned red grape varietals. Sangiovese, Tuscanys main grape varietal, is famously thin skinned, although Sangiovese Grosso, the Sangiovese clone used to make Brunello di Montalcino, is much thicker skinned.

In addition to Pinot Noir, other thin skinned red grape varietals include Grenache, Cabernet Franc, Merlot, Nebbiolo and Gamay. Grenache and Merlot are typically grown in drier, Mediterranean like climates, Bordeaux being something of an exception, and are less prone to mold outbreaks.

Cabernet Franc, Gamay and Nebbiolo can thrive in cooler climates in regions that can be prone to rainy weather during harvest season. They are good candidates to produce resveratrol rich wines.

Pinot Noir, however, is usually the northernmost planted red grape varietal, and typically reaches its most complex expression when grown in cool climates. Combined with its notoriously thin skins makes it the ideal candidate for producing wines with elevated levels of resveratrol.

Thats why Bernau, believes the defense response is greatest in the Pinot Noir variety He notes, however, that the impact of grape varieties on resveratrol levels needs more extensive study.

Resveratrol is a powerful antioxidant. That means it will combine readily with oxygen. In the body antioxidants inhibit oxidation, hence the name, by combining and neutralizing potentially damaging oxidizing agents.

To maximize the level of resveratrol in a wine, Bernau argues, its necessary to minimize the wines contact with oxygen.

As a general rule, winemakers want to limit oxygen contact with grapes, especially the grape must during fermentation.

Whole cluster Pinot noir grapes being emptied from a fermentation tank prior to being crushed.

Oxygen combines with phenolic compounds in wine or fermenting grape must and causes them to oxidize, resulting in a loss of fruity flavors and diminishing aroma. Oxidation can also lead to browning in a wine and the creation of aldehydic, nut like, flavors.

Oxidation is an inevitable consequence of aging wines. Thats why older wines tend to lose the purple and crimson coloration of their youth and become browner, more brick like in color, and often exhibit less intense fruit aromas and flavors. Presumably that means that older wines are likely to contain less resveratrol.

Whole cluster fermentation, a popular technique among Pinot Noir producers and the signature style of Beaujolais, is especially suited, Bernau believes, for maximizing resveratrol levels in wine.

Grapes that are vinified as whole clusters are not destemmed or crushed prior to vinification. Instead, they are placed as whole bunches in a fermenter. Typically, the grapes at the bottom of the fermenter are split open by the weight of the grapes on top of them, and some juice is released, but the majority of the grapes remain whole.

Once the fermenter is filled, carbon dioxide is pumped into the tank to flush out any oxygen; creating an anaerobic environment. The technique is called carbonic maceration. In this wine making process most of the actual fermentation occurs within the grape itself, thus limiting even more the fermenting grape juices exposure to oxygen. After the fermentation is over, the grapes are gently crushed to release the juice.

Carbonic maceration is used to produce light bodied, fresh and fruit forward red and ros wines. One of the characteristics of such wines is that they have a distinctive bubble gum flavor note. If you detect a bubble gum flavor in a wine, then the odds are that at least a portion of that wine was produced using carbonic maceration.

Since contact with oxygen reduces resveratrol levels, Bernau believes that you should not decant a wine if you are looking to preserve the resveratrol level.

He also notes that there is no relationship between a wines appearance and the level of resveratrol it contains. Since resveratrol is found in the skins of grapes, extended contact should theoretically increase resveratrol levels.

Deeply hued wines, presumably an indication of extended skin contact, do not, however, necessarily have higher resveratrol levels argues Bernau, the issue is extraction at lower levels of oxygen thats why clusters fermented whole result in more resveratrol content than those macerated through punch downs or pump overs.

There are still a lot of questions about resveratrol that remain to be answered. Its health benefits have not been definitively settled. How to maximize resveratrol levels in wine production, the impact of vineyard management techniques, the effect of different grape varietals, the consequences of different closures during bottling, all await further study.

For now, however, if you are looking to maximize the health benefits of drinking red wine, reaching for a bottle of whole cluster fermented, cool climate Pinot Noir, like the kind produced in Oregons Willamette Valley, would be a good place to start!

More here:
Why Pinot Noir May Be The Best Wine For Your Health - Forbes

Resveratrol Market to Witness Robust Expansion throughout the Forecast 2021-2031 Future Market Insighgts – NewsMaker

Posted: at 1:51 am


A recent market study published by Future Market Insights on theResveratrol market offers global industry analysis for 2016-2020& opportunity assessment for 20212031s. The study offers a comprehensive assessment of the most important market dynamics. After conducting a thorough research on the historical, as well as current growth parameters of theResveratrol market, the growth prospects of the market are obtained with maximum precision.

To Get Sample Copy of Report Visit @ https://www.futuremarketinsights.com/reports/sample/rep-gb-2744

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The global Resveratrol market is segmented in detail to cover every aspect of the market and presentComplete market intelligence to readers.

For More Details, Ask Analyst @ https://www.futuremarketinsights.com/ask-question/rep-gb-2744

Report Chapters

Chapter 01Executive Summary

The executive summary of theResveratrol market includes the market proprietaryGlobal Market Outlook, Demand-side Trends, Supply-side Trends, Technology Roadmap Analysis, Analysis and Recommendationson the globalResveratrolmarket.

Chapter 02 Market Overview

Readers can find the detailed segmentation and definition of theResveratrol market in this chapter, which will help them understand basic information about theResveratrol market. This section also highlights the inclusions and exclusions, which help the reader understand the scope of theResveratrol market report.

Chapter 03Key Market Trends

The key market trend is assessed in this chapter which gives brief idea about Key Trends Impacting the Market, Product Innovation / Development Trends. Which help in understand the market trends in resveratrol market.

Chapter 04Key Success Factors

In this chapter readers will find about these key success factors: Product Adoption / Usage Analysis, Product USPs / Features, Strategic Promotional Strategies of resveratrol market.

Chapter 05 Global Resveratrol market Demand Analysis and Forecast 2016-2031

This chapter includes detailed analysis of the historical Resveratrol market (2016-2020), along with an opportunity analysis for the forecast period (2021-2031). Readers can also find the absolute $ opportunity for the current year (2020 2021) and incremental opportunity for the forecast period (2021-2031).

Chapter 06 Global Resveratrol market - Pricing Analysis

This chapter includes global as well as regional pricing analysis by source. The pricing influencing factors are also explained in this chapter. The readers can understand the manufacturer level, distributor level as well as retail level pricing analysis for 2021 and 2031.

Chapter 07Global Resveratrol Market Demand (in Value or Size in US$ Mn) Analysis 2016- 2020 and Forecast, 2021-2031

In this chapter Historical Market Value (US$ Mn) Analysis, 2016-2020, Current and Future Market Value (US$ Mn) Projections, 2021-2031 in which Y-o-Y Growth Trend Analysis and Absolute $ Opportunity Analysis are given according to the resveratrol market.

Chapter 08 Market Background

The associated industry assessment of theResveratrol market is carried out in this section. The macroeconomic factors affecting growth of theResveratrol market are provided in this section and the impact of these macroeconomic indicators on theResveratrol market is analyzed. The processing overview and technological advancements in theResveratrol market is also provided.

Chapter 08(a)GlobalResveratrol market Value Chain

Profit margins at each level of theResveratrol market are analyzed and readers can find detailed information on top importers and exporters as well as the value chain of theResveratrol market.

Chapter 08(b) Market Dynamics

The drivers and restraints impacting the growth of theResveratrol market are explained in this chapter. Opportunities and ongoing trends in theResveratrol market are also comprehensively discussed.

Chapter 09 GlobalResveratrol market Analysis 2016-2020& Forecast2021-2031by Product Type

Based on Product Type, theResveratrol market is segmented intoExtract (Plant-based), Fermentation (Yeast-based), and Synthetic (Chemical Synthesis).In this chapter, readers can find information about key trends and developments in theResveratrol market and market attractiveness analysis based on Product Type.

So On

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Resveratrol Market to Witness Robust Expansion throughout the Forecast 2021-2031 Future Market Insighgts - NewsMaker

How a glass of wine could ease the agony of endometriosis for millions… – The Sun

Posted: at 1:51 am


DRINKING a glass of wine a day could ease the agony of endometriosis for millions of sufferers, experts have revealed.

Researchers at the Iran University of Medical Sciences found that compounds included in red wine could help treat common symptoms of the illness.

1

One in ten women are thought to be plagued by endometriosis and it takes around seven and a half years from the onset of symptoms for a woman to be diagnosed with the condition.

Endometriosis is where tissue that is similar to the lining of the womb grows in other places.

This can be the ovaries and fallopian tubes.

It can affect women of any age and can cause chronic pain, irregular bleeding and infertility.

At present, there is no cure for endometriosis and many cases are treated with anti-inflammatory medication.

THE SYMPTOMS OF ENDOMETRIOSIS

THE main symptoms associated with endometriosis are:

This is where compounds found in red wine can help.

The study published in Nature journal, conducted by experts in Iran looked at an ingredient called resveratrol.

This is an antioxidant-rich compound that is found in red wine.

Experts looked at how effective this would be in treating patients with endometriosis and found that the ingredient was able to suppress the condition, controlling inflammation.

Researchers tested the ingredient in a lab on endometriosis cells.

They collected the cells from 40 patients who were suffering from stage 3 and 4 endometriosis.

They also tested the ingredient on 15 patients who did not suffer with the condition.

The cells were isolated before being treated with resveratrol.

The experts said there were three genes and proteins that caused cells to grow outside the uterus and that resveratrol suppressed them all.

The researchers added: According to the findings, resveratrol may ameliorate endometriosis progression through reducing the expression of these genes in endometrial cells.

They said further research was needed to see how the ingredient could be used.

It comes after it was last month revealed that a drug that is currently used to treat rare metabolic conditions in children is now being trialled on endometriosis patients.

MYSTIC MEGApril 16: Secrets dont sit well with you and now is the time to say so

CARAVAN GLAMIm teen traveller & husband pays for my hair, nails & lashes- its tradition

NOTE OKAYExhausted neighbour writes brutal note begging woman dump whiny a*s boyfriend

CLEAR VIEWMan buys green morphsuit so hes invisible during girlfriends Zoom calls

IN THE PINKMum completely revamps her patio by ditching jet wash & using 1 cream instead

MOP THE HELLBritain's most extreme cleaners - including woman who PAINTS floor twice daily

Dichloroacetate helps to control lactate levels, which have found to be at high levels in patients suffering with endometriosis.

Experts at the University of Edinburgh are currently conducting a trial with 30 women as the search continues for an effective endometriosis treatment.

When testing the drug the experts found that the pelvic walls of women with the condition differ from those without the disease.

When the cells were treated with dichloroacetate they returned to normal behavioural patterns.

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How a glass of wine could ease the agony of endometriosis for millions... - The Sun

Global Resveratrol Market 2021 Trending Technologies, Competitors Analysis, and Industry Insights SoccerNurds – SoccerNurds

Posted: at 1:51 am


The Resveratrol market offers an extensive analysis of the crucial industry aspects including drivers, restraints, limitations, growth prospects and opportunities, threats, and macro and micro-economic factors. The study offers decision-makers all the crucial statistical data to help them gain maximum returns on their investments and capitalize on the emerging growth prospects. The Resveratrol Market research report draws focus on the strengths and weaknesses of the key players of the market through a comprehensive SWOT analysis and Porters Five Forces analysis to project the growth rate.

Get the PDF Sample Copy (Including FULL TOC, Graphs and Tables) of this report @https://www.in4research.com/sample-request/31245

Following Top Key Players are Profiled with Global Positioning:

The report contains a serious examination of the key players working in the Resveratrol market and covers inside and out information identified with the serious scene of the market and the ongoing methodologies and items that will help or influence the market in the coming years.

The global Resveratrol market report further segments the market based on product types offered by the market, applications, and key geographies of the market. The research study assesses the market in terms of market size, volume, revenue, and share.

Global Resveratrol Market Segmentation By Type:

Global Resveratrol Market Segmentation By Applications:

Global Resveratrol Market Segmentation By Regions:

Get Updated COVID19 Impact Analysis on Resveratrol Market @ https://www.in4research.com/impactC19-request/31245

This report provides a critical analysis of the global Resveratrol market in respect to the COVID-19 pandemic and its adverse impact on the manufacturing and global sales of the product. It provides an extensive study on the impact of the COVID-19 pandemic on the global Resveratrol market and explains how it would affect the business operations of the industry soon.

Global Resveratrol market report client gets detailed and verified data about the business. Likewise, this report covers the top to bottom factual investigation and the market elements and requests which give an entire situation of the business. The report gives the distinctive business challenges which are affecting business sector development a positive and negative way.

Chapters Define in TOC (Table of Content) of the Report:

Chapter 1: Resveratrol Market Overview, Drivers, Restraints and Opportunities, Segmentation overview

Chapter 2: Market Competition by Manufacturers

Chapter 3: Production by Regions

Chapter 4: Consumption by Regions

Chapter 5: Production, By Types, Revenue, and Market share by Types

Chapter 6: Consumption, By Applications, Market share (%) and Growth Rate by Applications

Chapter 7: Complete profiling and analysis of Manufacturers

Chapter 8: Manufacturing cost analysis, Raw materials analysis, Region-wise manufacturing expenses.

Chapter 9: Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10: Resveratrol Marketing Strategy Analysis, Distributors/Traders

Chapter 11: Market Effect Factors Analysis

Chapter 12: Market Forecast

Chapter 13: Resveratrol Market Research Findings and Conclusion, Appendix, methodology and data source.

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Global Resveratrol Market 2021 Trending Technologies, Competitors Analysis, and Industry Insights SoccerNurds - SoccerNurds

Leaders in Cannabis Formulations: Part 2 – Cannabis Industry Journal

Posted: at 1:51 am


Editors Note: In Part 1 of this series, green sat down with Drew Hathaway, senior food scientist at Stillwater Brands. Click here to see Part 1.

Natural cannabinoid distillates and isolates are hydrophobic oils and solids, meaning that they do not mix well with water and are poorly absorbed in the human body after consumption. By formulating these ingredients using a patented delivery system technology, trademarked VESIsorb, Geocann has overcome common obstacles associated with fat-soluble active ingredients, including poor stability, bioavailability, absorption, and solubility. In addition, Geocann has peer-reviewed, published evidence of the dramatic improvements in Cmax, AUC, and Tmax(time to peak absorption directly related to fast-acting benefits).

Geocann is a cannabis formulation company with its headquarters in Fort Collins, Colorado, and additional offices in Chicago, Illinois and Zurich, Switzerland. The company is led by an impressive leadership team of scientists, pharmacists, researchers and natural product industry leaders. Geocanns technology platform has been successfully applied to a wide range of cannabis product applications, including soft gel and hard-shell capsules, functional foods (e.g. gummies) and beverages, powder systems, tinctures, sublingual sprays and topically applied formulations. Brand partners in the U.S. utilizing Geocanns technology for hemp applications include Nestl Health Science, Cannaray and Onnit, and brand partners for medical and adult-use cannabis applications include Curaleaf, Sunderstorm and CannaCraft, among others.

We spoke with Jesse Lopez, CEO and Founder of Geocann, about their product formulation technology in cannabis and how they work with brand partners in the U.S and internationally. Lopez started Geocann in 2018 alongside the success hes experienced at SourceOne Global Partners (founded in 2003 by Lopez), a leading formulation company in the nutraceuticals space with a reputation for pioneering innovative products that combine science-backed ingredients with patented drug delivery system technologies to address the most pressing consumer health concerns, such as heart health, cognitive function, inflammatory response, metabolic syndrome and type II diabetes, among others.

Aaron Green: Jesse, first off, how did you get involved in the cannabis industry?

Jesse Lopez: Our focus at SourceOne Global Partners has been on natural products for nearly two decades. Some of the folks involved with our natural products business decided that they would get involved in the cannabis business and they asked for my support at the Advisory Board level. I agreed to serve and figured I better learn about the cannabis industry! We realized that there was a tremendous opportunity for utilizing our drug delivery system technology to enhance the value of these cannabis-based products. Due to the regulatory environment, strategic legal counsel and new investments necessary to take an immediate leadership position in the cannabis industry we launched Geocann in 2018 with an office in a fully legal state at the time, Colorado.

Green: How do you select the natural products you work with at SourceOne?

Lopez: We really focus on science-backed natural product ingredients that may require high doses to reach therapeutic blood levels. By combining these science-backed ingredients with patented technologies which we own the global rights to these products offer desirable differentiation for leading brands, such as dramatically improved absorption and bioavailability, patent protection and trademarked intel inside branding.

Green: What are some of the other natural products you have experience with?

Lopez: We work with a range of some of the most popular nutraceuticals such as coenzyme Q10 and omega-3 fish oil to the more innovative natural products like resveratrol. We also work with vitamin D, and other immunity-based ingredients that can be enhanced using our delivery system technology to deliver greater benefits to the people that are taking those products.

Green: What is the technology and how does it work?

Lopez: I think its important to recognize our technology partner, Vesifact, in Zurich, Switzerland, who is the inventor of the VESIsorb technology platform and serves as the scientific research, technical support, production, and product development arm of SourceOne and Geocann. We are very proud of this symbiotic relationship where our role at Geocann and SourceOne is to provide the commercial development, sales, marketing and strategic distribution infrastructure. We promote our partnership openly on our website and in our marketing materials because of their unrivaled leadership position in the global marketplace.

They have consistently been recognized as a top 10 global organization for health-related nanotechnology patent activity, ahead of many of the most well-known pharmaceutical companies in the world. It is an intellectual property portfolio that has been used to provide solutions to the most difficult product formulation challenges over the yearsin pharmaceuticals, medical devices, nutraceuticals, cosmetics, and now cannabis applications. Together, our focus has been on delivering novel solutions in these diverse fields of use and product applications based upon VESIsorb formulation technology.

Each active compound identified with its own set of formulation, absorption and bioavailability challenges requires a customized solution that allows the full potential health benefits to be realized from success in the lab to commercial scale up. This is the process and we have successfully delivered unmatched solutions for close to twenty years from coenzyme Q10 to now both psychoactive and non-psychoactive cannabinoid product formulations in a wide range of product applications.

We saw the exploding interest in CBD with our nutraceutical partners and demanding consumers worldwide but chose to start Geocann to keep the markets served separate. We were confident that the VESIsorb technology would provide much needed solutions for CBD as a wellness product, but also adult-use and medical cannabis products regarding fast acting and product stability needs.

Green: Whats the problem in cannabinoid bioavailability that Geocanns technology helps to solve?

Lopez: It is well-recognized in the scientific literature that CBD, THC and other cannabinoids, in general, show limited bioavailability due to their lipophilicity, poor aqueous solubility and extensive first-pass metabolism.

OurVESIsorb technology was designed to address the poor bioavailability of drugs and natural bioactives like cannabinoids exhibiting poor water solubility but high membrane permeability (Biopharmaceutical Classification System: Class II compounds). The VESIsorb technology is a lipid-based formulation that self-assembles on contact with an aqueous phase into a colloidal delivery system. This colloidal solubilization improves the transport of the cannabinoids through the aqueous phase of the GI-lumen to the absorptive epithelium, dramatically improving bioavailability.

VESIsorb is typically characterized as a SEDDS (self-emulsifying drug delivery system). Whats unique about our VESIsorb SEDDS is the long history of safe and effective use worldwide and the large number of products that, over the years, weve successfully developed. With decades of experience delivering novel formulation solutions, there is significant and valuable know how that we bring to each formulation challenge. This know how allows us, for example, to develop cannabinoid formulationsthatprovide lymphatic absorption pathway advantages in addition to standard gastrointestinal absorption, therefore optimizing therapeutic blood levels for maximum benefits.

Needless to say, there are various methods that attempt to address the poor cannabinoid bioavailability.Unfortunately, too often, companies make claims that they have water soluble cannabinoids but offer little evidence to validate their claims.The popular misconception is that some degree of water solubility will consistently translate to improved bioavailability. This is clearly not accurate.We know scientifically that pharmacokinetic performance is highly variable. A review paper I read recently comparing water soluble delivery system formulation types illustrated this fact. There was greater than an eight-fold difference in bioavailabilityamongst the various water-soluble formulations.

Green: Can you tell me some details about your global license with Vesifact?

Lopez: Our technology exclusivity is based upon given categories. So, when we say we have global exclusivity for nutraceuticals, that can be as Ive already mentioned, omega-3, coenzyme Q10, or resveratrol as examples, and this business is managed by SourceOne. With regards to our global exclusivity for cannabinoids and terpenes whether we formulate these ingredients to create a functional drink, or were creating a gummy, or creating a softgel capsule or powder-filled hard-shell capsule, or sublingual, or topical all of those product applications are covered by ourexclusivity for the technology and is managed by Geocann.

The beauty of our technology is that weve already achieved success with all of those product applications. Thats one of the big advantages of our technology versus some other approaches trying to address the challenges of cannabinoid bioavailability.

Green: What kind of validation and clinical studies have you done so far in the cannabinoid space?

Lopez: We were the first to have stability data with creating our formulation in a soft gel capsule with CBD. We recently submitted to the European market for novel food application. We invested hundreds of thousands of dollars in proprietary safety studies that are required to achieve novel food status in Europe and FDA GRAS in the U.S. We have proprietary stability data as well as proprietary toxicology data from multiple, self-funded clinical studies. Many companies that submit for the EU novel food application are only referencing the existing scientific literature about the pharmacokinetics of cannabinoids, whereas we have our own peer-reviewed, published study. In our study, we compared our VESIsorb-CBD formulation to the industry standard MCT Oil-CBD formulation in a crossover design where we were able to demonstrate how we could dramatically improve the bioavailability of CBD.

Green: Can you talk about the benefits of your technology with regards to bioavailability and onset time?

Lopez: When you start talking about onset time we move into a broader discussion relative to cannabinoids. Weve been very successful with marijuana, especially as it relates to THC, because of the dramatic improvement in time to Tmax, and how much faster we reach Tmax than a standard THC formula. Our formulation is generally four times faster compared to standard formulations.

When it comes to area under the curve and Cmax, we show improvements of four to six times a standard THC or CBD product. Further, when we start looking at the differences between other studies that have been published, we show an even greater improvement based upon study comparisons to what other people have done, even compared to products like GW Pharmaceuticals Sativex Oromucosal Spray.

Green: Can you address the SEDDS formulation and liver metabolism?

Lopez: Weve dramatically overcome challenges with the first-pass effect. We have also formulated our products to address lymphatic absorption. So, were coming at it from a number of different angles.

We disagree with people who talk about water solubility as an end-all be-all solution. When you look at the range of published studies, whether its nanoparticles or liposomal systems or micro-emulsions, they all are water soluble systems, but yet the data shows theres dramatic differences in the real efficacy of those approaches, and what the actual improvement in blood levels are. Ultimately, those blood levels represent the efficacious nature of the products whether were talking about CBD, or talking about THC.

Green: As a Colorado-based company you work with cannabis partners across the US. Can you tell me about your relationship with marijuana product formulators and brands and how you structure your licensing agreements across state boundaries?

Lopez: In a recent article aboutthe leading fast acting gummies, the two companiesthey focused on were Sunderstorm with the Kanha Nano gummies and Curaleaf with their Select Fast Acting Nano gummies. Both of those companies use our VESIsorb technology. Were very proud of our relationship and the success theyre having as leaders in most dominant states with that particular product application.

Onset time has always been a challenge with gummies. And weve dramatically improved onset. Actually, weveshown statistically significant improvements for all measured pharmacokineticparameters in a recent peer-reviewed published study. We demonstratedmuch higher total absorption in maximum plasma concentration (Cmax), total exposure [area under the curve (AUC)]) and the time to reach the peak concentration (Tmax).

We say powered by VESIsorb technology the product is faster, stronger, longer.

Green: How does the experience differ from a standard oil- or isolate-based formulation?

Lopez: The only way that I can answer that question is weve had 100% success with the companies we work with in their initial trials. When someone tells me that a group of employees are going to try the product and theyre heavy users of cannabis and they are smokers, I think, wow, you know, gummies have to be really successfully formulated for someone like that to be pleased with the high. Then they come back and say, thats the best that Ive had in four years! and theyre totally blown away. Thats completely different than a peer reviewed published study, but for sure, thats the kind of feedback and anecdotal evidence that we get. I think thats why that application is growing so much faster now because weve overcome this onset issue.

Green: Do you give exclusive rights on a state-by-state basis?

Lopez: Were very selective about who we work with. Exclusivity is always part of the discussion. But at the same time, its really more about protecting the investment in the people that we partner with and not cannibalizing a given market. So, there are some exclusive relationships in the U.S. and internationally, like Heritage Cannabis and Pathway Health Corp in Canada, but for the most part, I would say simply, we were very selective about who we do business with and open to new partnerships.

Green: What kind of support do you provide to your licensing partners?

Lopez: We provide 100% formulation and technical support. We provide the SEDDS and then they use their own legal, licensed cannabis and their own equipment. Our system requires no special equipment or investment in changes to their process. So, not only do we provide formulation expertise, but our system is really easy to use both in a lab environment as well as producing large scale commercial productions.

Green: What geographies are you in currently with the cannabinoid formulations?

Lopez: We are global in scope. Weve been very fortunate to have success not only in the US and Canada, but Europe, Brazil and Australia as well. Our level of participation will vary whether were talking about medical marijuana, adult-use or hemp extract and CBD.

Green: If somebody is interested in learning more about your product or potentially becoming a license partner, how would they how would they reach out to you to set that up?

Lopez: If they went to our website, http://www.geocann.com, its pretty easy to reach us and I am grateful that so many companies are doing that.

Green: Great, thanks Jesse that concludes the interview!

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Leaders in Cannabis Formulations: Part 2 - Cannabis Industry Journal

Beverage brand bets on pterostilbene, unique turmeric constituent to boost health benefits – NutraIngredients-usa.com

Posted: at 1:51 am


The brand, called Happy Being, is the work of two recent Williams College grads, Dutch Buckley and Josemaria Silvestrini. The pair said they became interested in a health promoting beverage when sharing each other experiences with health challenges faced by various family members. Was there a product they would recommend their family members use that would improve their overall health on day-to-day basis?

The pair teamed with another co-founder, Chris Conway, a seasoned health products entrepreneur. One of his previous startups is called Everyday Throat Spray, an immune support product that combines various herbs with colloidal silver. Conway also operates a personalized nutrition service called Solutions 4 Health and is a former owner of standalone vitamin store.

We analyzed the marketplace and felt there really wasnt a lot out there what we would consider to be a true health promoting functional beverage, Conway said.

Buckley said his and Silvestrinis conversations with Conway opened their eyes to how much control individuals have over their own health.

We learned from talking with Chris about the role that epigenetics play, Buckley said. We wanted to create products that had not just a high perceived value but a high actual value.

One of the key ingredients in the product, which is being sold as a dietary supplement, is a 50 mg dose of pterostilbene. Conway said the research on this polyphenol, found in blueberries and other botanicals, was persuasive. The ingredient is similar to resveratrol in its anti oxidant and healthy aging effects, but its slightly different chemical structure imparts a greater bioavailability, Conway said.

In the research we have access to pterostilbene came up over and over, Conway said.

One recent issue with the ingredient has been an assertion that it raised LDL cholesterol levels in some subjects. Conway said the brand took that seriously and had its advisers had looked into the question.

We had our medical team take a look at that research very aggressively and they determined that that study was not something to really to be concerned about, he said.

In keeping with a theme of maximum bioavailability, the company chose a turmeric ingredient devoid of curcuminoids, which are usually though to be the powerhouse constituents of this popular botanical. The ingredient, branded as Turmacin, is manufactured by Indian ingredient developer Natural Remedies. It is a water soluble ingredient rich in the tumerosaccharides of the turmeric plant, which the developer claims have powerful health properties of their own. Natural Remedies markets the ingredient for joint support, but in the Happy Being formulation it is included for over inflammation control.

Silvestrini said the choice came down to one that would easily work in a beverage application. There are turmeric beverages on the market, but many suffer from the insoluble turmeric particles settling out of the solution. The traditional benefits of turmeric as part of a curry-based diet came from ingesting high amounts of the botanical on a daily basis and in the context of a fat-containing meal, so the poor unit absorption of the turmeric was less of an issue. Neither a large dose or a big slug of fat fits into a functional beverage value proposition.

The company had a lot of data on its ingredient in terms of its reduction of inflammatory makers. We really wanted to go with an option with a high bioavailability, Silvestrini said.

The products also include a green tea extract supplying 35 mg of EGCG per serving. Rounding out the ingredients list is a 1 gram dose of elderberry fruit powder for immune support.

The formulation rests on a base of organic white tea flavored in three options: peach rose, blueberry raspberry and lemongrass min. The product is positioned as a low calorie beverage at 25 calories per bottle, sweetened with a blend of cane sugar and monk fruit extract.

The co-founders faced the same conundrum many product developers using branded ingredients do: How much good stuff can you include and still keep costs under control? At the moment the product is in the premium price category at about $5 per bottle which is in line with a few other functional beverage competitors that pack in the functional ingredients. But the companys executives hope that as distribution scales up (the company is only a few weeks beyond its formal launch) those costs can come down with economies of scale. And in any case, Silvestrini said, the product is competing in a marketplace where many consumers think nothing of dropping $5 on a drink at a Starbucks.

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Beverage brand bets on pterostilbene, unique turmeric constituent to boost health benefits - NutraIngredients-usa.com

Chocolates are fun, but your heart needs better help than that – pentictonherald.ca

Posted: February 14, 2021 at 4:55 pm


Valentines Day, the largest chocolate and flower day of the year happens tomorrow. Youre welcome to all the gents reading this, you've still got time to pick up something for your sweetheart.

In addition to flowers, chocolate, wine and heart-shaped pizzas, paradoxically February is also heart-health month. As much as wed like to believe consuming a box of dark chocolates and a bottle of red wine after dinner can be good for the heart, the palette is by far the body part experiencing the greatest benefits.

Now, before you all go labelling me as anti-chocolate and no fun, I am a chocolate lover. In fact Ive created several chocolate recipes that are not only delicious, but healthy. Something Ive been able to share and help my clients stay on track with their health goals and not feel deprived. And on the rare occasion, Ill have a glass of red wine.

Dark chocolate and red wine both contain resveratrol, a component that does promote heart health. What most people dont know however, is that the amount of resveratrol youd ingest over dessert with your sweetheart, isnt enough to make a significant difference in your health.

As youve heard (or read) me say before, we can get all the nutrients our body needs from food. Theres no question God gave us great stuff here on this planet. The question is, do we? An article published by the Kressler Institute in 2018 reported, More than half the calories Americans consume, come from nutrient-depleted, ultra-processed foods... and went on to say that Nearly one-third (31%) of the U.S. population is at risk for at least one vitamin deficiency or anemia.

United States stats are always easier to dig up, but trust me, Canadians are right there too.

Since were smack dab in the middle of heart month, let's look at three supplements that are known for building and supporting a healthy heart. Ive already mentioned resveratrol. Coenzyme Q10 or CoQ10, and Omega 3.

As with any nutrient, taking a supplement should not be considered a replacement for the healthy foods that also contain the same nutrients. Supplements are to come alongside and fill the gaps, not provide a get-out-of-eating-your-veggies free card.

Of these three, if you take supplements at all, you're most likely using, or at least have heart of, omega 3s. Several types of fish including salmon, lake trout, sardines, herring, anchovies, as well as nuts, seeds, flaxseed, and chia all contain omega 3 fatty acids. Great for supporting brain function, alleviating rheumatoid arthritis, and joint pain, omega 3s also help to lower blood fat levels.

In other words, omega 3s help bring down elevated triglycerides and lowers cholesterol, which also brings down your risk of heart disease and stroke. And unless youre eating fish daily, supplementing is definitely a good idea.

Resveratrol, found in red grapes and cocoa beans red wine and dark chocolate is known for its antioxidant properties and a 2015 review posted on PubMed concluded high doses may help reduce the pressure exerted on artery walls when the heart beats, bringing down blood pressure.

Of course, consuming high doses of red wine or chocolate for that matter would produce the opposite effect, creating inflammation. So, supplementing is the way to go.

Researchers also found supplementing with resveratrol had a positive impact on overall cholesterol levels and may also help decrease plaque buildup inside

Unlike resveratrol and omega 3, Coenzyme Q10, or CoQ10, is something our bodies produce naturally.

According to a June 2019 article by Dr. Josh Axe, CoQ10 helps cells produce energy and neutralize free radicals, the damaged cells that cause illness and aging, improve heart health.

It offsets negative effects of statin drugs, slows down DNA damage due to aging, helps maintain ph balance, may slow or reverse the spread of some cancers, supports cognitive function, may improve male infertility, treats symptoms of fibromyalgia.

The amount of CoQ10 our bodies produce reduces with age. And although consuming foods that contain CoQ10 such as meats, poultry, fish, eggs, beans and nuts is something everyone should be doing, Dr. Axe goes on to say that for people who, struggle with certain health conditions, such as heart disease having chronic diseases, high levels of stress, deficient in vitamin B, mitochondria diseases, taking statin drugs, food alone may not be enough as these conditions further impede CoQ10 production.

And as the heart is just one of many areas CoQ10 is needed for optimal health, it's in our best interest to keep those levels up.

As with anything you put in your body, quality matters. Like your car, the better quality fuel you put in, the better performance youre going to get. Whether its food or supplements, same goes for your body. And in case there was any doubt, that old adage you get what you pay for, is true.

Februarys the perfect time to give your heart and yourself some love. Youre worth it.

Tania Gustafson is a nutritionist and fitness coach.

On the web: fuelignitethrive.com.

Email: tania@fuelignitethrive.com. Find healthy chocolate recipes at the 8 Weeks is All it Takes group on Facebook.

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Chocolates are fun, but your heart needs better help than that - pentictonherald.ca

Does Red Wine Have Any Effect on Weight Loss? – Healthline

Posted: at 4:55 pm


Red wine is the alcoholic drink of choice for many people, and its gotten a lot of buzz for its potential health benefits.

The drink, made from fermented red grapes, is loaded with antioxidants, but it can also be full of calories and sugar.

If youre trying to lose weight, you may be wondering if red wine could help you or if it would just be a hindrance.

This article reviews red wines nutrient content, what the evidence says about red wine and weight control, and how you can enjoy red wine while still losing weight.

A 5-ounce (148-mL) serving of red wine contains (1):

Most of the calories in red wine come from alcohol, which provides seven calories per gram, and the remainder comes from carbs (2).

Keep in mind that there are several different types of red wine, all with varying amounts of alcohol and sugar content, which will affect their total calorie count. Additionally, there will be some variation among brands.

A 5-ounce (148-mL) serving of red wine contains 125 calories, mostly from alcohol and carbs. There will be some variation among types and brands of red wine.

Several studies have assessed the link between alcoholic beverages and weight.

When it comes to weight management, there appear to be both pros and cons to drinking red wine.

Red wine is rich in resveratrol and other antioxidants that may benefit blood sugar control, heart health, and inflammation. Additionally, moderate wine consumption may help protect against excess weight gain (2, 3).

Red wine and other flavonoid-rich foods like olive oil, nuts, fruits, and legumes are considered staple foods in the Mediterranean-style diet, which has been associated with better weight control than a standard American diet (4, 5).

Unfortunately, evidence on the effects of red wine itself is fairly mixed. Some animal studies have found that red wine consumption decreases body weight and body fat levels, but others have found the opposite (6, 7, 8).

Additionally, a study in 29 people with obesity found that red wine antioxidants appeared to not affect blood sugar control (9).

However, other human studies have noted that moderate alcohol consumption may help improve blood sugar control potentially making it easier to manage weight (10, 11).

More research is needed before the effects of red wine on weight control are fully understood.

Several studies have noted that excess alcohol consumption is linked to weight gain especially in men (2, 12, 13).

Alcohol contains more calories per gram than carbs and protein, and many alcoholic beverages like beer, wine, and mixed drinks may also be loaded with sugar.

Because of this, it can be easier to consume more calories than you intend to when drinking alcohol (2, 14, 15).

Additionally, overconsumption of alcohol may lead to insulin resistance and blood sugar control problems, which may be a precursor to weight gain and type 2 diabetes (16).

Note that 5 ounces (148 mL) of wine is considered 1 serving, and moderate drinking is defined as no more than 2 servings of alcohol per day for men and 1 serving of alcohol per day for women (15).

Red wine is rich in the antioxidant resveratrol, but research is mixed regarding its positive weight effects. Excess alcohol consumption including red wine may lead to weight gain.

Luckily, you dont have to completely avoid drinking red wine if youre trying to lose weight.

Here are some ways that you can enjoy red wine without hindering your weight loss efforts:

As long as youre watching your portion sizes and drinking in moderation, wine shouldnt have a huge effect on your weight.

Additionally, if you notice that your weight loss is slowing down and nothing has changed except the amount or frequency of your red wine intake, try cutting back to see if that helps.

You can drink red wine and still lose weight as long as you limit how much you drink and track your calories.

Red wine is rich in antioxidants, but its also full of calories from alcohol and carbs. This makes it a mixed bag when it comes to weight loss.

Too much red wine, or any alcoholic drink, may hinder weight loss and contribute to weight gain. That said, red wine in moderation may provide some protective effects against weight gain.

To enjoy red wine while losing weight, make sure to stick to a single serving, avoid sugary dessert wines, and track your calories.

See the article here:
Does Red Wine Have Any Effect on Weight Loss? - Healthline

What Happens To Your Body When You Eat Grapes | Eat This Not That – Eat This, Not That

Posted: at 4:55 pm


As far as healthy snacks go, it doesn't get much better than grapes. They're super convenient to pack and take with youand they taste good, to boot. Best of all, they're about 84% water. Simple, meaning you get an instant dose of hydration from munching on them. Grapes come in literally thousands of different varieties and colors, all of them delicious in their own unique way. But what happens to your body when you eat grapes? Well, a lot of things. While grapes offer a bevy of health benefits, they can also do more harm than good if you go overboard with your snackingwhich, let's be honest, is pretty easy to do with this fruit.

A 1-cup serving of red or green grapes contains 28% of your daily recommended intake for vitamin K, a nutrient that's essential for bone and heart health. Not only that, but they're extremely low in fat, sodium, and cholesterol, and an excellent source of vitamin C. Studies have shown that eating grapes doesn't just support your physical health, but also your cognitive health, too: One 2017 studyfound that when adults took a grape supplement daily, they improved their test scores for attention, memory, and language. That said, grapes are also high in sugar and carbs, and low in protein.

Grapes are incredibly versatileyou can snack on them right off the vine, incorporate them into smoothies, toss them into salads, or even freeze them for a popsicle-like treat. Now, if you're curious about what happens to your body when you eat grapes, read on. And for more healthy tips, be sure to check out our list of The 7 Healthiest Foods to Eat Right Now.

Grapes pack a whopping 23 grams of sugar per cup.However, certified nutritionist Paul Claybrook, MS, notes that this fruit is relatively low on the glycemic index, meaning they shouldn't cause your blood sugar to spike too much if you eat them in moderation.

"Your blood sugar will increase but not as significantly as something like soda would cause," he explains. "Part of the reason for this is that grapes contain some fiber, which slows down the speed at which your body can absorb nutrients, including sugar. There isn't a whole lot of fiber (just under a gram per cup) but it's enough to keep your blood sugar in a reasonable range as long as you aren't pigging out on them."

Grapes also contain a compound called resveratrol, which research has shown may increase insulin sensitivity, thus having a beneficial effect on your blood sugar levels.

Studies even say that Controlling This Hormone May Help Lower Blood Sugar.

You've heard of antioxidants, right? Those powerful substances that defend your body from free radical damage? Well, grapes are chock-full of them, and they can help protect and repair your cells from oxidative stresswhich is linked to the development of chronic diseases like cancer, heart disease, and diabetes.

"Oxidative stress simply means that there are too many free radicals (waste products) and not enough antioxidants (waste neutralizers) in your body to mop them up," explains Claybrook. "The result is damage to tissues that can lead to disease. Fortunately, grapes contain tons of antioxidants including flavonoids, phenolics, vitamin C, quercetin lutein, beta carotene, and resveratrol."

Research has revealed that grapes contain over 1,600 beneficial plant compounds, and since the highest concentration of antioxidants is in the seeds and the skin, it's better to eat them whole than simply drink grape juice. Additionally, it's also worth noting that red grapes are higher in antioxidants than green ones because they contain anthocyanins, a type of flavanoid that's responsible for their color.

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Chronic inflammation can cause a number of long-term symptoms and health issues, including muscle aches and joint pain, weight gain, headaches, fatigue, and gastrointestinal problems. It's also been linked to cancer, heart disease, Alzheimer's, type 2 diabetes, arthritis, and other serious conditions.

Luckily, according to Claybrook, the diversity of powerful antioxidants found in grapes can help to reduce inflammation in the body. Specifically, resveratrol is known to have anti-inflammatory properties. Multiple studieshave found that taking grape powder extract can increase the levels of anti-inflammatory compounds in your blood.

Here are Instant Ways to Reduce Your Inflammation, According to a Doctor.

"While grapes are very healthy, too much of a good thing can still be a problem," says Claybrook.

If you were to eat, say, 2 cups of grapes, you'd be getting almost 47 grams of sugarthat's almost the equivalent of two candy bars.

"Sugar causes weight gain, so you don't want to eat grapes by the pound," adds Claybrook. "Grapes could also cause gas, bloating, diarrhea, and an upset stomach if you overdo it."

One serving is about 1/2 cup or 16 grapeswhich may seem small, but controlling your portion sizes of this fruit will allow you to reap the benefits without the risks of digestive issues and weight gain.

One cup of grapes contains an impressive 288 milligrams of potassium, which plays a key role in lowering blood pressure. Not only that but studies have shown that red grapes contain compounds that may help to reduce total and "bad" LDL cholesterol.

"The polyphenols in grapes have been shown to lower the risk of atherosclerosis (hardening of the arteries)," adds Claybrook. "They do this of course by eliminating free radicals but also improve the function of the tissues and help avoid LDL cholesterol from being damaged and sticking to blood vessel walls. They also help maintain the elasticity of blood vessels, thus reducing blood pressure and keep platelets from sticking together and creating clogs."

Here are 17 Foods That Lower Cholesterol.

Grapes are a stellar source of vitamin C, packing 27% of the RDI in 1 cup. As you may or may not know, vitamin C is an essential nutrient that benefits your immune system, which may explain why test-tube studies have shown that grape skin extract can protect against the flu virus.

In fact, 2013 research that compared the immune-boosting effects of hundreds of foods found that red grapes stood outmainly due to the resveratrol, which works with vitamin D to raise the expression of a specific gene involved in immune function.

Here are 8 Ways to Support a Healthy Immune System, According to Harvard.

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What Happens To Your Body When You Eat Grapes | Eat This Not That - Eat This, Not That

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