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Resveratrolthe hype continues – Harvard Health

Posted: October 14, 2021 at 1:55 am

ARCHIVED CONTENT:As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date each article was posted or last reviewed. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

Oh, the giddy abandon that overtakes some headline writers when crowning a story about resveratrol, a chemical found in red wine. Heres a sampling of the latest:

All that for an article published today in the journal Cell suggesting that resveratrol blocks the action of a muscle enzyme called phosphodiesterase 4 in mice. Dont get me wrong: its interesting research, that couldemphasis on couldopen the door someday to new treatments for heart disease, diabetes, memory loss, and other chronic conditions. But it doesnt merit the hype that comes with almost any new research on resveratrol.

Resveratrol is a compound that various plants make to fight off bacteria, fungi, and other microbial attackers, or to withstand drought or lack of nutrients. It has been found in red and purple grapes, blueberries, cranberries, mulberries, lingonberries, peanuts, and pistachios. Resveratrol is also abundant in the roots of Japanese knotweed, a plant that has become a hard-to-eradicate invader in the United States.

In 1992, two Cornell University plant scientists suggested that resveratrol might be responsible for the cardiovascular benefits of red wine. Since then, hundreds of reports have indicated that resveratrol mayemphasis on mayprotect against cancer, cardiovascular disease, vascular dementia, and Alzheimers disease, and extend the life span.

Exactly how resveratrol might do all this is still a mystery. One possibility is that it turns on genes that make sirtuins, ancient proteins found in virtually all species. Activating sirtuins kicks off a response that fights disease and prolongs life. The Cell researchers were trying to figure out just how resveratrol might turn on sirtuin genes.

Virtually all of the positive studies on resveratrol have come from cultures of cells or laboratory experiments with yeast, roundworms, fruit flies, the short-lived turquoise killifish, or mice. The few human studies have looked at specific intermediate markers, such as levels of antioxidants, heart rate variability, blood flow to the brain, and amounts of cancer proteins. None have measured long-term health or survival.

Another big unknown is side effects. Resveratrol acts on many different tissues in the body. It is chemically related to estrogen. In some situations, high doses of resveratrol boost the activity of estrogen, in others they block estrogen. That makes resveratrol supplements iffy for women with cancer of the breast, ovary, uterus, or other estrogen-sensitive tissue, those trying to become pregnant, or those taking an oral contraceptive.

Resveratrol makes platelets in the bloodstream less sticky, and so could increase the risk of bleeding in people who take warfarin (Coumadin), clopidogrel (Plavix), aspirin, ibuprofen, or other nonsteroidal anti-inflammatory drugs.

Another cloud: a company called Sirtris Pharmaceuticals, which was established to develop drugs from resveratrol, pulled the plug on the program in 2010 when a clinical trial showed that one of these drugs might be linked to kidney damage.

If you believe that resveratrol will help you live longer and healthier, get it from food or wine, not by choking down resveratrol pills. Why? Eating red grapes, blueberries, and pistachios, or having a glass of your favorite red wine, are pleasurable ways to take in resveratrol. Plus you get all the other healthful plant products that come with the resveratrol. Getting it via supplement is dull, and you cant always trust what you are getting. If you choose to take a supplement, shop carefully. A review by the independent ConsumerLab found that one brand cost just 15 cents per 100 milligrams of resveratrol, while another cost $2.76 per 100 milligrams.

Its worth keeping an eye on resveratrol research. But its far too soon to be promoting it as a fountain of youth or wonder drug.

As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

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Resveratrolthe hype continues - Harvard Health

Resveratrol NZ – Resveratrol Supplements For Sale | About …

Posted: at 1:55 am

Resveratrol is an exciting natural compound found in red wine, red grape skin, Japanese Knotweed, peanuts, and some berries. The plants and berries produce a natural antioxidant known as 'phytoalexin', as an antibiotic to fight bacteria and fungus. Harnessing this power has become the subject of many studies.

Res-V is About Healths resveratrol antioxidant formula. This concentrated resveratrol formula combines powerful antioxidants to support brain, heart and joint health, as well as supporting the body's natural inflammatory response. As the first provider to bring Resveratrol to New Zealand, we are the most trusted providers. About Health also offers a range of natural health products and health supplements which are available online. Browse our range online today!

Resveratrol capsules can be a safe way to consume resveratrol. Although you can consume resveratrol through diet alone, sometimes this is not possible. For example, red wine is a source of resveratrol and other polyphenols found in grape skin however the quantity you would need to consume to get an adequate amount would be prohibitive.

If youre looking to buy resveratrol supplements in New Zealand, check out our Res-V products at About Health online.

Resveratrol benefits are widely discussed, and studies show that it can be useful in preventing the progression of chronic inflammatory diseases, such as cardiovascular disease and diabetes.

Resveratrol is the subject of extensive research into numerous health benefits and many scientists also believe it (along with other natural substances found in grape skin) to be responsible for the 'French Paradox' - the French have low rates of heart disease compared to many other countries, despite the fact they have many known risk factors, including a diet high in saturated fat, smoking and drinking lots of coffee. It is theorised that this effect may be due to the consumption of moderate amounts of red wine - a pastime enjoyed by many French people.

Resveratrol is the key ingredient in About Healths Res-V products. This is expertly combined with red grape skin, grape seed extract, green tea, pine bark and turmeric to naturally support:

At low doses, resveratrol stimulates the immune system. When taken correctly, resveratrol can offer health benefits for people with autoimmune and inflammatory diseases. However it is important to be careful and always take as directed, as resveratrol may induce immunosuppression if taken in very high doses.

Antioxidants such as resveratrol can neutralise the damaging free radicals to help protect cells in the body. Resveratrol also has anti-inflammatory properties due to its ability to inhibit certain enzymes.

Resveratrol can support a range of health outcomes. In customer testimonials, people report having higher energy levels, increased mobility, and greater overall health. Most people can safely take resveratrol, however if you are on other medications or are pregnant it may be wise to check with your doctor first.

You can take resveratrol supplements at any time of the day, with or without food.

To buy Resveratrol supplements in New Zealand, browse our range online today.

Resveratrol is generally safe to take, however it can slow blood clotting so you should avoid taking resveratrol if you are on blood thinning medications or have a surgery coming up. If you are considering resveratrol supplements and are unsure if they are right for you, consult your doctor or a trusted health professional.

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Resveratrol NZ - Resveratrol Supplements For Sale | About ...

4 Foods that Are Good Sources of Resveratrol | Live Science

Posted: at 1:55 am

All things in moderation. That's what my mom always said, and I think it is sound advice, especially in light of the results of recent survey.

A study published in June in the Journal of Physiology suggests that consuming too many antioxidants, such as the resveratrol found in red wine, may block some of the health benefits of exercise, specifically reduced blood pressure and cholesterol.

This study was performed on men around 65 years old, so it isn't clear whether the results would be similar for women or other age groups. The men weren't drinking wine, but they were taking resveratrol supplements, of 250 milligrams daily.

Let's put this into context. The amount of resveratrol found in one glass of wine can range from 0.2 milligrams to 2.0 mg, according to the Linus Pauling Institute. While250 mg may seem excessive, it's not uncommon for resveratrol supplements. to include as much as 900 milligrams of resveratrol. [Top 10 Bad Things That Are Good For You]

So what does this tell us? All things in moderation (thanks, mom). In truth, more research must be done to determine whether there could be ill effects from consuming too much of any one antioxidant, but until then, I suggest going the natural route. If you want to get more resveratrol, consume it in your diet. This way, you'll get more than just one isolated nutritional component, and you'll also get fiber that will tell you when it's time to stop eating.

Here are four foods that are good sources of resveratrol:

Red Grapes: Grapes don't have to be fermented to contain this antioxidant. It's actually found in the skin of red grapes along with other nutrients, such as minerals manganese and potassium and vitamins K, C and B1.

Peanut Butter: Peanut butter is great for dressing up apples and celery, but it also contains some resveratrol (up to .13 mg per cup). Peanut butter is a great source of niacin and manganese.

Dark Chocolate: In dark chocolate, resveratrol blends nicely with other antioxidants and also minerals, such as iron, copper and manganese. Who doesn't like chocolate?

Blueberries: Blueberries don't have quite as much resveratrol as grapes, but they are also a great source of other antioxidants, dietary fiber, vitamins C and K and manganese.

Healthy Bites appears weekly on LiveScience. Deborah Herlax Enos is a certified nutritionist and a health coach and weight loss expert in the Seattle area with more than 20 years of experience. Read more tips on her blog,Health in a Hurry!

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4 Foods that Are Good Sources of Resveratrol | Live Science

Induction of apoptosis in human hormone-refractory prostate cancer cell lines by using resveratrol in combination with AT-101 – DocWire News

Posted: at 1:55 am

This article was originally published here

Andrologia. 2021 Oct 11:e14267. doi: 10.1111/and.14267. Online ahead of print.


The aim of this study was to determine the appropriate doses of AT-101 and resveratrol combination in the in vitro hormone-refractory prostate cancer (PC) cell lines, in order to evaluate the cytotoxic and genotoxic effects of this combination on the proliferation of cancer cells, namely PC-3, DU-145 and LNCAP. Cytotoxicity in PC cell lines was analysed by using the XTT Cell Proliferation Assay. DNA damage was performed with the cell death assay. Apoptotic protein levels were performed by Roche Human Apoptosis Array. IC50 values were determined by XTT analysis. The strongest combined doses (100 M resveratrol + 5M AT-101) were found to have the strongest synergistic apoptotic and cytotoxic effects on DU-145 cells at 72 hr. While the combined use of resveratrol and AT-101 increased the expression of markers in apoptotic cell pathways on cells, a decrease in the expression of anti-apoptotic markers was detected (p 0.05). Combined applications of these compounds showed an important synergism in the hormone-refractory PC cell lines, and it was determined that after the post-translational modification, they were significantly effective on the apoptotic pathway. These results have revealed that the combination of resveratrol and AT-101 holds great expectation as a new chemotherapeutic application in the treatment of human prostate cancer.

PMID:34633104 | DOI:10.1111/and.14267

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Induction of apoptosis in human hormone-refractory prostate cancer cell lines by using resveratrol in combination with AT-101 - DocWire News

Resveratrol Suppresses Annulus Fibrosus Cell Apoptosis through Regulating Oxidative Stress Reaction in an Inflammatory Environment – DocWire News

Posted: at 1:55 am

This article was originally published here

Biomed Res Int. 2021 Sep 27;2021:9100444. doi: 10.1155/2021/9100444. eCollection 2021.


During disc degeneration, the increase of inflammatory cytokines and decrease of disc cell density are two prominent features. Enhanced inflammatory reaction contributes to disc annulus fibrosus (AF) cell apoptosis. In this study, we investigated whether resveratrol can suppress AF cell apoptosis in an inflammatory environment. Rat disc AF cells were cultured in medium with or without tumor necrosis factor- (TNF-). Resveratrol was added along with the culture medium supplemented with TNF-. Caspase-3 activity, cell apoptosis ratio, expression of apoptosis-associated molecules (Bcl-2, Bax, caspase-3, cleaved PARP, and cleaved caspase-3), reactive oxygen species (ROS) content, and the total superoxide dismutase (SOD) activity were measured. Our results showed that TNF- significantly increased caspase-3 activity and AF cell apoptosis ratio and upregulated gene/protein expression of Bax, caspase-3, cleaved caspase-3, and cleaved PARP, whereas it downregulated the expression of Bcl-2. Moreover, TNF- significantly increased ROS content but decreased the total SOD activity. Further analysis demonstrated that resveratrol partly attenuated the effects of TNF- on AF cell apoptosis-associated parameters, decreased ROS content, and increased the total SOD activity in the AF cells treated with TNF-. In conclusion, resveratrol attenuates inflammatory cytokine TNF--induced AF cell apoptosis through regulating oxidative stress reaction in vitro. This study sheds a new light on the protective role of resveratrol in alleviating disc degeneration.

PMID:34616848 | PMC:PMC8490034 | DOI:10.1155/2021/9100444

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Resveratrol Suppresses Annulus Fibrosus Cell Apoptosis through Regulating Oxidative Stress Reaction in an Inflammatory Environment - DocWire News

Brainfood : Top 6 Foods that enhance the Brain Health – Krishi Jagran

Posted: at 1:55 am


Man's mental prowess is a very sharp tool that can often become blunt if put in situations of excess stress. Thus the degradation of one's mental prowess with age is just inevitable.Nutritionists and doctors alike thus do advise their people to just maintain their healthy brains via consuming foods rich in lutein, omega 3 fatty acids and folic acids.

Which respectively act as an antioxidant to decrease inflammation, prevent cognitive decline, and are used to treat people suffering from memory loss, Alzheimer's, and Dementia.

Listed below are some food items rich in these and are scientifically proven to be good for ones brain.

Fatty fishes are the main sources of omega -3 fatty acids which not only are helpful in reducing the symptoms of Attention deficit hyperactivity disorder (ADHD) in children but is also good for mental health during early childhood for kids and pregnant mothers. According to psychiatric reports people with low omega 3 content in their bodies also had mental disorders.

Peanuts are rich in Vitamin E and Resveratrol out of which vitamin E helps to decrease oxidative stress on the brain and Resveratrol according to random clinical trials helps in increasing cerebral blood flow, cerebral vasodilator responsiveness to hypercapnia, and cerebrospinal fluid level.

For all the vegetarians who are looking for alternative sources of omega 3 fatty acids. Flax seeds, avocados and walnuts are your best bet. They are not only rich sources of omega 3 fatty acids but also lower cholesterol and balance blood sugar, while also counteracting oxidative stress and inflammation which are two main drivers of cognitive decline.

Broccoli is a vegetable that is rich in antioxidants like vitamin C and flavonoids. Vitamin c plays a vital role in the differentiation and growth of neurons and hence plays a role in protecting them and speeding up impulse transmission of electronic impulses, making the vitamin crucial to cognitive performance. Broccoli also contains compounds called glucosinolates, which when broken down form isothiocyanates. That helps lower the risk for neurodegenerative diseases like Alzheimers.

If there was any vegetable that could be given the title of "brain vegetable", it would be kale. Reason being that it contains almost no oxalates making it easy for the brain to absorb. While also having proteins, iron folate and vitamin B6 which are used to create brain chemicals like serotonin and dopamine.

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Brainfood : Top 6 Foods that enhance the Brain Health - Krishi Jagran

IISER Scientists Claim that Drugs Used to Treat Diabetes, Obesity, and Ageing Could Treat COVID-19 | The Weather Channel – Articles from The Weather…

Posted: at 1:55 am

Representative Image

A team of scientists at the Indian Institute of Science Education and Research (IISER) Bhopal have, in a review, identified the biomolecular relationships between COVID-19, ageing, and diabetes.

The review, published in the journal Molecular and Cellular Biochemistry, presented that existing drugs used to treat diabetes, obesity, and ageing can potentially treat COVID-19. Similar naturally existing biomolecules were also explored in combination for the COVID treatment.

"There are classes of compounds such as polyphenols found in plant-based food, curcumin (found in turmeric), and resveratrol (found in grapes), have been shown to not only slow down the ageing process, but also possess anti-viral properties," said Dr Amjad Husain, Principal Scientist, and CEO of Innovation and Incubation Center for Entrepreneurship (IICE), IISER Bhopal, in a statement.

Some other polyphenols that the researchers have identified as being beneficial for both COVID-19 treatment and comorbidity conditions such as diabetes and ageing may include catechins (present in green tea, cocoa and berries), procyanidins (found in apples, cinnamon and grape skin), and theaflavin (found in black tea).

The researchers also present evidence of some existing potential anti-ageing drugs such as Rapamycin that can be explored for the COVID-19 treatment because of the common biochemical pathways associated with these diseases. Another such example is the drug Metformin, which is usually used to control blood sugar.

The review showed that at the molecular level, there are intersecting pathways that are common to diabetes, ageing, and COVID-19. All three conditions are associated with oxidative stress and lower immune response, and complications arising from them lead to the onset of numerous other diseases such as cardiovascular disorders, eye diseases, neuropathy (nerve diseases), and nephropathy (kidney problems).

The researchers believe that an ideal therapeutic candidate for COVID-19 should target the pathways common to diabetes, ageing, and the SARS-CoV-2 infection.

Further, computational studies showed that lipids present in cell membranes play an essential role in coronavirus infectivity.

Natural compounds such as polyphenols may affect the binding of the virus to host receptors and the molecular interactions required for virus replication and release, thereby stopping the infection in its early stages, the team explained.


The above article has been published from a wire agency with minimal modifications to the headline and text.

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IISER Scientists Claim that Drugs Used to Treat Diabetes, Obesity, and Ageing Could Treat COVID-19 | The Weather Channel - Articles from The Weather...

MIND diet reduces the odds of developing dementia – The New Daily

Posted: at 1:55 am

This year, coverage of dementia research has been dominated by the controversial approval in the US of the drug Aduhelm, which was found to reduce the amyloid beta plaque that gums up the brain.

The drugs ability to slow cognitive decline, however, was limited.

Meanwhile, a relatively new diet, called the MIND diet big on leafy greens, nuts, berries and olive oil has been linked to a slower cognitive decline and lower risk of Alzheimers disease (AD) dementia in older adults.

The diet was first proposed in a landmark 2015 study as a buffer against AD.

Participants who adhered rigorously to the diet lowered their risk of AD by as much as 53 per cent. These early findings set off a media sensation.

More broadly, the diet has been found to reduce the odds of developing clinically diagnosed mild cognitive impairment or dementia.

A 2019 Australian study of people aged 60 and older saw these odds reduced by an impressive 19 per cent.

Perhaps even more impressive, a new US study suggests the MIND diet supports cognitive resilience in the elderly a phenomenon where some people diagnosed with brain pathologies dont experience cognitive dysfunction, at least for a time.

As the authors write: Identifying modifiable lifestyle factors that act independently of brain pathologies is critical in AD research, in part, because pharmacological interventions that focus on brain pathology have failed to reduce or slow cognitive decline, despite some evidence of clearance of amyloid plaque from the brain.

The diet was developed by the late Dr Martha Clare Morris, author of the 2015 study. She was Professor of Epidemiology at Rush University Medical Centre in Chicago.

The MIND diet is a hybrid of the the popular Mediterranean diet and the DASH diet which are both designed to prevent cardiovascular disease, high blood pressure and stroke.

MIND stands for the Mediterranean-DASH Intervention for Neurodegenerative Delay and is specifically designed to boost brain health and protect against dementia

Its said to be a simpler diet to follow, with a focus on 10 foods to eat more of, and five foods to either avoid or consume now and then.

It makes loose recommendations in terms of servings.

Green, leafy vegetables: Six or more servings per week. These include spinach, cooked greens and salads.

Non-starchy vegetables: Include at least one vegetable such as beetroot, carrots or tomatoes in addition to the green leafy vegetables at least once a day.

Berries: Eat berries at least twice a week for their antioxidant properties. These can be strawberries, blueberries, raspberries or blackberries for their antioxidant benefits.

Nuts: Try to get five servings of nuts or more each week. The diet doesnt specify what kind of nuts, but walnuts and almonds have proven benefits.

Olive oil: Use olive oil not just for cooking but as a substitute for butter or margarine.

Whole grains: At least three servings daily of whole grains, such as oatmeal, quinoa, brown rice, whole-wheat pasta and 100 per cent whole-wheat bread.

Fish: At least once a week. Fatty fish like salmon, sardines, trout, tuna and mackerel are best because of their high amounts of omega-3 fatty acids.

Beans: Include beans, lentils, soybeans or chickpeas with at least four meals every week.

Poultry: Chicken or turkey at least twice a week. But not fried chicken. Minced turkey is a good substitute for minced beef or lamb.

Wine: No more than one glass daily. Both red and white wine may benefit the brain, but the red wine compound resveratrol appears to be protective against Alzheimers disease.

Butter and margarine: Less than one tablespoon daily.

Cheese: Limit cheese consumption to less than once per week. Its a tough one, but cheese is all fat and salt.

Red meat: No more than three servings each week.

Fried food: Less than once a week if you cant avoid it. Fast-food restaurants, just say no.

Pastries and sweets: Ice cream, biscuits, brownies, cakes, doughnuts, lollies and so forth. Limit these to no more than four times a week. Less is better.

Why avoid these foods? Because theyre full of trans fats, saturated fats and, in the case of desserts, sugar.

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MIND diet reduces the odds of developing dementia - The New Daily

How many calories are in a glass of wine? – Medical News Today

Posted: August 2, 2021 at 1:51 am

The number of calories in a glass of wine can range from around 120165, depending on the type of wine.

Wine is one of the oldest beverages and has been popular for centuries. Even today, it continues to be one of the most consumed drinks in the world. According to the Wine Institute, people in the United States drink more than 3 gallons of this fermented grape juice each year.

Wine has an alcohol content that creates a feel-good effect in the brain, and many of the chemicals in wine can have beneficial health effects.

Experts associate wine drinking with reduced inflammation and lower blood pressure A daily glass of wine may also help prevent heart disease and stroke.

This article compares the calorie content in different types of wine and the source of these calories. It also contrasts wine with other alcoholic beverages, and explores some of the health benefits of wine.

The following chart lists the number of calories in some popular glasses of wine, typically five fluid ounces.

Wine is an alcoholic beverage that manufacturers create by fermenting grape juice. It is the alcohol concentration of carbohydrates that provides the calories in wine.

As the name suggests, sweet wines are often sweeter than dry wines. Manufacturers may add more sugar to these wines, contributing to a more significant number of calories than their dry counterparts.

A single glass of wine does not contribute many calories to someones daily energy intake. However, people may find it easy to overindulge. Most individuals have more than a single glass of wine in a sitting, leading to an overall increase in calorie intake.

Most glasses of wine contain around 120 calories, with sweet wine containing considerably more calories at 165 calories per glass.

When comparing the calorie content of wine and other popular alcoholic beverages, people must consider the serving size. Bars and restaurants may serve wine, spirits, and beer in different quantities.

Here are some example calories for popular alcoholic drinks:

The calorie content of wine falls in the middle of these standard alcoholic beverage options. However, wine, specifically red wine, offers health benefits that these other drinks do not.

The alcoholic and polyphonic components of wine have beneficial antioxidant, lipid regulating, and anti-inflammatory effects.

Past studies have found that moderate alcohol consumption can provide health benefits, including increasing the amount of good cholesterol in the body and decreasing the risk of diabetes.

There are no conclusive recommendations regarding wine consumption. But many studies have found that moderate consumption of red wine protects against:

Crushed grapes are the basis of wine. Grapes contain the natural antioxidant resveratrol, and this significant antioxidant concentration likely provides red wine with its many health benefits.

Additionally, resveratrol has anti-inflammatory characteristics. These anti-inflammatory properties help to protect the heart and nervous system and make also have antiaging effects.

Red wine also contains the compound proanthocyanidin. This bioactive chemical may contribute to heart health and protect against heart disease and other inflammatory conditions.

The antioxidants found in red wine are beneficial in reducing oxidative stress. The body naturally produces reactive oxygen and nitrogen species (RONS) through some natural processes, damaging cells and tissues.

To combat this, the body also has antioxidant defenses to neutralize any damage. However, if there are not enough antioxidants to combat RONS, oxidative stress can occur.

Oxidative stress plays a role in several conditions, including cardiovascular diseases, chronic kidney disease, chronic obstructive pulmonary disease, neurodegenerative diseases, and cancer.

So, while red wine may not cure these conditions, it may help prevent them by managing oxidative stress.

The alcohol in red wine, combined with its polyphenol content, can help to improve and maintain endothelial function.

Endothelial cells are crucial in keeping capillaries functional and bringing blood to all tissues of the body. Because of this, the endothelium plays a role in preventing conditions including:

Red wine helps maintain endothelial function, meaning that it also plays a role in protecting against various diseases and conditions.

Individuals should remember to drink in moderation. Instead of providing health benefits, excessive drinking may cause problems, such as obesity, liver damage, stroke, cancer, and a negative impact on heart health.

Learn more about the potential health benefits of wine here.

Wine comes from fermented, crushed grapes, and its calories come primarily from its alcohol and carbohydrate content.

There are many types of wine, including red, white, sweet, and rose. These wines have a calorie content ranging from 120165 calories for a single glass.

When compared to other alcoholic drinks, the calorie content for wine falls in the middle. However, red wine, in particular, offers many health benefits that other alcoholic beverages lack.

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How many calories are in a glass of wine? - Medical News Today

The One Supplement You Should Take Every Morning Over 50 To Take 10 YEARS Off Your Face – SheFinds

Posted: at 1:51 am

Supplements can seem a little bit like magic. Take one and all of your dietary needs can be addressed, right? Not quite. Maintaining a balanced diet with plenty of protein, carbs, and fats is the most important thing you can do for both your health and your skin. But if you are experiencing vitamin or mineral deficiencies and are looking for ways to boost your health and make your complexion glow, there are specific nutrients that can help. Lisa Moskovitz, RD, CDN and CEO of NY Nutrition Group, spoke with SHEFinds.com about the one supplement you should take every morning over 50 if you want to feel and look your best.

Beauty Experts Swear By This Collagen Powder For Younger Looking Skin


Healthy, youthful skin never goes out of style - no matter how much you age, Moskovitz says. While we can't Benjamin Button our bodies, we can certainly take measures to slow down the aging process and enhance the tone and texture of our epidermis. The first step is to always practice healthy habitsincluding eating a balanced, nutrient-dense diet, staying hydrated, logging in enough sleep and participating in regular exercise. Outside of these health pillars, asupplementcan help fill in nutritional gaps ensuring a smoother skin surface.



So, which supplement ingredient should you look to first? According to Moskovitz, the benefits of resveratrol can not be understated. If you're not familiar, resveratrol is a powerful polyphenol found in the skins of red grapes, red wine, blueberries and peanuts, Moskovitz says. It fights against oxidative stress that can accelerate the aging process, both internally and externally, and directly treats fine facial lines or wrinkles. One supplement that contains resveratrol and other effective vitamins that Moskovitz recommends is Oh Grape by Groove, which she calls a high-quality multivitamin that contains all the essentials to preserve your youthful appearance. The MVP of this concoction is 500mg of resveratrol.


Aside from containing high amounts of resveratrol, Moskovitz credits Oh Grape for containing a hefty dose of vitamin C that directly improves collagen absorption. Collagen is a protein found naturally in our bodies, but it starts to deteriorate starting in our twenties, Moskovitz says. Collagen loss contributes to tarnished skin tone and texture. We can boost collagen by eating a well-balanced diet and by consuming enough vitamin C-rich foods,such as strawberries, oranges, red peppers, and broccoli, orsupplements.


Finally, its important not to neglect vitamin D, as a deficiency in this vitamin can lead to red, itchy and dry skin - none of which translate to a youthful glow, Moskovitz says.

VItamin D is hard-to-come-by in your diet and limited to eggs,cod liver oil, bony fish, and fortified juices or milk products, Moskovitz says. That is why deficiencies are highly common.That said, I always recommend my clients adopt healthy behaviors andsupplementwhen necessary, especially if they want to be as proactive and preventive as possible. Thissupplementis taken once a day with, or without food.

And remember: always consult a doctor before you start any new supplement regimen.

The One Supplement You Should Take Every Morning Over 50 To Take 10 YEARS Off Your Face - SheFinds

Detailed Analysis of Trans Resveratrol Market 2021-2026 with Top Company Profiles like DSM, Evolva, Sabinsa, InterHealth, Maypro, JF-NATURAL, and more…

Posted: at 1:51 am

The Trans Resveratrol market report provides a detailed analysis of global market size, regional and country-level market size, segmentation market growth, market share, competitive Landscape, sales analysis, the impact of domestic and global market players like DSM, Evolva, Sabinsa, InterHealth, Maypro, JF-NATURAL, etc., value chain optimization, trade regulations, recent developments, opportunities analysis, strategic market growth analysis, product launches, area marketplace expanding, and technological innovations.

The Key Areas That Have Been Focused in the Report:

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Trans Resveratrol Market Segmentation:

Trans Resveratrol market is split by Type and by Application. For the period 2016-2026, the growth among segments provides accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.

Trans Resveratrol Market Report based on Product Type:

Trans Resveratrol Market Report based on Applications:

The key market players for global Trans Resveratrol market are listed below:

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Promising Regions & Countries Mentioned in Trans Resveratrol Market Report:


Consumption Forecast, Market Opportunities & Challenges, Risks and Influences Factors Analysis, Market Size by Application, Market Size by Manufacturers, Market Size by Type, Trans Resveratrol Consumption by Regions, Trans Resveratrol Production by Regions, Production Forecasts, Value Chain and Sales Channels Analysis, Key Findings in the Global Trans Resveratrol Study, Manufacturers Profiles

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Impact of COVID-19 on Trans Resveratrol Market

The report also contains the effect of the ongoing worldwide pandemic, i.e., COVID-19, on the Trans Resveratrol Market and what the future holds for it. It offers an analysis of the impacts of the epidemic on the international Market. The epidemic has immediately interrupted the requirement and supply series. The Trans Resveratrol Market report also assesses the economic effect on firms and monetary markets. Futuristic Reports has accumulated advice from several delegates of this business and has engaged from the secondary and primary research to extend the customers with strategies and data to combat industry struggles throughout and after the COVID-19 pandemic.

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Detailed Analysis of Trans Resveratrol Market 2021-2026 with Top Company Profiles like DSM, Evolva, Sabinsa, InterHealth, Maypro, JF-NATURAL, and more...

4 Paulas Choice Products That Would Get a Green Light From Your Derm – Well+Good

Posted: at 1:51 am

The ingredient(s) derms love: zinc oxide and resveratrol

Why they get the greenlight: Sunscreen plus antioxidants: a dream duo beloved by every derm in existence. (Slight exaggeration, but weve never met one who has said otherwise!). Simply put, these umbrella termsfound here in the form of zinc oxide and resveratrol, respectivelyoffer unparalleled protection against signs of premature aging. (ICYMI: UV rays and free radicals speed up sunspots, sagging, and other afflictions that make your skin appear older than it is.)

Because this formulas SPF component is zinc-based, it may warrant extra brownie points from certain skin pros. As per previous insight, zinc oxides benefits extend beyond sun protection. Specifically, it can help treat inflammation, and calm reactive skin, making it ideal for those with inflammatory skin conditions like acne and rosacea. Worried about a tell-tale zinc oxide white cast? This particular product creates a lightweight physical barrier that, when sheered out, blends seamlessly.

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4 Paulas Choice Products That Would Get a Green Light From Your Derm - Well+Good

Heart Healthy Foods: 25 Foods That Are Good for Your Heart – Parade Magazine

Posted: July 19, 2021 at 1:51 am

Every year, 647,000 Americans die from heart disease and heart-related conditions, according to the Centers for Disease Control and Prevention (CDC). In fact, its the leading cause of death in the United States.

In terms of prevention, living a healthy lifestyle is the best thing you can do. Some activities that can increase risk of developing heart disease include smoking, a lack of exercise, heavily drinking alcohol, and eating a diet high in cholesterol, fat, salt, and sugar. To stay as heart-healthy as possible, its best to avoid this activities and try to eat a diet that consists of heart healthy foods.

Wondering which foods are good for your heart? Weve got you covered.

Known as the fruit with the healthy fats, avocados are super nutritious thanks to their high concentration in dietary fiber, antioxidants, and other minerals. All of these things work together to keep your heart healthy, but a study from Penn State University also suggests that an avocado a day can lower LDL cholesterol levels.

Avocados contain heart healthy monounsaturated fatty acids, which can help lower LDL cholesterol (the bad kind), Laura Yautz, RDN, LDN, NBC-HWC, registered dietician and owner of Being Nutritious, tells Parade. In addition, avocados contain potassium and fiber, two essential components of heart health, which can work to lower blood pressure and cholesterol, respectively!

Sure, all fruits are relatively high in sugar, but the heart-healthy benefits of berriesstrawberries, blueberries, blackberries, cranberries, aa berries, bilberries, goji berries, raspberries, and even grapes!certainly outweigh the negatives of their natural sugar content.

Berries are a good source of polyphenols, especially anthocyanins, micronutrients, and fiber, explains Harland Adkins, a registered dietitian nutritionist and founder of Fast Food Menu Prices. In epidemiological and clinical studies, these constituents have been associated with improved cardiovascular risk profiles.

Adkins adds, Black raspberries and strawberries have been shown to help lower cholesterol in people who are obese or have metabolic syndrome.

Spinach is good for you in just about every way possiblenot solely for your heart. But besides the benefits it has for your eyes, reduced blood pressure, and even cancer prevention, spinachs high levels of omega-3 fatty acids, antioxidants, B vitamins, fiber, folate, calcium, and iron work wonders for your heart.

Spinach is most known for its folate content, but its also a great addition to heart healthy diets, Yautz explains. Spinach contains a healthy dose of vitamin K (ask your doctor if youre on a blood thinner!), vitamin A, iron, and fiber, all while being low in calories, so you can fill your plate up!

All dark leafy greens are heart-healthy foods, but kale in particular is a superfood. According to the American Heart Association (AHA), kale is high in potassium, which can reduce your risk of blood pressure and also heart disease.

Kale, like spinach, is very high in vitamin K, which is important to help your blood clot properly, Yautz says. Its also high in vitamins A and C. But unlike spinach, its a cruciferous vegetable (like broccoli and cauliflower), so it contains special compounds that may be particularly helpful in preventing clogged arteries.

Related: 125 Quotes About Heart Disease

Collard greens are another dark leafy green, cruciferous vegetable that works hard to keep your heart feeling strong. This superfood also can prevent cancer, features anti-inflammatory properties, and because theyre high in potassium, magnesium, and vitamin C, theyve been known to lower hypertension and support the heart.

Collard greens are an excellent source of vitamin A, vitamin C, and calcium, a rich source of vitamin K, and a good source of iron, vitamin B-6, and magnesium, Adkins explains. They also contain thiamin, niacin, pantothenic acid, and choline. Thanks to their many nutrients, collard greens have been associated with cancer prevention, detox support, anti-inflammatory properties, heart health, and digestive support.

Definitely dont underestimate the power of nuts when it comes to supporting your heart. As Yautz explains, Walnuts contain the highest amount of ALA (a plant-based form of Omega-3) of any of the tree nuts, making it an excellent heart healthy staple. They are also high in magnesium, which can help your heart maintain a normal rhythm.

Another nut thats great for your heart is the almond. Yautz explains, Almonds are a great source of vitamin E, a type of antioxidant that helps prevent cell damage. It can be particularly helpful for those who do or have smoked, and/or are exposed to air pollution, to help mitigate the effect.

Plus, they can be roasted, thrown into a salad, or eaten raw, and are known as a health, unsaturated fat that increases the bodys good cholesterol and decreases its bad cholesterol.

You know how that old adage goesbeans, beans, theyre good for your heart! We wont finish the rhyme here for the sake of being appropriate, but this kid-friendly diddy is true.

Beans are incredibly healthy, especially for your heart, high in both protein and fiber, and theyre amazingly versatile, Yautz says. Many studies have been conducted on their health benefits. They are known to help decrease blood cholesterol levels, and consuming 1/2 cup a day is associated with a lower risk of having a heart attack and heart disease in general.

Black beans are not only high in fiber, but they keep your blood sugar levels in check, control your cholesterol, and can even lower blood pressure.

Related: Can a Broken Heart Cause Actual Heart Damage? Heres What Doctors Say

Fatty fish is one of the best heart-healthy foods there is thanks to its high levels of Omega-3 fatty acids. In fact, the American Heart Association recommends eating salmon as much as twice a week.

Yautz adds, Salmon is well known for its healthy fat profile. The main type of fat is a polyunsaturated fat, known as omega-3. Eating fish high in Omega-3s has been linked to decreased coronary heart disease (CHD), including fatal CHD, myocardial infarction, and sudden cardiac death. Wild caught salmon is a better source than farmed.

High in lycopene, which can lower LDL levels and also blood pressure, eating tomatoes semi-frequently can reduce your risk of heart disease.

Tomatoes claim to fame is their lycopene content, which is widely known for its benefit to prostate health. But lycopene can also protect your heart! Studies have shown lycopene may lower your risk of stroke, and of having additional cardiac events, Yautz explains.

Chia seeds are also a superfood and theyre unique in that they contain the antioxidant quercetin. Quercetin reduces risk of heart disease, as well as other heart-related conditions as well.

Chia seeds are full of heart protecting antioxidants, as well as ALA Omega-3 fats, Yautz says. This tiny seed is also showing promise as being able to potentially lower triglycerides, inflammation, and blood pressure, as well as raising HDL (the good cholesterol).

Its the one youve been waiting foryes, its true! Dark chocolate is, in fact, good for your heart.

Dark chocolate is rich in flavanols, and a heart healthy addition with a caveat: all the added sugar, cream or milk, and cocoa butter tend to negate its effects, Yautz says. Choose the darkest chocolate you can to reap the benefits, such as lower total cholesterol, LDL cholesterol, and triglycerides.

Just like nuts, many seeds are considered to be heart-healthy food as well. Flax seeds are high in the Omega-3 fatty acids that hearts love and are even known to reduce the risk of stroke.

Flax, like chia, is high in Omega-3, and is particularly helpful in managing blood pressure and cholesterol, Yautz says.

Its a win-win!

Another heart-healthy seed is the hemp seed. These little-seeds-that-could regulate your heart beat, reduce bad cholesterol levels, and fight hard against coronary heart disease.

Hemp seeds are lower in both omega-3s and fiber then either chia or flax seeds, but they are high in protein a complete protein at that. They do have a high ratio of Omega-6 to Omega 3, which isnt problematic in the context of an otherwise healthy diet, but something to be aware of. They also contain iron and zinc, two minerals important for cardiac function, Yautz adds.

Cooking with oilespecially if its in place of butteris a meaningful decision for your heart. As Yautz explains, When it comes to oils for heart health, olive oil takes the cake. Studies have shown olive oil can help reduce cardiovascular disease and coronary artery disease. The benefit seems to cap out at about 1/2 tablespoon per day, though. Oils of all kinds are high in calories, so its preferable to replace fats like butter and margarine with olive oil instead of simply adding olive oil to the diet, to avoid unintentional weight gain.

As oranges are high in both fiber and potassium, this citrus fruit makes a great addition to any heart-healthy diet. After all, the more you eat of both, the less likely you are to develop a fatal heart disease.

Oranges are an excellent source of potassium, making them a good food for heart health. Potassium can help control blood pressure, because it acts opposite to sodium, Yautz says. While sodium attracts water and promotes retention, potassium helps the body release water, thereby reducing blood pressure.

Aside from their high levels of potassium, another heart-healthy benefit of oranges is their pectin.

Oranges have the cholesterol-fighting fiber pectin, Adkins says. In one study, two cups of OJ a day boosted blood vessel health. It also lowered blood pressure in men.

Just as fatty fish is good for the heart, fish oil is one of the best foods for the heart as well.

Fish oil is high in Omega-3s, and often recommended for its heart promoting benefits. While the omega-3s in flax, chia, and hemp are mostly in the form of ALA (alpha linolenic acid), the Omega-3s in fish oil are in the form of DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid), which are more usable by the body, Yautz explains. ALA must first be made into DHA and EPA.

Tuna is another fatty fish that has benefits for the heart because of its high levels of Omega-3 fatty acids. But, you should be wary of the tuna you choose.

Tuna is another great source of Omega-3 fats, Yautz says. Look for bluefin tuna, which is a better source of Omega-3s, and has a lower chance of being contaminated with heavy metals.

When you think heart-healthy food, you may not immediately envision garlic, but in reality, garlic has long been used as a medicinal herb, thanks to its health benefits.

Garlic and garlic supplements may have positive effects on heart health by preventing cell damage, regulating cholesterol, and lowering blood pressure, Adkins explains. Other research shows that garlic supplements may also reduce plaque build-up in the arteries. This is due to the presence of a compound called allicin, which is believed to have a multitude of therapeutic effects.

In addition to all those heart-healthy benefits, garlic may improve memory as well.

Fish and almonds arent the only significant source of heart-healthy proteins. As Yautz points out, Edamame is the most unprocessed form of soybeans, and incredibly nutritious. Its high in protein a complete proteinand also boasts tons of fiber and antioxidants. Studies show edamame may improve cholesterol and triglycerides, as well as reduce blood pressure. Other studies are being conducted on its ability to improve arterial stiffness, and improve markers of inflammation.

Sardines are jam-packed with Omega-3 fatty acids as well as fish oils that can regulate heart rhythms. Yautz adds, Unlike salmon and tuna, however, sardines are very low on the food chain. That means the likelihood of heavy metal contamination is very low. Just make sure to look for sardines without too much sodium.

Related: The Best and Worst Cooking Oils for Your Heart

Thank goodness! Of course, red wine has to be drank in moderation in order to reap its heart-healthy benefits, but some research shows that the antioxidants in red wines can prevent coronary artery disease and ultimately, decrease your risk of a heart attack.

If you drink alcohol, a little red wine maybe a heart-healthy choice, Adkins explains. Resveratrol and catechinstwo antioxidants in red winemay protect artery walls. Alcohol can also boost HDL, the good cholesterol [but] too much alcohol hurts the heart.

Yautz adds, Alcohol in excess can damage the heart, and contribute to high blood pressure. So, if you dont drink, dont start, but if you do, do so in moderation only (one or less 5-ounce glass of wine per day for women and two for men).

Another fatty fish rich in Omega-3 fatty acids, its recommended to eat mackerel at least once weekly in order to reduce your risk of a heart attack.

Mackerel are similar to sardines in their lower likelihood of heavy metal contamination, Yautz says. Eat it, and the other fatty fish on this list, at least once a week to help prevent heart attacks and other serious heart problems.

According to the Cleveland Heart Lab, herbs like cinnamon, cardamom, ginger, turmeric, and berberine can be used to prepare other foods for an added heart-healthy benefit.

Yautz adds, Herbs and spices are incredibly concentrated sources of antioxidants. Including a variety in liberal amounts on your food daily can contribute to lower inflammation, lower blood pressure, and lower cholesterol.

Get good vibes and health tips delivered right to your inbox!

Drinking tea could reduce risk of heart disease and stroke, but it should be done frequently in order to reap the benefits. In fact, the European Journal of Preventative Cardiology published research that found drinking green tea three or more times per week is ideal for improving the health of the heart.

Drinking green tea daily can also contribute to heart health! Studies show green tea may lower both LDL cholesterol and triglycerides, Yautz says. As long as youre careful about what you put in itadding sugar, creamer, etc. may offset those benefits!

Next up, important lifestyle changes to make for a healthy heart.

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Heart Healthy Foods: 25 Foods That Are Good for Your Heart - Parade Magazine

Food that can help ease stress – Jacaranda FM

Posted: at 1:51 am

Stress is defined as a stateof mental or emotional strain or tension resulting from adverse or demandingcircumstances.

It is caused by a variety of things including; anything that puts high demands on you, major life changes, financial problems, and relationship difficulties. The current state of events in South Africa is also leading to a lot of uncertainty.

Stress can lead to otherhealth complications including; depression,weight problems,anxiety, sleep problems, and thinking and memory problems.

All of us will deal with stressat some point in our lives and it is important that you seek help from a professionalwhen you feel overwhelmed and are struggling to cope.

READ:Three foods that can help you fight stress

Dietitian Sylven Masoga saysthere is no specific food that can reduce stress, but it's the ingredients containedin the food item that can help reduce stress.

You need food that containsVitamin C, such as grapes and oranges. That Vitamin C can destroy the freeradicals which are usually released when a person is suffering from stress related oxidation," says Masoga.

The dietitian recommendseating one orange a day or a bunch of grapes.

He also recommends eatingfoods that contain Vitamin A and Vitamin E.

READ: Expert tips on how to better manage stress

An example of these foods areyellow vegetables (pumpkin, carrots, gem squash etc.).

Vitamin A and Vitamin Econtaining foods will minimise the oxidation that will occur as a result ofstress in your blood, says the dietitian.

He adds: The intake ofVitamin A and Vitamin E protects the lining of the cells inside your body sothat they cannot be damaged by release of the free radicals.

The dietitian recommendseating foods that contain lycopene, phytochemical, and resveratrol.

Examples of such foods aretomatoes, guava, green vegetables, watermelon, papaya, pink grapefruit, and theskin of the grapes, peanuts, blueberries, cranberries, broccoli, pears, celery, and spinach.

The dietitian says such foods preventthe development of the free radicals.

He warns against eating foodsthat contain saturated fat and trans-fat.

READ: DrD on how to plan for a year-end holidays that bring more joy that stress

Image courtesy of iStock/ @Chinnapong

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Food that can help ease stress - Jacaranda FM

22 Purported Resveratrol Benefits – SelfHacked

Posted: April 16, 2021 at 1:52 am

Resveratrol, a polyphenol abundant in red wine, has some antioxidant and heart-protective properties. However, its bioavailability is poor and most of its purported benefits have not been confirmed in humans. Read this science-based review to learn more.

Resveratrol is a small polyphenol that came to scientific attention during the 1990s. Since then, it has been hyped by supplement manufacturers and news outlets alike.

Resveratrol is high in grape skin, as grapes produce resveratrol in defense against toxins and parasites. It is also found in various berries, peanuts, soy, and Itadori tea made from Japanese Knotweed [1].

Limited studies have explored its antioxidant, anti-inflammatory, anti-aging, and phytoestrogen activity. Resveratrol does hold some potential for improving chronic diseases. Researchers are also exploring its ability to mimic the effects of caloric restriction in animals, which might affect lifespan [2, 3].

According to some clinical trials, resveratrol nose sprays may improve symptoms of hay fever or allergic rhinitis. Scientists came up with nose sprays as a great way to bypass resveratrols poor bioavailability and get it straight to localized, problematic body areas.

In one study of 100 people, an intranasal spray containing resveratrol 0.1% reduced nasal symptoms and improved quality of life in adults with hay fever used three times daily for 4 weeks [4].

In another trial of 68 children with pollen-induced hay fever, an intranasal spray with resveratrol 0.05% and one other ingredient (beta-glucan 0.33%) improved itching, sneezing, runny nose, and nasal blockage. It was given three times daily for 2 months [5].

Limited evidence suggests that red wine, in moderation, supports heart health.

On the other hand, resveratrol supplements probably dont aid in heart disease prevention.

Therefore, scientists think that other compounds in red wine may be more important, while resveratrol may or may not contribute to this effect.

Additional, large-scale studies are needed to determine the specific effects of different components in red wine, especially in people with blood pressure and heart problems.

In 67 men at high heart disease risk, alcohol-free red wine reduced blood pressure (both diastolic and systolic) after 4 weeks. It increased nitric oxide, which relaxes blood vessels. Regular red wine (9 oz glass/day) also slightly reduced blood pressure and increased nitric oxide, but less so than dealcoholized wine. A control group that only drank gin didnt see any benefits [6].

One analysis of 19 studies concluded that drinking 1 2 glasses of wine daily (150 300 ml) reduces heart disease risk [7].

Interestingly, based on the first study, the alcohol in red wine may actually reduce the beneficial effect of resveratrol and other polyphenols. This especially holds true for people who already have high blood pressure or those at high risk.

In healthy people, though, moderate intake of red wine may indeed improve heart health.

In a study of 80 healthy, young people, a smaller amount of red wine (100 ml/day) over 3 weeks boosted blood vessel health, nitric oxide, and the number of cells that regenerate blood vessels (endothelial progenitor cells). Drinking water, beer, or vodka didnt achieve these effects [8].

In cells, resveratrol increased the enzyme that makes nitric oxide (NO synthase) [9].

According to animal and cellular studies, resveratrol also reduces the formation of plaques in arteries, known as atherosclerosis. It also reduces the clumping of platelets, reduces blood lipids, and lowers inflammatory substances that increase risk of atherosclerosis [10].

In cells, resveratrol increases the expression of the PON1 gene, which reduces inflammation and helps detox pesticides and drugs [11].

Clinical studies suggest that drinking small amounts of red wine daily might support heart healthbut resveratrol supplements probably dont.

Researchers are investigating the effects of resveratrol on liver disease and bile flow.

Most clinical research suggests that resveratrol is not beneficial for non-alcoholic fatty liver disease (NAFLD). According to one analyses of four small clinical studies, resveratrol (300-3000 mg daily) taken for 3 months does not affect liver enzymes, insulin resistance, or weight in patients with NAFLD [12].

In animals, it prevented and improved conditions of obstructed bile flow (by blocking MMP-2 and MMP-9). It also prevented liver damage in animals with sepsis, or blood poisoning from serious infections. These effects remain to be explored in clinical studies [13, 14, 15].

Resveratrol likely doesnt improve non-alcoholic liver disease. Its oher purported effects on the liver remain unexplored in humans.

The following purported benefits are only supported by limited, low-quality clinical studies.

There is insufficient evidence to support the use of resveratrol for any of the below-listed uses.

Remember to speak with a doctor before taking resveratrol supplements. Resveratrol should never be used as a replacement for approved medical therapies.

One study suggested that resveratrol helps with glucose metabolism. In 11 healthy but obese men, resveratrol (150 mg/day) increased insulin sensitivity and lowered blood sugar levels after 30 days [16].

However, additional clinical studies are lacking. Therefore, existing evidence does not support the use of resveratrol for lowering blood sugar.

It also raised SIRT1 and PGC-1a levels. SIRT is an enzyme crucial for turning off harmful genes that increase fat deposits, blood sugars, and inflammation in the body, while PGC-1a supports healthy mitochondria [16].

Resveratrol lowered blood sugars in studies on rats with diabetes. It prompts cells to take in more glucose, which reduces insulin resistance. Resveratrol also protects the insulin-secreting beta cells in the pancreas, which helps increase insulin when its low and decrease it when its too high [17].

Scientists have yet to explore resveratrols effects on insulin resistance and diabetes in humans.

Despite some promising early findings, its still uncertain whether resveratrol supports healthy blood sugar control in people at risk of type 2 diabetes.

According to one research team, resveratrol may help balance the response to estrogen, which affects reproductive health in both men and women.

In male rats, resveratrol increased testosterone and sperm count without any adverse effects. Scientists think it may activate the HPG hypothalamic-pituitary-gonadal axis that controls sex hormone release from the hypothalamus via the pituitary in the brain [18].

In women, resveratrol may act in a somewhat different way. In one trial of 40 postmenopausal women, resveratrol (1g/day for 12 weeks) didnt affect estrogen or testosterone but increased the protein that binds sex hormones and carries them through the blood (SHBG) by 10%. It also improved estrogen metabolism, which may lower the risk of breast cancer [19].

In animals, it blocks the enzyme that makes estrogen (aromatase) and mildly activates estrogen receptors. Resveratrol binds to estrogen receptors much weaker than estrogen does, which has a balancing effect: it may help increase estrogen-like activity when this female sex hormone is low (as after menopause) or decrease it when its too high. More human studies are needed [20, 21].

Based on limited evidence, reveratrol may affect some hormonal and metabolic markers in postmenopausal women. Data are still inconslusive.

In a clinical trial of 20 people with acne, a gel with resveratrol showed positive results over 2 months. It reduced acne severity by almost 70% and improved overall skin health by over 50% with no adverse effects. The team discovered that cosmetic products with resveratrol are stable and dont degrade when kept in the fridge (at 4C/40F) [22].

No clinical evidence supports the use of resveratrol for any of the conditions listed in this section.

Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.

Scientists believe resveratrol may have dual antioxidant activity: as a direct antioxidant and as a compound that may increase other antioxidant enzymes, genes, and pathways.

Antioxidant claims underlie many of its purported health benefits. Based on this theory, oxidative stress and inflammation trigger or worsen numerous diseases from heart disease and diabetes to cancer and cognitive decline [3].

Resveratrol increased antioxidant enzymes in cellular and animal studies, including the following:

At the same time, limited studies suggest that resveratrol reduces free radicals and inflammatory substances (including iNOS, Myeloperoxidase, NADPH oxidase) [23].

Scientists are investigating whether resveratrol activates antioxidant enzymes in cells and animals, but human data are not available.

Aside from its indirect antioxidant effects on inflammation, resveratrol is theorized to affect specific inflammatory processes.

For one, it may block inflammatory COX enzymes, which are also the main target of commonly used painkillers and anti-inflammatory drugs (NSAIDs like Motrin). However, resveratrols mechanism and anti-inflammatory potential hasnt been clinically confirmed [25].

Some scientists suspect that resveratrol also blocks the following inflammatory players (in animals or cells):

Researchers propose that resveratrol acts on several anti-inflammatory pathways, but this hasnt been proven in humans.

Resveratrol may not be the philosophers stone that will confer you immortality, but scientists are looking to see if it can beneficially impact some important aging-related disease pathways.

Based on animal and cellular research, they hypothesize that resveratrol may combat some age-related disorders by [28, 29]:

Well present some interesting aging-related resveratrol research and hypotheses below. Nonetheless, the whole anti-aging theory of resveratrol remains unproven.

One of the theories scientists use to explain aging involves so-called cellular senescence. With aging, cells become senescent and less resilient to stress, they lose their function and start producing inflammatory substances [30].

This loss of function and inflammation on a cellular level then extends to organs and tissues: the brain, heart, muscles, skin, and gut and the body as a whole also start to degenerate and lose function, especially if the body cannot or does not eliminate the dysfunctional cells through a process called autophagy [30].

SIRT1 is an enzyme that can turn off genes that trigger cellular senescence. Scientists are wondering if, by activating SIRT1, resveratrol may epigenetically hinder the aging process, at least based on cellular studies [3, 31].

Autophagy is a normal process that triggers the destruction of damaged cells, recycling the products of broken-down cells to make new and healthy ones. Autophagy is our bodys main Quality Control Officer.

Some theories have linked aging and age-related diseases to impaired autophagy. Though these theories are still a topic of research, they have yet to be confirmed or rejected.

Autophagy theories also led to the recent boom in caloric-restriction practices. Caloric restriction is said to promote longevity and healthy aging by activating autophagy [32].

However, caloric restriction is not safe for everyone. It may be especially tricky for older or thin people who struggle to get enough nutrients in their daily diet.

In animal studies, resveratrol confers similar benefits to caloric restriction and increases autophagy induction without the need to reduce daily calorie intake. These effects have not been investigated in humans yet [32].

Clinical studies are needed to determine whether or not resveratrol can extend lifespan in humans.

Some scientsts hypothesize that reveratrol turns on anti-aging pathways like SIRT1 and autophagy, but theyve only tested their theories in cells and animals so far.

Glial cells, specifically astrocytes, provide support and protection to neurons and their damage or dysfunction is linked to many brain-related diseases [33].

One of the ways in which astrocytes protect neurons is by removing excess glutamate (a neurotransmitter) from synapses and the extracellular space that surrounds neurons. Excess glutamate in the brain can lead to excitotoxicity and ultimately neuronal damage or even death [33].

In a cellular study, resveratrol increased their glutamate uptake. Theoretically, this is linked to better protection from brain degeneration and stroke. However, we cant draw this conclusion from a cell-based study [33].

In animal studies, resveratrol reduced seizures and protected the hippocampus, the brains main memory hub. It also increases IGF-1 in the hippocampus, which may improve cognition [34, 35].

One research group suggested that resveratrol may protect the brain by acting on the gut-brain axis [36].

According to this unproven theory, resveratrols potential benefits may not even depend on it being absorbed and passing the blood-brain barrier. In mice, resveratrol stimulated gut nerves, which passed the signal on to the hippocampus. Resveratrol was undetectable in the hippocampus, it improved cognition only by activating nerves in the gut [36].

In a study on brain cells, resveratrol increased the activity of the antioxidant gene heme-oxygenase 1, which protects the brain from damage. The effect was enhanced by melatonin [24].

In mice with late-onset Alzheimers disease, long-term resveratrol supplementation reduced cognitive impairment and disease biomarkers. It could also activate AMPK, which maintains energy balance in the brain under challenging conditions [37, 38].

Nonetheless, clinical studies have not yet examined the effects of resveratrol on brain health. Thus, this purported benefit remains unproven.

Animal experiments point to resveratrols brain-protective potential, but clinical studies are still lacking.

Some scientists believe that the gut microbiome can protect against diseases of the arteries [39].

In one study, resveratrol protected blood vessels in mice without APOE, stopped harmful bacteria in their gut from secreting harmful oxidative substances (like TMAO), and balanced their microbiome. It increased beneficial gut bacteria (such as Lactobacillus and Bifidobacterium), which raised the production of bile acids [39].

According to some, resveratrol may counter lower bile acid production and the weaker ability to eliminate cholesterol in people with heart disease. However, clinical trials are lacking to support such claims [40].

No clinical evidence supports the use of resveratrol in people who struggle with obesity. The existing animal research should guide future human studies.

In mice fed a high-fat diet, resveratrol reduced oxidative stress and prevented the death of protective immune cells called Tregs [41].

Resveratrol stopped fat cells from making new fats and triggered their death, in cell-based studies. It accomplishes this by turning off genes that cause weight gain (such as PPAR gamma) while activating genes that enhance energy use and mitochondrial health (SIRT3, UCP1) [42, 43].

Additionally, resveratrol may boost weight loss by blocking several key fat-creating enzymes (called fatty acid synthase, lipoprotein lipase, and hormone-sensitive lipase) [42].

This purported benefit remains unproven.

Stem cells in the connective tissue are presented with several possibilities: to develop into fat cells, bone-building cells, joint, or muscle cells. Resveratrol activates the fat-burning pathway (SIRT1), which blocks genes that increase fat storage (PPAR gamma). This epigenetic shift causes stem cells to develop into bone-building cells, which may boost bone health [44].

According to some, resveratrol may synergize with Vitamin D and vitamin K2 to protect the bones and increase their mineralization [45].

Evidence is lacking to support the use of reveratrol for bone health, weight control, and microbiome or bile imbalances.

The effects of resveratrol on cancer prevention in humans are unknown.

Scientists are investigating resveratrol for its potential to prevent cancer, especially liver cancer and some other cancer cell types [46, 47, 48].

In mice, resveratrol applied to the skin before UVB exposure prevented skin cancers. Given orally, it was active against esophageal cancer in rats [49, 50].

Since resveratrol is an antioxidant phytoestrogen, some scientists are investigating its effects on breast cancer. In cells, it blocks the enzyme aromatase, which makes estrogen. High activity of this enzyme and high estrogen levels worsens a common type of breast cancer that has receptors for estrogen (receptor-positive or ER+) [51, 52].

In animal studies, resveratrol prevented and reduced the growth of breast cancer. Clinical studies have not yet determined its efficacy and safety in breast cancer patients [51].

Aside from its hormonal effects, scientists are wondering whether resveratrol can regulate another cancer enzyme called topoisomerase II. In cells from a deadly brain tumor (glioblastoma), resveratrol blocked the activity of this cancer enzyme, which should guide further research efforts [53].

There is no evidence that resveratrol can help prevent cancer in humans.

According to some unproven theories, resveratrol may increase muscle-building pathways and block processes that degrade proteins (proteolysis). For example, it increased the size of fish and enhanced their muscle growth in one study [54].

In another study, resveratrol supplementation enhanced the exercise training response, upper muscle strength, and aerobic performance in rats [55].

Scientists are questioning if its effects stem from epigenetic changes like activating fat- and sugar-burning sirtuins (SIRT1) and other molecules that heighten energy levels (AMPK and PGC-a). Future studies might give us some answers [55].

In mice, high-dose resveratrol had a good anti-radiation effect. It prevented the decline in bone marrow and white blood cells from radiation, helping to maintain proper immune function. It also increased the antioxidant and detox enzyme SOD without causing adverse effects. These effects remain completely unproven in humans, though [56].

Scientists found that noise increases free radicals, which can cause ear damage and hearing loss. In mice exposed to damaging noise, resveratrol protected against hearing loss by neutralizing free radicals and improving blood flow in the ears [57].

In a different rat study, resveratrol prevented ear damage from the toxic chemotherapy drug cisplatin [58].

Clinical research is needed.

The impact of resveratrol on muscle growth, radiation, and hearing loss in humans is still unknown.

Resveratrol has some virus-fighting action, according to cell-based or animal studies. It was effective against:

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22 Purported Resveratrol Benefits - SelfHacked

What Is the Difference Between Resveratrol & Grape Seed …

Posted: at 1:52 am

Unlike grape seed extract, resveratrol comes from grape skins.

Both resveratrol and grape seed extract are derived from grapes, but unlike grape seed, resveratrol is extracted from grape skins like those used to make red wine. Although both substances have similar actions in the body, they each have some individual recommended medicinal uses. You might take grape seed extract for different health benefits than resveratrol. Before you begin taking either alternative remedy, consult your doctor to discuss the correct dosage and possible drug interactions.


Resveratrol is also found in peanuts and purple grape juice. Because resveratrol is found in the highest concentrations in red wine, wine is considered the main dietary source of resveratrol. Grape seed extract is taken from the seeds or from whole grapes. Grape seed extract contains substantial amounts of flavonoids, vitamin E and linoleic acid, among other important constituents.


Both resveratrol and grape seed extract act as powerful antioxidants in the body. Antioxidants combat free radicals, which can attack and kill your body's cells, as well as damage cell DNA. Antioxidants also play a role in certain medical conditions like heart disease and cancer, as well as in aging. The antioxidant actions in grape seed extract are attributed to the constituents known as oligomerica proanthocyanidin complexes, or OPCs, while resveratrol itself is a constituent of grape skins that bears the antioxidant effects. Additionally, resveratrol is considered a phytoestrogen, which is a plant-based substance that acts in a similar way to the estrogen hormone in your body.


Due to its antioxidant and estrogen-like actions in the body, resveratrol is sometimes used to treat heart disease and prevent cancer. Grape seed extract's antioxidant actions account for its potential use in treating chronic venous insufficiency, high cholesterol, edema and hypertension, as well as in preventing cancer, according to the University of Maryland Medical Center. Grape seed extract is also sometimes recommended for treating diabetes, hemorrhoids and poor night vision, and for skin anti-aging purposes. Additionally, grape seed may help treat burns, atherosclerosis, constipation and other gastrointestinal conditions, as well as promote wound healing, according to the Memorial Sloan-Kettering Cancer Center. No widely accepted, conclusive scientific research supports the use of resveratrol or grape seed extract to prevent or treat any medical condition, however.


A typical dose of resveratrol is 500 mg per day, according to the University of Pittsburgh Medical Center. For grape seed extract, a daily dosage of 200 to 400 mg is used to treat edema and 150 to 300 mg to treat chronic venous insufficiency, notes the University of Maryland Medical Center. You could take 25 to 150 mg of grape seed extract up to three times daily for general antioxidant effects. Grape seed extract is usually standardized to contain 40 to 80 percent proanthocyanidins. Ask your physician about the dosage that's right for you before taking grape seed extract or resveratrol.


Resveratrol's estrogenic effects could potentially increase the growth of breast cancer cells, making the remedy unsafe for women who have or are at risk of having estrogen-sensitive types of cancer, warns the University of Pittsburgh Medical Center. Grape seed extract may offer blood-thinning effects, making the remedy possibly unsafe if you're also taking anticoagulant drugs like Coumadin, warns the Memorial Sloan-Kettering Cancer Center. The same is true if you have a bleeding disorder like hemophilia, notes the University of Maryland Medical Center.

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What Is the Difference Between Resveratrol & Grape Seed ...

8 Reasons To Love Red Wine | Prevention

Posted: at 1:52 am

Beneficial Booze

Any hardworking gal knows that kicking back with a girlfriend and a glass of red wine is a fabulous way to de-stress. The best part? Your red-wine habit also happens to come with some happy health benefits, such as protecting your ticker and even slimming your waistline. Check out these eight reasons why winding down with a glass of vino is a good call all around.

MORE: 9 Very Best Solutions To Solve Your Snoring (Prevention Premium)

1. Lower your cholesterol

High-fiber Tempranillo red grapeswhich are used to make certain red wines, like Riojamay actually have a significant effect on cholesterol levels,according to a study from the Universidad Complutense de Madrid in Spain.

Healthy study participants who consumed the same grape supplement found in red wine saw their LDL, or "bad cholesterol," levels decrease by 9% among healthy. Participants withhigh cholesterol experienced a drop of 12%. What's the big deal? Excess LDL ends up getting deposited in arterial walls and forming plaque, which causes arteries to stiffen and blood pressure to rise, ultimately leading to heart attacks, says Arthur Agatson, MD, an associate professor of medicine at the University of Miami and author ofThe South Beach Heart Program.

MORE: 12 Foods That Lower Cholesterol Naturally

2. Protect your heart

On top of lowering bad cholesterol, polyphenolsthe antioxidants in red winecan help keep blood vessels flexible and reduce the risk of unwanted clotting, saysJohn Folts, PhD, a professor of cardiovascular medicine and nutrition at the University of WisconsinMadison.

"They're nearly as effective as aspirin," says Folts. But be careful: Chronic heavy drinking damages the heart, so, as with most things, moderation is key.(If you prefer an aspirin to protect your ticker, be sure to follow these3 aspirin safety tips.)

MORE: 28 Days To A Healthier Heart

3. Control blood sugar

The skin of red grapesa rich source of red wine's natural compound resveratrolmay actually help diabetics regulate their blood sugar, finds recentresearch published in the journalNutrition. Study participants who took a250 mg resveratrol supplement once a day for three months had lower blood glucose levels than those who didn't take the pill. Plus, resveratrol-takers also had significant decreases in total cholesterol and systolic blood pressure. Researchers suspect that resveratrol may help stimulate insulin secretion or activate a protein that helps regulate glucose and insulin sensitivity.

4. Boost your brain

Resveratrol may also be the key to keeping your memory sharp, says Philippe Marambaud, PhD, a senior research scientist at New York's Litwin-Zucker Research Center for the Study of Alzheimer's Disease and Memory Disorders. The compound has been shown to hamper the formation of beta-amyloid protein, a key ingredient in the plaque found in the brains of people with Alzheimer's.Marambaud suggests flexing your noodle by doing crossword puzzles and brain teasers for an hour then cooling down with a glass of wine. New to brain teasers? We've got you covered with 7 Brain Games That Make You Smarter.

5. Fight off a cold

If you hate getting sick (and who doesn't?), the antioxidants in red wine may help keep you healthy.A 2010 study in the American Journal of Epidemiology found that among 4,000 faculty members at five Spanish universities,those who drank more than 14 weekly glasses of wine for a year were 40% less likely to come down with a common cold.Why? According to the National Institutes of Health, antioxidants are believed to fight infection and protect cells against the effects of free radicals, which may play role in cancer and other diseases.

Another antioxidant boost? They may also lower sex hormone levels to protect against breast cancer,says a study from Cedars-Sinai Medical Center in Los Angeles.(Stay up to date on the latest breast cancer news with ourBreast Cancer Center.)

6. Stop cancer

According to researchers at the University of Virginia, the resveratrol you get from drinking one glass of red wine three or four times a week may be enough to starve any nascent cancer cells. The scientists dosed human cancer cells with resveratrol and found that the compound inhibited the key action of a cancer-feeding protein.

MORE: The Ultimate Anti-Cancer Diet

7. Get slim

Clearly, resveratrol is a bit of a limelight hog when it comes to the healthful compounds in vino. But research in the Journal of Biological Chemistry suggests piceatannol, the chemical compound our bodies convert from resveratrol, deserves some credit. This compound was shown to actually prevent the growth of fat cells in a series of lab tests. How? Researchers say that piceatannol binds to the insulin receptors of fat cells, essentially blocking the pathways necessary for immature fat cells to mature and grow.

8. Jazz up dinner

Who said your red wine consumption had to be limited to the glass? You can include the drink in your dinner, either as a sauce (in which case we suggest our yummy DIY red wine sauce) or complimentary ingredient, and still reap its benefits.

Need inspiration? We love these four recipes:

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8 Reasons To Love Red Wine | Prevention

Caudalie unlocks a centuries-old secret of youthful skin with its bestselling resveratrol line – CNN

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Youre not alone in feeling like you aged a decade in the last year. And youre also not the only one who secretly partially dreads the idea of seeing your co-workers, friends and family after such a long time away from face-to-face contact after all, cucumber peels and exfoliating brushes werent exactly on the top of anyones daily to-do list.

So whats the answer to washing away all the extra years you psychically packed into your skin while you kept the world from crumbling all around you for over a year? Caudalie has a suggestion: Hit the wine bottle. Just not quite in the way you think.

For centuries, in the heart of wine country in France, wine grapes were the secret to the glowing, spot-free skin of the women who worked the vineyards making some of the finest vintages the world has ever seen. But it wasnt until the mid-1990s in Bordeaux that Mathilde and Bertrand Thomas, working with Professor Joseph Vercauteren, finally pinpointed the actual science behind the beauty secrets local women had known for so long. The result was Caudalie, a beauty company that harnessed the unsurpassed power of the anti-aging polyphenols found in the grape seeds that most wineries simply let go to waste. And in the last year, Caudalies resveratrol collection has skyrocketed in popularity with good reason.

Working with a Harvard University genetics professor, Caudalie patented a combination of resveratrol, a natural phenol found in grapevines to help regenerate healthy cells after damage, and hyaluronic acid, a substance found naturally in your body whose function is to keep your skin and eyes well lubricated. That elixir has been found to be twice as effective as retinol in keeping skin visibly firm. And thats the mixture that Caudalie has used as the key to its line of resveratrol skin and beauty products.

Its the reason why Resveratrol-Lift Instant Firming Serum has become such a hit, with users swearing by it. Theyve gone on record saying theyre getting noticeable results within weeks, with Caudalies resveratrol serum leaving them feeling fresh and not oily or overly scented but still keeping the skin smooth and hydrated. Look it up for yourself: Its earned over 100 5-star reviews.

In keeping with Mathilde Thomas philosophy, all resveratrol products are at least 97% natural and follow the universal Caudalie rule of no parabens, phenoxyethanol, phthalates, mineral oils, PEGs, silicones or animal-derived ingredients. In addition, Caudalie has committed to zero-waste packaging by 2022, meaning all packaging will soon be completely recycled, recyclable or refillable, using less paper and no plastic film. That means a reduction in Caudalies carbon footprint of a whopping 40%. So when you buy Caudalie, youre not just restoring your own beauty; youre helping preserve our planets.

As we all start to finally return to our daily regimens of self-care, Caudalies resveratrol line should be part of your go-to skin care products when you wake up and when you go to bed. Because the secret to glowing, youthful skin is out and this is one vintage you dont want to pass up.

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Caudalie unlocks a centuries-old secret of youthful skin with its bestselling resveratrol line - CNN

Resveratrol in red wine could help to treat endometriosis – The Drinks Business

Posted: at 1:52 am

Researches at the Iran University of Medical Sciences have found that the anti-inflammatory properties of resveratrol in red wine could help to treat endometriosis.

As reported by Wine Spectator, the study was published in the online journalNature.

Endometriosisis a condition where tissue similar to the lining of the womb starts to grow in other places, such as the ovaries and fallopian tubes. It can affect women of any age and can cause chronic pain, irregular bleeding and infertility.

There is no cure for endometriosis, which is treated with anti-inflammatory medication.

The Iran study aimed to find out how effective resveratrol an antioxidant-rich compound found in red wine was in treating the symptoms of endometriosis.

The researches tested the antioxidant in the lab on endometrial cells, collecting endometrial cells from 40 patients suffering from stage 3 or 4 endometriosis, along with 15 patients without the condition.

After isolating the cells, the scientists treated them with varying amounts of resveratrol.

As reported by Wine Spectator, three genes and the proteins they produce cause endometrial cells growing outside the uterus.

The researchers found that resveratrol suppressed all three of the offending genes, controlling inflammation and keeping the condition under control.

According to the findings, resveratrol may ameliorate endometriosis progression through reducing the expression of these genes in endometrial cells, the researchers reported, adding that further research was needed.

The findings give hope to women suffering from the condition, who may benefit from the anti-inflammatory effects of a daily glass of red wine.

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Resveratrol in red wine could help to treat endometriosis - The Drinks Business

Why Pinot Noir May Be The Best Wine For Your Health – Forbes

Posted: at 1:52 am

Glass of red wine and electrocardiogram

The benefits of drinking red wine have long been debated. Numerous studies have suggested that there is a link between moderate red wine consumption and heart health, but the issue has yet to be definitively settled.

According to the Mayo Clinic:

Red wine, in moderation, has long been thought of as hearthealthy. Thealcoholand certain substances inred winecalled antioxidants may help prevent coronary artery disease, the condition that leads to heart attacks. Any links betweenred wineand fewer heart attacks, (however) aren't completely understood.

The health benefits associated with drinking red wines are mainly associated with a powerful antioxidant called resveratrol. The Mayo Clinic has suggested that:

Resveratrol might help prevent damage to blood vessels, reduce low-density lipoprotein (LDL) cholesterol (the "bad" cholesterol) and prevent blood clots.

It also notes, however, that other studies found no benefits from resveratrol in preventing heart disease and that more research is needed.

Before you rush off to buy another bottle of your favorite red wine, however, you should note that the level of resveratrol in red wines can vary widely.

According to Jim Bernau, the president of Willamette Valley Vineyards, one of Oregons leading Pinot Noir producers, cool climate Pinot Noir, especially whole cluster fermented wines, are more likely to deliver high levels of resveratrol than other varietal red wines.

Jim Bernau, President, Willamette Valley Vineyards

Bernau notes that resveratrol is a fungicide, a polyphenolic compound an antimicrobial deterrent and repellant that is naturally produced by grape plants to protect grapes from molds. Its found in the skin of the grapes.

Red grape varieties grown in cool regions that are prone to high levels of humidity during harvest time, and more prone to mold damage, will produce higher levels of resveratrol than red grapes grown in drier regions.

Thin skinned grapes are even more vulnerable to being attacked by molds, so those varieties of grapes, he believes, also tend to produce even higher levels of resveratrol. According to Bernau, local climatic conditions post veraison, regardless of where the thin-skinned grapes are grown, is the determining factor.

There are many thin-skinned red grape varietals. Sangiovese, Tuscanys main grape varietal, is famously thin skinned, although Sangiovese Grosso, the Sangiovese clone used to make Brunello di Montalcino, is much thicker skinned.

In addition to Pinot Noir, other thin skinned red grape varietals include Grenache, Cabernet Franc, Merlot, Nebbiolo and Gamay. Grenache and Merlot are typically grown in drier, Mediterranean like climates, Bordeaux being something of an exception, and are less prone to mold outbreaks.

Cabernet Franc, Gamay and Nebbiolo can thrive in cooler climates in regions that can be prone to rainy weather during harvest season. They are good candidates to produce resveratrol rich wines.

Pinot Noir, however, is usually the northernmost planted red grape varietal, and typically reaches its most complex expression when grown in cool climates. Combined with its notoriously thin skins makes it the ideal candidate for producing wines with elevated levels of resveratrol.

Thats why Bernau, believes the defense response is greatest in the Pinot Noir variety He notes, however, that the impact of grape varieties on resveratrol levels needs more extensive study.

Resveratrol is a powerful antioxidant. That means it will combine readily with oxygen. In the body antioxidants inhibit oxidation, hence the name, by combining and neutralizing potentially damaging oxidizing agents.

To maximize the level of resveratrol in a wine, Bernau argues, its necessary to minimize the wines contact with oxygen.

As a general rule, winemakers want to limit oxygen contact with grapes, especially the grape must during fermentation.

Whole cluster Pinot noir grapes being emptied from a fermentation tank prior to being crushed.

Oxygen combines with phenolic compounds in wine or fermenting grape must and causes them to oxidize, resulting in a loss of fruity flavors and diminishing aroma. Oxidation can also lead to browning in a wine and the creation of aldehydic, nut like, flavors.

Oxidation is an inevitable consequence of aging wines. Thats why older wines tend to lose the purple and crimson coloration of their youth and become browner, more brick like in color, and often exhibit less intense fruit aromas and flavors. Presumably that means that older wines are likely to contain less resveratrol.

Whole cluster fermentation, a popular technique among Pinot Noir producers and the signature style of Beaujolais, is especially suited, Bernau believes, for maximizing resveratrol levels in wine.

Grapes that are vinified as whole clusters are not destemmed or crushed prior to vinification. Instead, they are placed as whole bunches in a fermenter. Typically, the grapes at the bottom of the fermenter are split open by the weight of the grapes on top of them, and some juice is released, but the majority of the grapes remain whole.

Once the fermenter is filled, carbon dioxide is pumped into the tank to flush out any oxygen; creating an anaerobic environment. The technique is called carbonic maceration. In this wine making process most of the actual fermentation occurs within the grape itself, thus limiting even more the fermenting grape juices exposure to oxygen. After the fermentation is over, the grapes are gently crushed to release the juice.

Carbonic maceration is used to produce light bodied, fresh and fruit forward red and ros wines. One of the characteristics of such wines is that they have a distinctive bubble gum flavor note. If you detect a bubble gum flavor in a wine, then the odds are that at least a portion of that wine was produced using carbonic maceration.

Since contact with oxygen reduces resveratrol levels, Bernau believes that you should not decant a wine if you are looking to preserve the resveratrol level.

He also notes that there is no relationship between a wines appearance and the level of resveratrol it contains. Since resveratrol is found in the skins of grapes, extended contact should theoretically increase resveratrol levels.

Deeply hued wines, presumably an indication of extended skin contact, do not, however, necessarily have higher resveratrol levels argues Bernau, the issue is extraction at lower levels of oxygen thats why clusters fermented whole result in more resveratrol content than those macerated through punch downs or pump overs.

There are still a lot of questions about resveratrol that remain to be answered. Its health benefits have not been definitively settled. How to maximize resveratrol levels in wine production, the impact of vineyard management techniques, the effect of different grape varietals, the consequences of different closures during bottling, all await further study.

For now, however, if you are looking to maximize the health benefits of drinking red wine, reaching for a bottle of whole cluster fermented, cool climate Pinot Noir, like the kind produced in Oregons Willamette Valley, would be a good place to start!

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Why Pinot Noir May Be The Best Wine For Your Health - Forbes

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