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Chocolates are fun, but your heart needs better help than that – pentictonherald.ca

Posted: February 14, 2021 at 4:55 pm

Valentines Day, the largest chocolate and flower day of the year happens tomorrow. Youre welcome to all the gents reading this, you've still got time to pick up something for your sweetheart.

In addition to flowers, chocolate, wine and heart-shaped pizzas, paradoxically February is also heart-health month. As much as wed like to believe consuming a box of dark chocolates and a bottle of red wine after dinner can be good for the heart, the palette is by far the body part experiencing the greatest benefits.

Now, before you all go labelling me as anti-chocolate and no fun, I am a chocolate lover. In fact Ive created several chocolate recipes that are not only delicious, but healthy. Something Ive been able to share and help my clients stay on track with their health goals and not feel deprived. And on the rare occasion, Ill have a glass of red wine.

Dark chocolate and red wine both contain resveratrol, a component that does promote heart health. What most people dont know however, is that the amount of resveratrol youd ingest over dessert with your sweetheart, isnt enough to make a significant difference in your health.

As youve heard (or read) me say before, we can get all the nutrients our body needs from food. Theres no question God gave us great stuff here on this planet. The question is, do we? An article published by the Kressler Institute in 2018 reported, More than half the calories Americans consume, come from nutrient-depleted, ultra-processed foods... and went on to say that Nearly one-third (31%) of the U.S. population is at risk for at least one vitamin deficiency or anemia.

United States stats are always easier to dig up, but trust me, Canadians are right there too.

Since were smack dab in the middle of heart month, let's look at three supplements that are known for building and supporting a healthy heart. Ive already mentioned resveratrol. Coenzyme Q10 or CoQ10, and Omega 3.

As with any nutrient, taking a supplement should not be considered a replacement for the healthy foods that also contain the same nutrients. Supplements are to come alongside and fill the gaps, not provide a get-out-of-eating-your-veggies free card.

Of these three, if you take supplements at all, you're most likely using, or at least have heart of, omega 3s. Several types of fish including salmon, lake trout, sardines, herring, anchovies, as well as nuts, seeds, flaxseed, and chia all contain omega 3 fatty acids. Great for supporting brain function, alleviating rheumatoid arthritis, and joint pain, omega 3s also help to lower blood fat levels.

In other words, omega 3s help bring down elevated triglycerides and lowers cholesterol, which also brings down your risk of heart disease and stroke. And unless youre eating fish daily, supplementing is definitely a good idea.

Resveratrol, found in red grapes and cocoa beans red wine and dark chocolate is known for its antioxidant properties and a 2015 review posted on PubMed concluded high doses may help reduce the pressure exerted on artery walls when the heart beats, bringing down blood pressure.

Of course, consuming high doses of red wine or chocolate for that matter would produce the opposite effect, creating inflammation. So, supplementing is the way to go.

Researchers also found supplementing with resveratrol had a positive impact on overall cholesterol levels and may also help decrease plaque buildup inside

Unlike resveratrol and omega 3, Coenzyme Q10, or CoQ10, is something our bodies produce naturally.

According to a June 2019 article by Dr. Josh Axe, CoQ10 helps cells produce energy and neutralize free radicals, the damaged cells that cause illness and aging, improve heart health.

It offsets negative effects of statin drugs, slows down DNA damage due to aging, helps maintain ph balance, may slow or reverse the spread of some cancers, supports cognitive function, may improve male infertility, treats symptoms of fibromyalgia.

The amount of CoQ10 our bodies produce reduces with age. And although consuming foods that contain CoQ10 such as meats, poultry, fish, eggs, beans and nuts is something everyone should be doing, Dr. Axe goes on to say that for people who, struggle with certain health conditions, such as heart disease having chronic diseases, high levels of stress, deficient in vitamin B, mitochondria diseases, taking statin drugs, food alone may not be enough as these conditions further impede CoQ10 production.

And as the heart is just one of many areas CoQ10 is needed for optimal health, it's in our best interest to keep those levels up.

As with anything you put in your body, quality matters. Like your car, the better quality fuel you put in, the better performance youre going to get. Whether its food or supplements, same goes for your body. And in case there was any doubt, that old adage you get what you pay for, is true.

Februarys the perfect time to give your heart and yourself some love. Youre worth it.

Tania Gustafson is a nutritionist and fitness coach.

On the web: fuelignitethrive.com.

Email: tania@fuelignitethrive.com. Find healthy chocolate recipes at the 8 Weeks is All it Takes group on Facebook.

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Chocolates are fun, but your heart needs better help than that - pentictonherald.ca

Does Red Wine Have Any Effect on Weight Loss? – Healthline

Posted: at 4:55 pm

Red wine is the alcoholic drink of choice for many people, and its gotten a lot of buzz for its potential health benefits.

The drink, made from fermented red grapes, is loaded with antioxidants, but it can also be full of calories and sugar.

If youre trying to lose weight, you may be wondering if red wine could help you or if it would just be a hindrance.

This article reviews red wines nutrient content, what the evidence says about red wine and weight control, and how you can enjoy red wine while still losing weight.

A 5-ounce (148-mL) serving of red wine contains (1):

Most of the calories in red wine come from alcohol, which provides seven calories per gram, and the remainder comes from carbs (2).

Keep in mind that there are several different types of red wine, all with varying amounts of alcohol and sugar content, which will affect their total calorie count. Additionally, there will be some variation among brands.

A 5-ounce (148-mL) serving of red wine contains 125 calories, mostly from alcohol and carbs. There will be some variation among types and brands of red wine.

Several studies have assessed the link between alcoholic beverages and weight.

When it comes to weight management, there appear to be both pros and cons to drinking red wine.

Red wine is rich in resveratrol and other antioxidants that may benefit blood sugar control, heart health, and inflammation. Additionally, moderate wine consumption may help protect against excess weight gain (2, 3).

Red wine and other flavonoid-rich foods like olive oil, nuts, fruits, and legumes are considered staple foods in the Mediterranean-style diet, which has been associated with better weight control than a standard American diet (4, 5).

Unfortunately, evidence on the effects of red wine itself is fairly mixed. Some animal studies have found that red wine consumption decreases body weight and body fat levels, but others have found the opposite (6, 7, 8).

Additionally, a study in 29 people with obesity found that red wine antioxidants appeared to not affect blood sugar control (9).

However, other human studies have noted that moderate alcohol consumption may help improve blood sugar control potentially making it easier to manage weight (10, 11).

More research is needed before the effects of red wine on weight control are fully understood.

Several studies have noted that excess alcohol consumption is linked to weight gain especially in men (2, 12, 13).

Alcohol contains more calories per gram than carbs and protein, and many alcoholic beverages like beer, wine, and mixed drinks may also be loaded with sugar.

Because of this, it can be easier to consume more calories than you intend to when drinking alcohol (2, 14, 15).

Additionally, overconsumption of alcohol may lead to insulin resistance and blood sugar control problems, which may be a precursor to weight gain and type 2 diabetes (16).

Note that 5 ounces (148 mL) of wine is considered 1 serving, and moderate drinking is defined as no more than 2 servings of alcohol per day for men and 1 serving of alcohol per day for women (15).

Red wine is rich in the antioxidant resveratrol, but research is mixed regarding its positive weight effects. Excess alcohol consumption including red wine may lead to weight gain.

Luckily, you dont have to completely avoid drinking red wine if youre trying to lose weight.

Here are some ways that you can enjoy red wine without hindering your weight loss efforts:

As long as youre watching your portion sizes and drinking in moderation, wine shouldnt have a huge effect on your weight.

Additionally, if you notice that your weight loss is slowing down and nothing has changed except the amount or frequency of your red wine intake, try cutting back to see if that helps.

You can drink red wine and still lose weight as long as you limit how much you drink and track your calories.

Red wine is rich in antioxidants, but its also full of calories from alcohol and carbs. This makes it a mixed bag when it comes to weight loss.

Too much red wine, or any alcoholic drink, may hinder weight loss and contribute to weight gain. That said, red wine in moderation may provide some protective effects against weight gain.

To enjoy red wine while losing weight, make sure to stick to a single serving, avoid sugary dessert wines, and track your calories.

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Does Red Wine Have Any Effect on Weight Loss? - Healthline

What Happens To Your Body When You Eat Grapes | Eat This Not That – Eat This, Not That

Posted: at 4:55 pm

As far as healthy snacks go, it doesn't get much better than grapes. They're super convenient to pack and take with youand they taste good, to boot. Best of all, they're about 84% water. Simple, meaning you get an instant dose of hydration from munching on them. Grapes come in literally thousands of different varieties and colors, all of them delicious in their own unique way. But what happens to your body when you eat grapes? Well, a lot of things. While grapes offer a bevy of health benefits, they can also do more harm than good if you go overboard with your snackingwhich, let's be honest, is pretty easy to do with this fruit.

A 1-cup serving of red or green grapes contains 28% of your daily recommended intake for vitamin K, a nutrient that's essential for bone and heart health. Not only that, but they're extremely low in fat, sodium, and cholesterol, and an excellent source of vitamin C. Studies have shown that eating grapes doesn't just support your physical health, but also your cognitive health, too: One 2017 studyfound that when adults took a grape supplement daily, they improved their test scores for attention, memory, and language. That said, grapes are also high in sugar and carbs, and low in protein.

Grapes are incredibly versatileyou can snack on them right off the vine, incorporate them into smoothies, toss them into salads, or even freeze them for a popsicle-like treat. Now, if you're curious about what happens to your body when you eat grapes, read on. And for more healthy tips, be sure to check out our list of The 7 Healthiest Foods to Eat Right Now.

Grapes pack a whopping 23 grams of sugar per cup.However, certified nutritionist Paul Claybrook, MS, notes that this fruit is relatively low on the glycemic index, meaning they shouldn't cause your blood sugar to spike too much if you eat them in moderation.

"Your blood sugar will increase but not as significantly as something like soda would cause," he explains. "Part of the reason for this is that grapes contain some fiber, which slows down the speed at which your body can absorb nutrients, including sugar. There isn't a whole lot of fiber (just under a gram per cup) but it's enough to keep your blood sugar in a reasonable range as long as you aren't pigging out on them."

Grapes also contain a compound called resveratrol, which research has shown may increase insulin sensitivity, thus having a beneficial effect on your blood sugar levels.

Studies even say that Controlling This Hormone May Help Lower Blood Sugar.

You've heard of antioxidants, right? Those powerful substances that defend your body from free radical damage? Well, grapes are chock-full of them, and they can help protect and repair your cells from oxidative stresswhich is linked to the development of chronic diseases like cancer, heart disease, and diabetes.

"Oxidative stress simply means that there are too many free radicals (waste products) and not enough antioxidants (waste neutralizers) in your body to mop them up," explains Claybrook. "The result is damage to tissues that can lead to disease. Fortunately, grapes contain tons of antioxidants including flavonoids, phenolics, vitamin C, quercetin lutein, beta carotene, and resveratrol."

Research has revealed that grapes contain over 1,600 beneficial plant compounds, and since the highest concentration of antioxidants is in the seeds and the skin, it's better to eat them whole than simply drink grape juice. Additionally, it's also worth noting that red grapes are higher in antioxidants than green ones because they contain anthocyanins, a type of flavanoid that's responsible for their color.

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Chronic inflammation can cause a number of long-term symptoms and health issues, including muscle aches and joint pain, weight gain, headaches, fatigue, and gastrointestinal problems. It's also been linked to cancer, heart disease, Alzheimer's, type 2 diabetes, arthritis, and other serious conditions.

Luckily, according to Claybrook, the diversity of powerful antioxidants found in grapes can help to reduce inflammation in the body. Specifically, resveratrol is known to have anti-inflammatory properties. Multiple studieshave found that taking grape powder extract can increase the levels of anti-inflammatory compounds in your blood.

Here are Instant Ways to Reduce Your Inflammation, According to a Doctor.

"While grapes are very healthy, too much of a good thing can still be a problem," says Claybrook.

If you were to eat, say, 2 cups of grapes, you'd be getting almost 47 grams of sugarthat's almost the equivalent of two candy bars.

"Sugar causes weight gain, so you don't want to eat grapes by the pound," adds Claybrook. "Grapes could also cause gas, bloating, diarrhea, and an upset stomach if you overdo it."

One serving is about 1/2 cup or 16 grapeswhich may seem small, but controlling your portion sizes of this fruit will allow you to reap the benefits without the risks of digestive issues and weight gain.

One cup of grapes contains an impressive 288 milligrams of potassium, which plays a key role in lowering blood pressure. Not only that but studies have shown that red grapes contain compounds that may help to reduce total and "bad" LDL cholesterol.

"The polyphenols in grapes have been shown to lower the risk of atherosclerosis (hardening of the arteries)," adds Claybrook. "They do this of course by eliminating free radicals but also improve the function of the tissues and help avoid LDL cholesterol from being damaged and sticking to blood vessel walls. They also help maintain the elasticity of blood vessels, thus reducing blood pressure and keep platelets from sticking together and creating clogs."

Here are 17 Foods That Lower Cholesterol.

Grapes are a stellar source of vitamin C, packing 27% of the RDI in 1 cup. As you may or may not know, vitamin C is an essential nutrient that benefits your immune system, which may explain why test-tube studies have shown that grape skin extract can protect against the flu virus.

In fact, 2013 research that compared the immune-boosting effects of hundreds of foods found that red grapes stood outmainly due to the resveratrol, which works with vitamin D to raise the expression of a specific gene involved in immune function.

Here are 8 Ways to Support a Healthy Immune System, According to Harvard.

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What Happens To Your Body When You Eat Grapes | Eat This Not That - Eat This, Not That

Global Resveratrol Market Report 2020 Industry Trends, Share and Size, Expected CAGR, Top Manufacturers and Consumer Analysis across the Region and…

Posted: at 4:55 pm

Resveratrol Market Overview

The report study researched by Adroit Market Research gives comprehensive knowledge and valuable insights about the Resveratrol Market. Also, the study attempts to deliver significant and detailed insights into the current market prospect and emerging growth scenarios. The report on the Resveratrol Market also emphasizes on market players as well as the new entrants in the market landscape.

The Resveratrol Market report is a precise and deep-dive study on the current state that aims at the major drivers, market strategies, and imposing growth of the key players. Worldwide Resveratrol Industry also offers a granular study of the dynamics, segmentation, revenue, share forecasts, and allows you to make superior business decisions. The report serves imperative statistics on the market stature of the prominent manufacturers and is an important source of guidance and advice for companies and individuals involved in the Resveratrol industry.

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By Geographical Regions

Asia Pacific: China, Japan, India, and Rest of Asia Pacific Europe: Germany, the UK, France, and Rest of Europe North America: The US, Mexico, and Canada Latin America: Brazil and Rest of Latin America Middle East & Africa: GCC Countries and Rest of Middle East & Africa

Highlights of the Report:

Accurate market size and CAGR forecasts for the period 2019-2026 Identification and in-depth assessment of growth opportunities in key segments and regions Detailed company profiling of top players of the global Resveratrol Market Status and Trend Analysis 2019-2026 (COVID-19 Version) Exhaustive research on innovation and other trends of the global Resveratrol Market Status and Trend Analysis 2019-2026 (COVID-19 Version) Reliable industry value chain and supply chain analysis Comprehensive analysis of important growth drivers, restraints, challenges, and growth prospects

Competitive Analysis:

The Resveratrol industry company profile section of the report includes their basic information like website, legal name, market position, and headquarters, top competitors by market revenue or capitalization, and past background together with contact information.

The competitive evaluation of the application market brings monitoring into the product usage types of the current top players. Also, the study focusses on characteristic features & Resveratrol price, valuable reviews on the crucial products in the global market. The report offers key facts and figures on the Resveratrol market statistics, key competitors and is a significant source of guidance and business direction and an individuals interests in the Resveratrol industry.

Some of the Important and Key Players of the Global Resveratrol Market:

Jeunesse Global, DSM Nutritionals, Sirtris Pharmaceuticals Inc., Ltd., Resveratrol Enhanced Pty Ltd, Hill Pharmaceutical Co., Andorra Life, Terraternal, ResVitale LLC, Endurance Products Company, ASN Pharmaceutical LLC, Xieli Pharmaceutical, RevGenetics, GlaxoSmithKline and Evolva among others.

Complete Summary with TOC Available @ https://www.adroitmarketresearch.com/industry-reports/resveratrol-market?utm_source=bh

The report provides market size with 2019 as the base year in consideration and a yearly forecast until 2025 in terms of Revenue (USD Million). The estimates for all segments including type and application have been provided on a regional basis for the forecast period mentioned above. We have implemented a mix of top-down and bottom-up approaches for market sizing, analysing the key regional markets, dynamics, and trends for various applications.

The report of Resveratrol Market studies the key players present in the market. The chapter includes the competitive landscape section which provides the full and in-depth analysis of the current market trends, changing technologies, and developments that will be beneficial for the companies, which are competing in the market. The report offers an overview of revenue, demand, and supply of data, futuristic cost, and growth analysis during the projected year. In addition to a brief overview of the company, analysts shed light on their valuation and evolution. It also discusses the list of important products and the ones in the pipeline. The competitive landscape is analysed by understanding the approaches of the companies and the initiatives they have taken in recent years to triumph over the intensive competition.

Resveratrol Market Segmentation

Type Analysis of Resveratrol Market:

Form Segment, (Liquid supplements,Powdered form,Red wine pill), Type Segment, (Grape seed extract,Natural resveratrol,Japanese knotweed extract), Distribution channel Segment, (Drug stores,Departmental stores,Hypermarket/supermarket,Online stores,Others)

Applications Analysis of Resveratrol Market:

Application Segment, (Cosmetics,Pharmaceuticals,Dietary supplements,Others)

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This report provides pin-point evaluation for changing competitive dynamics of Resveratrol market It supplies a forward-looking viewpoint on Various factors driving or restraining keyword market growth It supplies an eight-year forecast assessed based on the way the Resveratrol market is predicted to increase This will help in knowing the key product segments along with their future It provides pin point evaluation of altering competition dynamics and keeps you ahead of competitors This will help in making informed business decisions by having complete insights of Resveratrol market and by making in-depth evaluation of Resveratrol market segments

Key benefits to buy this report: What are the key market trends? What are the market dynamics? What are the constraints on category growth? What are the category growth drivers? What are the demand-supply shifts? Who are the suppliers in this market?

Table of Contents: Resveratrol MarketChapter 1. Resveratrol Market OverviewChapter 2: State of the World Market and Forecasts by RegionChapter 3: State of the World Market and Forecast by TypeChapter 4: Global Market State and Prospects for the Downstream SectorsChapter 5: Analyzing Market DriversChapter 6: The State of Market Competition of Major ProducersChapter 7: Major Producers and Market DataChapter 8: Exploration and Production Market AnalysisChapter 9: Cost and Gross Profit AnalysisChapter 10: Analyzing Marketing Status

For any queries get in touch with Industry Expert @ https://www.adroitmarketresearch.com/contacts/enquiry-before-buying/503?utm_source=bh

About Us :

Adroit Market Research is an India-based business analytics and consulting company incorporated in 2018. Our target audience is a wide range of corporations, manufacturing companies, product/technology development institutions and industry associations that require understanding of a Markets size, key trends, participants and future outlook of an industry. We intend to become our clients knowledge partner and provide them with valuable Market insights to help create opportunities that increase their revenues. We follow a code- Explore, Learn and Transform. At our core, we are curious people who love to identify and understand industry patterns, create an insightful study around our findings and churn out money-making roadmaps.

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Global Resveratrol Market Report 2020 Industry Trends, Share and Size, Expected CAGR, Top Manufacturers and Consumer Analysis across the Region and...

I Live in the Mountains, and This $30 Hyaluronic Acid Moisturizer Is the Only Thing That Hydrates My Skin – Yahoo Lifestyle

Posted: at 4:55 pm

Winky Lux Cream


I've been spending the winter in the mountains of New Hampshire, which is wonderful for my mental health and terrible for my skin. While I thought subjecting my skin to Boston's city pollution was bad, it's apparently much more adverse to harsh, sub-zero winds and frequent snowstorms. I'd slather expensive cream on my red, chapped cheeks only to wake up with a sprinkling of acne and an oily complexion. Thankfully, I discovered the newly formulated Winky Lux Dream Gele Moisturizer, and my skin is finally at peace.

If I'm being honest, I was initially skeptical because this cream is only $30. If my $100 celebrity-touted products weren't doing the trick, why would a budget-friendly option? Desperation and curiosity led me to try it anyways. Plus, my New Year's resolution was to clean up my skincare a bit, so I liked that it's vegan, cruelty-free, phthalate-free, sulfate-free, and paraben-free.

Shop now: $30; winkylux.com

When I tried the cream, I was impressed that it not only felt lightweight, but that it also melted in, almost like my parched skin was finally taking a long drink of water. The formula was cooling and gave my irritated skin the same sort of relief aloe vera gives a sunburn which makes sense, because aloe vera is one of the key ingredients. I also liked that the formula contained salicylic acid so I'd avoid the dreaded post-moisturizer breakouts.

I let the cream melt into my skin overnight and assessed the results in the morning. Like any good cream containing hyaluronic acid and glycerin, the moisturizer helped to soften and hydrate my dry, flaky patches overnight. Unlike any other cream I'd tried, though, I woke up with a clearer, brighter complexion than the night before. Not only was I free of acne, but the moisturizer appeared to have this plumping effect (thank you, caffeine) that made me look downright dewy. Honestly, I was a little embarrassed to go into the kitchen looking so glowy when the rest of my household was nursing mild winter-induced wind burns.

The cream's newly enhanced formula also contains resveratrol, an ingredient that helps to protect the skin's natural moisture barriers from environmental aggressors, so now I'm proactive against the elements by blending the cream with my sunscreen for my morning walks. Tip: This also makes for a great primer if you're wearing makeup during the day.

Going forward, I'll be saving myself the trouble of purchasing overly priced creams and sticking to Winky Lux's Dream Gele Moisturizer. Shop the top-rated cream now and glow later.

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I Live in the Mountains, and This $30 Hyaluronic Acid Moisturizer Is the Only Thing That Hydrates My Skin - Yahoo Lifestyle

[Full text] Application of Radiosensitizers in Cancer Radiotherapy | IJN – Dove Medical Press

Posted: at 4:55 pm


Cancer remains one of the greatest challenges to human health. World Health Organization (WHO) reported that about 8.8 million deaths worldwide were due to cancer in 2015, and the deaths are expected to break through 13 million in 2030 according to the report by the International Agency for Research on Cancer (IARC). To reduce the deaths from cancer, several strategies have been developed in recent years to improve cancer therapy including surgery, radiotherapy, chemotherapy, immunotherapy, targeted therapy, hormone therapy, stem cell transplant and precision medicine.1 Among them, radiotherapy (RT) is considered as one important and effective modality to kill or control tumors since Marie Curie, the Nobel Prize winner, discovered radioactivity.2 Typically, RT is a treatment modality to cancer cells by using high-energy photon radiation such as X-rays, gamma ()-rays, and others. RT can take effect via direct and indirect mechanisms to destroy cancer cells and tumor tissue (Figure 1).

Figure 1 Schematic of the mechanism of ionizing radiation (IR) in RT. In the case of direct effect, IR directly damages the DNA, which, if unrepaired, results in cell death or permanent growth arrest. In the case of indirect effect, ROS are formed by the radiolysis of a large amount of water and oxygen, and then the ROS damage the DNA. There are many types of DNA damage, such as base change, SSB, DSB, cross-linkage with protein or with other DNA molecules.

In the direct action, radiation directly induces single-strand breaks (SSB) and double-strand breaks (DSB) in DNA, resulting in the termination of cell division and proliferation, or even cell necrosis and apoptosis. In the case of indirect action, radiation induces the generation of ROS, which can induce cellular stress in, and injure biomolecules, and and ultimately alter cellular signaling pathways. Clinical studies have shown that more than half (about 70%) of patients need to receive RT, and in some cases RT is the only kind of cancer treatment.3 Therefore, there is a great need to develop approaches to improve radiosensitivity.

Innovative technologies can provide alternative strategies to improve RT efficiency. For example, image-guided radiation therapy (IGRT) is the use of imaging during radiation therapy to improve the precision and accuracy of treatment delivery. IGRT can be used to treat tumors in areas of the body that move, such as the lungs. RT machines are equipped with imaging technology to allow your doctor to image the tumor before and during treatment. By comparing these images to the reference images taken during simulation, the patients position and/or the radiation beams may be adjusted to more precisely target the radiation dose to the tumor. To help align and target the radiation equipment, some IGRT procedures may use fiducial markers, ultrasound, MRI, X-ray images of bone structure, CT scan, 3D body surface mapping, electromagnetic transponders or colored ink tattoos on the skin.4 Intensity-modulated radiation therapy (IMRT) is an advanced mode of high-precision RT that uses computer-controlled linear accelerators to deliver precise radiation doses to a malignant tumor or specific areas within the tumor.5 Although the abovementioned innovative technologies greatly improve the therapeutic effect, there are still obstacles such as cancer stem cells and tumor heterogeneity making it difficult to use RT alone to cure tumors. Radiosensitizers with the ability to increase the radiosensitivity of tumor tissue and pharmacologically decrease normal tissue toxicity are expected to be an efficient way to improve RT.6

Radiosensitizers are compounds that, when combined with radiation, achieve greater tumor inactivation than would have been expected from the additive effect of each modality. G E Adams, a pioneer in the field of RT, classified radiosensitizers into five categories: (1) suppression of intracellular thiols or other endogenous radioprotective substances; (2) formation of cytotoxic substances by radiolysis of the radiosensitizer; (3) inhibitors of repair of biomolecules; (4) thymine analogs that can incorporate into DNA; and (5) oxygen mimics that have electrophilic activity.7,8 This classification was based on the mechanism of DNA damage and repair and indicated the direction for radiosensitizers at the early stage. However, with the continuous technological innovation, more and more materials and drugs with radiotherapy sensitization have been defined as radiosensitizers. In addition, some in-depth mechanisms for radiosensitization have also been discovered.9,10 According to the latest research, radiosensitizers can be classified into three categories based on their structures: small molecules (Figure 2), macromolecules (Table 1), and nanomaterials (Table 2).11 In the following part, the applications, the main role, and influencing factors of these three types of radiosensitizers are first summarized, especially those have currently entered clinical trials. Second, the development status and the mechanism of action of the radiosensitizer are also summarized. Third, the future development and application of the radiosensitizer was presented.

Figure 2 Molecular structures of some representative small-molecule radiosensitizers discussed in this paper.

Table 1 Some Macromolecule Radiosensitizers Discussed in This Paper

Table 2 The List of Nanomaterials Used for Radiosensitization

Hypoxia in tumor microenvironment is one of the major limitations to radiotherapy. Tumor cells in the hypoxic microenvironment are much more resistant to radiation than in the normal oxygen microenvironment.1214 Oxygen enhancement ratio (OER) or oxygen enhancement effect in radiobiology refers to the enhancement of the therapeutic or detrimental effect of ionizing radiation due to the presence of oxygen. This so-called oxygen effect is most notable when cells are exposed to an ionizing radiation dose.15,16 Oxygen, a potent radiosensitizer, promotes free radical formation through its unique electronic configuration. As the most electrophilic cellular molecule, oxygen is easily reduced by electrons formed from the incident radiation. After oxygenated tumor irradiation, energy transfer results in the radiolysis of water with the initial formation of an ion radical that then forms the highly reactive hydroxyl radical after reaction with another water molecule. Oxygen leads to the formation of peroxide after reaction with the hydroxyl radical. Then, the peroxide results in permanent cellular and DNA damage.13

Accompanied with solid tumor growth, the surrounding vasculatures are not in sufficient quantities to supply oxygen to the new cells, the cancer cell mass becomes heterogeneous gradually, and necrosis occurs following ischemia. Normally, cancer cells undergo apoptosis through the p53 pathway, while those heterogeneous cells adapt to the hypoxic environment efficiently by activation of additional signaling pathways, especially the hypoxia-inducible factor (HIF) pathway.1719 Studies showed that HIF-1 was associated with vascular endothelial growth factor (VEGF) signaling pathway, glucose transport, and glycolysis pathway, which could help the tumor to build vasculature.1921 Under hypoxia, the cancer cells are more aggressive and resisted radiotherapy significantly. Thus, hypoxia often occurs in most solid tumors and leads to radioresistance both through increasing free radical scavenging and changing patterns of gene expression.22,23

More and more research has been devoted to overcoming hypoxia problems, from using high-pressure oxygen tanks and blood substitutes that carried oxygen, to using intricate, accurate approaches that proportionated differences in partial pressure of oxygen (PO2) between tumors and healthy tissue.24,25 Hyperbaric oxygen is the most direct method to ameliorate hypoxia in tumor cells, while this method is inconvenient and may increase complications sometimes.26,27 A new radiosensitizer, Kochi oxydol-radiation therapy for unresectable carcinomas (KORTUC), is being evaluated by a Phase I/II clinical trial (NCT02757651) for the treatment of malignant tumors that contain numerous hypoxic cancer cells and/or large quantities of antioxidative enzymes.28

Oxygen mimetics, using the chemical properties of molecular oxygen as a template, have higher electron affinity and better diffusion properties to anoxic tissue than oxygen. As oxygen mimetics can theoretically substitute for oxygen in fixing radiation-induced damage of DNA, making it nonrepairable and hence lethal. Therefore, oxygen mimetics are considered as true radiosensitizers. The most representative oxygen mimetics are nitro-containing compounds and nitric oxide (NO).13

The prototype of electron-affinity radiosensitizers is nitrobenzene, and then researchers focus on nitroimidazole and its derivatives.2931 Nitroimidazoles, which undergo enzymatic and radiation-induced redox reactions. These agents are intrinsic inactive, their effect becomes evident only in the presence of ionizing radiation to fix or stabilize DNA radical lesions in oxygen-deficient cells.32 Misonidazole, a 2-nitroimidazole, is one of the earliest developed nitroimidazoles. In preclinical studies, misonidazole showed better radiosensitizing effect than 5-nitro imidazole or metronidazole (Flagyl) in the majority of solid murine tumors.3335 However, the results were unsatisfactory in clinical trials, since severe neurotoxicity was caused by misonidazole.3639 Metronidazole, a 5-substituted nitroimidazole, which has less electron-affinic was proven as an inferior radiosensitizer.40,41 In conclusion, because of the dose-limiting toxicity at clinically tolerable doses, misonidazole and metronidazole are not the ideal candidates in radiotherapy.42

In view of the issues discussed above, further efforts have been made to improve the pharmacokinetic properties of nitroimidazoles. Second-generation nitroimidazole radiosensitizers, such as etanidazole or nimorazole, are designed to increase the hydrophilicity of the reagents and thereby reduce neurotoxicity. For example, etanidazole has better hydrophilicity than misonidazole because its side chain is modified by hydroxyl.43 Although etanidazole presents lower preclinical toxicity and higher efficacy, it shows no obvious benefit for head and neck cancer patients in randomized studies.44 Nimorazole, a 5-nitroimidazole, is recommended for the treatment of head and neck cancers in Denmark since its beneficial effects in several clinical trials. Moreover, it has been further explored in an EORTC international trial.4551 Notably, the DAHANCA 28 trial demonstrated that hyperfractionated, accelerated radiotherapy with concomitant cisplatin and nimorazole (HART-CN) for patients was feasible and yielded favorable tumor control.52 Other nitro compounds have also been exploited for hypoxia radiosensitization. Dinitroazetidine, RRx-001, has been evidenced as an effective radiosensitizer with low toxicity and is now being evaluated in the NCT02871843 clinic trial.53

Nitrogen oxides, in particular, NO, act as radiosensitizers through many direct and indirect mechanisms. Similar to the oxidative stress induced by oxygen, NO can fix or stabilize radiation-induced DNA damage through nitrosative stress pathways.54 Oxidative and nitrosative stress pathways involve the generation of reactive species. For example, nitrous acid, peroxynitrite (ONOO), and nitric acid produce cytotoxic effects through mechanisms including DNA cross-linking, protein nitrosylation, glutathione depletion, and inhibition of mitochondrial respiration.5558 As an uncharged free radical, NO can diffuse across cell membranes freely and bind to soluble guanylate cyclase (sGC) to induce cyclic GMP production, thereby regulating vascular physiology.5961 Researchers have reported that 5-nitroimidazoles and sanazole can release NO.62,63

A phase I study of non-small-cell lung cancer (NSCLC) patients suggested that NO donation increased tumor perfusion and, therefore, promoted tumor growth.64 However, a phase II study of prostate cancer patients claimed that low-dose NO had no direct cytotoxic effect, but could decrease hypoxia through improving blood flow in tumor tissue.65 Some anticancer drugs approved by US Food and Drug Administration (FDA), such as bevacizumab, sorafenib, and etaracizumab played their roles by blocking the VEGF pathway to some extent.66 VEGF is overexpressed in anoxia environment, which leads to endothelial cell proliferation and neovascularization. In angiogenesis, there is a positive and negative feedback regulation relationship between VEGF and NO, which maintains vascular homeostasis precisely.67 In addition, Liebmann et al proved that pretreatment with NO improved the survival of mice after irradiation.68

In recent years, more and more researchers reported that active compounds from Chinese herbs such as curcumin,6971 resveratrol,7274 dihydroartemisinin7577 and paclitaxel,7880 could enhance tumor radiotherapy sensitivity (Figure 2). Curcumin is a polyphenolic active compound extracted from turmeric. Curcumin exerts anti-inflammatory effect by inhibiting the transcription factor NF-B, which is involved in both tumorigenesis and radioresistance.81 In a preclinical study, Chendil et al reported that when treated with RT and curcumin together, the human prostate cancer cell line, PC3 presented threefold fewer surviving and the mechanism was supposed to have a relationship with NF-B.82 In addition, nanocurcumin as a radiosensitizer is being evaluated by a Phase II clinical trial (NCT02724618). Other relevant research on mutant p53 Ewings sarcoma cells proved that radiosensitivity of curcumin was associated with other p53-response genes.83

Resveratrol is an active compound extracted from grapes, knotweed, peanuts, mulberry and other plants. Tan et al proved that resveratrol enhanced the radiosensitivity in nasopharyngeal carcinoma cells by downregulating E2F1.73 Liao et al found that resveratrol enhanced radiosensitivity in human NSCLC NCI-H838 cells by inhibiting NF-B activation.84 Dihydroartemisinin is a derivative of artemisinin, which can shorten the G2/M phase, while increases the G0/G1 and S phase, thereby reducing the radiation resistance.85 Although the relevant clinical research has not yet been carried out, researchers have demonstrated that resveratrol8689 and dihydroartemisinin9092 possessed radiosensitization on cancer cells in vitro.

Paclitaxel is widely known as a very good natural anticancer drug.93,94 As a new type of antimicrotubule drug, paclitaxel can inhibit the microtubule networks formation and prevent the tumor cells proliferation to achieve radiosensitization.95 Results showed that paclitaxel could obviously enhance the radiosensitivity of inoperable patients with locally advanced esophageal cancer and improve the prognosis of patients with acceptable therapeutic effect.96 A three-arm randomized Phase III trial (NCT02459457)comparison of paclitaxel-based three regimens concurrent with radiotherapy for patients with local advanced esophageal cancer and a Phase III study (NCT01591135) of comparing paclitaxel plus 5-fluorouracil vs cisplatin plus 5-fluorouracil in chemoradiotherapy for locally advanced esophageal carcinoma are underevaluated.

Some bioreductive agents, such as aromatic N-oxides, transition metal complexes, quinones, aliphatic N-oxides and nitro compounds, have radiosensitization effects by virtue of their preferential cytotoxicity toward hypoxic cells.11 Tirapazamine (TPZ), a hypoxia-selective radiosensitizer, has shown promising results in clinical trials.97,98 Under hypoxic environments, TPZ can be reduced by reductase in cells to a metabolite that produces free radical and then leads to SSB, DSB, and base damage on DNA.99 A Phase I clinical trial of TPZ with cisplatin and radiotherapy in small cell lung cancer showed prolonged survival of patients.100 A Phase II study of TPZ with chemoradiotherapy in locally advanced head and neck cancer reported improvements in failure-free survival and response of patients.101 However, further phase III trials of TPZ with chemoradiotherapy in locally advanced head and neck cancer concluded that there was no obvious improvement in patient survival.102 In addition, SN30000 (previously known as CEN-209), an analog of TPZ, with more favorable diffusion property that provides greater toxicity in hypoxic cancer cells than TPZ, is currently under development by the Drug Development Office of Cancer Research UK.103

AQ4N, a representative to aliphatic N-oxide, can be reduced to AQ4 by cytochrome P450 isoenzymes or nitric oxide synthase 2A.104 In vivo experiments showed that combined utilization of AQ4N with radiotherapy resulted in increased antitumor efficacy, as well as negligible toxicity to normal tissue compared with radiation alone.105 Positive results were also evidenced in Phase I clinical trials.106 A Phase I clinical trial in glioblastoma and head and neck tumor patients proved that AQ4N could be specifically activated in hypoxic regions of solid tumors.107 Unfortunately, a Phase II clinical trial of AQ4N with radiotherapy and temozolomide in glioblastoma began in 2006, was in a pending status (NCT00394628).

TH-302 (evofosafamide), a similar compound that can be reduced to bromo-isophosphoramide mustard in hypoxic conditions, has radiosensitization activity, especially in hypoxic cells.108,109 In preclinical models of rhabdomyosarcoma (skeletal muscle) and NSCLC, TH-302 combined with radiotherapy treatment resulted in significant tumor growth delay.110 In addition, in a study in patient-derived xenograft models of pancreatic cancer, combination treatment of TH-302 and radiotherapy was more efficient than either treatment alone.111 TH-302 can specifically target the hypoxic tumor cells and induce DNA damage simultaneously in adjacent tumor tissue of the hypoxic zone, and thus holds potential radiosensitization effects in solid tumor treatment.112 However, on the database of US National Institutes of Health clinical trials, only one of the 26 trials listed proposed combination treatment of TH-302 with radiotherapy (NCT02598687), and it was withdrawn because two phase III trials did not meet their primary endpoint.113

Mitomycin C, a quinone-based anticancer therapeutic, can be activated via DNA cross-linking. In preclinical study, mitomycin C showed only slight toxicity in hypoxic cells, which promotes the development of other hypoxia-sensitive quinones selection.114 Among them, porfiromycin (POR) and apaziquone (EO9) are bioreductive prodrugs, represent the leading candidates.104 Preclinical studies concluded that POR held higher hypoxic selectivity than mitomycin C.115 Although preclinical trials proved POR had acceptable toxicity, the following Phase 3 trial demonstrated that POR had a poorer therapeutic effect than mitomycin C.116 Preclinical studies indicated that EO9 had greater antitumor property than mitomycin C, indicating EO9 can be a ideal radiosensitizer.117

Other types of chemical radiosensitizers have also seen some progress and some of them are in preclinical evaluations. For example, chemicals that influence cell signaling, suppress radioprotective substances, pseudosubstrates and targeted delivery systems are exploited. With the development of research on radioresistance mechanism, it has been found that multiple signal pathways are related to radioresistance, providing more targets for radiosensitization, such as PI3KAktmTOR,118 Wnt,119 MAPK,120 MDM2121 and c-METPI3KAkt.122 For example, BKM120, the oral PI3K inhibitor, can inhibit the activity of PI3K/Akt by targeting the PI3K-Akt pathway, thereby increasing cell apoptosis and inhibiting DNA double-strand break repair in liver cancer cells.123 BEZ235, a dual PI3KmTOR inhibitor, can improve the radiosensitivity of colorectal cancer cells.124 AMG 232, a picomolar affinity piperidinone inhibitor of MDM2, can suppress tumor growth on a mouse model.121

Suppression of radioprotective substances, such as glutathione (GSH), is another strategy of radiosensitization. Inhibition of GSH can prevent DNA damage repair and lead to increased damage in tumor cells, which improves the efficacy of radiotherapy in turn.125 In addition, pseudosubstrates lead cells undergoing DNA synthesis unable to distinguish thymidine and its halogenated analogs efficiently. It is a new area of clinical research to use halogenated pyrimidine analogs, like bromodeoxyuridine (BrdUrd) and iododeoxyuridine (IdUrd), as potential clinical radiosensitizers.126 One study demonstrated that electron affinities of 5-halogenated deoxyuridine led to enough ability to bind a radiation-produced secondary electron, thereby increasing the sensitivity of radiotherapy.127

In addition, research on new indications for existing drugs provides a new paradigm for the development of radiosensitizers. For instance, papaverine, an ergot alkaloid first isolated from Papaver somniferum in 1848, has been used for treatment of vasospasm, cerebral thrombosis, pulmonary embolism and erectile dysfunction.128 Denko et al identified papaverine as an inhibitor of mitochondrial complex I and proved that papaverine could increase oxygenation and enhance radiation response.128 A phase I trial (NCT03824327) study on papaverine and stereotactic body radiotherapy (SBRT) for NSCLC or lung metastases is under evaluation. In summary, small-molecule chemicals as radiosensitizers initiated in the past five years under clinical trials are summarized in Table 3.

Proteins and peptides, such as antibodies and short peptides, have high affinity with antigens and receptors overexpressed on the surface of tumor cells, making them usable as radiosensitizers.129 For instance, HER3-ADC, a maytansine-based antibody-drug conjugate targeting HER3, which induces cell arrest in the G2/M phase to inhibit DNA damage repair and thereby improves radiosensitivity of HER3-positive pancreatic cancer cells.130 SYM004, a epidermal growth factor receptor targeting antibody, can inhibit DNA double strand breaks repair and induces apoptosis via downregulating MAPK signaling, and thereby improves radiosensitivity in tumor cells.120 Cetuximab and nimotuzumab, binding the epidermal growth factor receptor (EGFR), can increase radiation-induced apoptosis and DNA damage, and thereby improve the radiosensitivity of human epidermal-like A431 cells.131 The hepatocyte growth factor (HGF)/Met signaling pathway which mediates DNA double-strand break repair is upregulated in the majority of cancers. AMG102, a monoclonal antibody against HGF, can inhibit DNA damage repair and increase radiosensitivity of glioblastoma multiforme.132 In addition, proteins and peptides in serum, such as C-reactive peptide,133 HSP134 and paraoxonase-2135 contribute to radioresistance and can be used as radiotherapy targets. ECI301, a mutant derivative of macrophage inhibitory protein-1a, can be assisted by HSP-70 and HMGB1, thereby enhancing the effect of radiotherapy.134 Other proteins, like DNAzyme (DZ1)136 and NKTR-214,137 can also improve the effect of radiotherapy.

MicroRNAs (miRNAs), which encode by endogenous genes are noncoding single-stranded RNA molecules containing about 22 nucleotides. Studies have shown that some specific miRNAs can be used to improve radiotherapy efficacy138,139 and some miRNAs can be used as radiotherapy sensitization targets.140 For example, miR-621 targets SETDB1 in hepatocellular carcinoma can be used as a tumor radiosensitizer directly.141 miR-205 targets zinc finger E-box binding homeobox 1 (ZEB1) and the ubiquitin-conjugating enzyme Ubc13 to enhance the radiosensitivity of breast cancer cells.142 miR-144-5p targets ATF2 to enhance radiosensitivity of NSCLC.143 miR-146a-5p enhances radiosensitivity in hepatocellular carcinoma through activation of DNA repair pathway.144 miR-150 modulates AKT pathway in NK/T cell lymphoma to enhance radiosensitivity.145 miR-99a targets mTOR pathway to enhance the radiosensitivity of NSCLC.146 miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense.147 Transcriptional activation of miR-320a induces cancer cell apoptosis under ionizing radiation conditions.148 However, inhibition of miR-21-5p promotes the radiation sensitivity of NSCLC.149 Inhibition of miR-630 enhances radiotherapy resistance in human glioma by directly targeting CDC14A.150 Furthermore, a clinical study included 55 atypical meningioma patients found in seven upregulated miRNAs (miR-4286, miR-4695-5p, miR-6732-5p, miR-6855-5p, miR-7977, miR-6765-3p, miR-6787-5p) and seven downregulated miRNAs (miR-1275, miR-30c-1-3p, miR-4449, miR-4539, miR-4684-3p, miR-6129, miR-6891-5p) in patients. Those miRNAs may induce radioresistant and radiosensitive, respectively.

siRNA, known as short interfering RNA or silencing RNA, is a class of double-stranded RNA, noncoding RNA molecules, typically 2027 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway.151 HuR is a protein related to radiotherapy resistance, knockdown of HuR by siRNA resulting DNA damage and enhanced radiosensitivity.152 S100A4, a member of the S100 family of transcription factors, modulates various activities of malignant tumor cells through different mechanisms. A short siRNA against S100A4 enhances the radiosensitivity of human A549 cells.153 NBS1 plays an important role in the radiation-induced DNA double-strand breaks reparation, siRNA targets NBS1 can increase radiation sensitivity of cancer cells.154 Survivin, a member of the inhibitor of apoptosis (IAP) protein family, is overexpressed in most cancers resulting in aggressive behavior of tumor and therapy resistance. Downregulation of survivin by siRNA can enhance radiosensitivity in head and neck squamous cell carcinoma.155 Therefore, numerous siRNAs can be used as radiosensitizers by silencing genes related to radioresistance.

Similar to siRNAs, oligonucleotides also play important roles in gene expression regulation. Since they are easy to design and synthesize, antisense oligonucleotides have great potential to develop as radiosensitizers.11 Telomerase expresses in many kinds of tumors (>85%), while the expression of telomerase is restricted in normal tissues. A study indicated that expression of telomerase could be inhibited by radiolabeled oligonucleotides, which targeted the RNA subunit of telomerase, thereby inducing DNA damage in telomerase-positive tumor cells.156 In addition, the phosphorothioate-modified antisense oligonucleotides (PS-ASODN) against human telomerase reverse transcriptase were reported to promote radiotherapy effect in liver cancer.157 Furthermore, Park et al reported that inhibition of cyclic AMP response element-directed transcription using decoy oligonucleotides enhanced tumor-specific radiosensitivity.158 Yu et al demonstrated that antisense oligonucleotides targeted human telomerase RNA (hTR ASODN) could improve the radiosensitivity of nasopharyngeal carcinoma cells.159 The radiosensitization mechanism of macromolecules was summarized in Figure 3.

Figure 3 Radiosensitization mechanism of macromolecules. (A) Proteins and peptides. (a1) Direct interaction of key proteins. (a2) Loading of radioactive seeds. (a3) Radiosensitizers delivery. (a4) Conjugation with nanomaterials. (B) miRNAs can then bind with mRNAs to implement radiosensitization. (b1) Downregulation by inhibitors. (b2) Upregulation. (C) siRNAs can improve radiosensitivity by binding and degrading complementary mRNAs. (D) Oligonucleotides improve the radiosensitivity by complementary binding with DNAs.

The X-ray absorption coefficient () represents the relationship between the X-ray absorption phenomenon (E) and atomic number (Z), =Z4/(AE3), where is the density and A is the atomic mass of the element.160 Therefore, the change of atomic number (Z) causes a significant change of X-ray absorption coefficient (). Noble metal nanomaterials, such as gold (Au, Z=79), silver (Ag, Z=47) and platinum (Pt, Z=78) can effectively absorb X-ray energy and interact with radiation in tumor cells, and then emit photoelectrons, auger electrons, compton electrons and other secondary electrons. These secondary electrons not only interact with DNA directly, but also react with water to increase the production of ROS and further increase the sensitivity of tumor cells to radiation. This process is a physical sensitization mechanism.161 Furthermore, functionalized noble metal nanomaterials promote the generation of ROS, transfer the cell cycle into a radiosensitive state, and inhibit p53 signaling pathway to induce cell autophagy and lysozyme body function disorder, thereby increasing radiotherapy sensitivity. This process is a biochemical sensitization mechanism.162,163

Gold nanoparticles with good chemical stability, easy preparation, controllable size and shape, easy surface functionalization, high biocompatibility, and low toxicity have proven satisfactory radiosensitizing effects in various tumors.164167 Silver nanoparticles and platinum nanoparticles are also commonly used in biomedicine.168,169 Research found that silver nanoparticles combined with radiotherapy could enhance the radiosensitivity of human glioma cells in vitro and extended the survival time of glioma mice.170,171 Liu et al demonstrated that silver nanoparticles could induce apoptosis of cancer cells through G2/M phase arrest after radiation, and they suggested that silver nanoparticles could be used as a nanoradiosensitizer for hypoxic glioma radiotherapy.172 Recently, Fathy reported that thymoquinone-capping silver nanoparticles represented a promising engineered nanoformulation for enhancing cancer radiosensitivity.173 Li et al demonstrated that platinum nanoparticles could enhance radiosensitivity through increasing DNA damage, ROS stress, and cell cycle arrest.163 They also proved that platinum nanoparticles could convert endogenic H2O2 to O2 in cancer cells, thus significantly improving radiosensitivity without apparent toxicity to animals in vivo.163

Similar to noble metal nanomaterials, gadolinium (Gd, Z=64), hafnium (Hf, Z=72), tantalum (Ta, Z=73), tungsten (W, Z=74), and bismuth (Bi, Z=83) are also metal elements with large atomic coefficients and have a great X-ray attenuation capability.174176 Based on this, numerous studies have focused on these heavy metal nanomaterials to investigate their radiotherapy sensitization. However, they usually cause damage to healthy tissues with direct contact.177 Therefore, their stable forms such as oxides, sulfides, and selenides are explored as the radiosensitizers.178180

Gadolinium-based nanoparticles are usually known as magnetic resonance imaging (MRI) contrast agents. It should be noted that researchers discovered a family of gadolinium-based nanoparticles called AGuIX for combined MRI and radiosensitization.181 Results showed that AGuIX could interact with X-rays and -rays at a certain concentration. After internalization through the enhanced permeability and retention (EPR) effect, AGuIX could be resident in the tumor for a long time before being cleared by the kidneys.182 Preclinical animal experiments proved that AGuIX held obvious radiosensitization effects in several tumor models without obvious toxicity.183 A Phase I clinical trial (NCT03308604) to evaluate the optimal dose of AGuIX combined with chemoradiation in patients with locally advanced cervical cancer; a Phase II clinical trial (NCT03818386) using AGuIX gadolinium-chelated polysiloxane based nanoparticles and whole brain radiotherapy in patients with multiple brain metastases; and a single-arm phase II trial (NCT04094077) aiming to evaluate the efficacy of AGuIX during fractionated stereotactic radiotherapy of brain metastasis are being evaluated.

Hafnium, in the same family as titanium and zirconium, is chemical inertness. The oxidation state of hafnium, hafnium dioxide (HfO), was usually used in radioactive protective coatings, biosensors, and X-ray contrast agents.184,185 Jayaraman et al demonstrated that HfO2 nanoparticles had excellent biocompatibility.185 Researchers from France discovered that HfO can be used as a radiosensitizer with low cytotoxicity.186 A Phase I trial (NCT03589339) combining hafnium oxide nanoparticles (NBTXR3) with anti-PD-1 therapy in microsatellite instability-high solid malignant tumour and a Phase III clinical trial (NCT02805894) of NBTXR3 in prostate adenocarcinoma are under evaluation.

Tantalum is a nontoxic, biologically inert element with good biocompatibility.187 Studies found that TaOx and Ta2O5 could be used as CT imaging contrast agents.188190 Brown et al found Ta2O5 nanoparticles showed a radiasentizition effect on radioresistant glioma cells.191 Song et al showed hollow shell tantalum oxide (HTaOx) had a large X-ray attenuation capability and could enhance radiation therapy effects by Compton scattering and Auger effect.192 In addition, TaOx can be used as functional group carrier to load drugs, thereby improving tumor hypoxic environment. For example, HTaOx loaded with catalase, which reacted with H2O2 in the tumor microenvironment, then improved the oxygen content and overcame the radiotherapy tolerance of hypoxic tumor cells, thereby improving the radiotherapy effect.193

Tungsten and bismuth also have significative applications in medicine.194,195 Hossain et al concluded that bismuth nanoparticles had stronger radiosensitizing effect than gold and platinum nanoparticles at the same physical and chemical conditions.196 Yu et al found that the ultra-small semi-metallic Bi nanoparticles with LyP-1 peptide modified at 3.6 nm showed obvious radiosensitization effect.197 Recently, a large number of studies shown that some nanomaterials of tungsten and bismuth had excellent photothermal absorption conversion performance and strong X-ray absorption capacity, therefore they can be used for tumor radiosensitization as well as synergistic therapy of hyperthermia and radiotherapy.198201

In addition, research about several high Z metal elements combined together to further improve the radiosensitization effect were also explored. For example, SiBiGdNP chelated Bi and Gd in organosilane to improve the sensitivity of radiotherapy.202 GdW10O36 contained both W and Gd to expect they had better radiotherapy sensitization effect.203

Ferrite-based nanomaterials can catalyze the generation of free radicals through Fentons reaction (1) and HaberWeiss reaction (2) to enhance the effect of radiosensitization.204

Fe2+ + H2O2 Fe3+ + OH + OH

Fe3+ + H2O2 Fe2+ + OOH + H+ (1)

Fe3+ + O2 Fe2+ + O2

Fe2+ + H2O2 Fe3+ + OH + OH (2)

Studies proved that Fe3O4 had a dose-enhancing effect for radiotherapy, especially superparamagnetic Fe3O4 nanoparticles (SPIONS) possessing MRI imaging property had good application prospects in image-guided tumor radiotherapy.205

The composition of the spinel structure ferrite is usually stated as MFe2O4, where M=Fe, Zn, Co, Mn, Ni.206 Among them, ZnFe2O4, MnFe2O4, CoFe2O4 nanoparticles were widely investigated.207 For example, Meidanchi et al confirmed that ZnFe2O4 nanoparticles interacted with -rays to produce photoelectric effect resulting in a higher release level of electron in radioresistant cells.208 Studies also indicated that ZnFe2O4 nanoparticles could be used as radiosensitizers.208,209 Salunkhe et al demonstrated that MnFe2O4 and CoFe2O4 nanoparticles could improve the therapeutic efficacy of cancer through multimodal image-guided combination therapy.210

Semiconductor quantum dots have unique properties, such as quantum dimension effect, surface effect, and quantum confinement effect, making them great candidates in biomedicine applications.211 Until now, numerous studies focused on using semiconductor quantum dots as photosensitizers and radiosensitizers for tumor treatment have been reported.212214 When the electronic energy levels are in the range of 15 eV, the semiconductor nanomaterials can absorb the photon energy and perform as photosensitizers, showing photocatalytic properties. When the electronic energy levels are at keV and MeV (X-rays and -rays), semiconductor nanomaterials can enhance absorption of high-energy photons acting as radiosensitizers and causing damage to cancer cells.212 Nakayama et al synthesized a semiconductor nanomaterial PAA-TiOx to generate hydroxyl radicals under the irradiation of X-rays, which increased DNA damage and inhibited tumor growth significantly.215 Morita et al clarified the radiosensitization mechanism of PAA-TiOx nanoparticles by releasing H2O2 to relieve hypoxia in tumor cells.216 TiO2 nanotubes have been reported to enhance the radiosensitization effect through regulating G2/M cycle arrest and reducing DNA repair of tumor cells.177 The mechanism of radiosensitization of metal-based nanomaterials is shown in Figure 4.

Figure 4 Radiosensitization mechanism of metal-based nanomaterials. The process contains physical and biochemical sensitization mechanism.

Many nonmetallic nanomaterials also possess the function of radiosensitization.217 For example, C60, fullerene, has potent anticancer activities, however, the potential toxicity to normal tissues limits its further use. Therefore, nanocrystals of C60 (Nano-C60) with negligible toxicity to normal cells have been developed as a radiosensitizer.218 In addition, nanodiamonds and carbon nanotubes can reduce radioresistance of tumor cells by promoting ROS generation, destroying DNA double-strands, and regulating the cell cycle.219,220 Selenium (Se) nanoparticles not only work as chemotherapeutic drugs, but also improve the antitumor effect of X-rays by activating ROS to induce DNA damage in cancer cells.221

Nano-based delivery systems are efficient approaches for drug targeted transportation, which can deliver radiosensitizers, such as chemicals, oxygen carriers, siRNAs and catalases to the tumor sites and have attracted wide interest of researchers recently.222 More importantly, nanobased delivery systems can precisely deliver radioactive particles like223 Ac (releasing a-particles), 131I, and 125I to tumor sites.223 With the development of nanotechnology, nanobased delivery systems have great potential for radiosensitizer delivery.

However, there is still a challenge to achieve clinical translation of nanobased delivery systems, factors like physicochemical properties of the nanoformulations, radiation sources, and indications block their clinical translation.223 In addition, long circulation lifetime of nanodelivery systems may increase the risk of long-term toxicity.224 Another critical factor is stability in body fluid of nanodelivery systems. Because the aggregation of nanoparticles in body fluid will influence the pharmacokinetics and the cellular response and generate serious side effects such as blocking the blood vessels.222 Therefore, attention should be paid to these factors when designing the nanodelivery systems. Size is also an important factor, small size and high Z nanoparticles often hold better radiosensitizing effect than larger-size ones.223 In particular, the small size nanoparticles with positive charge can bind to negative charged DNA and can be eliminated by renal clearance conveniently. In addition, functional modification of nanostructures using biocompatible materials can improve their stability and targeting.225

Radiosensitizers have been developed for decades from the earliest free radical damage and fixation strategies to gene regulation, from chemicals to biological macromolecules and nanomaterials. Although each radiosensitizer has dialectical advantages and limitations, the mechanisms of sensitization are similar. The main mechanisms include: (I) inhibiting radiation-induced repair of DNA damage, increasing the degree of DNA damage; (II) disturbing the cell cycle and organelle function to improve cytotoxicity; and (III) inhibiting the expression of radiation resistance genes or promoting the expression of radiation sensitive genes.

Although small molecules, macromolecules, and nanomaterial radiosensitizers are being developed, and some nanoradiosensitizers have been used for clinical research (Table 4), the result still cannot meet clinical translation needs. Therefore, there is an urgent need to find new targets of radiotherapy and new mechanisms of sensitization, and after that to develop more effective radiosensitizing drugs. First of all, multitarget radiosensitizers often have more obvious efficacy than single target, researchers can focus on screening multitarget radiosensitizers or drug combinations. New approaches, in particular, nanotechnology based as radiosensitizers have shown promise. Nanomaterials with low cytotoxicity, good biocompatibility, and ease of functionalization need to be explored. In addition, other technologies, such as molecular structure analysis, molecular cloning technology, and bioinformatics analysis can accelerate the development of new radiosensitizers. Moreover, development of new drug delivery systems can also improve radiosensitization efficacy. Finally, the application of artificial intelligence and machine learning in new drug discovery and clinical trials, may guide development of new radiosensitizers and optimization of existing radiosensitizers.

Table 4 Clinical Translation of Some Nanoradiosensitizers

This work was supported by Innovation Capacity Support Plan of Shaanxi Province (2018TD-002), the National Natural Science Foundation of China (No. 82000523), the Natural Science Foundation of Shaanxi province (Grant No. 2020JQ-087, 2020JQ-095), the Young Talent Support Plan of Xian Jiaotong University (YX6J001), the Fundamental Research Funds for the Central Universities (xzy012019070).

The authors report no conflicts of interest in this work.

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20. Boyle RG, Travers S. Hypoxia: targeting the tumour. Anticancer Agents Med Chem. 2006;6(4):281286. doi:10.2174/187152006777698169

21. Maxwell PH. The HIF pathway in cancer. Semin Cell Dev Biol. 2005;16(45):523530. doi:10.1016/j.semcdb.2005.03.001

22. Al Tameemi W, Dale TP, Al-Jumaily RMK, Forsyth NR. Hypoxia-modified cancer cell metabolism. Front Cell Dev Biol. 2019;7:4. doi:10.3389/fcell.2019.00004

23. Pettersen EO, Ebbesen P, Gieling RG, et al. Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium. J Enzyme Inhib Med Chem. 2015;30(5):689721. doi:10.3109/14756366.2014.966704

24. Cabrales P, Intaglietta M. Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids. ASAIO J. 2013;59(4):337354. doi:10.1097/MAT.0b013e318291fbaa

25. Hardavella G, Karampinis I, Frille A, Sreter K, Rousalova I. Oxygen devices and delivery systems. Breathe (Sheffield, England). 2019;15(3):e108e116. doi:10.1183/20734735.0204-2019

26. Choudhury R. Hypoxia and hyperbaric oxygen therapy: a review. Int J Gen Med. 2018;11:431442. doi:10.2147/ijgm.S172460

27. Stpie K, Ostrowski RP, Matyja E. Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours. Med Oncol (Northwood, London, England). 2016;33(9):101. doi:10.1007/s12032-016-0814-0

28. Ogawa Y, Kubota K, Ue H, et al. Phase I study of a new radiosensitizer containing hydrogen peroxide and sodium hyaluronate for topical tumor injection: a new enzyme-targeting radiosensitization treatment, Kochi oxydol-radiation therapy for unresectable carcinomas, type II (KORTUC II). Int J Oncol. 2009;34:609618. doi:10.3892/ijo_00000186

29. Chapman JD, Webb RG, Borsa J. Radiosensitization of mammalian cells by p-nitroacetophenone. Int J Radiat Biol Relat Stud Phys Chem Med. 1971;19(6):561573. doi:10.1080/09553007114550741

30. Adams GE, Asquith JC, Dewey DL, Foster JL, Michael BD, Willson RL. Electron affinic sensitization. Int J Radiat Biol Relat Stud Phys Chem Med. 1971;19(6):575585. doi:10.1080/09553007114550751

31. Higgins GS, OCathail SM, Muschel RJ, McKenna WG. Drug radiotherapy combinations: review of previous failures and reasons for future optimism. Cancer Treat Rev. 2015;41(2):105113. doi:10.1016/j.ctrv.2014.12.012

32. Spisz P, Zdrowowicz M, Makurat S, et al. Why does the type of halogen atom matter for the radiosensitizing properties of 5-halogen substituted 4-thio-2-deoxyuridines? Molecules. 2019;24(15):2819. doi:10.3390/molecules24152819

33. Brown JM. Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582. Radiat Res. 1975;64(3):633647. doi:10.2307/3574253

34. Dische S, Saunders MI, Lee ME, Adams GE, Flockhart IR. Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses. Br J Cancer. 1977;35(5):567579. doi:10.1038/bjc.1977.90

35. Brown JM. Clinical trials of radiosensitizers: what should we expect? Int J Radiat Oncol Biol Phys. 1984;10(3):425429. doi:10.1016/0360-3016(84)90063-4

36. Dische S, Saunders MI, Flockhart IR, Lee ME, Anderson P. Misonidazole-a drug for trial in radiotherapy and oncology. Int J Radiat Oncol Biol Phys. 1979;5(6):851860. doi:10.1016/0360-3016(79)90070-1

37. Barker HE, Paget JTE, Khan AA, Harrington KJ. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat Rev Cancer. 2015;15(7):409425. doi:10.1038/nrc3958

38. Overgaard J, Hansen HS, Andersen AP, et al. Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: report from the DAHANCA 2 study. Int J Radiat Oncol Biol Phys. 1989;16(4):10651068. doi:10.1016/0360-3016(89)90917-6

39. Urtasun RC, Chapman JD, Feldstein ML, et al. Peripheral neuropathy related to misonidazole: incidence and pathology. Br J Cancer Suppl. 1978;3:271275.

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41. Bonnet M, Hong CR, Wong WW, et al. Next-generation hypoxic cell radiosensitizers: nitroimidazole alkylsulfonamides. J Med Chem. 2018;61(3):12411254. doi:10.1021/acs.jmedchem.7b01678

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43. Coleman CN, Wasserman TH, Urtasun RC, et al. Final report of the phase I trial of the hypoxic cell radiosensitizer SR 2508 (etanidazole) radiation therapy oncology group 83-03. Int J Radiat Oncol Biol Phys. 1990;18(2):389393. doi:10.1016/0360-3016(90)90105-s

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[Full text] Application of Radiosensitizers in Cancer Radiotherapy | IJN - Dove Medical Press

Trans Resveratrol Market Expected to Witness the Highest Growth – The Courier

Posted: February 9, 2021 at 6:52 pm

The latest report on Trans Resveratrol Market provides an overall assessment of the world market Trans Resveratrol by classifying it into terminal applications, types, and regions. The report presents a comprehensive analysis of the competitive landscape and strategies that have positively influenced the market. Furthermore, the report provides an overview of current market dynamics by looking at different key segments based on product, types, applications, end-to-end industries, and market scenario.

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Leading Essential Players of Trans Resveratrol Market Report:

Trans Resveratrol Market segments by product type taking into account output, turnover (value), price trends:

Market segment by applications that take consumption growth rate and market share into consideration:

Scope/Extent of the Trans Resveratrol Market Report:

The Trans Resveratrol market research report concentrates on the analysis of demand and supply at the regional and national global level. From a global perspective, the report presents Trans Resveratrol markets per size, analyzing historical data and future perspectives. The report focuses on a number of key areas, including North America, Europe, Asia-Pacific and the West.

2019 has been considered the base year and the report provides a market estimate for 2020-2026. The report looks at the world market for the Trans Resveratrol (size, capacity, production, and consumption) in key regions.

Do not hesitate to consult our analyst prior to purchasing the report at https://www.regalintelligence.com/enquiry/207288

Additionally, in the Trans Resveratrol market research reports, the following points are included with an in-depth review of each point:

Table of Contents

Chapter 1: An overview of the market includes the definition, specifications, and classification of the market Trans Resveratrol, characteristics, scope, and applications.Chapter 2: Analysis of product costs and prices: structure of manufacturing costs, cost of raw materials and suppliers, manufacturing process, the structure of the industrial chain.Chapter 3: Market demand and supply analysis which includes commercial production capacity and date, distribution of manufacturing plants, R&D status, and technology source, analysis of raw material sources.Chapter 4: Forces that keep the marketplace going.Chapter 5 and 6: Regional Market Analysis that includes North America, Europe, China, Japan, Southeast Asia, and India, Trans Resveratrol Market Analysis (by Type).Chapter 7 and 8: Industrial structure, Demand, and Supply Gap Analysis.Chapter 9: Market Trend Analysis, Regional Market Trend, Market Trend according to Product Type.Chapter 10: Trans Resveratrol Turnover Channels, Distributors, Retailers, Dealers, Research Findings and Conclusion, Appendix along with Data Source.

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Trans Resveratrol Market Expected to Witness the Highest Growth - The Courier

Resveratrol Market Healthy Pace throughout the Forecast during 2018-2028 Jumbo News – Jumbo News

Posted: at 6:51 pm

FMI has compiled a study on resveratrol, which offers an analysis and forecast of theresveratrol market in its publication titled Resveratrol Market: Global Industry Analysis 2013 2017 and Opportunity Assessment 2018 2028. This report on resveratrol market covers some of the vital facets which are key influencing factors on the demand and supply for various resveratrol products over the next several years. An in-depth review of growth drivers, potential challenges, unique trends, and opportunities for market participants equip readers to fully comprehend the overall landscape of the resveratrol market. The report on resveratrol market also covers analysis of key regions and countries of particular interest which are anticipated to become frontrunners or remain laggards over the forecast period. The report covers a historical analysis of the market from 2013 to 2017 and provides forecasts from 2018 to 2028 in terms of volume in metric tons and revenue in US$.

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Resveratrol is polyphenolic compound and an antioxidant agent that is extracted from fruits (grapes, blueberry, and others), and plants. The presence of resveratrol as a key compound in red wine was established in the early 1990s, theorizing that moderate consumption of red wine could help explain the relatively low incidence of cardiovascular disease. Resveratrol has since been a part of several research studies supporting its varied health benefits, ranging from prevention and/or treatment of neurodegenerative diseases, cancer, cardiovascular disease, metabolic disorders, among others, prompting its utilization infunctionalfoods,dietary supplements, pharmaceutical products, cosmetics and personal care, among others.

This report on resveratrol market has been broken down into different chapters to enhance clarity and provide context. A brief executive summary at the beginning of the report consists of some of the key findings of the study on resveratrol market, as well as market estimates and growth rates for important segments. The following chapter presents the definitions and scope of the study, as well as the coverage in terms of the way the resveratrol market is structured. Subsequently, the chapter on market background presents the evolution of resveratrol, relevant economic indicators such as GDP and per capita food consumption, including an assessment of the supply chain, policy developments and regulatory scenario, dynamics impacting the resveratrol market as well as an explanation of the factors considered important to develop forecasts and estimates. The report on resveratrol market also includes a chapter on pricing analysis, highlighting price point variations between different regions and products, including pricing forecasts. The following chapters dive deep into the global resveratrol market, covering detailed information based on product categories, end use, and sales channel. The next set of chapters provide region-wise analysis and forecasts of the resveratrol market, covering vital aspects of the market in North America, Latin America, Europe, East Asia, South Asia, Oceania, and the Middle East and Africa.

A dashboard view of some of the key companies operating in the resveratrol market in terms of their offerings, regional presence, and other metrics is a precursor to detailed profiles of these participants including financial information, strategy overview, and SWOT analysis, market share, as well as analyst commentary. Some of the key players analyzed in the resveratrol market report include DSM Nutritionals, Sabinsa Corporation, InterHealth, MAYPRO INDUSTRIES, Evolva, LAURUS LABS Limited, Resvitale LLC, Endurance Products Company, Chongqing Kerui Nanhai Pharmaceutical Co., Ltd., Jiaxing Taixin Pharmaceutical Chemical Co., Ltd., Shanghai Natural Bio-engineering Co., Ltd, Chengdu Yazhong Bio-Pharmaceutical Co., Ltd., and Xieli Pharmaceutical.

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To develop the market estimates for resveratrol, the overall production of resveratrol from different methods such as natural and synthetic was estimated, followed by identifying the utilization of resveratrol in volume terms by analysing permissible limits and review of ingredient labels in different regions and countries. This information was then validated by understanding the revenue generated from sales of resveratrol by key producers for top countries globally. Prices of resveratrol products have been obtained from manufacturers, distributors, and wholesalers for bulk quantities at a country-level.

Our team of analysts reviews and interpret data from a variety of sources. Data attributed to FMI are derived by using a combination of various approaches, which are then consolidated, interpreted, and extrapolated by FMI analysts. Data is sourced from government statistics, trade associations, company annual reports and investor presentations, press articles and directories, technical publications, and online databases which are cross-referenced with FMIs reports and internal repository of data to filter and validate the collected information. Intelligence gathered from desk research is supplemented by extensive interviews with selected key expert participants across the value chain not only to gain information specific to their role and operations but also to obtain their perspective and insights of the issues impacting the resveratrol market.

Global Resveratrol Market: Segmentation

Analysis by Product Type

Analysis by Form

Analysis by End Use

Analysis by Region

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Resveratrol Market Healthy Pace throughout the Forecast during 2018-2028 Jumbo News - Jumbo News

Absorbable Tissue Spacer Market to reach US $145.0 million by 2028 – Global Insights on Trends, Key Growth Drivers, Restraints, Challenge, Recent…

Posted: at 6:51 pm

Dallas, Texas, Feb. 08, 2021 (GLOBE NEWSWIRE) -- The Global Absorbable Tissue Spacer Market Size 2019, by Product (Hydrogel Based Spacers and Biodegradable Balloon Spacers), by Application (Radiotherapy and Infection Management), by End User (Hospitals, Ambulatory Surgical Centers, and Others), by Region and Forecast 2018 to 2028 study provides an elaborative view of historic, present and forecasted market estimates.

The global absorbable tissue spacer market is growing at a CAGR of over 4.0%. Increasing incidence of cancer in male population is one of the major factors for market development across the globe. Rapid increase in number of cases diagnosed with prostate cancer in likely to fuel the market growth in coming years.

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Global Absorbable Tissue Spacer Devices Market, 2018-2028 (USD Million) Adroit Market Research report on global absorbable tissue spacer market gives a holistic view of the market from 2018 to 2028, which includes factors such as market drivers, restraints, opportunities, challenges and regulatory scenario. The market has been studied for historic years from 2018 to 2019, with the base year of estimation as 2019 and forecast from 2020 to 2028. The report covers the current status and future traits of the market at global as well as country level. In addition, the study also assesses the market competition with Porter's five forces analysis and positions the key players based on their product portfolio, geographic footprint, strategic initiatives and overall revenue. Prominent players operating in the global market have been studied in detail.

The global market is segmented on the basis of product, end user and application. The product segment is further broken down to hydrogel based spacers and biodegradable balloon spacers). In terms of application, the market is bifurcated into radiotherapy and infection management). On the basis of end user the market is segmented into hospitals, ambulatory surgical centers, and others. Hydrogel-based absorbable tissue spacers accounted for more than 60% of the market in 2019.

Read the complete report: https://www.adroitmarketresearch.com/industry-reports/absorbable-tissue-spacer-market

Key players in the market include Biocomposites, Bioprotect Ltd, Boston Scientific, BD, Palette Life Sciences and many more. Key players are replacing non-absorbent materials with bio-absorbent materials due to their advantages and high number of product approvals from regulatory bodies. Such trend is likely to bring more bio-based spacers in the market.

Based on segmentation global absorbable tissue spacer market is fragmented into product, application, end user and regional industry. By product, global absorbable tissue spacer market is splintered into hydrogel based spacers, biodegradable balloon spacers. Based on application the market is classified into radiotherapy, infection management. Based on end user the market is classified into hospitals, ambulatory surgical centers & others. Further, absorbable tissue spacer market is also fragmented on the basis of regional diversification, identifying Europe, North and South America, MEA and APAC as major growth spots in absorbable tissue spacer market.

Table of Content:

1. Introduction

2. Research Methodology

3. Market Outlook

4. Absorbable Tissue Spacer Market by Product, 2018-2028 (USD Million)

5. Absorbable Tissue Spacer Market by End use, 2018-2028 (USD Million)

6. Absorbable Tissue Spacer Market by End-User, 2018-2028 (USD Million)

7. Absorbable Tissue Spacer Market by Region 2018-2028 (USD Million)

8. Competitive Landscape

9. Company Profiles

10. Appendix

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Global Resveratrol Market by Product (Natural Resveratrol {Grape seed extracted, Knotweed extracted}, Synthetic Resveratrol), By Application (Cosmetics, Dietary Supplements, Pharmaceutical, and Others), By Form (Liquid, Solid/Powder, Pill), By Distribution Channel (Retail Stores, Online Stores, Others), By Region (North America, Europe, Asia Pacific, Latin America, Middle East and Africa), Global Forecast 2018 to 2028

Global Wound Debridement Market Size 2019, by Product (Gels, Ointment & creams, Surgical devices, Medical gauzes, Ultrasonic devices, Others), by Method (Autolytic, Enzymatic, Surgical, Mechanical, Others), by Wound Type (Pressure ulcers, Diabetic foot ulcers, Venous leg ulcers, Burn wound, Others), by Region and Forecast 2018 to 2028

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Adroit Market Research is a global business analytics and consulting company incorporated in 2018. Our target audience is a wide range of corporations, manufacturing companies, product/technology development institutions and industry associations that require understanding of a markets size, key trends, participants and future outlook of an industry. We intend to become our clients knowledge partner and provide them with valuable market insights to help create opportunities that increase their revenues. We follow a code Explore, Learn and Transform. At our core, we are curious people who love to identify and understand industry patterns, create an insightful study around our findings and churn out money-making roadmaps.

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Absorbable Tissue Spacer Market to reach US $145.0 million by 2028 - Global Insights on Trends, Key Growth Drivers, Restraints, Challenge, Recent...

Add these foods to your diet to beat cancer – The Indian Express

Posted: at 6:51 pm

Whenever you are recuperating from an illness, or are looking to gain your strength, it is advisable that you eat healthy. It is known that your diet plays a significant role in reducing the risk of many diseases, including cancer. Shweta Mahadik, a dietician at Fortis Hospital, Kalyan, advises that people, especially those undergoing treatment for cancer, incorporate certain fruits and vegetables in their diet so as to slow down its growth and reduce certain side-effects of treatment.

* Apples: Apples contain a variety of phytochemicals, including quercetin, catechin, phloridzine, and chlorogenic acid, which are major antioxidants. Apples are a good source of dietary fibre and polyphenol compounds that work with gut microbes to boost cancer-fighting defences. Many studies have found consumption of apples can lower the risk of estrogen receptor, which is the negative form of breast cancer.

* Oranges: Some citrus fruits, particularly tangerines and oranges, have anti-angiogenic and anti-tumor activity. It is noted that individuals who eat citrus fruit daily have a lower risk of certain cancers, including those of lung, colorectal, and stomach. Two flavonoids abundant in citrus fruits are nobiletin and ascorbic acid (vitamin C), which have been shown to inhibit the growth and spread of tumors.

* Cranberries: Cranberry contains ursolic acid and proanthocyanidins. Regular consumption of cranberry extract inhibits the growth of breast cancer, colon cancer, cervical cancer, glioblastoma, leukemia, lung cancer, melanoma, oral cavity cancer, prostate cancer, and renal cancer cell lines.

* Berries: Berries are a rich source of many nutrients such as vitamins A, C, E, carotenoids, folate, calcium, selenium, simple and complex phenols and phytosterols. Anthocyanosides and resveratrol are one of the most active antioxidants found in blueberries. These antioxidants have anti-cancer effects, including radical scavenging activity, activation of phase II detoxifying enzymes, and decreased proliferation and inflammation of cells. Resveratrol, which is also found in the skin of red grapes, has several health benefits. It also displays chemotherapeutic properties such as anti-inflammation.

The dietician suggests some ideas for improving your cancer therapy response:

If there is the loss of appetite:

Eat five or six smaller meals per day Start with a high-protein diet while your appetite is strongest Keep favourite high-calorie foods and beverages within easy reach Try to be as physically active as you can, to help stimulate your appetite

For nausea and vomiting:

Have small and frequent meals Eating foods and sipping on clear liquids at room temperature or cooler may be easier to tolerate Avoid high-fat, greasy, spicy, or overly sweet foods Avoid foods with a strong odour Sip on beverages between meals rather than with meals For vomiting, avoid eating until vomiting is controlled, then try sipping on small amounts of clear liquids such as broth or cranberry juice. It may also be beneficial to nibble on plain foods such as bread, khakra, crackers

For fatigue:

Try to drink plenty of fluids. Being dehydrated can make fatigue worse. Aim for at least eight cups of hydrating fluid each day unless advised to restrict fluids for another medical condition. Hydrating fluids include water, fruit juices, broth, soup, smoothies.


Drink plenty of liquids such as water, fruit juices, soup broth, lemon water, black tea with lemon Eat small amounts of soft, bland foods Include water-soluble foods such as bananas, apple, oats in your diet

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Add these foods to your diet to beat cancer - The Indian Express

Impact of Covid-19 on Trans Resveratrol Market Influencing the Industry Development and Forecast | DSM, Evolva, Sabinsa, InterHealth, Maypro, etc KSU…

Posted: February 5, 2021 at 11:53 pm

Reports Monitor has recently added a new report to its vast depository titledGlobal Trans Resveratrol Market. The report studies vital factors about theGlobal Trans Resveratrol Marketthat are essential to be understood by existing as well as new market players. The report highlights the essential elements such as market share, profitability, production, sales, manufacturing, advertising, technological advancements, key market players, regional segmentation, and many more crucial aspects related to theGlobal Trans Resveratrol Market.

A holistic study of the market is made by considering a variety of factors, from demographics conditions and business cycles in a particular country to market-specific microeconomic impacts. The study found the shift in market paradigms in terms of regional competitive advantage and the competitive landscape of major players.

The following Top manufacturers are evaluated in this report: DSM, Evolva, Sabinsa, InterHealth, Maypro, Laurus Labs, JF-NATURAL, Great Forest Biomedical, Shaanxi Ciyuan Biotech, Chengdu Yazhong, Changsha Huir Biological-tech, Xi'an Gaoyuan Bio-Chem, Xi'an Sinuote & amp; More.

More Insightful information | Request a sample copy @ https://www.reportsmonitor.com/request_sample/1108913

Market by TypeSyntheticPlant ExtractFermentationMarket by ApplicationDietary SupplementCosmeticFood and BeverageOthers

Some of the main geographic regions included in this report are: 1. North America (United States and Canada and rest of North America)2. Europe (Germany, France, Italy and the rest of Europe)3. Asia-Pacific (China, Japan, India, South Korea and the rest of Asia-Pacific)4. LAMEA (Brazil, Turkey, Saudi Arabia, South Africa and the rest of LAMEA)

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What does the report offer?

The Global Trans Resveratrol Market report analyzes the production of goods, supply, sales and the current state of the market in detail. In addition, the report examines the market share of production and sales of products, as well as capacity, production capacity, sales trends, cost analysis and revenue generation. Several other factors such as import / export status, industrial statistics, supply and demand ratio, gross margin and the structure of the industrial chain were also studied in the Global Trans Resveratrol Reports.

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To conclude, the Trans Resveratrol report mentions the key geographies, the market landscapes as well as the product price, revenues, volume, production, supply, demand, rate of market growth and forecasts etc. This report also provides a SWOT analysis, an investment feasibility analysis and a return on investment. analysis.

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Impact of Covid-19 on Trans Resveratrol Market Influencing the Industry Development and Forecast | DSM, Evolva, Sabinsa, InterHealth, Maypro, etc KSU...

6 Things To Do Now To Live Longer And Stay Younger – Femina

Posted: at 11:53 pm

When we talk about living longer and staying younger, we usually focus on two things, eating right and exercising. Of course, these two are inevitable to lead a healthy, disease-free life, but there are factors beyond this.

Telomeres are the end cap of chromosomes (found inside the nucleus of our cells), which protect chromosome from deterioration. When cell division happens, the length of telomeres gets shorter. If we can slow down the process of shortening of telomeres, the cells will be healthier, and their lifespan will get longer. While shortening of telomeres is natural, early shortening is undesirable as it will contribute to accelerated ageing. The impact of lifestyle factors like smoking, lack of exercise, unhealthy diet, and lack of nutrients in diet, accelerate the shortening of telomeres, thus accelerating the ageing process.

Sirtuins area group of proteins, which is involved in regulation of our metabolism with the help of a catalyst, NAD+. Higher levels of sirtuins and NAD+ is directly linked to increasing human lifespan. A proper lifestyle including ample physical activity and a healthy diet can increase the level of sirtuins, which in turn increase the health span. Researchers are toiling to find the pathways through which some activators of sirtuins that are natural compounds like curcumin, help in longevity.

We all need calories to survive, but are we taking only the required amount of it? Excess intake of calories is considered to be one of the root causes of lifestyle diseases. Calorie restriction without malnutrition helps to increase longevity as it enhances the removal of metabolic toxins from our body through a process known as autophagy.

Gut micro biomes, the friendly microorganisms present in our gut also play an important role in making us healthy and live longer as it helps in enhancing our immunity, reducing the chronic inflammations and degenerative changes, which in turn help to increase our health-span and lifespan.

5. Get Your Natural Antioxidants

Antioxidants are compounds which can nullify the damaging effect of free radicals, thereby improve health and increase lifespan. It is high time to think beyond ACES (vitamins A,C,E and selenium), the commonly known antioxidants, as there are other powerful antioxidants like resveratrol, co-enzyme-Q10, and glutathione that directly impact a healthy ageing process.

The meaning of health has evolved over time; from being physically healthy, it has now evolved to a state of complete physical, mental and social well-being. Wellness starts when a person becomes aware of what keeps him healthy and prevents diseases and lives accordingly. Our mental and our social well-being is as important as physical health. Stress directly impacts our body and can accelerate the ageing process. Meditation, building positive social relationships, practising kindness and forgiveness are some of the simple methods we can incorporate into our life with mega benefits. Wellness is a process, not a destination; it is a way of living and embracing this process is one of the best solutions to live long and stay young.

Also read: 5 Detox Drinks To Have Have On An Empty Stomach For Weight Loss

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6 Things To Do Now To Live Longer And Stay Younger - Femina

Resveratrol Market Overview with Detailed Analysis, Competitive landscape, Forecast to 2026 Jumbo News – Jumbo News

Posted: at 11:53 pm

The Resveratrol market study now available at MarketStudyReport.com, is a detailed sketch of the business sphere in terms of current and future trends driving the profit matrix. The report also indicates a pointwise outline of market share, market size, industry partakers, and regional landscape along with statistics, diagrams, & charts elucidating various noteworthy parameters of the industry landscape.

Executive Summary:

The Resveratrol market report contains a descriptive study of this business vertical with respect to primary growth stimulants, opportunities, and restraints.The research on market thoroughly investigates this industry vertical by explicating the key development trends, limitations, challenges, and opportunities that will mold the business dynamics in the coming years.Proceeding further, it highlights the top regional markets and reveals the major areas to further business development, while providing a comprehensive account of the prominent companies in this domain.Apart from this, it also gauges the impact of the COVID-19 pandemic on revenue generation and breaks down the business strategies employed by well-established organizations to adapt to the changes in this industry.

Request a sample Report of Resveratrol Market at:https://www.marketstudyreport.com/request-a-sample/3224230?utm_source=jumbonews.co.uk&utm_medium=Ram

Industry experts claim that the Resveratrol market is projected to exhibit a robust growth rate of XX% over the forecast period.

Information pertaining to the competitive landscape and regional terrain along with factors influencing the various market segments are highlighted in the report. Moreover, the document examines the effect of the COVID-19 pandemic on the profitability graph and suggests strategies for stakeholders to adapt to the instabilities in the supply and demand channels.

Market rundown:

Regional fragmentation: Americas, APAC, Europe, Middle East & Africa

Product gamut:

Application scope:

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Competitive landscape:

Key features of this report are:

Important Questions answered in this report are:

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2. Global HPV Testing Market Growth (Status and Outlook) 2021-2026Read More: https://www.marketstudyreport.com/reports/global-hpv-testing-market-growth-status-and-outlook-2021-2026

Read More Reports On: https://www.marketwatch.com/press-release/global-sliding-vane-air-motor-market-is-anticipated-to-grow-at-a-strong-cagr-by-2025-2021-02-03

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Resveratrol Market Overview with Detailed Analysis, Competitive landscape, Forecast to 2026 Jumbo News - Jumbo News

Global Resveratrol Market by Manufacturers, Types, Regions and Application Research Report Forecast to 2026 – The Courier

Posted: February 4, 2021 at 9:53 am

The report named GlobalResveratrol Market2020 by Company, Regions, Type, and Application, Forecast to 2025 is a broad audit of the market size and patterns with values. The report is a thorough report on worldwide market investigation and experiences. The report is an arrangement of itemized market outline dependent on sorts, application, patterns and openings, consolidations and acquisitions, drivers and restrictions, and a world coming to. The report centers around the arising patterns in the worldwide and provincial spaces on all the huge segments, for example, market limit, cost, value, request and supply, creation, benefit, and serious scene. It offers a board translation of the worldwide Resveratrol industry from a scope of data that is gathered through respectable and checked sources.

NOTE:Our experts observing the circumstance across the globe clarifies that the market will create gainful possibilities for makers post COVID-19 emergency. The report means to give an extra outline of the most recent situation, financial stoppage, and COVID-19 effect on the general business.

Market Rundown:

The report investigates past patterns and future possibilities in this report which makes it exceptionally conceivable for the examination of the market. The report gives subtleties of the market by definitions, applications, market plot, item conclusions, and cost structures. The examination moreover shows the market contention scene and a relating point by point examination of the huge dealer/makers in the worldwide Resveratrol market. At that point, it presents another endeavor SWOT examination, adventure likelihood, and assessment. The report offers a figure assessment of the valuation of the market 2020-2025.

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The report talks about an entire attitude toward the difficulties existing among the business alongside the rising dangers, imperatives, and constraints. The report contains a full breakdown of the market elements like drivers, development possibilities, item portfolio, mechanical progressions, and a full investigation of the critical contenders of the market. The overall Resveratrol market is segmental into types, applications, innovation, end-clients, business verticals, and key geologies.

The central participants concentrated in the report include:Shaanxi Ciyuan Biotech, InterHealth, Chengdu Yazhong, Evolva, Changsha Huir Biological-tech, Xian Sinuote, Sabinsa, Xian Gaoyuan Bio-Chem, Great Forest Biomedical, Laurus Labs, JF-NATURAL, DSM, Maypro

The main sorts of worldwide market items shrouded in this report are:Synthetic, Fermentation, Plant Extract

The most generally utilized downstream fields of the worldwide market canvassed in this report are:Dietary Supplement, Cosmetic, Food and Beverage

Key areas and nations are canvassed in the worldwide Resveratrol market as follows: North America (the United States, Canada, and Mexico), Europe (Germany, France, UK, Russia, and Italy), Asia-Pacific (China, Japan, Korea, India, and Southeast Asia), South America (Brazil, Argentina, and so forth), Middle East and Africa (Saudi Arabia, Egypt, Nigeria, and South Africa)

The report comprises of a summed up market study and in general insights about the business occasions to key partners to grow their business and catch incomes. The worldwide Resveratrol market report offers definite examination upheld by solid insights on special and income by players for the time frame 2015-2020. Different subtleties included are organization depiction, significant business, item presentation, ongoing turns of events, deals by area, type, application, and by deals channel.

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Global Resveratrol Market by Manufacturers, Types, Regions and Application Research Report Forecast to 2026 - The Courier

These Diet Tips Help You In Cancer Therapy Responses, Says Expert – Femina

Posted: at 9:53 am


Your diet plays a significance role in reducing the risk of developing cancer. In the same way, filling up on healthy food is important if you are being treated for, or recovering from cancer. Here are some fruits that contain health-promoting compounds that may slow down cancer growth and reduce certain side effects of treatment.

Shweta Mahadik, dietician, Fortis Hospital, Kalyan lists down fruits that help you during your cancer treatment and tips on improving your therapy response:

ApplesApples contain a variety of phytochemicals, including quercetin, catechin, phloridzine, and chlorogenic acid, which are all major antioxidants. Apples are a good source of dietary fibre and polyphenol compounds that work with gut microbes to boost cancer-fighting defences. Many studies found that consumption of apples lowers risk of estrogen receptor ie, negative form of breast cancer.

OrangesSome citrus fruits, particularly tangerines and oranges, have anti-angiogenic and anti-tumour activity. It is noted that individuals who eat citrus fruit daily have lower risk of certain cancers, including lung cancer, colorectal cancer and stomach cancer. Two flavonoids abundant in citrus fruits are nobiletin and ascorbic acid (vitamin C), which have been shown to inhibit the growth and spread of tumours.


Cranberry contains ursolic acid and proanthocyanidins. Regular consumption of cranberry extract inhibits the growth of breast cancer, colon cancer, cervical cancer, glioblastoma, leukaemia, lung cancer, melanoma, oral cavity cancer, prostate cancer and renal cancer cell lines.

BerriesBerries are a rich source of many nutrients such as vitamin A, C, E, carotenoids, folate, calcium, selenium, simple and complex phenols and phytosterols. Anthocyanosides and resveratrol are one of the most active antioxidants found in blueberries. These antioxidants have anti-cancer effects, including radical scavenging activity, activation of phase II detoxifying enzymes, and decreased proliferation and inflammation of cells. Resveratrol, which is also found in the skin of red grapes, also has several health benefits. It also displays chemotherapeutic properties such as anti-inflammation

Nausea And Vomiting

- Have small and frequent meals.-Eating foods and sipping on clear liquids at room temperature or cooler may be easier to tolerate.- Avoid high-fat, greasy, spicy, or overly sweet foods.- Avoid foods with strong odour.- Sip on beverages between meals rather than with meals.- For vomiting, avoid eating until vomiting is controlled then try sipping on small amounts of clear liquids such as broth or cranberry juice. It may also be beneficial to nibble on plain foods such as bread, khakra or crackers.

Fatigue- Try to drink plenty of fluids. Being dehydrated can make fatigue worse. Aim for at least eight cups of hydrating fluid each day unless advised to restrict fluids for another medical condition. Hydrating fluids include water, fruit juices, broth, soup, smoothies.

Diarrhoea- Drink plenty of liquids such as water, fruit juices, soup broth, lemon water, black tea with lemon.- Eat small amounts of soft, bland foods.- Include water soluble foods such as bananas, apple, and oats in our diet.

Eating certain fruits rich in vitamin C can significantly improve your health, especially during and after cancer treatment. Many fruits provide antioxidants to help fight the growth of cancer cells and may even offer other health benefits to help ease certain side effects of treatment. Enjoying these healthy fruits in combination with a well-rounded diet that includes vegetables, and legumes (beans), good whole grain choices include whole wheat, oats/oatmeal, rye, barley, brown rice, millets, etc, can get you started on the road to recovery.

Also Read:Expert Speak: Minimising The Side Effects Of Breast Cancer Treatment

These Diet Tips Help You In Cancer Therapy Responses, Says Expert - Femina

Food For Concentration: Brain-Boosting Food Items That May Keep You Sharp And Help Excel in Exams – India.com

Posted: at 9:53 am

CBSE has released the timetable for class 10 and 12 examinations and we are sure most of the students must have already started to feel the pressure of the upcoming exams. But, stress is not going to help you excel. It will only add to the anxiety that you are experiencing right now due to constant overwhelming thought of how to do well in the exam. So how to deal with it and improve your academic performance? Also Read - Short-term exercise equals big-time brain boost: study

The simplest answer is to opt for food items known for boosting brain health and improving your memory. Yes, you read that right. Foods that you eat have a significant impact on the structure and performance of your brain, which is an energy-intensive organ that requires certain nutrients to stay healthy. Providing it those vitamins and minerals can help you score good marks in your board exams. So, without wasting much time lets straight talk about 5 brain-boosting foods every student must eat daily especially if preparing for the examination.

Being rich in antioxidants called anthocyanin, caffeic acid, catechin, and quercetin, berries can reduce inflammation and oxidative stress that are known to affect your brains performance. According to a study published in the journal, Neural Regeneration Research, eating berries daily can improving communication between brain cells, boost learning and memory, and reduce cognitive decline.

These food items contain important antioxidants and omega-3 fatty acids, that are linked to better brain function. Nuts and seeds contain vitamin E which prevents oxidative stress caused by free radicals in the body. A research published in the journal Nutrients has revealed that eating nuts and seeds every day can improve cognition.

One of the healthiest food items available around us is avocados. They contain healthy unsaturated fat and support your brain health. Having avocados daily can lower the risk of cognitive decline and improve your brain performance by contributing to healthy blood flow to this organ.

Peanuts can keep you energized for a long due to their unsaturated fats and protein content. Peanuts have certain significant nutrients including vitamin E and resveratrol that keep the brain healthy.

Broccoli is low in calories and rich in dietary fiber, which is good for your brain. It contains a compound called glucosinolates which helps in reducing oxidative stress in the body and prevents brain-related diseases. Broccoli is also jam-packed with vitamin C and flavonoids. These are antioxidants known for boosting your brain health.

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Food For Concentration: Brain-Boosting Food Items That May Keep You Sharp And Help Excel in Exams - India.com

Resveratrol Market to Witness the Highest Growth Globally in Coming Years 2021-2027 Murphy’s Hockey Law – Murphy’s Hockey Law

Posted: February 1, 2021 at 10:54 am

Global competitive benchmarking of Resveratrol Market with historical, present, and forecast analysis from 2015-2026 is presented in this report. The Resveratrol top companys revenue shares, latest trends, and dynamics are studied in-depth in this research report. Also, the growth opportunities at the regional level including North America, European countries, South America, Middle Eastern & African countries, and Asian countries are covered in this report. The report is segmented based on Resveratrol Product insights & Types, Application insights, top companies, and more. The graphical and tabular representation of every Resveratrol Industry segment is offered for ease of understanding.

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Various key players adopting to mergers & acquisitions, product launches, partnerships to strengthen their Resveratrol Industry foothold is covered by the Reports Check team. All the crucial details like market size value in 2021, revenue forecast by 2026, growth rate, base year estimation (2020), historical & forecast industry performance are evaluated comprehensively.

Globally, the prominent players in Resveratrol Industry are as follows:

Jeunesse Global, DSM Nutritionals, Sirtris Pharmaceuticals Inc., Ltd., Resveratrol Enhanced Pty Ltd, Hill Pharmaceutical Co., Andorra Life, Terraternal, ResVitale LLC, Endurance Products Company, ASN Pharmaceutical LLC, Xieli Pharmaceutical, RevGenetics, GlaxoSmithKline and Evolva among others.

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The company rankings, competitive landscape based on market size, share, revenue, Resveratrol product demand, production, capacity, utilization, and many other factors are analyzed. The market drivers, SWOT analysis of every market player, future opportunities, restraints, and its impact on Resveratrol Industry dynamics is evaluated. Key sustainability strategies adopted by players during pandemic times are also stated. The pandemic impact on various Resveratrol Industry verticals like production, supply, demand, transport, availability of raw materials is studied. The changes in government policies, implications on Resveratrol trade across different countries, revenue impact, the decline in demand are also considered.

Resveratrol Market Segmentation

The key product types and outlook by Revenue (USD Million, from 2015-2026) is as follows:

Form Segment, (Liquid supplements,Powdered form,Red wine pill), Type Segment, (Grape seed extract,Natural resveratrol,Japanese knotweed extract), Distribution channel Segment, (Drug stores,Departmental stores,Hypermarket/supermarket,Online stores,Others)

The top applications and outlook by Revenue (USD Million, from 2015-2026) is as follows:

Application Segment, (Cosmetics,Pharmaceuticals,Dietary supplements,Others)

The regional outlook by Revenue (USD Million, from 2015-2026 covers the countries namely the United States, Canada, Mexico, United Kingdom, France, Germany, Russia, Spain, Italy, China, Japan, India, South Korea, Indonesia, Philippines, Brazil, South Africa, Saudi Arabia, UAE, Turkey and rest of the world is covered.

The CAGR from 2021-2026 with the estimated market size is calculated in this report. The value chain analysis, Resveratrol volume analysis, production capacity, supply, demand, consumer analysis is conducted. The research methodology and Resveratrol information procurement consists of data gathered from primary and secondary research, paid databases, Hoovers, Factiva, and secondary databases. Also, paid primary interviews are conducted with key opinion leaders like VPs of the Resveratrol Industry of that respective company, marketing managers, CEOs, product managers, R&D people, and more.

Report Highlights:

1.Key extracts and highlights from the table of contents are shown below:2.Introduction, Market Scope, Definitions3.Product types, classification, and portfolio4.Executive summary, Resveratrol parent and ancillary market outlook5.Resveratrol penetration globally and growth prospect mapping6.Market drivers, restraints, Porters Five Forces, PESTLE analysis7.Product market share analysis and Resveratrol segment dashboard based on each product type, applications, regions, and top countries8.Top company profiles, market share, revenue, sales data & company rankings9.Business profiles of top Resveratrol manufacturers, product portfolio, business strategies & key financial data10.Product benchmarking, strategic initiatives, revenue, share, size analysis11.Production, demand, investment feasibility, mergers & acquisitions study12.New product launches, regulatory scenarios in Resveratrol market, developments, innovations & more13.Forecast Resveratrol Industry outlook, market variables, scope, market size, and revenue estimation till 202614.Application and end-user based forecast industry outlook15.Product types based market outlook and forecast opportunities16.Data sources, research methodology, conclusion

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Resveratrol Market to Witness the Highest Growth Globally in Coming Years 2021-2027 Murphy's Hockey Law - Murphy's Hockey Law

Style News: Caudalie’s new anti-ageing range, Ying The Label and Risis team up – The Straits Times

Posted: at 10:54 am

Caudalie debuts new anti-ageing range

French skincare brand Caudalie has released a new anti-ageing range of products that comes with Harvard Medical School's stamp of approval.

The improved Resveratrol-Lift line was created from a partnership between Caudalie founder Mathilde Thomas and the school's Dr David Sinclair, an acclaimed biologist who specialises in the science of ageing.

They patented a new combination of ingredients, adding vegan collagen booster to the existing formula of vine resveratrol and hyaluronic acid, which is also patented.

A known anti-ageing antioxidant, resveratrol can be found in grape skin - a tribute to Caudalie's roots, which originated in a vineyard in France. The new recipe is said to be twice as effective as retinol and to help the skin produce five times the amount of natural collagen.

The Resveratrol-Lift range comprises the Instant Firming Serum ($98), Firming Night Cream ($84), Lightweight Firming Cashmere ($82) day cream and Firming Eye Gel-Cream ($79).

All the products have fully recyclable packaging - a first for the brand.


INFO: Available at Sephora stores and website

Local brands Ying The Label and RISIS have joined hands for a sustainable capsule of accessories.

Called Re:loop, the collection features upcycled fabric necklaces by Ying, paired with RISIS's signature orchid charms. The gold used for the charms was recycled from unused wastage, according to RISIS chief executive Verene Ng.

The necklaces, priced at $228, come in six fabric designs and four gold finishings for the orchid charm. Shoppers can mix and match the fabric and charms.

The collaboration came about after Ying founder Phuay Li Ying discovered during the circuit breaker that her tailor had plenty of uncut fabricleft over. It spurred her to find creative ways to upcycle the fabrics.


INFO: Available at The Ying Atelier at 01-18, KAP Mall, and RISIS's boutique in The Shoppes at Marina Bay Sands, B2M-244


French luxury brand Dior has revamped its signature Rouge Dior lipstick with a refillable case. The lipstick's exterior retains its sleek silver trim and "CD" initials, but you can now pop the lipstick bullet in and out of the case.

A Rouge Dior lipstick, available in 35 shades here, costs $56. Refills (price to be confirmed) will be launched on Aug 15. The house also introduced two new finishes - an extra-matte Velvet with long-lasting comfort and a bright Metallic.

INFO: Available at Dior Beauty boutiques and counters


Spanish luxury house Loewe has a new member in its Puzzle bag family: the Nano Puzzle, a rescaled version of the iconic silhouette and the smallest iteration of the handbag yet.

Released in a rainbow of colourways, the Nano Puzzle ($1,990) is made of calfskin and finished with a herringbone-patterned cotton lining and palladium metal fixings. It is also the only Puzzle bag to include a detachable metallic chain.

The geometric Puzzle is the first handbag designed by creative director Jonathan Anderson when he joined the brand in 2013. It quickly became a favourite among fashion insiders and is now a modern icon.

INFO: Available at all Loewe stores

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Style News: Caudalie's new anti-ageing range, Ying The Label and Risis team up - The Straits Times

Organic Wine Market: Understand the Key Growth Drivers Developments and Innovations by 2027 KSU | The Sentinel Newspaper – KSU | The Sentinel…

Posted: at 10:53 am

The global Organic Wine Market is treading along a lucrative pathway, mainly due to industrial advancements. The favourability of industrial restructuring for the vendors operating in the global Market has given a thrust to market growth. The strategic initiatives taken by the leading vendors have helped them in clocking in fresh revenues in recent times. The global Market is projected to witness the inflow of increased revenues from leading stakeholders and investors. These investors are assessing the potential for growth endowed by the global Market. The investment decision of the leading investors is projected to be based on their analysis of market lucrativeness.

Some of the key players operating in this market include:

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Impact of COVID-19 on Organic Wine Market

The report also includes the impact of ongoing global crisis i.e. COVID-19 on the Organic Wine Market and what the future holds for it. It provides an analysis of the effects of the pandemic on the global economy. The outbreak has directly disturbed the demand and supply chain. The report also analyzes the financial impact on firms and financial markets. Researchmoz has gathered insights from several delegates of the industry and got involved in the primary and secondary research to provide the clients with data and strategies to combat the market challenges during and after COVID-19 pandemic.

Organic Wine Market: Overview

The global market value for the organic wine stood at ~US$ 11 Bn in 2020, finds Transparency Market Research (TMR) in a recent study. According to the report, the market is expected to reach ~US$ 30 Bn by 2030, at a CAGR of ~10.8% during the forecast period.

Organic wine will continue to trend due to the increasing demand from various industries, including nutraceuticals, pharmaceuticals, confectionery, and bakery goods. Organic wine is used for medical purposes, due to the presence of resveratrol, as it helps in preventing diseases and ageing; improves immunity, body warmth; and helps in better metabolism. Furthermore, the global organic wine is driven by the growing consumer inclination toward low and no alcohol wine option backed by increasing health and wellness awareness.

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Organic Wine Market: Strategies

The study objectives of this report are:

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Organic Wine Market: Understand the Key Growth Drivers Developments and Innovations by 2027 KSU | The Sentinel Newspaper - KSU | The Sentinel...

Global Trans Resveratrol Market Research Report (Opportunities, Threats, Trends, Applications, And Growth Forecast To 2027) NeighborWebSJ -…

Posted: January 25, 2021 at 5:49 am

The Global Trans Resveratrol Market Business Perspective, Comprehensive Analysis, and Forecast 2021-2027 throughout the forecast period. Trans Resveratrol market report provides comprehensive research upgrades and data linked to promoting increases, requirement, and opportunities in the World.

Global Trans Resveratrol Market Report is an idea and in detail study of the present state expected at the major drivers, market strategies, and key players enlargement. The study also involves the important Achievements of the market, Research & Development, new product launch, product responses, and regional growth of the most important competitors operating in the market on a universal and local scale.

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Trans Resveratrol Market Research Report Will Be Sympathetic For:

The Top Key Players Profiled In This Report Are:

DSMEvolvaInterHealthMayproLaurus LabsJF-NATURALGreat Forest BiomedicalShaanxi Ciyuan BiotechChengdu YazhongSabinsaChangsha Huir Biological-techXian Gaoyuan Bio-ChemXian Sinuote

The analysis offers detailed segmentation of this global Trans Resveratrol market-based on Services, Product-Types, Applications and also Regional Analysis

By Type:

SyntheticPlant ExtractFermentation

By Applications:

Dietary SupplementCosmeticFood and Beverage

Major regional sections studied in this research comprise using its new bifurcation as above stated and significant nations as North America, Europe, Asia-Pacific, Middle East, and Africa, and South America. This segmentation includes the requirement for Trans Resveratrol predication on different services and products in most areas and states. Europe has ruled Trans Resveratrol markets. North America and the Asia Pacific are growing at high speed in Trans Resveratrol market as a result of employment, traditional tools, and advancements.

Any Questions? Feel Free To Enquire Here. We will Put You On The Right Path:https://www.eonmarketresearch.com/enquiry/77760

Table of Content:

Chapter 1 About the Trans Resveratrol Industry

Chapter 2 Global Market Competition Landscape

Chapter 3 Global Trans Resveratrol Market share

Chapter 4 Supply Chain Analysis

Chapter 5 Company Profiles

Chapter 6 Globalisation and Trade

Chapter 7 Distributors and Customers

Chapter 8 Import, Export, Consumption and Consumption Value by Major Countries

Chapter 9 Global Trans Resveratrol Market Forecast through 2027

Chapter 10 Key success factors and Market Overview

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