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Longevity – SNPedia

Posted: January 31, 2018 at 9:43 pm


Research on longevity, which can also be thought of as maximal lifespan, is more popularly associated with extending human life than with the more strict connotation of life expectancy (more at Wikipedia). Heredity and other factors (such as birth order and age of the mother at the time of the person's birth) influence longevity. [1]

There are at least 3 potentially overlapping classes of SNPs (or other genetic polymorphisms) that can be considered to affect longevity. First, many SNPs may influence susceptibility to diseases that shorten longevity; these can be found in SNPedia associated with those diseases, and related information is summarized on the heritability page. Second, some SNPs are being discovered based on their prevalence in people who live beyond average human lifespan; these SNPs may enhance longevity. Third, certain SNPs may be to able to affect longevity only in certain environmental contexts, for example SNPs that shorten or lengthen longevity only if an individual with a given genotype is also exposed to certain diets or toxins (such as cigarette smoke).

SNPs from the latter two categories include:

A 2017 GWAS analysis of parental longevity in 300,000 UK Biobank participants of European descent found 10+ SNPs to be associated with combined mothers' and fathers' attained age (and a few others just with paternal or maternal age); these 10+ SNPs and the longevity-associated allele were [PMID 29227965]:

Overall, it's useful to realize that SNPs are likely to influence your risk of dying from 9 of the top 10 causes of death (in developed countries), as noted below (based on 2000 US data):

10.1126/science.1190532 identified 150 snps however numerous questions about the plausibility of the results, led to it's eventual retraction.

http://genomics.senescence.info/download.html

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Longevity - SNPedia

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