Pear Therapeutics Announces Publication of Economic Analysis Showing Cost-Effectiveness of reSET-O in Treating Opioid Use Disorder – BioSpace
Posted: February 25, 2021 at 6:49 am
Feb. 23, 2021 13:00 UTC
BOSTON & SAN FRANCISCO--(BUSINESS WIRE)-- Pear Therapeutics, Inc., today announced publication of new analysis demonstrating the cost-effectiveness of reSET-O, the first and only FDA-authorized Prescription Digital Therapeutic (PDT) for the treatment of opioid use disorder (OUD). The analysis, published in the peer-reviewed journal Postgraduate Medicine, showed that reSET-O plus treatment-as-usual (TAU) (i.e., transmucosal buprenorphine, face-to-face counseling and contingency management) decreased total health care costs and resulted in improved post-treatment quality-adjusted life year (QALY) gains.
OUD is one of the deadliest and costliest health conditions in the United States, generating close to 50,000 deaths and costing an estimated 40 to 70 billion dollars in annual medical costs each year, mostly from the more than 80% of untreated patients. Already high OUD-related deaths jumped after the start of the COVID-19 pandemic, and relapse rates due to the ongoing pandemic are expected to further increase the use of emergency department visits and inpatient stays, which are primary direct cost drivers in OUD, said Yuri Maricich, M.D., Chief Medical Officer of Pear Therapeutics. This analysis showed that reSET-O has the potential to improve population health while reducing costs, further highlighting the importance of providing holistic, low-barrier care to one of our most vulnerable populations.
In the study, a decision analytic model evaluated the cost-effectiveness of reSET-O relative to TAU alone over 12 weeks. Clinical effectiveness data (abstinence and health utility) were obtained from a clinical trial, and a resource utilization and cost data were utilized from a recent claims data analysis to reflect less frequent face-to-face counseling with reSET-O. Results of this model showed population-level gains in quality-adjusted life years at a lower cost with reSET-O treatment vs TAU alone. In addition to clinical value, these results emphasize the limited economic risk of reSET-O as an adjunct to TAU.
The full paper, Cost-Effectiveness Analysis of a Prescription Digital Therapeutic for the Treatment of Opioid Use Disorder, is available online by clicking here.
These results are further supported by recently published real-world clinical and economic data showing the potential for improved health outcomes and decreased treatment costs for patients using reSET-O1-4.
About OUD
In recent years, OUD has been responsible for approximately two out of every three deaths related to substance use disorder (SUD)5. The cost of OUD to the U.S. healthcare system alone is estimated at approximately $40-70 billion per year, and is largely driven by excess hospital and emergency department encounters6,7. The ultimate treatment goal of patients with OUD is sustained abstinence and recovery of their lives8. However, less than 35% of adults with OUD in 2019 received treatment for opioid use in the past year, highlighting the need for expanded access to comprehensive OUD treatment9.
reSET-O Important Safety Information
Indications for Use
reSET-O is intended to increase retention of patients with Opioid Use Disorder (OUD) in outpatient treatment by providing cognitive behavioral therapy, as an adjunct to outpatient treatment that includes transmucosal buprenorphine and contingency management, for patients 18 years or older who are currently under the supervision of a clinician. reSET-O is indicated as a prescription-only prescription digital therapeutic.
Important Safety Information:
Warnings: reSET-O is intended for patients whose primary language is English and who have access to an Android/iOS tablet or smartphone. reSET-O is intended only for patients who own a smartphone and are familiar with use of smartphone apps (applications).
reSET-O should not be used by individuals outside active OUD treatment. It is not intended to replace treatment by you, the patients medical provider. It should be used as an adjunct to clinician treatment, buprenorphine treatment and contingency management.
reSET-O is not intended to be used as a stand-alone therapy for Opioid Use Disorder (OUD). reSET-O does not represent a substitution for a patients medication. Patients should continue to take their medications as directed by their healthcare provider. The ability of reSET-O to prevent potential relapse after therapy discontinuation has not been studied.
Clinicians should not use reSET-O to communicate with their patients about emergency medical issues. Patients should be clearly instructed not to use reSET-O to communicate to their clinician any urgent or emergent information. In case of an emergency, patients should dial 911 or go to the nearest emergency room.
This Press Release does not include all the information needed to use reSET-O safely and effectively. Please see the Clinician Brief Summary Instructions for reSET-O for more information.
About Pear Therapeutics
Pear Therapeutics is the leader in prescription digital therapeutics, or PDTs. Pear aims to redefine medicine by discovering, developing, and delivering clinically validated software-based therapeutics to provide better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. Pear has a pipeline of products and product candidates across therapeutic areas, including the first three PDTs with disease treatment claims from FDA. Pears lead product, reSET, for the treatment of substance use disorder, was the first PDT to receive marketing authorization from FDA to treat disease. Pears second product, reSET-O, for the treatment of opioid use disorder, was the first PDT to receive Breakthrough Designation. Pears third product, Somryst for the treatment of chronic insomnia, was the first PDT submitted through FDAs traditional 510(k) pathway while simultaneously reviewed through FDAs Software Precertification Pilot Program. For more information, visit Pear at http://www.peartherapeutics.com.
References:1. Yuri A. Maricich, MD, Xiaorui Xiong, PhD, Robert Gerwien, PhD, Alice Kuo, BA Fulton Velez, MD MBA, Bruce Imbert, MD PhD, Keely Boyer, MBA, Hilary F. Luderer, PhD, Stephen Braun, BA, Karren Williams, PhD (2020): Real-World evidence for a prescription digital therapeutic to treat Opioid Use Disorder, Journal of Current Medical Research and Opinion, DOI:10.1080/03007995.2020.1846023.2. Fulton F. Velez , Sam Colman , Laura Kauffman , Charles Ruetsch & Kathryn Anastassopoulos (2020): Real-world reduction in healthcare resource utilization following treatment of opioid use disorder with reSET-O, a novel prescription digital therapeutic, Expert Review of Pharmacoeconomics & Outcomes Research, DOI: 10.1080/14737167.2021.1840357.3. Weijia Wang, Nicole Gellings Lowe, Ali Jalali & Sean M. Murphy (2021) Economic modeling of reSET-O, a prescription digital therapeutic for patients with opioid use disorder, Journal of Medical Economics, 24:1, 61-68, DOI: 10.1080/13696998.2020.1858581.4. Yuri A. Maricich, Warren K. Bickel, Lisa A. Marsch, Kirstin Gatchalian, Jeffrey Botbyl & Hilary F. Luderer (2020) Safety and efficacy of a prescription digital therapeutic as an adjunct to buprenorphine for treatment of opioid use disorder, Current Medical Research and Opinion, DOI: 10.1080/03007995.2020.1846022.5. Jalal H, Buchanich JM, Roberts MS, et al. Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016. Science. 2018 Sep 21;361(6408).6. Substance Abuse and Mental Health Services Administration. (2020). Key substance use and mental health indicators in the United States: Results from the 2019 National Survey on Drug Use and Health (HHS Publication No. PEP20-07-01-001, NSDUH Series H-55). Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. Retrieved from https://www.samhsa.gov/data/ 7. The Council of Economic Advisers. The underestimated cost of the opioid crisis 2017. Available from: https://www.whitehouse.gov/briefings-statements/cea-report-underestimated-cost-opioid-crisis/.8. Lofwall MR, Walsh SL, Nunes EV, et al. Weekly and Monthly Subcutaneous Buprenorphine Depot Formulations vs Daily Sublingual Buprenorphine With Naloxone for Treatment of Opioid Use Disorder: A Randomized Clinical Trial. JAMA Intern Med. 2018;178(6):764-773.9. Food & Drug Administration. Opioid use disorder: endpoints for demonstrating effectiveness of drugs for medicationassisted treatment guidance for industry. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/opioid-use-disorder-endpoints-demonstrating-effectiveness-drugs-medication-assisted-treatment. Accessed September 29, 2020.
View source version on businesswire.com: https://www.businesswire.com/news/home/20210223005315/en/
Read the rest here:
Pear Therapeutics Announces Publication of Economic Analysis Showing Cost-Effectiveness of reSET-O in Treating Opioid Use Disorder - BioSpace
- Nehi Bali's Hoslistic Health Courses Land In The UAE - About Her - February 25th, 2021
- Combine Fasting & Holistic Health With This Four-Week Program - mindbodygreen.com - February 25th, 2021
- Why fusion of modern, alternative medicine is unfeasible - Hindustan Times - February 25th, 2021
- Indiana Regenerative Medicine Welcomes Annamarie Salyer to the Practice - Zionsville Monthly Magazine - February 25th, 2021
- BJP deems Rajasthan budget disappointing, ruling Congress says its presented a holistic one - Hindustan Times - February 25th, 2021
- Regenerative Medicine Market in Demand: Sentiment is Shifting Towards Growth | Size, Growth, Demand, Opportunities, Analysis and Forecast To 2028 KSU... - February 25th, 2021
- Homeopathic Medicine Market Size 2021 | Analysis, Regional Outlook, Competitive Strategies And Forecast up to 2027 - NY Market Reports - February 25th, 2021
- Cannabis Brand Cookies Enters The CBD And Mushroom Medicine Game With Caps Line - Forbes - February 25th, 2021
- A Guide to Acupuncture Businesses in Hoboken and Jersey City - hobokengirl.com - February 25th, 2021
- 3 keys to quality, head-to-toe... - Bothell-Kenmore Reporter - February 25th, 2021
- Need a little TLC? The Licking News - The Licking News - February 25th, 2021
- Global Cell and Gene Therapy Market to Reach $25.00 Billion by 2027, Reports BIS Research - PRNewswire - February 25th, 2021
- Emergency Internet Subsidy Will Aide in Closing Digital Gap in Black Communities - BroadbandBreakfast.com - February 25th, 2021
- MOVE IT OR LOSE IT! - Boothbay Register - February 19th, 2021
- The Supplement That Pros Use To Look & Feel More Awake - mindbodygreen.com - February 19th, 2021
- 'I don't want to introduce my friends to my partner' - Times of India - February 19th, 2021
- Most Trending Report of Precision Medicine Market is Expected to Contribute Towards the Growth During The Forecast Period 2021-2026 | KSU | The... - February 19th, 2021
- The unintended consequences of the Macpherson report - Spectator.co.uk - February 19th, 2021
- 'Adaptive' Yoga Opens This Practice to Everyone - WebMD - February 19th, 2021
- Finding the unexpected positives during COVID times - Harvard Gazette - February 19th, 2021
- Novartis and the Bill & Melinda Gates Foundation collaborate to discover and develop an accessible in vivo gene therapy for sickle cell disease -... - February 19th, 2021
- Demystifying the healing practice of Naturopathy - The Times of India Blog - February 19th, 2021
- Medical Remedies Solutions for Skin Burns Market Potential Growth, Share and Demand Analysis of Key Players 3M, Molnlycke Health Care, ConvaTec, Paul... - February 19th, 2021
- Growth of digital health from Covid-19 creating unforeseen insurance perils, according to Willis Towers Watson - GlobeNewswire - February 19th, 2021
- Comprehensive Analysis on Sleep Medicine Industry Market based on types and application - AlgosOnline - February 19th, 2021
- History in real time: special collections team's effort to document COVID-19 - The Collegian - The Collegian - February 19th, 2021
- Think About It: Azarenka examines food as medicine with Dr. Rupy Aujla - Tennis Magazine - February 17th, 2021
- Stanford's John Tanner Named 2020 USOPC College Coach Of The Year - SwimSwam - February 17th, 2021
- Global Organoids And Spheroids Market Is Projected to Grow at an Exponential Rate over 2020 to 2028 | Market Top Players Analysis, Revenue,... - February 17th, 2021
- Bernard Lown, doctor at the vanguard of cardiac care, antiwar activist who shared Nobel Peace Prize, dies at 99 - The Boston Globe - February 17th, 2021
- Global Seaweed Products Market 2021 Covering Key Factors and Competitive Outlook By Seakura, Kelpak, Seagate Products, Cargill KSU | The Sentinel... - February 17th, 2021
- How Parsley Health Pivoted From Chic Clinics To A National Telehealth Platform - Forbes - February 14th, 2021
- Hispanic, Latinx residents of N.J. say they need more COVID vaccine info - especially in Spanish - NJ.com - February 14th, 2021
- New Research on COVID-19: Greek Herbs Are Powerful - The Pappas Post - February 14th, 2021
- Experts Unpack Longevity Secrets From 5 Different Cultures Around the Globe - Well+Good - February 14th, 2021
- Regenerative Medicine Market-Segmentation And Analysis By Recent Trends, Development And Growth By Regions To, Analysis, Forecast To 2026 KSU | The... - February 14th, 2021
- Perspectives on Transitioning Step 1 of the United States Medical Lice | AMEP - Dove Medical Press - February 14th, 2021
- Arab World Needs A Renaissance Of The Sciences - OpEd - Eurasia Review - February 14th, 2021
- General Medicine Education Publishing Market Competitive Intelligence and Tracking Report 2020 2026 | RELX plc, Kaplan, Inc., McGraw-Hill Education ... - February 14th, 2021
- The National Academy of Sports Medicine Launches a Revolutionary Personal Training Program that Makes It Quick, Easy and Affordable to Start a... - February 14th, 2021
- Precision Medicine Software Market: Analysis of Rising Business Opportunities with Prominent Investment Ratio by 2026 | Syapse, Inc., 2bPrecise LLC,... - February 14th, 2021
- Working in Wellness: The Allure of Acupuncture - Mpls.St.Paul Magazine - February 14th, 2021
- Covid-19 impact on Artificial Intelligence in Healthcare Market Business Opportunities, Analysis and Overview by 2026 | Welltok, Inc., Intel... - February 11th, 2021
- CRISPR and CAS Gene Market Breakdown, Development and New Market Opportunities & Forecasts | Caribou Biosciences Inc., CRISPR Therapeutics, Mirus... - February 11th, 2021
- AACN Announces 2021 Election Results for Board of Directors and Nominating Committee - Newswise - February 11th, 2021
- This group of workers could help turnaround quality of life -- and the economy - CNN - February 11th, 2021
- Sports Medicine Market Size, Top Key Players, Applications, Business Statistics, Trends and Forecast 2021-2027 NeighborWebSJ - NeighborWebSJ - February 7th, 2021
- Changing the face of medical education - The Borneo Post - February 7th, 2021
- Dr. Armand Amselem Shares His Inputs on the Evolution of Dentistry and Its Latest Trends - Daily Front Row - February 5th, 2021
- Can Integrative Health Solutions Help Employees While Cutting Costs? - EHS Today - February 5th, 2021
- Black pastors receive COVID-19 vaccine, hoping to encourage others - Pastor Jerry Young receiving Covid-19 vaccination - Themississippilink - February 5th, 2021
- Engelbert Humperdinck begs for prayers as his wife has Covid and Alzheimer's - Mirror Online - February 5th, 2021
- Global Magnetic Resonance, Computed Tomography, and Nuclear Medicine Imaging Market Landscape Assessment By Type, Opportunities And Higher Growth Rate... - February 5th, 2021
- Could Implicit Bias Affect Imaging Screens in the Pediatric ED? - PatientEngagementHIT.com - February 5th, 2021
- From Madinah to the Muslim world: A new museum dedicated to the life of the Prophet - Arab News - February 5th, 2021
- New Jersey Health And Wellness Clinic The Youth Fountain Is Offering Holistic Weight Loss Treatments - Press Release - Digital Journal - February 5th, 2021
- Sports Medicine Market Present Scenario, Key Vendors, Industry Share, and Growth Forecast up to 2028 KSU | The Sentinel Newspaper - KSU | The... - February 5th, 2021
- Aesthetic Medicine and Cosmetics Market Size And Forecast (2020-2026)| With Post Impact Of Covid-19 By Top Leading Players- NuYu Medispa,Medica... - February 5th, 2021
- This Is The Largest Barrier To Medical Cannabis Use In Florida - The Fresh Toast - February 3rd, 2021
- New clinics to change face of health care in Grand Forks - Grand Forks Herald - February 3rd, 2021
- More new restaurants are coming to the Philadelphia area. Heres what they will be serving. - The Philadelphia Inquirer - February 3rd, 2021
- Legendary MD Anderson faculty member Dr. Emil J Freireich passes away at 93 - HOUSTON Emil J Freireich M.D. a trailblazing oncologist who developed... - February 3rd, 2021
- [Full text] Non-Surgical Interventions for Hospitalized Adults with Class II or Cl | DMSO - Dove Medical Press - February 3rd, 2021
- Lighted Mirror Medicine Cabinets Consumption Market Report By Application, Type, Top Companies, Growth, Regional Outlook, and Forecast to 2027 ... - February 3rd, 2021
- Regenerative Medicine Market-Segmentation And Analysis By Recent Trends, Development And Growth By Regions To, Analysis, Forecast To 2026 - The... - February 3rd, 2021
- Husband-and-Wife Medical Duo Confront the Deficiencies of America's Healthcare System in New Documentary - PRNewswire - February 1st, 2021
- Reviving Mind Introduces 360 Mental Health Therapy and Wellness program - Woburn Daily Times - February 1st, 2021
- Opioid Management in the Dying Child With Addiction - American Academy of Pediatrics - February 1st, 2021
- Wellness foods often get seen through a Western lens. These Bay Area Asian Americans are trying to reclaim them - San Francisco Chronicle - January 30th, 2021
- What Is Health and Wellness? Article - MedicineNet - January 30th, 2021
- SkinCeuticals Announces Opening Of SkinLab In Partnership With Cosmetic Surgery Institute - PRNewswire - January 30th, 2021
- What Is a Mental Health Counselor? Plus Where You Can Find One - Healthline - January 30th, 2021
- How this New York medical school boosted diversity by 45% - American Medical Association - January 28th, 2021
- Fernwood Holistic Health: 'Right now, it's more important than ever to take care of your health' - Shoreline Times - January 28th, 2021
- Sri Ramakrishna Hospital's Holistic Approach to Childcare and Advice on How to Deal with Fevers in Babies and Children - PR Newswire India - January 28th, 2021
- Clever Care Health Plan Announces Addition to Board of Directors - PR Web - January 28th, 2021
- St. Petersburg clinic touts ancient form of cupping to heal muscles, reduce inflammation - FOX 13 Tampa Bay - January 28th, 2021
- SkinCeuticals Announces Opening Of SkinLab In Partnership With Cosmetic Surgery Institute - Monterey County Weekly - January 28th, 2021
- Lakeshore part of MENTOR program for rehabilitation and wellness - UAB News - January 28th, 2021
- Naturopathy 101 with Saimaa Miller are you open to holistic healing? - Prestige Online - January 28th, 2021