Reviewing the Literature on Calorie Restriction and Oxidative Stress
Posted: June 16, 2013 at 2:54 am
Oxidative theories of aging place the blame for the damage of aging on reactive oxidizing molecules, generated most notably in the mitochondria of your cells, and which tend to break the protein machinery they react with. Oxidative stress is the term given to ongoing damage (and efforts to repair it) caused by the presence of oxidative molecules in and around cells. Levels of oxidative stress can alter as a result of heat, exposure to ionizing radiation, the details of diet, and all sorts of other environmental influences.
The relationship between oxidative stress and the pace of aging is far from straightforward, however. There is more oxidative stress with age, but this is an expected result of carrying a high level of cellular and molecular damage. Some very long-lived species, such as naked mole rats, show very high levels of oxidative stress but don't appear to be particularly harmed by it. Mild oxidative stress can be beneficial, triggering increased cellular maintenance for a time to produce a net benefit. Oxidative compounds are also widely used in our biochemistry for necessary signaling purposes.
You can see the nature of this complex relationship between oxidative stress and aging by looking at what happens in interventions that reliably slow aging and extend life, such as calorie restriction in rodents:
Oxidative stress is observed during aging and in numerous age-related diseases. Dietary restriction (DR) is a regimen that protects against disease and extends lifespan in multiple species. However, it is unknown how DR mediates its protective effects. One prominent and consistent effect of DR in a number of systems is the ability to reduce oxidative stress and damage. The purpose of this review is to comprehensively examine the hypothesis that dietary restriction reduces oxidative stress in rodents by decreasing reactive oxygen species (ROS) production and increasing antioxidant enzyme activity, leading to an overall reduction of oxidative damage to macromolecules.
The literature reveals that the effects of DR on oxidative stress are complex and likely influenced by a variety of factors, including sex, species, tissue examined, types of ROS and antioxidant enzymes examined, and duration of DR. [In] a majority of studies, dietary restriction had little effect on mitochondrial ROS production or antioxidant activity. On the other hand, DR decreased oxidative damage in the majority of cases. Although the effects of DR on endogenous antioxidants are mixed, we find that glutathione levels are the most likely antioxidant to be increased by dietary restriction, which supports the emerging redox-stress hypothesis of aging.
While thinking about antioxidants and their effect on aging, it's important to remember that location matters immensely. Ingested antioxidants of the sort you can buy in the store are convincingly demonstrated to do nothing for your health, and there is evidence to suggest that they are actually mildly harmful - for example by blocking some of the oxidant-based signaling mechanisms the body uses to dial up cellular housekeeping and muscle growth responses after exercise. Meanwhile researchers are demonstrating benefits in mice by targeting designed antioxidant compounds to the mitochondria in cells, the place that most oxidants are generated. Those antioxidants are not yet available for the rest of us, however. The antioxidant pills from the store don't deliver their contents to your mitochondria, and are thus not terribly helpful.
Link: http://www.ncbi.nlm.nih.gov/pubmed/23743291
- Grand Traverse Co. Health Department Seeks Volunteers for Hagerty Center Vaccination Clinics - 9&10 News - January 20th, 2021
- How to live longer: Should you skip breakfast to promote longevity? Doctor weighs in - Express - December 28th, 2020
- China Long Avoided Talking About Mental Health. Then Covid Hit. - The New York Times - December 22nd, 2020
- With fitness centers shut down due to COVID-19, home gyms are on the rise - SW News Media - December 10th, 2020
- Review: Equinox Takes Luxe Fitness Into The Wild at Their First Outdoor Gym in LA - InsideHook - September 30th, 2020
- Colorados fitness industry starting to reawaken, but some studios will never reopen - Loveland Reporter-Herald - June 16th, 2020
- In sickness and in health: North Spokane couple weds in front yard during pandemic - The Spokesman-Review - May 18th, 2020
- Furry Friends Provide Big Benefits - June 20th, 2018
- CT Nutrition Consultants - Registered Dietitian - July 12th, 2017
- Channel Update - Fitness & Football Videos Only! - Video - August 10th, 2014
- Measuring the Impact of Cytomegalovirus in Younger People - September 1st, 2013
- Decreased mTOR Expression Provides 20% Mean Life Span Extension in Mice - September 1st, 2013
- A Collagen Patch to Spur Heart Tissue Repair - September 1st, 2013
- Statin Use Correlates With Higher Telomerase Activity - September 1st, 2013
- Children of Long-Lived Parents Have Better Immune Systems - September 1st, 2013
- A Two-Part Report on Global Futures 2045 - August 25th, 2013
- The Next Few Years of Research Into Alzheimer's Disease - August 25th, 2013
- A Look Back at Some of the Roots of Modern Thought on Radical Life Extension - August 25th, 2013
- Damaging the Biology of Mice to Make them Age More Rapidly Often Tells Us Little of Use - August 25th, 2013
- Calorie Restriction as a Means to Augment Cancer Therapies - August 25th, 2013
- Life Without Ageing: Aubrey de Grey and Tom Kirkwood to Debate Longevity Science at the British Science Festival - August 18th, 2013
- A Short Overview of 3-D Printing in Tissue Engineering - August 18th, 2013
- Another Way to Improve Memory in Old Mice - August 18th, 2013
- SENS Research Foundation Releases 2013 Research Report - August 18th, 2013
- Targeting Redox Biology to Reverse Mitochondrial Dysfunction - August 18th, 2013
- The Cost of Living Longer, Even in Good Health - August 11th, 2013
- Signs of Progress: Insurers Talk of Radical Life Extension - August 11th, 2013
- The Current State of Knowledge of Genetics and Longevity - August 11th, 2013
- A Video Tour of Alcor and Interview With Max More - August 11th, 2013
- And Now For Something Reprehensible - August 11th, 2013
- Opposing the Argument that Increased Longevity Will Slow Progress, and is Therefore Undesirable - August 4th, 2013
- Considering State Opposition to Life Extension Technologies - August 4th, 2013
- Steps Towards a Tissue Engineered Thymus - August 4th, 2013
- The Intersection of Kickstarter-Style Fundraising for Research and Distributed Development in Complex Problems - August 4th, 2013
- The Cost of Being Tall is a Shorter Life Expectancy - August 4th, 2013
- A Little Methionine Restriction Research - June 16th, 2013
- Calorie Restriction Versus Resveratrol Treatment - June 16th, 2013
- Arguing By Induction For an Absence of Boredom in an Ageless, Greatly Extended Healthy Life - June 16th, 2013
- Investigating Fingertip Regeneration in Mammals - June 16th, 2013
- The Incentives Associated With Becoming a Machine Entity - June 9th, 2013
- A Good Scientific Polemic on Aging - June 9th, 2013
- Quantifying Neurogenesis in Adult Humans - June 9th, 2013
- Considering the Details of Replacing the Brain - June 9th, 2013
- Overreacting in the Direction of Doing Nothing - June 9th, 2013
- Considering the Regenerative Signals Emitted by Transplanted Stem Cells - June 2nd, 2013
- A Bioprosthetic Heart - June 2nd, 2013
- Exercise Versus Peripheral Artery Disease - June 2nd, 2013
- Bracketed by Billionaires - June 2nd, 2013
- Stem Cell Transplants for Leukemia Showing Improved Outcomes - June 2nd, 2013
- Videos from the SENS Research Foundation Evidence Studios Event in December 2012 - May 26th, 2013
- Early Mortality Rates Predict Late Mortality Rates - May 26th, 2013
- Decellularization May Enable Use of More Donor Organs - May 26th, 2013
- Mitochondrially Targeted Antioxidant SS-31 Reverses Some Measures of Aging in Muscle - May 26th, 2013
- Arguing for the Role of Nuclear DNA Damage in Aging - May 26th, 2013
- Reviewing the Results of Calorie Restriction Primate Studies - May 19th, 2013
- A Possible Biomarker for Senescent Cells - May 19th, 2013
- Inhibiting ICMT as a Progeria Therapy - May 19th, 2013
- Are the Most Influential Futurists Those Who Put in the Work to Make Their Visions Real? - May 19th, 2013
- Excess Body Fat Hardens Arteries - May 19th, 2013
- Comments on Rapamycin and Metformin - May 12th, 2013
- The Present State of Artificial Retinas - May 12th, 2013
- The State of Electromechanical and Bioartifical Organs - May 12th, 2013
- Parabiosis Points to GDF-11 as a Means to Reverse Age-Related Cardiac Hypertrophy - May 12th, 2013
- Insights into Inflammaging - May 12th, 2013
- A Different Take on NF-?B and the Hypothalamus - May 5th, 2013
- T-Regulatory Cells More Numerous in the Aged Immune System - May 5th, 2013
- HMGA1 as a Potential Common Mechanism in Cancer - May 5th, 2013
- Recent Research Results from the Study of Naked Mole Rats - May 5th, 2013
- A Skeptical View of Mitochondrial DNA Damage and Aging - May 5th, 2013
- Recent Calorie Restriction Research - April 28th, 2013
- Joining the Dots in Genetic Parkinson's Disease - April 28th, 2013
- Considering the Electron Transport Chain in Aging - April 28th, 2013
- More Data on Granulocyte Transplant Cancer Therapies - April 28th, 2013
- Measures of Mitochondrial DNA Damage Lower in Long-Lived Mice - April 28th, 2013
- Aubrey de Grey on "The Undoing of Aging" - April 21st, 2013
- Mitochondrial Functional Mutations and Worm Longevity - April 21st, 2013
- Indy Mutations and Fly Longevity - April 21st, 2013
- Further Research on BubR1, Cellular Senescence, and Aging - April 21st, 2013
- Sterilized Dogs Live Longer - April 21st, 2013
- Robust Cancer Therapies Will Mean a Greater Use of Aggressive Stem Cell Therapies - April 14th, 2013